Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity

作     者：John S.Errett Michael Gale Jr. 

作者机构：Center for Innate Immunity and Immune Disease Department of Immunology School of Medicine University of Washington 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2015年第30卷第3期

页      面：163-173页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by National Institutes of Health grants AI083019  AI104002  and AI88778 

主　　题：RIG-I MDA5 pattern recognition receptor pathogen associated molecular pattern innate immunity virus infection 

摘      要：Innate immunity is critical for the control of virus infection and operates to restrict viral susceptibility and direct antiviral immunity for protection from acute or chronic viral-associated diseases including cancer. RIG-I like receptors(RLRs) are cytosolic RNA helicases that function as pathogen recognition receptors to detect RNA pathogen associated molecular patterns(PAMPs) of virus infection. The RLRs include RIG-I, MDA5, and LGP2. They function to recognize and bind to PAMP motifs within viral RNA in a process that directs the RLR to trigger downstream signaling cascades that induce innate immunity that controls viral replication and spread. Products of RLR signaling also serve to modulate the adaptive immune response to infection. Recent studies have additionally connected RLRs to signaling cascades that impart inflammatory and apoptotic responses to virus infection. Viral evasion of RLR signaling supports viral outgrowth and pathogenesis, including the onset of viral-associated cancer.