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Chinese Physics B 2024年第8期33卷 248-252页

作者：樊光琦杨志杰孙烽豪郑金梅韩云天黄明谦刘情操 College of Science Harbin Institute of TechnologyWeihai 264209China School of Information Science and Engineering Harbin Institute of TechnologyWeihai 264209China Harbin Institute of Technology Weihai 264209China

Using the semiclassical ensemble model,the dependence of relative amplitude for the recollision dynamics in nonsequential double ionization(NSDI)of neon atom driven by the orthogonally polarized two-color field(OTC)laser field is theoretically *** the dynamics in two typical collision pathways,recollision-impact-ionization(RII)and recollisionexcitation with subsequent ionization(RESI),is systematically *** results reveal that the V-shaped structure in the correlated momentum distribution is mainly caused by the RII mechanism when the relative amplitude of the OTC laser field is zero,and the first ionized electrons will quickly skim through the nucleus and share few energy with the second *** the relative amplitude increases,the V-shaped structure gradually disappears and electrons are concentrated on the diagonal in the electron correlation spectrum,indicating that the energy sharing after electrons collision is symmetric for OTC laser fields with large relative *** studies show that changing the relative amplitude of the OTC laser field can efficiently control the electron–electron collisions and energy exchange efficiency in the NSDI process.

关键词： nonsequential double ionization correlated electron–electron momentum distribution energy sharing of electrons orthogonally polarized two-color field laser field semiclassical ensemble models

Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1258-1270页

作者： Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu Huiping Guo Yuxin Chen Honghai Tang Daqi Wang mingqian huang Zheng-Yi Chen Xingxu huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key Laboratory of Hearing Medicine(Fudan University) Shanghai 200032China State Key Laboratory of Agrobiotechnology China Agricultural UniversityBeijing 100193China College of Biological Sciences China Agricultural UniversityBeijing 100193China School of Life Science and Technology Southeast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck Surgery Graduate Program in Speech and Hearing Bioscience and Technology and Program in NeuroscienceHarvard Medical SchoolBostonMA 02115USA Eaton-Peabody Laboratory Massachusetts Eye and Ear InfirmaryBostonMA 02114USA School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Institutes of Brain Science and the Collaborative Innovation Center for Brain Science Fudan UniversityShanghai 200031China

CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene ***,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in *** first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(***)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole ***,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction ***,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 ***,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond.

关键词： CRISPR/Cas editing hearing

Shoulder adhesive capsulitis in cancer patients undergoing positron emission tomography-computed tomography and the association with shoulder pain

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World Journal of Radiology 2021年第10期13卷 344-353页

作者： Daichi Hayashi Elaine Gould Robert Shroyer Eric van Staalduinen Jie Yang Musa Mufti mingqian huang Department of Radiology State University of New York at Stony BrookStony BrookNY 11794United States Department of Family Population and Preventive MedicineStony Brook MedicineStony BrookNY 11794United States

BACKGROUND Adhesive capsulitis is a relatively common condition that can develop in cancer patients during *** emission tomography-computed tomography(PET-CT)is routinely performed as a follow-up study in cancer patients after *** aware of PET-CT findings to suggest shoulder adhesive capsulitis may help to alert clinicians for the diagnosis of unsuspected shoulder *** To assess the association of shoulder adhesive capsulitis with cancer/therapy type and symptoms in cancer patients undergoing *** Our prospective study received Institutional Review Board *** informed consent was obtained from all patients,who answered a questionnaire regarding shoulder pain/stiffness at the time of PET-CT study,between March 2015 and April *** with advanced glenohumeral arthrosis,metastatic disease or other mass in the shoulder,or shoulder arthroplasty were *** of shoulder capsule 18F-fluorodeoxyglucose(FDG)uptake were *** Uptake Value(SUV)max and SUVmean values were measured at rotator interval(RI)and deltoid muscle in bilateral *** SUV(SUV of RI/SUV of deltoid muscle)was also *** assessed if SUV values are different between symptomatic and asymptomatic patients in both *** were age,gender,and therapy type(surgery,chemotherapy,radiation).Wilcoxon rank sum tests were used to compare unadjusted marginal differences for age,SUV measurements between symptomatic and asymptomatic *** linear regression models were used to examine the relationship between right or left shoulder SUV measurements and symptom status,after adjusting for *** significance level was set at P<*** Of 252 patients initially enrolled for the study(mean age 66 years,67 symptomatic),shoulder PET-CT data were obtained in 200 patients(52 were excluded due to exclusion criteria above).The most common cancer types were lymphoma(n=61),lung(n=54)and

