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Study of glue extrusion after endoscopic N-butyl-2-cyanoacrylate injection on gastric variceal bleeding

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World Journal of Gastroenterology 2009年第39期15卷 4945-4951页

作者： Yan-mei Wang liu-fang Cheng Nan Li Kai Wu Jun-Shan Zhai Ya-Wen Wang Department of Gastroenterology the Second Affiliated Hospital of PLA General Hospital Beijing 100091 China

AIM:To investigate glue extrusion after endoscopic N-butyl-2-cyanoacrylate injection on gastric variceal bleeding and to evaluate the long-term efficacy and safety of this ***:A total of 148 cirrhotic patients in our hospital with esophagogastric variceal bleeding(EGVB) were included in this study.N-butyl-2-cyanoacrylate was mixed with lipiodol in a 1:1 ratio and injected as a bolus of 1-3 mL according to variceal *** underwent endoscopic follow-up the next week,fourth week,second month,fourth month,and seventh month after injection and then every 6 mo to determine the cast *** abdominal X-ray fi lm and ultrasound or computed tomographic scan were also carried out in order to evaluate the time of variceal disappearance and complete extrusion of the *** average follow-up time was 13.1 ***:The instantaneous hemostatic rate was 96.2%.Early re-bleeding after injection in 9 cases(6.2%) was estimated from rejection of *** re-bleeding occurred in 12 patients(8.1%) at 2-18 *** glue cast was extruded into the lumen within one month in 86.1% of patients and eliminated within one *** erosion was seen at the injection position and mucosa edema in the second *** glue casts were extruded in 18 patients(12.1%) after one week and in 64 patients(42.8%) after two *** kinds of glue clumping shapes and colors on endoscopic examination were observed in 127 patients(86.1%) within one month,including punctiform,globular,pillar and *** one patients(27.9%) had glue extrusion after 3 mo and 28 patients(28.9%) after six *** extrusion time was not related to the injection volume of *** was seen in 70.2%(104 cases) *** main complication was re-bleeding resulting from *** prognosis of the patients depended on the severity of the underlying liver ***:Endoscopic injection of cyanoacrylate is highly effective for gastric varices *** glue clump

关键词： Gastric variceal bleeding Glue extruded N-butyl-2-cyanoacrylate Portal hypertension

N^2-(1-Methoxycarbonylethyl)guanosine,a new nucleoside coupled with an amino acid derivative from Amanita exitialis

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Chinese Chemical Letters 2009年第7期20卷 830-832页

作者： Yu Lang Chi Hui Ye Zhang Jing Hua Xue Jing Hao mei fang liu Xiao Yi Wei South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

A new purine nucleoside coupled with an amino acid derivative, N^2-（l-methoxycarbonylethyl）guanosine 1, along with β- carboline and russulaceramide was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom. Its structure was elucidated by spectroscopic methods. This is the first report of naturally occurring nucleosides in which an a-amino acid derivative is bonded through its a-amino nitrogen to a nucleobase aglycone by a C-N bond. The new compound was found to be toxic in brine shrimp lethality test （BST）. C 2009 Published by Elsevier B.V. on behalf of Chinese Chemical Society.

关键词： N^2-(1-Methoxycarbonylethyl)guanosine Guanosine Purine alkaloid Nucleoside Amanita Amanita exitialis

Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators

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World Journal of Stem Cells 2024年第6期16卷 670-689页

作者： Ying Gao mei-fang liu Yang Li Xi liu Yu-Jie Cao Qian-Fa Long Jun Yu Jian-Ying Li Department of Respiratory and Critical Care Medicine Shaanxi Provincial Rehabilitation HospitalXi’an 710000Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Ningxia Medical University(The First People’s Hospital of Yinchuan)Yinchuan 750001Ningxia Hui Autonomous RegionChina School of Clinical Medicine Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Neurosurgery Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Emergency Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina

BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung *** cell therapy and mesenchymal stem cells-extracellular vesicles(MSC-EVs)offer new hope for PF *** To investigate the therapeutic potential of MSC-EVs in alleviating fibrosis,oxidative stress,and immune inflammation in A549 cells and bleomycin(BLM)-induced mouse *** The effect of MSC-EVs on A549 cells was assessed by fibrosis markers[collagen I andα-smooth muscle actin(α-SMA),oxidative stress regulators[nuclear factor E2-related factor 2(Nrf2)and heme oxygenase-1(HO-1),and inflammatory regu-lators[nuclear factor-kappaB(NF-κB)p65,interleukin(IL)-1β,and IL-2].Similarly,they were assessed in the lungs of mice where PF was induced by BLM after MSC-EV ***-EVs ion PF mice were detected by pathological staining and western ***-cell RNA sequencing was performed to investigate the effects of the MSC-EVs on gene expression profiles of macrophages after modeling in *** Transforming growth factor(TGF)-β1 enhanced fibrosis in A549 cells,significantly increasing collagen I andα-SMA ***,treatment with MSC-EVs demonstrated a remarkable alleviation of these ***,the expression of oxidative stress regulators,such as Nrf2 and HO-1,along with inflammatory regulators,including NF-κB p65 and IL-1β,were mitigated by MSC-EV ***,in a parallel manner,MSC-EVs exhibited a downregulatory impact on collagen deposition,oxidative stress injuries,and inflammatory-related cytokines in the lungs of mice with ***,the mRNA sequencing results suggested that BLM may induce PF in mice by upregulating pulmonary collagen fiber deposition and triggering an immune inflammatory *** findings collectively highlight the potential therapeutic efficacy of MSC-EVs in ameliorating fibrotic processes,oxidative stres

关键词： Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis Oxidative stress response Epithelial-mesenchymal transition

A New Cytotoxic Acetogenin from the Seeds of Annona squamosa

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Chinese Chemical Letters 2003年第6期14卷 588-590页

作者： Hai Hui XIE, Xiao Yi WEI*, Ji Dong WANG, mei fang liu, Ren Zhou YANG South China Institute of Botany, Chinese Academy of Sciences, Guangzhou 510650 South China Institute of Botany Chinese Academy of Sciences

A new Annonaceous acetogenin, squamostolide (1), was isolated from the seeds of Annona squamosa. Its structure was elucidated based on spectroscopic methods and comparison with known compounds. It is the first example of Annonaceous acetogenin with each of the two ends of the aliphatic chain bearing a g-lactone. The new compound exhibited cytotoxic activity in vitro against bel-7402 and CNE2 human tumor cell lines.

关键词： Annona squamosa Annona acetogenins squamostolide cytotoxicity.

Soil Heavy Metal Pollution Around the Dabaoshan Mine,Guangdong Province,China

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Pedosphere 2007年第5期17卷 588-594页

作者： ZHOU Jian-Min DANG Zhi CAI mei-fang liu Cong-Qiang College of Environmental Science and Engineering South China University of Technology Guangzhou 510640 （China） Guangdong Key Laboratory of Agro-Environment Integrated Control Guangdong Institute of Eco-Environment and Soil Science Guangzhou 510650 （China） State Key Laboratory of Environment Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 （China）

Soil contamination in the vicinity of the Dabaoshan Mine, Guangdong Province, China, was studied through determi- nation of total concentrations and chemical speciation of the toxic metals, Cu, Zn, Cd, and Pb, using inductively coupled plasma mass spectrometry. The results showed that over the past decades, the environmental pollution was caused by a combination of Cu, Zn, Cd, and Pb, with tailings and acid mine drainage being the main pollution sources affecting soils. Significantly higher levels （P ≤ 0.05） of Cu, Zn, Cd, and Pb were found in the tailings as compared with paddy, garden, and control soils, with averages of 1486, 2516, 6.42, and 429 mg kg^-1, respectively. These metals were continuously dispersed downstream from the tallings and waste waters, and therefore their concentrations in the paddy soils were as high as 567, 1 140, 2.48, and 191 mg kg^-1, respectively, being significantly higher （P ≤ 0.05） as compared with those in the garden soils. The results of sequential extraction of the above metals from all the soil types showed that the residual fraction was the dominant form. However, the amounts of metals that were bound to Fe-Mn oxides and organic matter were relatively higher than those bound to carbonates or those that existed in exchangeable forms. As metals could be transformed from an inert state to an active state, the potential environmental risk due to these metals would increase with time.

关键词： chemical speciation combined pollution index (CPI) contaminated soil heavy metals

Molecular Cloning and Characterization of Human Homeobox Gene Nkx3.1 Promoter

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Acta Biochimica et Biophysica Sinica 2004年第1期36卷 64-67页

作者： An-Li JIANG, Jian-Ye ZHANG, Charles YOUNG, Xiao-Yan HU, Yong-mei WANG, Zhi-fang liu, and mei-Lan HAO ( Department of Biochemistry, School of medicine, Shandong University, Ji'nan 250012, China ' Department of Urology Research, Mayo Clinic ) Present address: Department of biochemistry, Health School of Ji'nan Department of Biochemistry School of medicine Shandong University Ji'nan 250012 China

Nkx3.l is a prostate-specific homeobox gene related strongly to prostate development and prostate cancer. To study its regulation of transcription, 1.06 kb 5' flanking region of Nkx3.1 gene and its 5' deletion mutants (861, 617, 417 and 238 bp) were obtained by PCR and cloned into pGL3-basic, a promoter-less luciferase reporter vector, to examine their promoter activities driving the reporter gene transcription. pRL-TK, a Renilla luciferase reporter vector was used as internal control, and pGL3-control and pGL3-basic were used as positive and negative control respectively. The promoter activities were determined by dual-luciferase reporter assay 48 h after pGL3 constructs were cotransfected with pRL-TK into prostate cancer cell LNCaP. The results showed that dual-luciferase reporter assay (M1/M2) of pGL3-1.06 kb cotransfection with pRL-TK was 2.7, which was about 1.5-fold higher than that of pGL3-control cotrans-fection with pRL-TK and 50-fold higher than that of pGL3-basic cotransfection with pRL-TK. T

关键词： homeobox gene Nkx3.1 promoter deletion mutagenesis LNCaP cell line

传搁时间约束下的运输与批处理机生产协调调度

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控制与决策 2017年第6期32卷 995-1000页

作者：宫华张二梅刘芳沈阳理工大学理学院沈阳110159

针对炼钢模铸系统钢锭高温运作的特点,提出带有传搁时间约束的生产前运输与批处理机生产协调的调度问题.工件的加工时间依赖于其传搁时间,每批工件的加工时间为该批工件中加工时间最大值.目标函数为最小化总完工时间与生产费用的线性组... 详细信息

针对炼钢模铸系统钢锭高温运作的特点,提出带有传搁时间约束的生产前运输与批处理机生产协调的调度问题.工件的加工时间依赖于其传搁时间,每批工件的加工时间为该批工件中加工时间最大值.目标函数为最小化总完工时间与生产费用的线性组合.通过复杂性分析,证明该问题是强NP难解问题.建立混合整数规划模型,基于动态规划提出两种特殊情况的最优算法,设计原问题的启发式算法并进行最坏情况下性能比分析.实验仿真结果验证了所提出启发式算法的有效性与稳定性.

关键词：批处理机运输协调传搁时间

Acupoint selection rules for acupoint application in lung diseases in the post-epidemic era

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TMR Integrative Medicine 2022年第2期6卷 1-10页

作者： An-Hong Dai Chun-Hong Luo Yi-Hao Zhou Gan Huang Zhi-Lin Huang Xue-Lian Zhang mei-fang liu Jing Shi You-Long Xiong Yunnan University of Traditional Chinese Medicine No.1076 Yuhua RoadChenggong DistrictKunming CityYunnan ProvinceChina The First Clinical Medical College of Yunnan University of Traditional Chinese Medicine Yunnan Provincial Hospital of Traditional Chinese MedicineNo.120 Guanghua StreetWuhua DistrictKunming CityYunnan ProvinceChina

Objective:To summarize the rules of acupoint selection of acupoint application to prevent and treat lung diseases under the background the post-epidemic era using data-mining ***:The CNKI,Wanfang database,and VIP database were searched for clinical study articles on lung diseases treated by acupoint application published in the past 5 ***-eligible papers were extracted to establish a database of acupoint application for lung disease using Microsoft Excel 2019,with the goal of analyzing the frequency of acupoints,acupoint-meridian association,acupoint-location association,specific acupoint frequency,and cluster *** rules,consisting of acupoints with an application frequency of≥10,were devised by the Apriori algorithm to explore the correlation between acupoint groups and to analyze the rules of the compatibility of acupoint ***:A total of 229 eligible papers met our inclusion ***-seven acupoints were applied,for a total frequency of acupoints of 1,035 *** these,acupoints for lung diseases were primarily distributed in the back-and-waist and chest-and-abdomen *** the analysis of the association rules,we obtained four groups of acupoint association rules based on acupoint clusters with a frequency≥10 and found that Feishu(BL 13),Tiantu(CV 22),Dazhui(GV 14),Dingchuan(EX-B1),and Danzhong(CV 17)constitute the core acupoints of prescriptions for clinical acupoint application to prevent and treat lung ***:It is clearly shown that the core acupoints are relatively concentrated and that the selected acupoints were mainly locally selected,which could be a matching reference for the long-term prevention and treatment of lung diseases,including COVID-19.

关键词： Acupoint application Lung diseases Acupoint selection rules Post-epidemic era Data-mining Association rules Cluster analysis

Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei liu Shilong fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives