Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19

作     者：Vincenzo De Marzo Antonio Di Biagio Roberta Della Bona Antonio Vena Eleonora Arboscello Harusha Emirjona Sara Mora Mauro Giacomini Giorgio Da Rin Paolo Pelosi Matteo Bassetti Pietro Ameri Italo Porto GECOVID study group Vincenzo De Marzo;Antonio Di Biagio;Roberta Della Bona;Antonio Vena;Eleonora Arboscello;Harusha Emirjona;Sara Mora;Mauro Giacomini;Giorgio Da Rin;Paolo Pelosi;Matteo Bassetti;Pietro Ameri;Italo Porto;GECOVID study group

作者机构：Cardiovascular Diseases UnitIRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Internal MedicineUniversity of GenovaGenovaItaly Infectious Diseases UnitIRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Health SciencesUniversity of GenovaGenovaItaly Emergency DepartmentIRCCS Ospedale Policlinico San MartinoGenovaItaly Department of InformaticsBioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly Laboratory UnitIRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Care UnitIRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Surgical Sciences and Integrated DiagnosticsUniversity of GenovaGenovaItaly 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2021年第18卷第5期

页      面：338-345页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：patients mortality admitted 

摘      要：BACKGROUND Increases in cardiac troponin(cTn)in coronavirus disease 2019(COVID19)have been associated with worse ***,data about the significance of cTn in elderly subjects with COVID19 are *** From a registry of consecutive patients with COVID19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,we selected those≥60 yearold and with cTnI measured within three days from the molecular diagnosis of SARSCoV2 *** available,a second cTnI value within 48 h was also *** relationship between increased cTnI and allcause inhospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three *** Of 343 included patients(median age:75.0(68.0−83.0)years,34.7%men),88(25.7%)had cTnI above the upperreference limit(0.046μg/L).Patients with increased cTnI had more comorbidities,greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal ***,they died more(73.9%vs.37.3%,P0.001)over 15(6−25)days of *** association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model(HR=1.61,95%CI:1.06−2.52,P=0.039)and was linear until 0.3μg/L,with a subsequent *** 191(55.7%)patients with a second cTnI measurement,49(25.7%)had an increasing trend,which was not associated with mortality(univariate HR=1.39,95%CI:0.87−2.22,P=0.265).CONCLUSIONS In elderly COVID19 patients,an initial increase in cTn is common and predicts a higher risk of *** cTn testing may not confer additional prognostic information.