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Customizable design ofmultiple-biomolecule delivery platform for enhanced osteogenic responses via‘tailored assembly system’

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Bio-Design and Manufacturing 2022年第3期5卷 451-464页

作者： Hyun lee min-kyu lee Ginam Han Hyoun-Ee Kim Juha Song Yuhyeon Na Chang-Bun Yoon SeKwon Oh Tae-Sik Jang Hyun-Do Jung Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon 14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon 14662Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL 60208USA Biomedical Implant Convergence Research Center Advanced Institutes of Convergence TechnologySuwon 443-270Republic of Korea School of Chemical and Biomedical Engineering Nanyang Technological University70 Nanyang DriveSingapore 637457Singapore Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do 15073Republic of Korea Surface R&D Group Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

Porous titanium(Ti)scaffolds have been extensively utilized as bone substitute scaffolds due to their superior biocompatibility and excellent mechanical ***,naturally formed TiO2 on the surface limits fast *** biomolecules have been widely utilized to overcome this issue;however,homogeneous porous Ti scaffolds could not simultaneously deliver multiple biomolecules that have different release *** this study,functionally graded porous Ti scaffolds(FGPTs)with dense inner and porous outer parts were fabricated using a two-body combination and densification *** with growth factor(BMP-2)and antibiotics(TCH)exhibited suitable mechanical properties as bone substituting material and presented good structural *** release of BMP-2 was considerably prolonged,whereas the release of TCH was comparable to that of homogenous porous titanium scaffolds(control group).The osteogenic differentiation obtained using FGPTs was maintained due to the prolonged release of *** antimicrobial properties of these scaffolds were verified using *** in terms of prior release *** addition,various candidates for graded porous Ti scaffolds with altered pore characteristics were presented.

关键词： Functionally graded porous titanium scaffold Tailored assembly system Mechanical tunability Multiplebiomolecule delivery Bone tissue engineering

Construction of tantalum/poly(ether imide)coatings on magnesium implants with both corrosion protection and osseointegration properties

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Bioactive Materials 2021年第4期6卷 1189-1200页

作者： Kwang-Hee Cheon Cheonil Park min-Ho Kang In-Gu Kang min-kyu lee Hyun lee Hyoun-Ee Kim Hyun-Do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheonGyeonggi-doRepublic of Korea Institute of Health Science Research Korea UniversitySeoul02841Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangjuRepublic of Korea

Poly(ether imide)(PEI)has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium(Mg),a potential candidate of biodegradable orthopedic implant ***,its innate hydrophobic property causes insufficient osteoblast affinity and a lack of ***,we modify the physical and chemical properties of a PEI-coated Mg implant.A plasma immersion ion implantation technique is combined with direct current(DC)magnetron sputtering to introduce biologically compatible tantalum(Ta)onto the surface of the PEI *** PEI-coating layer is not damaged during this process owing to the extremely short processing time(30 s),retaining its high corrosion protection property and adhesion *** Ta-implanted layer(roughly 10-nm-thick)on the topmost PEI surface generates long-term surface hydrophilicity and favorable surface conditions for pre-osteoblasts to adhere,proliferate,and ***,in a rabbit femur study,the Ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration *** results indicate that Ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications.

关键词： Magnesium Tantalum Poly(ether imide) Bio-functionalized coating Biodegradable orthopedic implants

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

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Bioactive Materials 2022年第3期7卷 239-250页

作者： min-kyu lee Hyun lee Cheonil Park In-Gu Kang Jinyoung Kim Hyoun-Ee Kim Hyun-Do Jung Tae-Sik Jang Department of Materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea Querrey Simpson Institute for Bioelectronics Northwestern UniversityEvanstonIL60208USA Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheon14662Republic of Korea Department of Biotechnology The Catholic University of KoreaBucheon14662Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju61452Republic of Korea

