Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

作     者：Min-Kyu Lee Hyun Lee Cheonil Park In-Gu Kang Jinyoung Kim Hyoun-Ee Kim Hyun-Do Jung Tae-Sik Jang 

作者机构：Department of Materials Science and EngineeringSeoul National UniversitySeoul08826Republic of Korea Querrey Simpson Institute for BioelectronicsNorthwestern UniversityEvanstonIL60208USA Department of Biomedical-Chemical EngineeringCatholic University of KoreaBucheon14662Republic of Korea Department of BiotechnologyThe Catholic University of KoreaBucheon14662Republic of Korea Department of Materials Science and EngineeringChosun UniversityGwangju61452Republic of Korea 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第3期

页      面：239-250页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：This study was supported by the Technology Innovation Program(Material parts package business)(No.20001221 Development of high strength and fatigue resistance metal and manufacturing technology for root analogue dental implants)funded by the Ministry of Trade Industry&Energy(MOTIE Korea). 

主　　题：Iron Tantalum Ion implantation Biodegradation Orthopedic implants 

摘      要：In recent years,pure iron(Fe)has attracted significant attention as a promising biodegradable orthopedic implant material due to its excellent mechanical and biological properties.However,in physiological conditions,Fe has an extremely slow degradation rate with localized and irregular degradation,which is problematic for practical applications.In this study,we developed a novel combination of a nanostructured surface topography and galvanic reaction to achieve uniform and accelerated degradation of an Fe implant.The target-ion induced plasma sputtering(TIPS)technique was applied on the Fe implant to introduce biologically compatible and electrochemically noble tantalum(Ta)onto its surface and develop surface nano-galvanic couples.Electrochemical tests revealed that the uniformly distributed nano-galvanic corrosion cells of the TIPS-treated sample(nano Ta-Fe)led to relatively uniform and accelerated surface degradation compared to that of bare Fe.Furthermore,the mechanical properties of nano Ta-Fe remained almost constant during a long-term in vitro immersion test(~40 weeks).Biocompatibility was also assessed on surfaces of bare Fe and nano Ta-Fe using in vitro osteoblast responses through direct and indirect contact assays and an in vivo rabbit femur medullary cavity implantation model.The results revealed that nano Ta-Fe not only enhanced cell adhesion and spreading on its surface,but also exhibited no signs of cellular or tissue toxicity.These results demonstrate the immense potential of Ta-implanted surface nanostructures as an effective solution for the practical application of Fe-based orthopedic implants,ensuring long-term biosafety and clinical efficacy.