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Genes & Diseases 2024年第3期11卷 72-74页

作者： Sha Yang mei deng Yunbiao Xiong Bing Xiong Junwu Fu Jia Wang Jiqin Zhang Guoqiang Han Jian Liu Ying Tan Guizhou University Medical College GuiyangGuizhou 550025China Department of Neurosurgery Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Anesthesiology Guizhou Provincial People's HospitalGuiyangGuizhou 550002China Department of Neurosurgery Chongqing Emergency Medical CenterChongqing400000China

The important role of immunogenic cell death(ICD)in many tumors is increasingly being ***,its mechanisms and potential as a biomarker and therapeutic target in glioblastoma(GBM)have not been well *** obtained GBM samples from the Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)databases,as well as the immunotherapy cohort from the IMvigor210 *** used unsupervised clustering to obtain two ICDrelated clusters,corresponding to the ICD-low and ICD-high subtypes respectively,and the tumor immune microenvironment and prognosis of the two subtypes were significantly different.

关键词： immune Cancer prognosis

A machine learning model for diagnosing acute pulmonary embolism and comparison with Wells score,revised Geneva score,and Years algorithm

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Chinese Medical Journal 2024年第6期137卷 676-682页

作者： Linfeng Xi Han Kang mei deng Wenqing Xu Feiya Xu Qian Gao Wanmu Xie Rongguo Zhang Min Liu Zhenguo Zhai Chen Wang Capital Medical University Beijing 100069China National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and MultimorbidityNational Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical SciencesDepartment of Pulmonary and Critical Care MedicineCenter of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Advanced Research Infervision Medical Technology Co.Ltd.Beijing 100025China Department of Radiology China-Japan Friendship HospitalBeijing 100029China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730China Department of Radiology Peking University China-Japan Friendship School of Clinical MedicineBeijing 100191China

Background:Acute pulmonary embolism(APE)is a fatal cardiovascular disease,yet missed diagnosis and misdiagnosis often occur due to non-specific symptoms and signs.A simple,objective technique will help clinicians make a quick and precise *** population studies,machine learning(ML)plays a critical role in characterizing cardiovascular risks,predicting outcomes,and identifying *** work sought to develop an ML model for helping APE diagnosis and compare it against current clinical probability assessment ***:This is a single-center retrospective *** with suspected APE were continuously enrolled and randomly divided into two groups including training and testing sets.A total of 8 ML models,including random forest(RF),Naïve Bayes,decision tree,K-nearest neighbors,logistic regression,multi-layer perceptron,support vector machine,and gradient boosting decision tree were developed based on the training set to diagnose ***,the model with the best diagnostic performance was selected and evaluated against the current clinical assessment strategies,including the Wells score,revised Geneva score,and Years ***,the ML model was internally validated to assess the diagnostic performance using receiver operating characteristic(ROC)***:The ML models were constructed using eight clinical features,including D-dimer,cardiac troponin T(cTNT),arterial oxygen saturation,heart rate,chest pain,lower limb pain,hemoptysis,and chronic heart *** eight ML models,the RF model achieved the best performance with the highest area under the curve(AUC)(AUC=0.774).Compared to the current clinical assessment strategies,the RF model outperformed the Wells score(P=0.030)and was not inferior to any other clinical probability assessment *** AUC of the RF model for diagnosing APE onset in internal validation set was ***:Based on RF algorithm,a novel prediction model was finally constructed for AP

关键词： Acute pulmonary embolism Machine learning Wells score Revised Geneva score Years algorithm

Inverse-designed Jones matrix metasurfaces for high-performance meta-polarizers

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Chinese Optics Letters 2024年第2期22卷 192-199页

作者：王志强李枫竣邓倩媚万舟李向平邓子岚 Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou 510632China

Polarizers have always been an important optical component for optical engineering and have played an indispensable part of polarization imaging *** polarizers provide an excellent platform to achieve miniaturization,high resolution,and low cost of polarization imaging ***,we proposed freeform metasurface polarizers derived by adjoint-based inverse design of a full-Jones matrix with gradient-descent *** designed multiple freeform polarizers with different filtered states of polarization(SOPs),including circular polarizers,elliptical polarizers,and linear polarizers that could cover the full Poincaré*** that near-unitary polarization dichroism and the ultrahigh polarization extinction ratio(ER)reaching 50 d B were achieved for optimized circular *** multiple freeform polarizers with filtered polarization state locating at four vertices of an inscribed regular tetrahedron of the Poincarésphere are designed to form a full-Stokes parameters micropolarizer *** work provides a novel approach,we believe,for the design of meta-polarizers that may have potential applications in polarization imaging,polarization detection,and communication.

