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Current Medical Science 2021年第5期41卷 880-887页

作者： Yuan-jun DENG Xue-ping LIN Xiao-qing LI Ping-fan LU Yang CAI Le-le LIU Guang-chang PEI min han Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Diagnosis of immunoglobulin A nephropathy(IgAN)requires the evaluation of renal biopsy ***,renal biopsy is an invasive procedure and is not frequently performed for various ***,recognized noninvasive biomarkers for predicting IgAN progression are urgently ***:In the present study,we included 86 IgAN patients with renal biopsy from June 2015 to May 2016 and had their plasma interleukin-7(IL-7)level measured with *** association between the plasma IL-7 level and clinico-pathological characteristics was *** staining was used to assay the in situ expression of IL-7 in *** blotting was perfonned to examine the production of extracellular matrix,p-mTOR and the markers of autophagy under the treatment of IL-7 after TGF-β1 stimulation in renal tubular epithelial ***:IL-7 was significantly decreased in patients with IgAN compared to healthy subjects(2.3077 vs.8.6294 pg/mL,Pming growth factor β1-induced extracellular matrix production by suppression of cellular autophagy via activation of mTOR1 ***:These results suggested that IL-7 might be a noninvasive biomarker for predicating *** protected renal proximal tubular epithelial cells from cellular fibrosis by inhibiting autophagy via mTORl signaling.

关键词： IgA nephropathy biomarker IL-7 cellular fibrosis

Crustal Movement in the Northern Part of North China Associated with Zhangbei Earthquake

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Earthquake Research in China 2002年第1期16卷 81-89页

作者： Yang Guohua, Wang min, and han YuepingFirst First Crustal Deformation Monitoring Center China Seismological Bureau Tianjin 300180 China

Crustal Deformation Monitoring Center, China Seismological Bureau, Tianjin 300180, China Crustal deformation in the northern part of North China associated with Zhangbei earthquake is analyzed using GPS data collected during 1992, 1996 and 1999, precise re-leveling data collected during 1992, 1998 and 2000, and INSAR result (September 22, 1997～May 6, 1998). The results indicate: ① The vertical deformation is not remarkable since 1992. The vertical crustal deformation in the central and northern part of North China in recent 10 years is of inheritance. The scope of the significant deformation is 15km×15km with a magnitude of 250mm when the event occurred. ② The horizontal deformation is not remarkable in any unit of North China. ③ Before and after the event (1992～1996 and 1996～1999), there is kinematic change of horizontal motion between different units. The activity mode along Yinshan tectonic zone changed from relative static state to left-lateral strike slip; The dominant extensional movement along Shanxi rift zone changed to right-lateral strike slip; Yanshan tectonic zone changed from left-lateral strike-slip with extension to left-lateral strike slip; Yanshan-Hebei transitional zone formed before the event disappeared after the event. ④ The scale of the deformation is closely related to the physical property of media and geological structure environment. Further analysis indicates that ① Zhangbei earthquake does not mean that the earthquake activity begins to be strengthened in North China; ② The crustal movement is normal at present; ③ Next stronger earthquake in North China might be located in Yanshan tectonic zone, especially at its both ends, and Shanxi tectonic zone.

关键词： Northern part of North China GPS INSAR Crustal movement Zhangbei earthquake Trend of earthquake activity

Gas-Phase Deposited Plasmonic Nanoparticles Supported on 3D-Graphene/Nickel Foam for Highly SERS Detection

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Chinese Journal of Chemical Physics 2019年第2期32卷 200-206,I0002页

作者： Peng Mao Qiang Chen Guang-hou Wang min han College of Electronic and Optical Engineering & College of Microelectronics Nanjing University of Posts and Telecommunications Nanjing 210023 China School of Physics and Astronomy University of Birmingham B15 2TT United Kingdom National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences and Collaborative Innovation Centre of Advanced Microstructures Nanjing University Nanjing 210093 China

In this work, we proposed a novel three-dimensional (3D) plasmonic nanostructure based on porous graphene/nickel foam (GNF) and gas-phase deposited Ag nanoparticles (NPs). Ag NPs with high density were directly deposited on the surface of 3D GNF by performing a novel cluster beam deposition approach. In comparison with traditional Ag substrate (SiO2/Ag), such hot-spots enriched 3D nanostructure showed extremely high electromag-netic field enhancement under incident light irradiation which could be used as a sensitive chemical sensor based on surface enhanced Raman scattering (SERS). The experimental results demonstrated that the proposed nanostructure showed superior SERS performance in terms of Raman signal reproducibility and sensitivity for the probe molecules. 3D full-wave simulation showed that the enhanced SERS performance in this 3D hierarchical plasmonic nanostructure was mainly obtained from the hot-spots between Ag NPs and the near-field coupling between Ag NPs and GNF sca olds. This work can provide a novel assembled SERS substrate as a SERS-based chemical sensor in practical applications.

