The European Union Reference Laboratory for Alternatives to Animal Testing
作者单位：European Commission DG Joint Research CentreInstitute for Health and Consumer Protection
会议名称：《中国毒理学会第六届全国毒理学大会》
会议日期：2013年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：正The European Union is strongly committed to the Replacement,Reduction and Refinement of testing on animals（the Three Rs principle）.The EU Directive 2010/63 on the protection of animals used for scientific purposes came into force in November 2010 and takes full effect from January *** represents a significant increase in animal welfare with respect to previous legislation（*** 86/ 609/EEC） and establishes a level playing field in the EU with regard to animals used in industry and aca-demia. The Directive actively promotes and implements the principle of the Three Rs and establishes a clear legal requirement for the development,validation and use of alternative-to-animal approaches and *** European Union Reference Laboratory for Alternatives to Animal Testing-EURL ECVAM, previously known as the European Centre for the Validation of Alternative Methods（ECVAM,established in 1991） has a long and proud track record in the development and validation of in vitro methods for safety and efficacy testing of chemical substances and biological agents（***） used in different sectors,whether for regulatory or research *** the new Directive,the mandate of EURL ECVAM has been broadened and strengthened and now includes （a） coordinating and promoting the development and use of alternatives to procedures including in the areas of basic and applied research and regulatory testing;（b） coordinating the validation of alternative approaches at Union level;（c） acting as a focal point for the exchange of information on the development of alternative approaches;（d） setting up,maintaining and managing public databases and information systems on alternative approa- ches and their state of development;and（e） promoting dialogue between legislators,regulators,and all relevant stakeholders,in particular,industry,biomedical scientists,consumer organisations and animal-welfare groups,with a view to the development,validation,regulatory acceptance,interna