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Biosafety Management for Biomedical Research Institutions

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Biosafety Management for Biomedical Research Institutions

首届国际生物经济高层论坛

作者： Shan Lu,md,phd University Of Massachusetts Medical School,Worcester,MA 01605,USA

Biosafety is an important component for the management of modern biomedical research. This presentation will provide a framework regarding to the operation of biosafety management directly related to the regular resea...

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Update on clinical trials with inhaled nitric oxide

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Acta Pharmacologica Sinica 1997年第6期 59-61页

作者： Claes G FROSTELL, md, phd\ (Department of Paediatric Anaesthesia and Intensive Care, KS/St Goran’s Hospital, 112 81 Stockholm, Sweden)

ＵｐｄａｔｅｏｎｃｌｉｎｉｃａｌｔｒｉａｌｓｗｉｔｈｉｎｈａｌｅｄｎｉｔｒｉｃｏｘｉｄｅＣｌａｅｓＧＦＲＯＳＴＥＬＬ，ＭＤ，ＰｈＤ（ＤｅｐａｒｔｍｅｎｔｏｆＰａｅｄｉａｔｒｉｃＡｎａｅｓｔｈｅｓｉａａｎｄＩｎｔｅｎｓ... 详细信息

ＵｐｄａｔｅｏｎｃｌｉｎｉｃａｌｔｒｉａｌｓｗｉｔｈｉｎｈａｌｅｄｎｉｔｒｉｃｏｘｉｄｅＣｌａｅｓＧＦＲＯＳＴＥＬＬ，ＭＤ，ＰｈＤ（ＤｅｐａｒｔｍｅｎｔｏｆＰａｅｄｉａｔｒｉｃＡｎａｅｓｔｈｅｓｉａａｎｄＩｎｔｅｎｓｉｖｅＣａｒｅ，ＫＳ／ＳｔＧｏｒａ...

关键词： nitric oxide respiratory therapy neonatology clinical trials

NEW SILICON LINERS USED TRANS-TIBIAL PROSTESIS

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NEW SILICON LINERS USED TRANS-TIBIAL PROSTESIS

The 6th International Conference on Biomedical Engineering and Rehabilitation Engineering

作者： Y.Takakura RPT MS K.Akasaka RPT phd Y.Takahashi PRT Y.Tone RPT K.Ookuma RPT O.Okuma RPT K.Takahashi md phd Y.Ishikura PO N.Ogawa,PO S.Kusano,md,phd T.Suyama,md,phd Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan International University of Health and Welfare OtawaraTochigiJapan Ishikura Gishi Seisakujo HigashimatsuyamaSaitama Ishikura Gishi Seisakujo HigashimatsuyamaSaitama Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan Saitama Medical Center Saitama medical SchoolKawagoeSaitama 350-8550Japan

＜正＞ Purpose of this study is to clarify the characteristics of new silicon liners for trans-tibialprosthesis with 18 case studies. These liners made the prosthesis possible to be used fromearly stage after operation. These protect the skin of the stump and patients feel comfortable,because it has excellent traction and shock absorption. We conclude that it is best if patients

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抗中性粒细胞胞浆抗体相关血管炎的治疗——系统综述

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美国医学会杂志（中文版） 2008年第2期27卷 87-101页

作者： Xavier Bosch, md, phd Antonio Guilabert, md Gerard Espinosa, md, phd EduardMirapeix,md,phd 丁欣(译) 张文(校) Departments of Internal Medicine ( Dr Bosch) Dermatology Dermatology Autoimmune Diseases Nephrology 不详

背景：免疫抑制疗法可显著提高抗中性粒细胞胞浆抗体（antineutrophil cytoplasmic antibody，ANCA）相关血管炎患者的生存率，但同时也可使ANCA相关血管炎（***，AAV）转变成为一种慢性复发性疾病。因此，进行长期治疗、有效控制并发... 详细信息

背景：免疫抑制疗法可显著提高抗中性粒细胞胞浆抗体（antineutrophil cytoplasmic antibody，ANCA）相关血管炎患者的生存率，但同时也可使ANCA相关血管炎（***，AAV）转变成为一种慢性复发性疾病。因此，进行长期治疗、有效控制并发症已成为我们面临的主要挑战。过去10年来，世界各国一直通力协作，共同寻求有效的治疗方法。目地：对有关AAV治疗的证据进行分析，为医生处理不同临床病例提供合理的治疗对策。资料来源：在MEDLINE中检索1966年至2007年3月发表的有关AAV治疗的英文文献，对与本文密切相关的检出文献中的参考文献进行分析。研究选取：有关AAV患者现有药物治疗或医疗干预的研究均被入选。重复发表研究、病例报告以及小型（病例数不足10例）非对照试验均被排除。数据综合：共选取2项汇总分析、20项前瞻性随机对照试验以及62项病例数超过10例的非对照试验或观察性研究。不同试验之间的观测指标和治疗方案存在差异。若病变仅局限于上呼吸道，则通过单独应用磺胺甲基异恶唑或联合应用磺胺甲基异恶唑＋糖皮质激素来诱导并维持疾病缓解状态。对于患有系统性疾病但无器官受累的患者而言，甲氨喋呤＋糖皮质激素可取代环磷酰胺用于诱导缓解。以甲氨喋呤为维持治疗用药时，疾病复发的几率较高，因此需进行严密的监测。患有系统性疾病且有器官受累的患者可采用环磷酰胺冲击治疗＋糖皮质激素来诱导缓解。联合使用硫唑嘌呤＋泼尼松（每日用药）可有效维持病情缓解。目前，血浆置换是晚期肾病患者进行免疫抑制剂治疗的最佳辅助手段。Churg—Stauss综合征患者可先采用大剂量糖皮质激素治疗，临床症状缓解后予以减量。死亡风险较高的患者应使用环磷酰胺。结论：尽管AAV的治疗方案应视各患者特定的临床情况而定，但目前不同类型AAV的治疗证据仍很匮乏。临床上仍然需要更加安全、有效的药物。