关键词： metasurface inverse design Jones matrix polarization imaging

Investigating the mechanisms of isochorismate synthase:An approach to improve salicylic acid synthesis and increase resistance to Fusarium head blight in wheat

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The Crop Journal 2024年第4期12卷 1054-1063页

作者： Ya-Zhou Zhang Jie Man Dan Xu Lan Wen Yinghui Li mei deng Qian-Tao Jiang Qiang Xu Guo-Yue Chen Yu-Ming Wei State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina

Salicylic acid(SA),a vital endogenous hormone,plays a crucial role in plant growth and the response to abiotic and biotic *** synthase(ICS)and phenylalanine ammonia lyase(PAL)are critical rate-limiting enzymes for SA *** head blight(FHB)seriously threatens the safety of wheat production,but increasing the content of SA can enhance FHB ***,the pathway of SA synthesis and regulation in wheat remains *** this study,three wheat ICS(TaICSA,TaICSB,and TaICSD)were identified,and their functions were validated in vitro for isomerizing chorismate to *** mutation of one or two homoeoalleles of TaICSA,TaICSB,and TaICSD in the wheat variety‘Cadenza’reduced SA levels under ultraviolet treatment and Fusarium graminearum infection,further enhancing sensitivity to *** of TaICSA can significantly enhance SA levels and resistance to *** further study SA synthesis pathways in wheat and avoid interference with pathogenicity related genes,the leaves of wild-type Cadenza and different TaICS mutant lines were subjected to ultraviolet treatment for transcriptomic *** results showed that 37 PALs might be involved in endogenous SA synthesis,and 82 WRKY and MYB family transcription factors may regulate the expression of ICS and *** results were further confirmed by *** conclusion,this study expands our knowledge of SA biosynthesis and identifies TaICSA,as well as several additional candidate genes that encode transcription factors for regulating endogenous SA levels,as part of an efficient strategy for enhancing FHB resistance in wheat.

关键词： Salicylic acid Chorismate Isochorismate RNA-seq Phenylalamine ammonia lyase

Unraveling the efficacy network: A network meta-analysis of adjuvant external beam radiation therapy methods after hepatectomy

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 205-214页

作者： Gao-Yuan Yang Zhi-Wei He Yong-Chang Tang Feng Yuan Ming-Bo Cao Yu-Peng Ren Yu-Xuan Li Xiao-Rui Su Zhi-Cheng Yao mei-Hai deng Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of General Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery The First Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436Guangdong ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Primary liver cancer is a malignant tumor with a high recurrence rate that significantly affects patient *** adjuvant external radiation therapy(RT)has been shown to effectively prevent recurrence after liver cancer ***,there are multiple RT techniques available,and the differ-ential effects of these techniques in preventing postoperative liver cancer re-currence require further *** To assess the advantages and disadvantages of various adjuvant external RT methods after liver resection based on overall survival(OS)and disease-free survival(DFS)and to determine the optimal *** This study involved network meta-analyses and followed the PRISMA *** data of qualified studies published before July 10,2023,were collected from PubMed,Embase,the Web of Science,and the Cochrane *** included relevant studies on postoperative external beam RT after liver resection that had OS and DFS as the primary *** magnitudes of the effects were determined using risk ratios with 95%confidential *** results were analyzed using R software and STATA *** A total of 12 studies,including 1265 patients with hepatocellular carcinoma(HCC)after liver resection,were included in this *** was no significant heterogeneity in the direct paired comparisons,and there were no significant differences in the inclusion or exclusion criteria,intervention measures,or outcome indicators,meeting the assumptions of heterogeneity and *** analysis revealed that patients who underwent stereotactic body radiotherapy(SBRT)after resection had longer OS than those who underwent intensity modulated radiotherapy(IMRT)or 3-dimensional conformal RT(3D-CRT).DFS analysis revealed that patients who underwent 3D-CRT after resection had the longest *** who underwent IMRT after resection had longer OS than those who underwent 3D-CRT and longer DFS than those who underwent ***

关键词： Primary liver cancer Hepatocellular carcinoma Network meta-analysis External beam radiation therapy Stereotactic body radiotherapy Intensity modulated radiotherapy

洞庭湖流域典型生态系统服务评估及权衡/协同关系研究

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长江流域资源与环境 2024年第2期33卷 310-321页

作者：廖江博毛德华邓美容湖南师范大学地理科学学院湖南长沙410081 洞庭湖流域生态环境变化与固碳增汇湖南省重点实验室湖南长沙410081

运用InVEST模型、GIS空间分析等方法,在子流域尺度上探究洞庭湖流域2000~2020年生态系统服务的时空特征,进而利用耦合协调度模型和地理探测器模型对水产出、水质净化、碳存储等三项关键生态系统服务进行权衡/协同分析。结果表明:(1)洞... 详细信息

