检索结果-南通市图书馆

Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease

World Journal of Gastroenterology 2017年第27期23卷 4958-4967页

作者： Uri Netz Jane Victoria Carter maurice Robert Eichenberger Gerald Wayne Dryden Jianmin Pan Shesh Nath Rai Susan Galandiuk Price Institute of Surgical Research the Hiram C.Polk Jr.MD Department of SurgeryUniversity of Louisville School of Medicine Department of Surgery A Soroka University Medical Center Faculty of Health Sciences Ben-Gurion University of the Negev Department of Medicine Division of GastroenterologyHepatology and Nutrition University of Louisville School of Medicine Louisville Department of Bioinformatics and Biostatistics University of Louisville School of Public Health and Information Sciences

To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood, and 7 single nucleotide polymorphisms (SNPs) were assessed. The main outcome measure (following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age, gender, race, and socioeconomic status disease, as well as disease characteristics (such as Montreal criteria). RESULTS121 patients were included. Twenty-one were non-responders, and 100 were ever-responders. Fas ligand SNP (rs763110) genotype frequencies, TNF gene -308 SNP (rs1800629) genotype frequencies, and their combination, were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype (P = 0.009, OR = 4.30, 95%CI: 1.45-12.80). The presence of the A (minor) TNF gene -308 allele correlated with three-fold higher odds of being a non-responder (P = 0.049, OR = 2.88, 95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF -308 A allele had nearly five-fold higher odds of being a non-responder (P = 0.015, OR = 4.76, 95%CI: 1.35-16.77). No difference was seen for the remaining SNPs. CONCLUSIONThe Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment

关键词： Anti-tumor necrosis factor Fas ligand Antibody Response Crohn’s disease Single nucleotide polymorphisms Genotype Tumor necrosis factor gene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis of ZnWO4-x xnanorods with oxygen vacancy for efficient photocatalytic degradation of tetracycline

引用

Progress in Natural Science:Materials International 2018年第4期28卷 408-415页

作者： maurice I.Osotsi Daniel K.Macharia Bo Zhu Zhaojie Wang Xiaofeng Shen Zixiao Liu Lisha Zhang Zhigang Chen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University State Environmental Protection Engineering Center for Pollution Treatment andControl in Textile Industry College of Environmental Science and Engineering Donghua University

Persistent organic pollutants(POPs)especially tetracycline pose a great threat to human health,and the photocatalytic degradation of tetracycline by ZnWO4nanomaterials has drawn much *** improve the photo-response range and photoactivity,we prepared ZnWO4-xsample with oxygen vacancies by solvothermally treating Zn(NO3)3and Na2WO4in water/ethanol/PEG-400 mixture where ethanol could act as a reducing agent to selectively remove some oxygen atoms from ***4-xsample is composed of nanorods with length of～50 nm and diameter of～20 ***,ZnWO4-xnanorods are brown and exhibit the obviously broadened photoabsorption from ultraviolet(UV)to near infrared(NIR)region,compared with the tradition white ZnWO4nanorod without oxygen vacancies and with UV absorption edge of 365 *** the irradiation of UV or ultraviolet-visible-near infrared(UV–Vis–NIR)light,ZnWO4-xnanorods can photocatalytically degrade 91%or 78%tetracycline,higher than those(67%or 71%)by *** enhanced photocatalytic efficiency can be attributed to the introduction of oxygen vacancies which have been found to reduce photogenerated electron-hole pair recombination and narrow band gap.

关键词： ZnWO4-x Oxygen vacancies Persistent organic pollutants (POPs) Tetracycline Photocatalytic Activity

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Automatic Generation of Water Masks from RapidEye Images

引用

Journal of Geoscience and Environment Protection 2015年第10期3卷 17-23页

作者： Gideon Okpoti Tetteh maurice Schonert BlackBridge AG Kurfürstendamm 22BerlinGermany

Water is a very important natural resource and it supports all life forms on earth. It is used by humans in various ways including drinking, agriculture and for scientific research. The aim of this research was to develop a routine to automatically extract water masks from RapidEye images, which could be used for further investigation such as water quality monitoring and change detection. A Python-based algorithm was therefore developed for this particular purpose. The developed routine combines three spectral indices namely Simple Ratios (SRs), Normalized Green Index (NGI) and Normalized Difference Water Index (NDWI). The two SRs are calculated between the NIR and green band, and between the NIR and red band. The NGI is calculated by rationing the green band to the sum of all bands in each image. The NDWI is calculated by differencing the green to the NIR and dividing by the sum of the green and NIR bands. The routine generates five intermediate water masks, which are spatially intersected to create a single intermediate water mask. In order to remove very small waterbodies and any remaining gaps in the intermediate water mask, morphological opening and closing were performed to generate the final water mask. This proposed algorithm was used to extract water masks from some RapidEye images. It yielded an Overall Accuracy of 95% and a mean Kappa Statistic of 0.889 using the confusion matrix approach.

关键词： Water Mask Image Threshold Simple Ratio Normalized Green Index Normalized Difference Water Index Logical and Morphological Operations RapidEye

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

合成橡胶的现状与未来

引用

合成橡胶工业 1990年第2期13卷 77-78页

作者： maurice Morton 美国Akron大学

当代的合成橡胶当代合成橡胶的作用,可从美国的橡胶消耗量中窥其一斑。在美国年产2Mt合成橡胶中,三分之二为SBR和BR;与之相反,目前美国天然橡胶的耗量却仅在总用胶量的四分之一。就世界范围而言,天然橡胶约占总用胶量的三分之一。当... 详细信息

当代的合成橡胶当代合成橡胶的作用,可从美国的橡胶消耗量中窥其一斑。在美国年产2Mt合成橡胶中,三分之二为SBR和BR;与之相反,目前美国天然橡胶的耗量却仅在总用胶量的四分之一。就世界范围而言,天然橡胶约占总用胶量的三分之一。当代合成橡胶分野成硫化胶和热塑性弹性体两大门类,并由此决定着它们的技术发展。硫化胶现在,合成橡胶已可提供众多天然橡胶所难以具备的理化性能。

关键词：合成橡胶硫化胶热塑性弹性体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

盘形滚刀的设计

引用

现代隧道技术 2007年第Z1期44卷 19-21页

作者： maurice Jones

　　本文主要讨论滚刀问题.滚刀已经成为TBM设计中的一个关键要素,以便在硬岩地层和夹有硬质材料的混合地层中实现较高的掘进速度.盘形滚刀由James Robbins于1956年首次推出,以后成为Robbins公司开发硬岩TBM系统的一个关键要素.……

关键词：盘形滚刀关键要素硬质材料硬岩地层掘进速度混合地层系统设计开发

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

L′ENSEIGNEMENT SUPERIEUR EN FRANCE

引用

法国研究 1988年第2期 115-118页

作者： Colette PERRIGAULT maurice COURTOIS

L’enseignement supérieur en France est un édifice complexe. Une de ses caractéristiques historiques est qu’il a évolué par ajouts successifs: faute de pouvoir réformer les institutions existantes—les universités—, le pouvoir politique lui a juxtaposé d’autres institutions soit plus modernes, soit répondant un besoin précis, avec l’espoir que la confrontation avec les nouvelles formes d’enseignement entrainerait une modernisation des anciennes.

关键词： der Pr Plus ENSEIGNEMENT SUPERIEUR EN FRANCE

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The European Union Reference Laboratory for Alternatives to Animal Testing

The European Union Reference Laboratory for Alternatives to ...

引用

中国毒理学会第六届全国毒理学大会

作者： maurice WHELAN European Commission DG Joint Research Centre Institute for Health and Consumer Protection

＜正＞The European Union is strongly committed to the Replacement,Reduction and Refinement of testing on animals（the "Three Rs" principle）.The EU Directive 2010/63 on the protection of animals used for scientific purposes came into force in November 2010 and takes full effect from January *** represents a significant increase in animal welfare with respect to previous legislation（*** 86/ 609/EEC） and establishes a level playing field in the EU with regard to animals used in industry and aca-demia. The Directive actively promotes and implements the principle of the Three Rs and establishes a clear legal requirement for the development,validation and use of alternative-to-animal approaches and *** European Union Reference Laboratory for Alternatives to Animal Testing-EURL ECVAM, previously known as the European Centre for the Validation of Alternative Methods（ECVAM,established in 1991） has a long and proud track record in the development and validation of in vitro methods for safety and efficacy testing of chemical substances and biological agents（***） used in different sectors,whether for regulatory or research *** the new Directive,the mandate of EURL ECVAM has been broadened and strengthened and now includes "（a） coordinating and promoting the development and use of alternatives to procedures including in the areas of basic and applied research and regulatory testing;（b） coordinating the validation of alternative approaches at Union level;（c） acting as a focal point for the exchange of information on the development of alternative approaches;（d） setting up,maintaining and managing public databases and information systems on alternative approa- ches and their state of development;and（e） promoting dialogue between legislators,regulators,and all relevant stakeholders,in particular,industry,biomedical scientists,consumer organisations and animal-welfare groups,with a view to the development,validation,regulatory acceptance,interna

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Applying Adverse Outcome Pathways to the protection of human health

Applying Adverse Outcome Pathways to the protection of human...

引用

中国毒理学会第六届全国毒理学大会

作者： maurice WHELAN European Commission DG Joint Research Centre Institute for Health and Consumer Protection

＜正＞Regulatory toxicology is undergo- ing an exciting *** in the past the emphasis has primarily been on observation of toxicological effects of substances using animal models,nowadays the aim is to combine a variety of different models to determine the mechanistic basis of those ***,this push towards more systematic use of mechanistic knowledge and reasoningin regulatory toxicological opens the door for predicting potential toxicological effects of a substance rather than having to measure them *** how do we go about establishing a knowledge-based framework for safety assessment decision making in relation to human health,and what practical steps can we take to harvest the knowledge we need and make it available in a form that can be exploited for regulatory purposes? Although there is already a phenomenal amount of mechanistic toxicological information available in the literature,researchers continue to dig deeper and *** with a gain in knowledge resolution,the trade-off is usually a loss in coverage,and eventually a loss of coherence. Thus an uncomfortable paradox is emerging where the more toxicological knowledge we generate as a scientific community,the more difficult it is to exploit for regulatory *** if we assume that in fact most of the knowledge on mechanisms and modes of toxicological action that we need to make informed safety assessment decisions actually exists,then efforts should be directed towards the collection,curation and dissemination of relevant knowledge to ensure that it is fully exploited in regulatory toxicology processes. In doing so it is likely that on occasion knowledge gaps will be identified which should trigger knowledge-discovery related research activities. However such considerations are of secondary concern in the *** now is the establishment of methodology and tools for the gathering and management of knowledge on mechanistic toxicology on an international s

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

^(18)F-FDG-PET/CT-guided radiotherapy of cervical lymph nodes in head and neck squamous cell carcinoma

引用

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 353-363页

作者： maurice C.Cox Sven van den Bosch Tim Dijkema Johannes H.A.M.Kaanders Department of Radiation Oncology Radboud University Medical Center6525 GA Nijmegenthe Netherlands

The use of positron emission tomography with fluor-18-fluorodeoxyglucose(FDG-PET)in clinical practice for patients with head and neck squamous cell carcinoma(HNSCC)has expanded rapidly,with implications for diagnostic staging,radiotherapy planning,adaptive radiotherapy,and post-therapy *** implementation of FDG-PET/CT in radiation treatment planning not only has consequences for target volume definition and dose prescription but is also associated with an increased overall survival in patients with ***-PET/CT-guided gradient dose prescription provides a window of opportunity for treatment de-intensification of the neck in order to decrease treatment-related toxicity without compromising oncological ***,interim FDG-PET/CT during radiotherapy can be useful to assess metabolic tumor response and enables opportunities for adaptive treatment *** goals are to increase treatment effectivity in poor responders and reduce unnecessary toxicity in patients with good early tumor *** prospective trials investigating adaptive radiotherapy based on interim PET-evaluation are needed,especially regarding human papilloma virus-negative HNSCC and patients treated with primary radiotherapy.

关键词： Head and neck cancer radiotherapy FDG-PET imaging nodal metastases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

隧道防水技术

引用

现代隧道技术 2007年第Z1期44卷 39-41页

作者： maurice Jones

　　除了抽水和堵漏外,还有更多的地下水控制措施.即使是需要采取这些措施,但地下水破坏情况的调查过程可能漫长且要花费人力、物力.最佳的办法是及早考虑潜在的问题,因此有必要正确进行现场调查.……

关键词：地下水现场调查破坏情况控制措施调查过程堵漏抽水

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：