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Pros and cons of liver transplantation in human immunodeficiency virus infected recipients

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World Journal of Gastroenterology 2014年第18期20卷 5353-5362页

作者： Umberto Baccarani Elda Righi Gian Luigi Adani Dario Lorenzin Alberto Pasqualucci matteo bassetti Andrea Risaliti Liver Transplant Unit Department of Medical and Biological SciencesUniversity Hospital of Udine33100 UdineItaly Division of Infectious Disease University Hospital of Udine33100 UdineItaly Department of Anaesthesiology University of Perugia33100 UdineItaly

Before the introduction of combined highly active antiretroviral therapy, a positive human immunodeficiency virus (HIV) serological status represented an absolute contraindication for solid organ transplant (SOT). The advent of highly effective combined antiretroviral therapy in 1996 largely contributed to the increased demand for SOT in HIV-positive individuals due to increased patients’ life expectancy associated with the increasing prevalence of end-stage liver disease (ESLD). Nowadays, liver failure represents a frequent cause of mortality in the HIV-infected population mainly due to coinfection with hepatitis viruses sharing the same way of transmission. Thus, liver transplantation (LT) represents a reasonable approach in HIV patients with stable infection and ESLD. Available data presently supports with good evidence the practice of LT in the HIV-positive population. Thus, the issue is no longer “whether it is correct to transplant HIV-infected patients”, but “who are the patients who can be safely transplanted” and “when is the best time to perform LT”. Indeed, the benefits of LT in HIV-infected patients, especially in terms of mid- and long-term patient and graft survivals, are strictly related to the patients’ selection and to the correct timing for transplantation, especially when hepatitis C virus coinfection is present. Aim of this article is to review the pros and cons of LT in the cohort of HIV infected recipients.

关键词： Liver transplantation Human immunodeficiency virus/hepatitis C virus coinfection Hepatocellular carcinoma Immunosuppression

Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19

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Journal of Geriatric Cardiology 2021年第5期18卷 338-345页

作者： Vincenzo De Marzo Antonio Di Biagio Roberta Della Bona Antonio Vena Eleonora Arboscello Harusha Emirjona Sara Mora Mauro Giacomini Giorgio Da Rin Paolo Pelosi matteo bassetti Pietro Ameri Italo Porto GECOVID study group Cardiovascular Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Internal Medicine University of GenovaGenovaItaly Infectious Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Health Sciences University of GenovaGenovaItaly Emergency Department IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly Laboratory Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Care Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Surgical Sciences and Integrated Diagnostics University of GenovaGenovaItaly

BACKGROUND Increases in cardiac troponin(cTn)in coronavirus disease 2019(COVID19)have been associated with worse ***,data about the significance of cTn in elderly subjects with COVID19 are *** From a registry of consecutive patients with COVID19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,we selected those≥60 yearold and with cTnI measured within three days from the molecular diagnosis of SARSCoV2 *** available,a second cTnI value within 48 h was also *** relationship between increased cTnI and allcause inhospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three *** Of 343 included patients(median age:75.0(68.0−83.0)years,34.7%men),88(25.7%)had cTnI above the upperreference limit(0.046μg/L).Patients with increased cTnI had more comorbidities,greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal ***,they died more(73.9%vs.37.3%,P<0.001)over 15(6−25)days of *** association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model(HR=1.61,95%CI:1.06−2.52,P=0.039)and was linear until 0.3μg/L,with a subsequent *** 191(55.7%)patients with a second cTnI measurement,49(25.7%)had an increasing trend,which was not associated with mortality(univariate HR=1.39,95%CI:0.87−2.22,P=0.265).CONCLUSIONS In elderly COVID19 patients,an initial increase in cTn is common and predicts a higher risk of *** cTn testing may not confer additional prognostic information.

关键词： patients mortality admitted

Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

Measurement of strong phases, D-D mixing, and CP violation using quantum correlation at charm threshold

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Frontiers of physics 2016年第1期11卷 1-15页

作者： matteo Rama Sezione di Pisa dell'Istituto Nazionale di Fisica Nucleate Pisa Italy

We review the measurements of the D decay strong-phase parameters based on quantum-correlated D^0D^-0 pairs produced in the e^＋e^→（3770） →D^0D^-0 process, and we discuss their role in the measurements of Cabibbo-Kobayashi-Maskawa angle 7 and D-/9 mixing. In addition, we present estimates of the size of quantum-correlated datasets necessary to support the 7 and charm mixing measurements conducted at the LHCb and Belle Ⅱ experiments. Finally, we review the methods for measuring the D-D^- mixing and cP violation parameters at a high-luminosity charm factory, giving sensitivity estimates.

关键词： quantum correlation charm mixing CP violation

Consultation-Liaison Psychiatry for Outpatients in a Great Metropolitan Hospital

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Psychology Research 2019年第1期9卷 1-5页

作者： matteo Porcellana Roberta bassetti Adelaide Panariello Mauro Percudani ASST Great Metropolitan Hospital Niguarda MilanItaly

