MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma
MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma作者机构：Department of Surgery Flinders University Room 3D211 Flinders Medical Centre Bedford Park South Australia 5042 Australia Department of Gastroenterology & Hepatology Flinders University Bedford Park South Australia 5042 Australia
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2010年第16卷第5期
页 面：531-537页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Barrett’s esophagus MicroRNA Esophageal adenocarcinoma Transdifferentiation Tumour suppressor
摘 要：Barrett s esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett s esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett s esophagus and its progression to cancer.
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