关键词： Plasmonic Cluster beam Nanoparticle Graphene Surface enhanced Raman

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基于互信息的选择性集成核极端学习机

控制与决策 2015年第11期30卷 2089-2092页

作者：韩敏吕飞大连理工大学控制科学与工程学院辽宁大连116024

针对集成学习中的准确性和差异性平衡问题,提出一种基于信息论的选择性集成核极端学习机.采用具有结构简单、训练简便、泛化性能好的核极端学习作为基学习器.引入相关性准则描述准确性,冗余性准则描述差异性,将选择性集成问题转化为变... 详细信息

针对集成学习中的准确性和差异性平衡问题,提出一种基于信息论的选择性集成核极端学习机.采用具有结构简单、训练简便、泛化性能好的核极端学习作为基学习器.引入相关性准则描述准确性,冗余性准则描述差异性,将选择性集成问题转化为变量选择问题.利用基于互信息的最大相关最小冗余准则对生成的核极端学习机进行选择,从而实现准确性和差异性的平衡.基于UCI基准回归和分类数据的仿真结果验证了所提出算法的优越性.

关键词：互信息选择性集成核方法极端学习机

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强化属性依赖关系的K阶贝叶斯分类模型

控制与决策 2019年第6期34卷 1234-1240页

作者：王利民姜汉民吉林大学计算机科学与技术学院长春130012

经典K阶贝叶斯分类模型(KDB)进行属性排序时,仅考虑类变量与决策属性间的直接相关,而忽略以决策属性为条件二者之间的条件相关.针对以上问题,在KDB结构的基础上,以充分表达属性间的依赖信息为原则,强化属性间的依赖关系,提升决策属性对... 详细信息

经典K阶贝叶斯分类模型(KDB)进行属性排序时,仅考虑类变量与决策属性间的直接相关,而忽略以决策属性为条件二者之间的条件相关.针对以上问题,在KDB结构的基础上,以充分表达属性间的依赖信息为原则,强化属性间的依赖关系,提升决策属性对分类的决策表达,利用类变量与决策属性间的条件互信息优化属性次序,融合属性约简策略剔除冗余属性,降低模型结构复杂带来的过拟合风险,根据贪婪搜索策略选择最优属性并构建模型结构.在UCI机器学习数据库中数据集的实验结果表明,该模型相比于KDB而言,具有更好的分类精度和突出的鲁棒性.

关键词：智能推理贝叶斯网络属性依赖强化属性次序优化属性约简冗余属性

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基于改进典型相关分析的混沌时间序列预测

大连理工大学学报 2008年第2期48卷 292-297页

作者：韩敏魏茹大连理工大学电子与信息工程学院辽宁大连116024

典型相关分析是目前常用的研究两个变量集间相关性的统计方法.针对线性典型相关分析法不能揭示变量间非线性关系,因而不适用于混沌系统等问题,将核典型相关分析与径向基函数神经网络相结合,提出了一种改进的核典型相关分析方法以解决映... 详细信息

典型相关分析是目前常用的研究两个变量集间相关性的统计方法.针对线性典型相关分析法不能揭示变量间非线性关系,因而不适用于混沌系统等问题,将核典型相关分析与径向基函数神经网络相结合,提出了一种改进的核典型相关分析方法以解决映射空间样本未知及逆矩阵求解困难等问题.首先利用两个径向基函数神经网络,通过训练使两个网络输出之间的相关系数达到最大,可同时得到两组典型相关变量.然后建立预测模型,对Lorenz混沌方程及大连月气温与降雨二变量混沌时间序列进行仿真,并与传统的线性回归预测方法进行比较,多组仿真结果证明了所述方法的有效性.

关键词：混沌时间序列预测典型相关分析核方法径向基函数神经网络

中国艾滋病发病和死亡的循环周期特征与非线性预测

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中华疾病控制杂志 2025年第1期29卷 55-60页

作者：刘超白莎莎韩敏董梦琪张娟娟河北大学统计学系保定071000 河北省公共卫生安全重点实验室保定071000 河北大学公共卫生学院预防医学系保定071002

目的分析中国艾滋病(acquired immunodeficiency syndrome,AIDS)发病和死亡的波动规律,揭示其循环周期特征,并预测短期内中国AIDS发病和死亡的情况。方法基于Census X-3季节调整法,分析中国2004年1月―2024年2月AIDS发病和死亡的季节... 详细信息

目的分析中国艾滋病(acquired immunodeficiency syndrome,AIDS)发病和死亡的波动规律,揭示其循环周期特征,并预测短期内中国AIDS发病和死亡的情况。方法基于Census X-3季节调整法,分析中国2004年1月―2024年2月AIDS发病和死亡的季节特征,在剔除季节因素影响后,使用霍德里克-普雷斯科特(Hodrick-Prescott,HP)滤波法剖析AIDS发病和死亡的循环周期特征,并借助非线性回归分析模型预测中国2024年3―12月AIDS的发病和死亡情况。结果中国AIDS发病和死亡数持续增加,各年份AIDS的发病和死亡具有季节性和趋势性变动特征,发病高峰期集中于每年的9―10月,死亡高峰期集中于每年的7―8月。中国AIDS的发病和死亡在2004年1月―2024年2月大致分为4个完整的循环周期,平均循环周期长度为60个月,且循环周期振动幅度不稳定。AIDS的发病和死亡随时间变化的关系曲线呈倒“U”型。结论中国AIDS发病和死亡的循环周期变长,预测结果显示中国AIDS发病和死亡将呈下降趋势,应密切关注AIDS流行情况,并积极采取防范与控制措施。

关键词：艾滋病发病死亡循环周期特征非线性预测

Scalp electroacupuncture at the Baihui acupoint (DU 20) improves functional recovery in rats with cerebral ischemia Association with increased expression of vascular endothelial growth factors

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Neural Regeneration Research 2011年第36期6卷 2822-2828页

作者： min-Wook Kim You Chul Chung Hee Chan Jung Moon-Seo Park Young-min han Yong-An Chung Lee-So Maeng Sang-In Park Jiyeon Lim Seung Chan Kim Woo-Seok Im Jin Young Chung minky Kim Manho Kim Institute of Catholic Integrative Medicine (ICIM) Incheon St. Mary’s Hospital Catholic University of Korea Incheon Korea Department of Rehabilitation Medicine Catholic University of Korea Seoul Korea Department of Neurology Seoul National University Hospital SNUMRC Seoul Korea Department of Biotechnology Yonsei University Seoul Korea Department of Neurology Seoul Medical Center Seoul Korea

In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.

关键词： electroacupuncture cerebrovascular disorder vascular endothelial growth factor Baihui acupoint functional improvement

Synthesis and Magnetic Properties of Gd_(3)(Fe, Co, Cr)_(29) Compounds

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Chinese Physics Letters 2001年第7期18卷 969-972页

作者： WANG Wen-Quan WANG Jian-Li YANG Dong TANG Ning YANG Fu-ming WU Guang-Heng JIN han-min State Key Laboratory of Magnetism Institute of PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics Jilin universityChangchun 130023

Formation and magnetic properties of the Gd_(3)Fe_(29-x-y)Co_(x)Cr_(y) compounds have been *** has been found that formation of single phase compounds Gd_(3)Fe_(29-x-y)Co_(x)Cr_(y) with Nd_(3)(Fe,Ti)_(29)-type structure depends strongly on the content of stabilizing element Cr,and the solid-solution limit of Co in Gd_(3)Fe_(29-x-y)Co_(x)Cr_(y) compounds increases with Cr *** Co-based Gd_(3)Co_(29-y)Cr_(y) compounds with Nd_(3)(Fe,Ti)_(29)-type structure have been successfully synthesized with y=6.5 and *** Curie temperature Tc of Gd_(3)Fe_(29-x-y)Co_(x)Cr_(y) compounds increases with increasing Co content x at fixed y,whereas increase of the Cr content leads to an obvious decrease of Tc of the Gd_(3)Co_(29-y)Cr_(y) *** dependence of the saturation magnetization at 5 K reaches a maximum around x=7.5 and y=*** is worth noting that substitution of Co for Fe results in a significant change of magnetocrystalline anisotropy of the Gd_(3)Fe_(29-x-y)Co_(x)Cr_(y) compounds and changes the easy magnetization direction from basal-plane to easy-axis when x>10 and y=4.

关键词： magnetization content substitution

Identification of MBF2 family genes in Bombyx mori and their expression in different tissues and stages and in response to Bacillus bombysepticus infection and starvation

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Insect Science 2016年第4期23卷 502-512页

作者： Chun-Yan Zhou Xing-Fu Zha Chun Liu min-Jin han Li-Ying Zhang Pan-Pan Shi He Wang Ren-Wen Zheng Qing-You Xia State Key Laboratory of Silkworm Genome Biology Southwest University Chongqing China

The Multiprotein bridge factor 2 （MBF2） gene was first identified as a coactivator involved in BmFTZ-F 1-mediated activation of the Fushi tarazu gene. Herein, nine homologous genes of MBF2 gene are identified. Evolutionary analysis showed that this gene family is insect-specific and that the family members are closely related to response to pathogens （REPAT） genes. Tissue distribution analysis revealed that these genes could be expressed in a tissue-specific manner. Developmental profiles analysis showed that the MBF2 gene family members were highly expressed in the different stages. Analysis of the expression patterns of nine MBF2 family genes showed that Bacillus bombysepticus treatment induced the up-regulation of several MBF2 family genes, including MBF2-4, -7, -9, -8. Furthermore, we found the MBF2 family genes were modulated by starvation and the expression of these genes recovered upon re-feeding, except for MBF2-5, -9. These findings suggested roles for these proteins in insect defense against pathogens and nutrient metabolism, which has an important guiding significance for designing pest control strategies.

关键词： immunity nutrient metabolism physiology whole-genome scanning