检索结果-南通市图书馆

Reconciling the Earth’s stratigraphic record with the structure of our galaxy

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2019年第6期10卷 2147-2151页

作者： michael Gillman Hilary Erenler school of Life sciences University of LincolnUK University of Northampton UK

The passage of our solar system through the spiral arms has been implicated as a contributor to global environmental *** suggestion of a consistent structure within the arms,informed by density wave theory,raises the possibility of repeating patterns of events at each arm *** we test the hypothesis that the structure of the arms of our galaxy influences the stratigraphic record on *** construct independent structural and temporal models and colbine these to compare the timings of arm tracers,materials from the earliest solar system and events on Earth,including the largest *** find that a recurring sequence of events across the four arms emerges with an average arm-passing time of 188 million *** suggest that the multiple temporal overlaps of events across arms,and their alignment with arm tracers and the earliest solar system,presents an opportunity for a greater understanding of both Earth-based phenomena and galactic structure.

关键词： spiral arms stratigraphy superchron Earliest solar system Extinctions Glaciations

Prion protein in myelin maintenance: what does the goat say?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第6期16卷 1216-1217页

作者： Fredrik s.skedsmo Arild Espenes michael A.Tranulis Department of Preclinical sciences and Pathology Norwegian University of Life SciencesOsloNorway

The cellular prion protein PrPC has been extensively studied because it can adopt a pathogenic three-dimensional conformation that causes rare,but invariably fatal,neurodegenerative prion diseases in humans and other *** disease-causing conformer of the protein is called PrPsc,of which oligomeric aggregates constitute prion agents that can bind to,and convert further,PrPC molecules into PrPsc(Prusiner,1998).Thus,in the poorly understood process of prion propagation,there is transfer of biological information encoded solely by protein *** can spread within a tissue secondary to a spontaneous conversion of PrPC to PrPsc or upon transmission of prion agents between individuals.

关键词： Prion convert invar

MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第5期16卷 531-537页

作者： Cameron M smith David I Watson michael Z michael Damian J Hussey Department of surgery Flinders University Room 3D211 Flinders Medical Centre Bedford Park South Australia 5042 Australia Department of Gastroenterology & Hepatology Flinders University Bedford Park South Australia 5042 Australia

Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer.

关键词： Barrett’s esophagus MicroRNA Esophageal adenocarcinoma Transdifferentiation Tumour suppressor

The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 149-160页

作者： NAssER MULLA YOUsEF KATIB AsIM M.ALMUGHAMsI DUAA s.ALKHAYAT MOHAMED MOsAAD sAMIR T.ALFOTIH RAWAN ALAOFI Department of Internal Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in saudi *** study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(Os).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in Os among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in Os(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the Os in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and Os(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in Os among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for Os were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with Os.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

What’s new in the 2020 World Health Organization Guidelines on Physical Activity and sedentary Behavior?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of sport and Health science 2021年第3期10卷 288-289页

作者： michael Pratt Herbert Wertheim school of Public Health&Human Longevity science University of California San DiegoLa JollaCA 92093-0628USA

Toward the end of 2020,the World Health Organization(WHO)released a new set of guidelines for physical activity and sedentary behavior.1 For any aspect of health,recognition by the WHO seems a good thing,and for the oft underappreciated field of physical activity,especially *** can we make of these guidelines?How much is really new?How strong is the science behind the guidelines?And will these guidelines really make a difference in population health around the world?In the following paragraphs,we will briefly address each of these questions.

关键词： really tar Health

The pelvic pop:an extremely rare case of internal penile fracture presenting with scrotal hematoma and review of the literature

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2021年第1期23卷 116-117页

作者： michael E Rezaee Martin s Gross section of Urology Department of SurgeryDartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756USA

Dear Editor,Penile fracture is an infrequent urologic emergency with a nationwide incidence of 1 in 100000 men in the United states.1 Blunt trauma during sexual intercourse(penile-perineal impact)is the primary cause of penile fracture,but a variety of alternative mechanisms of injury have been reported in the literature.2 The vast majority of penile fractures occur in the external corpus cavernosum and manifest with the classic“eggplant deformity.”The location of these fractures makes them amenable to repair through a circumcising,degloving incision.

关键词： fracture nationwide rare

Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica sinica 2015年第3期30卷 163-173页

作者： John s.Errett michael Gale Jr. Center for Innate Immunity and Immune Disease Department of Immunology School of Medicine University of Washington

Innate immunity is critical for the control of virus infection and operates to restrict viral susceptibility and direct antiviral immunity for protection from acute or chronic viral-associated diseases including cancer. RIG-I like receptors(RLRs) are cytosolic RNA helicases that function as pathogen recognition receptors to detect RNA pathogen associated molecular patterns(PAMPs) of virus infection. The RLRs include RIG-I, MDA5, and LGP2. They function to recognize and bind to PAMP motifs within viral RNA in a process that directs the RLR to trigger downstream signaling cascades that induce innate immunity that controls viral replication and spread. Products of RLR signaling also serve to modulate the adaptive immune response to infection. Recent studies have additionally connected RLRs to signaling cascades that impart inflammatory and apoptotic responses to virus infection. Viral evasion of RLR signaling supports viral outgrowth and pathogenesis, including the onset of viral-associated cancer.

关键词： RIG-I MDA5 pattern recognition receptor pathogen associated molecular pattern innate immunity virus infection

Controls of fault geometry and thermal stress on fault slip modes:Implications for permeability enhancement and injection-induced seismicity

在线全文

学校读者我要写书评

暂无评论

Petroleum Research 2021年第4期6卷 392-407页

作者： Dorcas s.Eyinla michael A.Oladunjoye Department of Geology Pan African UniversityLife and Earth Sciences Institute(PAULESI)University of IbadanIbadanNigeria Department of Earth sciences Adekunle Ajasin UniversityAkungba AkokoNigeria Department of Geology and Petroleum Geology School of GeosciencesUniversity of AberdeenAberdeenScotlandUnited Kingdom

Fluid pressurization within the fault zone generates increasing pore pressure and stress change which is liable to create shear and/or brittle fractures within the reservoir volumes and subsequently generating earthquakes of varying ***,we explored time-dependent fault weakening processes in the fault zone which are dependent on several factors,including the rate of cold-water injection,modes of injection(hydromechanical(HM)and thermo-hydro-mechanical(THM)interactions),and changing fault spatial configurations using data from Niger Delta *** variation in the stability of different fault models in withstanding stresses induced by HM and THM fluid interactions is *** permeability enhancement and the behaviour of slip event under isothermal and non-isothermal conditions revealed that stress and pore pressure perturbations have a first order control on the rate of fault dilation and *** is observed that the progressive cooling of the reservoir induced thermal stress which induced the timing of slip by unloading the fault to earlier seismic rupture in the non-isothermal case,and accelerates the magnitude of the fault reactivation and the accompanied induced *** to increased tendency of shear failure during injection,fracture opening through shear dilation is more enhanced in THM simulation as the fracture permeability is significantly higher than in *** effect becomes increasingly more dominant with intermediate fault angle and joint *** fault/joint configurations which were resistant to shear failure under isothermal injection had their frictional resistance broken by thermal *** results also indicate that there is higher pore pressure build-up in THM than in HM as the injection rate increases and reservoir temperature drops during cold injections..This study has demonstrated the importance of fully characterizing the fracture geometries and configurations of normal faulting regime in additio

关键词： Fault spatial arrangement Thermal stress Cold injection Injection-induced seismicity stress variation slip delay

Exotic parrots breeding in urban tree cavities: nesting requirements, geographic distribution, and potential impacts on cavity nesting birds in southeast Florida

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2019年第4期10卷 459-468页

作者： Joshua M.Diamond michael s.Ross Florida International University Earth & Environment

Background:Exotic parrots have established breeding populations in southeast Florida,including several species that nest in tree *** aimed to determine the species identity,nest site requirements,relative nest abundance,geographic distribution,and interactions of parrots with native cavity-nesting bird ***:We searched Miami-Dade County,Florida,and nearby areas for natural cavities and holes excavated by woodpeckers,recording attributes of potential nest *** inspected all cavities with an elevated video inspection system to determine occupancy by parrots or other *** mapped nearly 4000 citizen science observations of parrots in our study area corresponding to our study period,and used these to construct range maps,comparing them to our nesting ***:Not all parrots reported or observed in our study area were actively *** parrots were observed at tree cavities,which previous studies have suggested is evidence of reproduction,but our inspections with an elevated video inspection system suggest they never initiated nesting *** parrot species did successfully nest in tree cavities,Red-masked Parakeets(Psittacara erythrogenys)and Orange-winged Parrots(Amazona amazonica)being the most common(n=7 and 6 nests,respectively).These two parrots had similar nesting requirements,but Orange-winged Parrots use nests with larger entrance holes,which they often *** analysis of nests combined with citizen science data indicate that parrots are limited to developed *** most common parrots were less abundant cavity nesters than the native birds which persist in Miami’s urban areas,and far less abundant than the invasive European starling(sturnus vulgaris).Conclusions:Exotic parrots breeding elsewhere in the world have harmed native cavity-nesting birds through interference competition,but competitive interference in southeast Florida is minimized by the urban affinities of parrots in this ***

关键词： Amazona Cavity nest webs Invasive species Parakeets Psittacara Urban ecology