Consultation-liaison psychiatry remains the guardian of holistic approach to the patient and consultation services in general hospital could therefore be referred to as“filters”for mental health care,in particular for patients with minor depressive or anxiety *** is worth noting that psychiatric disorders,even when sub-clinical,worsen outcome whereas their early detection and treatment reduce health care costs *** present study was transversal,exploratory,and descriptive in order to investigate the sample of outpatients referred from general practitioners(GP)to service of consultation-liaison psychiatry of the ASST Great Metropolitan Hospital Niguarda of Milan over a 7-months *** from all psychiatric consultations for outpatients were collected by a structured clinical report including socio-demographic features,features of referrals,and features of *** hundred and eleven consultations were *** were mainly female(58.7%)with an average age between 45 and 55 years(27.6%);31.1%of these patients was at the first contact with a mental health *** diagnoses formulated were distributed as follows:The most common diagnoses were affective disorders(44.6%),followed by neurotic disorders(34.1%),personality disorders(6.8%),and finally,psychosis(6.2%).The study showed an example of a consultation-liaison service situated in a Great Metropolitan Hospital offering to GP the opportunity of a diagnostic assessment and shared management of minor psychiatric *** approach could lead to several vantages,such as the management in a non-psychiatric setting of patients with reduction of stigma and reduced costs for specific psychiatric services where are referred more severe patients.

关键词： consultation-liaison psychiatry primary care minor depressive and anxiety disorders

A machine learning approach to map crystal orientation by optical microscopy

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npj Computational Materials 2022年第1期8卷 70-78页

作者： Mallory Wittwer matteo Seita School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore

Mapping grain orientation in crystalline solids is essential to investigate the relationships between local microstructure and crystallography and interpret materials *** of the main techniques used to perform these studies is electron backscatter diffraction(EBSD).Due to the limited measurement throughput,however,EBSD is not suitable for characterizing samples with long-range microstructure heterogeneity,nor for building large material libraries that include numerous *** present a machine learning approach for high-throughput crystal orientation mapping,which relies on the optical technique called directional reflectance *** successfully apply our method on Inconel 718 specimens produced by additive manufacturing,which exhibit complex,spatially-varying *** results demonstrate that optical orientation mapping on a metal alloy is *** our method is data-driven,it can be easily extended to different alloy systems produced using different manufacturing processes.

关键词： alloy microstructure crystal

Hepatic effector CD8＋ T-cell dynamics

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Cellular & Molecular Immunology 2015年第3期12卷 269-272页

作者： matteo Iannacone Division of Immunology Transplantation and Infectious Diseases I RCCS San Raffaele Scientific Institute and Vita-Saiute San Raffaele University Milan Italy

CD8＋ T cells play a critical role in hepatitis B virus （HBV） pathogenesis. During acute, self-limited infections, these cells are instrumental to viral clearance; in chronic settings, they sustain repetitive cycles of hepatocellular necrosis that promote hepatocellular carcinoma development. Both CD8＋ T-cell defensive and destructive functions are mediated by antigen-experienced effector cells and depend on the ability of these cells to migrate to the liver, recognize hepatocellular antigens and perform effector functions. Understanding the signals that modulate the spatiotemporal dynamics of CD8＋ T cells in the liver, particularly in the context of antigen recognition, is therefore critical to gaining insight into the pathogenesis of acute and chronic HBV infection. Here, we highlight recent data on how effector CD8＋ T cells traffic within the liver, and we discuss the potential for novel imaging techniques to shed light on this important aspect of HBV pathogenesis.

关键词： CD8+ T cells hepatitis B virus intravital microscopy liver immunopathology platelets

A comprehensive review of extrusion-based additive manufacturing processes for rapid production of metallic and ceramic parts

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Advances in Manufacturing 2019年第2期7卷 155-173页

作者： Kedarnath Rane matteo Strano Department of Mechanical Engineering Politecnico di Milano Via La Masa 1 Milan Italy

The extrusion-based additive manufacturing (EAM) technique is recently being employed for rapid production of metals and ceramic components. This technique involves extruding the metal or ceramic material in solid powder form mixed with a binder (i.e., an expendable viscous fluid), which is removed from the part after 3D printing. These technologies rely on the large design freedom allowed and the cost efficiency advantage over alternative metal additive manufacturing processes that are based on high energy beams, such as laser or electron beams. The EAM of metals and ceramics is not yet widespread, but published scientific and technical literature on it is rapidly growing. However, this literature is still less extensive than that on the fused deposition modeling (FDM) of plastics or the selective laser melting (SLM) of metals. This paper aims at filling this gap. FDM and powder injection molding are identified as preceding or enabling technologies for EAM. This paper systematically reviews all aspects of the feedstock EAM processes used for production of complex-shaped parts. The unique characteristics and advantages of these processes are also discussed with respect to materials and process steps. In addition, the key process parameters are explained to illustrate the suitability of the EAM process for diverse application domains.

关键词： Feedstock extrusion Rapid production Complex-shaped metallic Ceramic parts

Mechatronic Design of a Robot for Upper Limb Rehabilitation at Home

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Journal of Bionic Engineering 2021年第4期18卷 857-871页

作者： Elio matteo Curcio Giuseppe Carbone Department of Mechanical Energyand Management EngineeringUniversity of Calabria Via BucciCubo 46C87036 RendeItaly

This paper addresses the design of a novel bionic robotic device for upper limb rehabilitation tasks at *** main goal of the design process has been to obtain a rehabilitation device,which can be easily portable and can be managed remotely by a professional *** allows to treat people also in regions that are not easily reachable with a significant cost *** potential benefits can be envisaged,for instance,in the possibility to keep social distancing while allowing rehabilitation treatments even during a pandemic *** attention has been devoted to design the main mechatronic components by developing specific kinematics and dynamics *** design process includes the implementation of a specific control hardware and *** experimental tests are reported to show the effectiveness and feasibility of the proposed design solution.

关键词： bionic robot design simulations parallel robots upper limb rehabilitation