运用InVEST模型、GIS空间分析等方法,在子流域尺度上探究洞庭湖流域2000~2020年生态系统服务的时空特征,进而利用耦合协调度模型和地理探测器模型对水产出、水质净化、碳存储等三项关键生态系统服务进行权衡/协同分析。结果表明:(1)洞庭湖流域生态系统服务的水产出服务和水质净化服务在不断地强化,而碳存储服务在不断地弱化。各项生态系统服务功能在空间上亦表现出差异性,2000和2010年水产出东南多于西北,到了2020年,西北部水产出出现最大值;N、P输出量的分布规律大体上上游少于下游,东部多于西部;碳存储则是在洞庭湖区最少,高值集中在上游区。(2)2000~2020年,整个流域两两生态系统服务之间处于中度协同水平,并向良好协同水平发展,两两生态系统服务存在明显的时空分布格局的差异。(3)洞庭湖流域生态系统服务之间非线性动态关系的形成受到自然和人文因素的影响,主要包括地形地势与气候变化、土地利用类型与分布格局,以及人类活动的干扰等,且自然因素的影响程度要大于人文因素。研究结果可为洞庭湖流域生态保护补偿机制建设提供理论依据。

关键词：生态系统服务权衡与协同 InVEST模型洞庭湖流域

Fine mapping and characterization of stripe rust resistance gene YrAYH in near-isogenic lines derived from a cross involving wheat landrace Anyuehong

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The Crop Journal 2024年第3期12卷 826-835页

作者： Li Long Jue Li Linyu Huang Huiling Jin Fangnian Guan Haipeng Zhang Sasa Zhao Hao Li Zhien Pu Wei Li Qiantao Jiang Yuming Wei Jian Ma Houyang Kang Shoufen Dai Pengfei Qi Qiang Xu mei deng Youliang Zheng Yunfeng Jiang Matthew James Moscou Guoyue Chen State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina College of Resources Sichuan Agricultural UniversityChengdu 611130SichuanChina The Sainsbury Laboratory Norwich Research ParkNorwich NR47UHEnglandUK United States Department of Agriculture-Agricultural Research Service Cereal Disease LaboratorySt.PaulMN 55108USA

Stripe rust,caused by Puccinia striiformis ***(Pst),is a devastating disease in wheat *** and characterizing new resistance genes/QTL is crucial for wheat breeding *** this study,we fine-mapped and characterized a stripe rust resistance gene,YRAYH,on chromosome arm 5BL in the Chinese wheat landrace Anyuehong(AYH).Evaluations of stripe rust response to prevalent Chinese Pst races in near-isogenic lines derived from a cross of Anyuehong and Taichung 29 showed that YrAYH conferred a high level of resistance at all growth *** mapping using a large segregating population of 9748 plants,narrowed the YRAYH locus to a 3.7 Mb interval on chromosome arm 5BL that included 61 annotated *** analysis of two NIL pairs identified 64 upregulated differentially expressed genes(DEGs)in the resistant NILs(NILs-R).Annotations indicated that many of these genes have roles in plant disease resistance *** a combined approach of fine-mapping and transcriptome sequencing,we identified a serine/threonine-protein kinase SRPK as a candidate gene underlying YrAYH.A unique 25 bp insertion was identified in the NILs-R compared to the NILs-S and previously published wheat *** InDel marker was developed and co-segregated with *** trait evaluation of the NILs suggested that YrAYH not only reduces the impact of stripe rust but was also associated with a gene that increases plant height and spike length.

关键词： Candidate gene analysis Crop protection Puccinia striiformis Transcriptome analyses

专利视角下航空航天领域稀土应用技术分布研究

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稀土 2024年第1期45卷 149-158页

作者：魏凤邓阿妹谷山强李涛中国科学院武汉文献情报中心湖北武汉430071 科技大数据湖北省重点实验室湖北武汉430071 南瑞集团公司江苏南京211106 国网电力科学研究院武汉南瑞有限责任公司湖北武汉430074

稀土元素在航空航天领域的应用是国内外关注重要领域。针对稀土在航空航天领域应用的技术创新状况,主要运用科学计量学和数学统计等方法,从申请国家和主要专利权人角度,开展稀土元素应用技术专利分析,发现航空领域稀土元素全球专利自申... 详细信息

稀土元素在航空航天领域的应用是国内外关注重要领域。针对稀土在航空航天领域应用的技术创新状况,主要运用科学计量学和数学统计等方法,从申请国家和主要专利权人角度,开展稀土元素应用技术专利分析,发现航空领域稀土元素全球专利自申请以来整体呈现增长趋势,尤其在2000年以后专利申请非常活跃,数量较大。稀土专利主要分布在合金、非金属产品及应用技术方面,2017—2019年尤其以陶瓷镀膜和飞机动力技术的专利申请较多,是这三年的热点领域。中美两国专利申请均超过其他国家,我国主要专利集中在钕、镧、铈、钇、钪等元素的应用上,美国则较多集中在钪、钇、铒、铈、钕、铽等元素的应用上,该领域全球主要专利权人是欧美公司。建议我国加强稀土在航空航天领域的系统研究布局,通过国际合作和自主创新等多种方式,提升我国稀土材料高端技术研发创新水平。

关键词：稀土元素航空航天专利科学计量法技术创新

Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology:Three case reports

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World Journal of Clinical Cases 2024年第22期12卷 5208-5216页

作者： Qing-mei deng Jian Zhang Yi-Yong Zhang Min Jia Du-Shan Ding Yu-Qin Fang Hong-Zhi Wang Hong-Cang Gu Science Island Branch Graduate School of University of Science and Technology of ChinaHefei 230031Anhui ProvinceChina Institute of Health and Medical Technology Hefei Institutes of Physical ScienceChinese Academy of ScienceHefei 230031Anhui ProvinceChina Medical Pathology Center Hefei Cancer HospitalChinese Academy of SciencesHefei 230031Anhui ProvinceChina

BACKGROUND Infectious diseases are still one of the greatest threats to human health,and the etiology of 20%of cases of clinical fever is unknown;therefore,rapid identification of pathogens is highly *** culture methods are only able to detect a limited number of pathogens and are time-consuming;serologic detection has window periods,false-positive and false-negative problems;and nucleic acid molecular detection methods can detect several known pathogens only ***-generation nanopore sequencing technology provides new options for identifying *** SUMMARY Case 1:The patient was admitted to the hospital with abdominal pain for three days and cessation of defecation for five days,accompanied by cough and *** sequencing of the drainage fluid revealed the presence of orallike bacteria,leading to a clinical diagnosis of bronchopleural *** sodium sulbactam treatment was *** 2:The patient was admitted to the hospital with fever and headache,and CT revealed lung *** treatment for Streptococcus pneumoniae,identified through nanopore sequencing of cerebrospinal fluid,was *** 3:The patient was admitted to our hospital with intermittent fever and an enlarged neck mass that had persisted for more than six *** antibacterial treatment,her symptoms *** nanopore sequencing results indicate that voriconazole treatment is effective for Aspergillus *** patient was diagnosed with mixed cell type classical Hodgkin's lymphoma with *** Three-generation nanopore sequencing technology allows for rapid and accurate detection of pathogens in human infectious diseases.

关键词： Nanopore sequencing technology Third-generation sequencing technology Infection Pathogen Case report

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非综合征性先天性关节融合的遗传学研究进展

中华医学遗传学杂志 2024年第8期41卷 1001-1009页

作者：邓媚谌芳杨永佳南华大学儿科学院·湖南省儿童医院医学遗传科长沙410007

先天性关节融合(CJS)是胚胎发育过程中关节形态发生失败所导致的异常,在临床上又分为综合征性(sCJS)和非综合征性(nsCJS)。常见的sCJS包括染色体病(如克氏综合征等)和单基因病(如Apert/Pfeiffer/Crouzon综合征、Holt-Oram综合征、Ehlers... 详细信息

先天性关节融合(CJS)是胚胎发育过程中关节形态发生失败所导致的异常,在临床上又分为综合征性(sCJS)和非综合征性(nsCJS)。常见的sCJS包括染色体病(如克氏综合征等)和单基因病(如Apert/Pfeiffer/Crouzon综合征、Holt-Oram综合征、Ehlers-Danlos综合征和尺桡骨融合伴血小板减少症等),可累及多个系统及器官,而nsCJS仅累及单一或多个关节。迄今为止,已发现7个基因(NOG、GDF5、FGF9、GDF6、FGF16、SMAD6和MECOM)的变异可能导致nsCJS。本文聚焦于这些基因,并对nsCJS的临床表型、遗传模式、常见变异及其作用机制进行文献回顾,同时通过对关节形态发生的相关信号通路进行分析,探讨可能导致nsCJS的其他候选基因。

关键词：关节形态发生非综合征性先天性关节融合 NOG基因 GDF5基因 GDF6基因 FGF9基因 FGF16基因 SMAD6基因 MECOM基因