Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis

作     者：Yuan-jun DENG Xue-ping LIN Xiao-qing LI Ping-fan LU Yang CAI Le-le LIU Guang-chang PEI Min HAN Yuan-jun DENG;Xue-ping LIN;Xiao-qing LI;Ping-fan LU;Yang CAI;Le-le LIU;Guang-chang PEI;Min HAN

作者机构：Department of NephrologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2021年第41卷第5期

页      面：880-887页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from Huazhong University of Science and Technology Research Funds for Self-dependent Innovation(No.2017KFYXJJ101) the National Natural Science Foundation of China(No.81703058,No.81970591,and No.82000656) 

主　　题：IgA nephropathy biomarker IL-7 cellular fibrosis 

摘      要：Objective:Diagnosis of immunoglobulin A nephropathy(IgAN)requires the evaluation of renal biopsy ***,renal biopsy is an invasive procedure and is not frequently performed for various ***,recognized noninvasive biomarkers for predicting IgAN progression are urgently ***:In the present study,we included 86 IgAN patients with renal biopsy from June 2015 to May 2016 and had their plasma interleukin-7(IL-7)level measured with *** association between the plasma IL-7 level and clinico-pathological characteristics was *** staining was used to assay the in situ expression of IL-7 in *** blotting was perfonned to examine the production of extracellular matrix,p-mTOR and the markers of autophagy under the treatment of IL-7 after TGF-β1 stimulation in renal tubular epithelial ***:IL-7 was significantly decreased in patients with IgAN compared to healthy subjects(2.3077 vs.8.6294 pg/mL,P0.0001).There was a significant difference in the plasma IL-7 level between tubular atrophy/interstitial fibrosis TO and T2 classes(P=0.0064).A lower plasma IL-7 value in patients at the time of biopsy indicated a poor renal *** addition,IL-7 was over-expressed in renal tubular epithelial cells and significantly attenuated transforming growth factor β1-induced extracellular matrix production by suppression of cellular autophagy via activation of mTOR1 ***:These results suggested that IL-7 might be a noninvasive biomarker for predicating *** protected renal proximal tubular epithelial cells from cellular fibrosis by inhibiting autophagy via mTORl signaling.