Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China

作     者：Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye Zhengtu Li;Yinhu Li;Ruilin Sun;Shaoqiang Li;Lingdan Chen;Yangqing Zhan;Mingzhou Xie;Jiasheng Yang;Yanqun Wang;Airu Zhu;Guoping Gu;Le Yu;Shuaicheng Li;Tingting Liu;Zhaoming Chen;Wenhua Jian;Qian Jiang;Xiaofen Su;Weili Gu;Liyan Chen;Jing Cheng;Jincun Zhao;Wenju Lu;Jinping Zheng;Shiyue Li;Nanshan Zhong;Feng Ye

作者机构：State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Beijing YuanShengKangTai(ProtoDNA)Genetech Co.Ltd.Beijing 100190China Department of Pulmonary and Critical Care MedicineGuangdong Second Provincial General HospitalGuangzhou 510317China Department of Computer ScienceCity University of Hong KongHong Kong 999077China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第12期

页      面：2129-2143页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the Guangzhou Institute of Respiratory Health Open Project(Funds provided by China Evergrande Group)(2020GIRHHMS14) Zhongnanshan Medical Foundation of Guangdong Province(2020B1111340004 and ZNSA-2020003) the Traditional Chinese Medicine Bureau of Guangdong Province(2020ZYYJ05) the funding from Guangzhou Institute of Respiratory Health 

主　　题：SRAS-CoV-2 longitudinal virological changes viral genome host gene expression 

摘      要：Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been ***,the clinical outcome and pathogenesis remain *** this study,we recruited 43 laboratory-confirmed COVID-19 *** found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom ***,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies ***,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P0.01 and FDR0.01)and increased when G227A occurred(P0.05 and FDR0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P0.05 and false discovery rate0.05).Prolonged viral RNA shedding often occurs but may not increase disease *** viral RNA shedding is associated with viral mutations and host factors.