关键词： Adhesive capsulitis Positron emission tomography-computed tomography Cancer Shoulder Pain Imaging

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自我调节常识模型在慢性病管理中的研究进展

中华护理杂志 2023年第18期58卷 2293-2298页

作者：黄云萌刘于汪秧秧黄明倩华中科技大学同济医学院附属同济医院护理部武汉市430000

慢性病患者的疾病认知对其进行自我疾病管理十分重要,自我调节常识模型描述了患者通过自我调节加强理解和管理疾病的过程,为分析疾病表征、应对与健康结局的关系提供了理论框架。该文对自我调节常识模型的产生与发展、理论框架、在慢性... 详细信息

慢性病患者的疾病认知对其进行自我疾病管理十分重要,自我调节常识模型描述了患者通过自我调节加强理解和管理疾病的过程,为分析疾病表征、应对与健康结局的关系提供了理论框架。该文对自我调节常识模型的产生与发展、理论框架、在慢性病管理中的应用进行综述,旨在提高医护人员对自我调节常识模型的认识,为促进慢性病患者的健康管理提供依据。

关键词：自我调节常识模型慢性病护理综述

Transferrin Is Up-Regulated by Microbes and Acts as a Negative Regulator of Immunity to Induce Intestinal Immunotolerance

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Research 2024年第3期7卷 761-774页

作者： Xiaopeng Tang mingqian Fang Ruomei Cheng Junkun Niu Xiaoshan huang Kuanhong Xu Gan Wang Yang Sun Zhiyi Liao Zhiye Zhang James Mwangi Qiumin Lu Aili Wang Longbao Lv Chao Liu Yinglei Miao Ren Lai Engineering Laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)and Sino-African Joint Research CenterNew Cornerstone Science InstituteKunming Institute of Zoologythe Chinese Academy of SciencesNo.17 Longxin RoadKunmingYunnan650201China School of Basic Medicine Qingdao UniversityQingdao 266071ShandongChina. Department of Gastroenterology First Affiliated Hospital of Kunming Medical UniversityYunnan Institute of Digestive DiseaseKunming 650032YunnanChina Yunnan Province Clinical Research Center for Digestive Diseases Kunming 650032YunnanChina Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204YunnanChina Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences University of Science and Technology of ChinaHefei 230027AnhuiChina Center for Evolution and Conservation Biology Southern Marine Science and Engineering Guangdong LaboratoryGuangzhou 511458GuangdongChina.

Cross-talks (e.g., host-driven iron withdrawal and microbial iron uptake between host gastrointestinal tract and commensal microbes) regulate immunotolerance and intestinal homeostasis. However, underlying mechanisms that regulate the cross-talks remain poorly understood. Here, we show that bacterial products up-regulate iron-transporter transferrin and transferrin acts as an immunosuppressor by interacting with cluster of differentiation 14 (CD14) to inhibit pattern recognition receptor (PRR) signaling and induce host immunotolerance. Decreased intestinal transferrin is found in germ-free mice and human patients with ulcerative colitis, which are characterized by impaired intestinal immunotolerance. Intestinal transferrin and host immunotolerance are returned to normal when germ-free mice get normal microbial commensalism, suggesting an association between microbial commensalism, transferrin, and host immunotolerance. Mouse colitis models show that transferrin shortage impairs host’s tolerogenic responses, while its supplementation promotes immunotolerance. Designed peptide blocking transferrin–CD14 interaction inhibits immunosuppressive effects of transferrin. In monkeys with idiopathic chronic diarrhea, transferrin shows comparable or even better therapeutic effects than hydrocortisone. Our findings reveal that by up-regulating host transferrin to silence PRR signaling, commensal bacteria counteract immune activation induced by themselves to shape host immunity and contribute for intestinal tolerance.

关键词： impaired immunity tolerance

基于人因工程理论的护理人力资源预测模型研究

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护理研究 2023年第1期37卷 52-61页

作者：黄明倩刘于汪秧秧黄云萌华中科技大学同济医学院附属同济医院湖北430030 华中科技大学同济医学院护理学院

目的:基于人因工程理论探索护理工作量的影响因素,构建护理人力资源预测模型。方法:回顾性收集2020年7月—2021年6月武汉市某三级甲等综合性医院149个护理单元的工作量和相关资料,采用逐步回归构建护理工作量预测模型。选取2021年7月—2... 详细信息