In recent years,pure iron(Fe)has attracted significant attention as a promising biodegradable orthopedic implant material due to its excellent mechanical and biological ***,in physiological conditions,Fe has an extremely slow degradation rate with localized and irregular degradation,which is problematic for practical *** this study,we developed a novel combination of a nanostructured surface topography and galvanic reaction to achieve uniform and accelerated degradation of an Fe *** target-ion induced plasma sputtering(TIPS)technique was applied on the Fe implant to introduce biologically compatible and electrochemically noble tantalum(Ta)onto its surface and develop surface nano-galvanic *** tests revealed that the uniformly distributed nano-galvanic corrosion cells of the TIPS-treated sample(nano Ta-Fe)led to relatively uniform and accelerated surface degradation compared to that of bare ***,the mechanical properties of nano Ta-Fe remained almost constant during a long-term in vitro immersion test(~40 weeks).Biocompatibility was also assessed on surfaces of bare Fe and nano Ta-Fe using in vitro osteoblast responses through direct and indirect contact assays and an in vivo rabbit femur medullary cavity implantation *** results revealed that nano Ta-Fe not only enhanced cell adhesion and spreading on its surface,but also exhibited no signs of cellular or tissue *** results demonstrate the immense potential of Ta-implanted surface nanostructures as an effective solution for the practical application of Fe-based orthopedic implants,ensuring long-term biosafety and clinical efficacy.

关键词： Iron Tantalum Ion implantation Biodegradation Orthopedic implants

关于典型火灾荷载下轰燃的支配因素研究(英文)

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消防科学与技术 2004年第1期23卷 15-19页

作者：李民圭韩国消防安全协会

为测量火灾实验的结果 ,必须研究导致火灾发生发展到出现轰燃的主要材料间的关系。文章提出 ,轰燃发生是由于可燃化学成分出现了快速分解所致。

关键词：火灾荷载轰燃实验

中日韩FTA的历史进程、阻碍因素及应对策略分析

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东北亚经济研究 2021年第4期5卷 59-70页

作者：马静李珉奎韩国国立釜庆大学校技术经营大学院韩国釜山48547

中日韩地理位置毗邻、文化源远流长,三国间的经贸关系在近20年间得到了迅速发展,在世界经贸中的份额和在国际经济中的地位日益重要。尽管中日韩三国之间有着潜力巨大的合作空间,但三国所在的东北亚地区尚未形成实质性的经济一体化。中... 详细信息

中日韩地理位置毗邻、文化源远流长,三国间的经贸关系在近20年间得到了迅速发展,在世界经贸中的份额和在国际经济中的地位日益重要。尽管中日韩三国之间有着潜力巨大的合作空间,但三国所在的东北亚地区尚未形成实质性的经济一体化。中日韩三国在现代服务产业各有比较优势,应大力发展基于中短期现代服务业类项目,并继续推动中日韩自贸协定的签署。

关键词：中日韩 FTA 历史进程应对策略

FEA technique of hot plate forming process using cell-typed die with cooling device

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中国有色金属学会会刊：英文版 2012年第S3期22卷 831-837页

作者： Jung-min lee In-kyu lee kyung-Hun lee Dae-Soon KIM Byung-min KIM Dongnam Regional Division Korea Institute of Industrial Technology School of Mechanical Engineering Pusan National University Industrial Technology Division Hyundai Heavy Industries

Hot plate forming using a cell-typed die is a process for forming a large thick plate with a spherical shape for the manufacture of a large spherical LNG ***-typed upper and lower dies made of a framework of steel plates fitted to make a grid pattern are used in this process,and an air-cooling device is separately installed inside the lower die.A finite element analysis (FEA) technique was developed,which included hot forming,air flow,cooling and thermal deformation analysis for the hot plate forming process using the cell-typed ***,the convective and interface heat transfer coefficients were used to reproduce analytically the effects of the cooling device in the hot plate forming analysis.A small-scale model test of the process was conducted to verify the FEA *** analysis results show that the curvature of the final plate agrees well with that of the designed experiment within a maximum relative error of 0.03% at the corner of the plate.