关键词： ANCA相关血管炎抗中性粒细胞胞浆抗体长期治疗系统综述环磷酰胺冲击治疗糖皮质激素治疗随机对照试验慢性复发性疾病

Acute hypervolemic hemodilution of hydroxyl ethyl starch 40 increase the propofol requirement at the time to loss of consciousness

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Acute hypervolemic hemodilution of hydroxyl ethyl starch 40 ...

2008年第七次华东六省一市麻醉学学术会议暨浙江省麻醉学术年会

作者： Yah Xiang,MS,Yuhong Li~*,md,phd,Shengmei Zhu,md,phd Department of Anesthesiology,First Affiliated Hospital,School of medicine,Zhejiang University,Hangzhou,People’s Republic of China

Background:Preoperative Acute hypervolemic hemodilution(AHHD)is used in anesthesia to reduce the loss of blood ceils during intraoperative *** aim to this study was to evaluate the influence of the hypervolemic hemodi... 详细信息

关键词： Acute hypervolemic hemodilution propofol hydroxylethyl starch 40

Effect of acute hypervolemic hemodilution of hydroxylethyl starch 40 on EC50 for propofol at two clinical end-points in volunteer

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Effect of acute hypervolemic hemodilution of hydroxylethyl s...

2007年浙江省麻醉学学术年会

作者： Yuhong Li md phd Yan Xiang MS Shengmei Zhu md phd Department of Anesthesiology,First Affiliated Hospital,School of medicine,Zhejiang University,Hangzhou,People’s Republic of China

Background: Acute hypervolemic hernodilution(AHHD)is a common method to save and avoid homologue blood transfusion during surgery. The aim to this study was to evaluate the influence of the hypcrvolemic hemodilution ofhydroxylethyl starch 40 on the EC50 for Propofol at two clinical end-points. Methods: We studies 20 patients volunteer undergoing AHHD after epidural anesthesia and 20 patients not receiving hcmodilution as a control group. All patients were ASA gradeⅠand aged 20-40 yr and underwent hip arthroplasty surgery. In AHHD group lactated Ringer’s solution 10 ml/kg was infused over 30 min before induction of anesthesia. 20 minutes after receiving 15 ml of ropivcaine 0.5％ epidurally, hydroxylethyl starch 40(HES 4％)20 ml/kg was infused within 30 *** control group the patients received only lactated Ringer’s solution 10 ml/kg. Then propofol was delivered by a Diprifusor target-controlled infusion(TCI). Probit analysis was used to estimate population values for predicted blood and effect-site propofol concentrations at the clinical end-points. Results: in patients undergoing AHHD, the effect-site EC, EC and EC of propofol were increased by 17％-19％(P＜0.05)at the time of loss of consciousness and 11％～16％(P＜0.05)at the time of recovery of consciousness, respectively, as compared with the patients in control group. Conclusions: We concluded that the patients undergoing AHHD were about 10％ less sensitive to propofol than the control. This should be taken into account when propofol is used as hypnotics during AHHD.

关键词： Acute hypervolemic hemodilution propofol hydroxylethyl starch 40 EC50

鞘内注射甘氨酸转运体-2抑制剂ALX1393对急性疼痛模型大鼠的抗伤害性感受作用

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麻醉与镇痛 2012年第1期8卷 51-57页

作者： Yasunori Haranishi, md Koji Hara, md, phd Tadanori Terada, md Seiya Nakamura, md, phd Takeyoshi Sara, md, phd 胡江（译） Department of Anesthesiology University of Occupationaland Environmental Health School of Medicine Kitakyushu Department of Anesthesiology Faculty of Medicine University of the Ryukyus Okinawa Japan

背景脊髓灰质背角的甘氨酸能神经元与减轻外周炎症引起的脊髓疼痛和慢性疼痛有关。神经元异构体甘氨酸转运体-2（ClyT2）可重吸收突触前释放的甘氨酸并调节甘氨酸能神经传递。本实验目的即研究甘氨酸转运体-2抑制剂ALX1393鞘内注射对急... 详细信息

背景脊髓灰质背角的甘氨酸能神经元与减轻外周炎症引起的脊髓疼痛和慢性疼痛有关。神经元异构体甘氨酸转运体-2（ClyT2）可重吸收突触前释放的甘氨酸并调节甘氨酸能神经传递。本实验目的即研究甘氨酸转运体-2抑制剂ALX1393鞘内注射对急性疼痛模型大鼠是否有抗伤害性感受作用。方法给雄性SD大鼠鞘内置管，通过甩尾实验、热板实验、爪压实验和甲醛实验评估ALX1393（4μg、20μg以及40μg）鞘内注射对大鼠的热性、机械性和化学性伤害，用旋转实验评估其运动功能影响。结果ALX1393对热性和机械性刺激的抗伤害性感受作用存在剂量依赖性关系。给药后15分钟出现最大效果，明显效果持续约60分钟。给予ALX1393后立即注射士的宁可完全拮抗其抗伤害性感受作用。在甲醛实验中，ALXl393有剂量依赖性的减轻疼痛作用，早期和晚期都有，而晚期效果更明显。与抗伤害性感受作用相反，ALX1393用到40μg对运动功能也没有影响。结论本研究证明了ALX1393对急性疼痛的抗伤害性感受作用。结果提示抑制性神经递质转运体有望成为急性疼痛的治疗靶点，Olyr2选择性抑制剂可能会成为新的治疗药物。

关键词：抗伤害性感受作用甘氨酸能神经元神经递质转运体选择性抑制剂急性疼痛鞘内注射模型大鼠甩尾实验

加巴喷丁减轻颈浅丛神经阻滞下甲状腺切除术后的延迟性疼痛

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麻醉与镇痛 2010年第3期6卷 39-45页

作者： Nicolas Brogly, md Jean-Michel Wattier, md Gregoire Andrieu, md Daliana Peres, md Emanuel Robin, md, phd Eric Kipnis, md, phd Laurent Arnalsteen, md Beatrice Thielemans, DPharm Bruno CarnaiUe, md, phd Francois Pattou, md, phd Benoit Vallet, md, phd Gilles Lebuffe, md, phd 李波(译) 舒化青(译) 姚尚龙(校) Department of Anesthesiology and Intensive Care-Section of Pain Department of Pharmacology Department of Endocrine and General Surgery Claude Huriez University Hospital rue Michel Polonovski 59037 Lille cedex France 不详

背景有研究证明手术前12服加巴喷丁可减轻手术后疼痛，然而加巴喷丁辅助用于区域麻醉和慢性疼痛的效果还不清楚。本研究选择颈浅丛神经阻滞（superficialcervicalplexusblock，SCPB）麻醉下行甲状腺切除术的患者，观察手术前口服加巴喷... 详细信息

背景有研究证明手术前12服加巴喷丁可减轻手术后疼痛，然而加巴喷丁辅助用于区域麻醉和慢性疼痛的效果还不清楚。本研究选择颈浅丛神经阻滞（superficialcervicalplexusblock，SCPB）麻醉下行甲状腺切除术的患者，观察手术前口服加巴喷丁对手术后早期和晚期（6个月之后）疼痛的作用。方法50例签署知情同意书的患者随机分成2组，即G组和P组，分别于手术前2小时口服1．2g加巴喷丁和安慰剂。通过数字量化评分（0—6分）评估手术前焦虑程度。患者于标准全麻诱导后行颈浅丛神经阻滞，分别记录手术中、手术后在麻醉恢复室和回到病房后患者的基本情况和镇痛药消耗量。数字量化评分（0—10分）评估手术后24小时静息时和吞咽时疼痛程度。如果静息时疼痛评分超过4分（最疼为10分），则每隔6小时静注1g扑热息痛或者50mg曲马多。手术前l天和甲状腺切除术后6个月，进行神经病理性疼痛诊断问卷。结果两组患者的一般资料、手术前焦虑程度评分、手术中用药、手术时间和手术后恢复室停留时间差异没有统计学意义。2组患者手术后24小时内镇痛药应用次数相似（G组：3[0—5]剂量／24小时；P组：3[1。5]剂量／24小时；P：NS）、静息时疼痛评分（G组：2，2『0．2。3．7]；P组：2[0—6．3]；P=NS）和吞咽时疼痛评分（G组：2．8[0．4～8．9]：P组：3[1．4。6．3]；P=NS）均没有差异。手术后6个月神经病理性疼痛诊断问卷评分超过3分者有8例，而手术前仅有2例（P=0．04）。延迟性神经病理性疼痛的8例患者中7例为单纯颈丛神经阻滞，仅有1例为手术前口服加巴喷丁辅助颈丛神经阻滞的患者（P=0．01）。结论手术前口服加巴喷丁没有改变颈丛神经阻滞下甲状腺切除术患者手术后的早期疼痛，但能预防手术后6个月出现的延迟性神经病理性疼痛。

关键词：颈浅丛神经阻滞甲状腺切除术手术后疼痛加巴喷丁切除术后延迟性神经病理性疼痛减轻

The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy