Applying Adverse Outcome Pathways to the protection of human health
作者单位：European Commission DG Joint Research CentreInstitute for Health and Consumer Protection
会议名称：《中国毒理学会第六届全国毒理学大会》
会议日期：2013年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：正Regulatory toxicology is undergo- ing an exciting *** in the past the emphasis has primarily been on observation of toxicological effects of substances using animal models,nowadays the aim is to combine a variety of different models to determine the mechanistic basis of those ***,this push towards more systematic use of mechanistic knowledge and reasoningin regulatory toxicological opens the door for predicting potential toxicological effects of a substance rather than having to measure them *** how do we go about establishing a knowledge-based framework for safety assessment decision making in relation to human health,and what practical steps can we take to harvest the knowledge we need and make it available in a form that can be exploited for regulatory purposes? Although there is already a phenomenal amount of mechanistic toxicological information available in the literature,researchers continue to dig deeper and *** with a gain in knowledge resolution,the trade-off is usually a loss in coverage,and eventually a loss of coherence. Thus an uncomfortable paradox is emerging where the more toxicological knowledge we generate as a scientific community,the more difficult it is to exploit for regulatory *** if we assume that in fact most of the knowledge on mechanisms and modes of toxicological action that we need to make informed safety assessment decisions actually exists,then efforts should be directed towards the collection,curation and dissemination of relevant knowledge to ensure that it is fully exploited in regulatory toxicology processes. In doing so it is likely that on occasion knowledge gaps will be identified which should trigger knowledge-discovery related research activities. However such considerations are of secondary concern in the *** now is the establishment of methodology and tools for the gathering and management of knowledge on mechanistic toxicology on an international s