关键词： cell-typed die hot plate forming spherical LNG tank heat transfer coefficient

Estimation of plasma density perturbation from dusty plasma injection by laser irradiation on tungsten target in DiPS

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Plasma Science and Technology 2020年第4期22卷 90-96页

作者： In Je KANG min-Keun BAE In Sun PARK min Ji lee kyu-Sun CHUNG Department of Electrical Engineering Hanyang UniversitySeoul 133791Republic of Korea Plasma Technology Research Center National Fusion Research InstituteGunsan 54004Republic of Korea

To investigate the interaction of dusty plasma with magnetized plasmas at divertor plasma simulator,radial profiles of plasma density(ne)and electron temperature were measured in terms of plasma discharge currents and magnetic flux intensity by using a fast scanning probes system with triple *** plasma with dusts(a generation rate of 3μg s-1 and a size of 1–10μm)was produced via interactions between a high-power laser beam and a full tungsten *** ne increases,the scale of the effects of dusty plasma injection on magnetized plasmas was ***,the duration of transient fluctuation was *** numerical estimation of plasma density perturbation due to dusty plasma injection,the result was 10%at a core region of the magnetized plasma with ne of(2–5)×10^11 cm^-3 at steady state condition.

关键词： plasma density perturbation dusty plasma tungsten dust DiPS

Outcomes of men aged≤50 years treated with radical prostatectomy:a retrospective analysis

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Asian Journal of Andrology 2019年第2期21卷 150-155页

作者： Byeongdo Song Hakmin lee min Seung lee Sung kyu Hong Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Seoul National University College of MedicineSeoul 03080Korea

Previous studies inv estigating prostate can cer(PCa)features in youn ger men have reported con flicting fin *** study aimed to investigate pathologic outcomes and biochemical recurrenee(BCR)status in younger men who underwent radical prostatectomy(RP)for *** of 2057 patients who underwent RP at Seoul National University Bundang Hospital(Seongnam,Korea)between 2006 and 2015 were reviewed;patients were divided according to age into the younger and older groups(men aged50 years,respectively).Postoperative BCR status and functional outcomes and clinicopathologic features were compared betwee n both *** an alyses were repeated after propensity score matchi *** men were more likely to have lowrisk disease(P<0.001),lower pathologic Gleason score(P<0.001)and pathologic stages(P<0.001)than older *** pathologic Gleason score(P=0.002)and rates of extracapsular extension(P=0.004)were lower in younger men after propensity score *** multivariate analysis,age at RP was not an independent predictor of BCR-free survival after RP(P=0.669).Moreover,at 1 year after RP,younger men with preoperative 5?item International Index of Erectile Function score≥22(n=228)showed more favorable results for urinary con tine nee(defi ned as nonuse of pads daily)(99.4%vs 95%,P=0.009)and erections sufficie nt for vaginal in tercourse(81.8%vs 55.5%,P=0.001).Youn ger men had more favorable clinicopathologic features at RP than their older *** age was not an independent predictor of BCR status outcome,younger men had better functional outcomes following RP.

关键词： age group prostate cancer prostatectomy

Dispersion of ultrafine SiC particles in molten Al-12Si alloy

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 33-36页

作者： Jin-Ju PARK Sang-Hoon lee min-Ku lee Chang-kyu RHEE Nuclear Materials Research Division Korea Atomic Energy Research Institute Daejeon 305-353 Korea

The bulk A1-12 Si eutectic composites were fabricated through a conventional liquid metal casting route, especially with the help of ultrafine ceramic powders made by self-propagating high-temperature synthesis （SHS） process. The SHS powders were fabricated by the chemical reaction between micro-sized SiC and A1 particles at very high combustion temperatures, producing the coarse A1 particles （several tens of microns） containing ultrafine SiC ceramic particles. Microstructural observation revealed that the addition of ultrafine SiC particles has a crumbling tendency of Si eutectic phase. It is suggested that the casting method combined with SHS process is promising for fabricating the Al-based MMC with ultrafine ceramic particles.

关键词： AI-12Si alloy dispersion self-propagating high-temperature synthesis (SHS) ultrafine ceramic SiC