目的:基于人因工程理论探索护理工作量的影响因素,构建护理人力资源预测模型。方法:回顾性收集2020年7月—2021年6月武汉市某三级甲等综合性医院149个护理单元的工作量和相关资料,采用逐步回归构建护理工作量预测模型。选取2021年7月—2021年12月共计10个住院部护理单元的工作量对预测模型进行验证。结果:不同单元的床位使用率、护理分级Ridit值、职业风险、病例组合指数和平均住院日对其护理工作量有影响(P<0.001);建立护理人力资源预测模型:某护理单元应配备护士人数=各护理单元护士总人数×(-2028065.592+522787.791×床位使用率+2130102.936×护理分级Ridit值+20274.444×职业风险+194676.133×CMI-37701.479×平均住院日)/总加权护理工作量。结论:基于人因工程理论构建的护理人力资源预测模型具有较强的实用性,可为各医疗机构科学配置护理人力资源提供依据。

关键词：人因工程理论护理工作量预测模型护理人力资源护理管理

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A thermodynamic perspective on electrode poisoning in solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1449-1455页

作者： Kevin huang Department of Mechanical Engineering University of South CarolinaColumbiaUSA

A critical challenge to the commercialization of clean and high-efficiency solid oxide fuel cell(SOFC)technology is the insuf-ficient stack lifespan caused by a variety of degradation mechanisms,which are associated with cell components and chemical *** components related degradation refers to thermal/chemical/electrochemical deterioration of cell materials under operating conditions,whereas the latter regards impurities in feedstocks of oxidant(air)and reductant(fuel).This article provides a thermodynamic perspective on the understanding of the impurities-induced degradation mechanisms in *** discussion focuses on using thermodynamic ana-lysis to elucidate poisoning mechanisms in cathodes by impurity species such as Cr,CO_(2),H_(2)O,and SO_(2) and in the anode by species such as S(or H_(2)S),SiO_(2),and P_(2)(or PH_(3)).The author hopes the presented fundamental insights can provide a theoretical foundation for search-ing for better technical solutions to address the critical degradation challenges.

关键词： impurities air fuel reaction activity

Fast Blood Oxygenation through Hemocompatible Asymmetric Polymer of Intrinsic Microporosity Membranes

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Research 2024年第1期2023卷 261-270页

作者： Xinxi huang Junping huang Pengcheng Su Wanbin Li Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

Membrane technology has attracted considerable attention for chemical and medical applications,among *** organs play important roles in medical science.A membrane oxygenator,also known as artificial lung,can replenish O_(2) and remove CO_(2) of blood to maintain the metabolism of patients with cardiopulmonary ***,the membrane,a key component,is subjected to inferior gas transport property,leakage propensity,and insufficient *** this study,we report efficient blood oxygenation by using an asymmetric nanoporous membrane that is fabricated using the classic nonsolvent-induced phase separation method for polymer of intrinsic *** intrinsic superhydrophobic nanopores and asymmetric configuration endow the membrane with water impermeability and gas ultrapermeability,up to 3,500 and 1,100 gas permeation units for CO_(2) and O_(2),***,the rational hydrophobic–hydrophilic nature,electronegativity,and smoothness of the surface enable the substantially restricted protein adsorption,platelet adhesion and activation,hemolysis,and thrombosis for the ***,during blood oxygenation,the asymmetric nanoporous membrane shows no thrombus formation and plasma leakage and exhibits fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 ml m^(−2) min^(−1),respectively,which are 2 to 6 times higher than those of conventional *** concepts reported here offer an alternative route to fabricate high-performance membranes and expand the possibilities of nanoporous materials for membrane-based artificial organs.

关键词： porosity asymmetric Oxygen

Sintering of phosphor-glass composites goes ultrafast

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Science China Materials 2024年第8期67卷 2711-2712页

作者： Xiaoyong huang College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China

Nowadays,with the rapid technological progress of high-quality lightings and high-end displays,high-power white light-emitting diodes(WLEDs)and high-brightness white laser diodes(WLDs)featuring with high energy density excitation,high output power and high device stability have been extensively investigated and regarded as the new-generation solid-state light sources[1–6].

关键词： diodes WLED white

Quantifying the strength of magnetic fields using baryon electric charge correlation

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Nuclear Science and Techniques 2024年第8期35卷 5-8页

作者： Xu‑Guang huang Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics National Natural Science Foundation of China and Fudan UniversityShanghai 200438China

Although heavy-ion collisions generate strong magnetic fields,their direct measurement is a challenging task.A new observable,the baryon electric charge correlation,was recently found to be sensitive to the magnetic field strength and thus could be used as a magnetometer for heavy-ion ***,this observable may shed light on the equation of state and phase structure of quantum chromodynamics(QCD)under magnetic *** and understanding the phase structure of quantum chromodynamics(QCD)is important in contemporary physics[1].

关键词： charge observable magnetic