Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

作     者：Giovanni Ribaudo Matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Giovanni Ribaudo;Matteo Giannangeli;Margrate Anyanwu;Alessandra Gianoncelli

作者机构：Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第6期

页      面：1701-1702页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：gateway homeostasis preserve 

摘      要：The umbrella termneurodege ne rative disorders(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3 ,5 -monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.