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教与学中心评估矩阵

中国大学教学 2019年第12期 57-60页

作者： mary c.wright 美国布朗大学谢里丹(Sheridan)教与学中心

本文的主要内容,一是关于布朗大学的开放式课程体系。这一课程体系的目的是为了提高学生自治能力和自我调适能力,该理念的关键在于"学生是自己课程的设计者"。二是有关布朗大学谢里丹(Sheridan)教与学中心开展的教与学项目。谢里丹教与... 详细信息

本文的主要内容,一是关于布朗大学的开放式课程体系。这一课程体系的目的是为了提高学生自治能力和自我调适能力,该理念的关键在于"学生是自己课程的设计者"。二是有关布朗大学谢里丹(Sheridan)教与学中心开展的教与学项目。谢里丹教与学中心既关注教学职业发展,也提供学术学习支持。三是关于教与学中心评估矩阵的研发过程及其应用。矩阵聚焦于组织结构、资源配置与基础建设、项目与服务三个方面。

关键词：布朗大学开放式课程体系教与学中心评估矩阵教学职业发展

A toast to a zebrafish germ cell induction cocktail

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Science china(Life Sciences) 2024年第6期67卷 1314-1315页

作者： mary c.Mullins Department of cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGcs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore campus for Research Excellence and Technological Enterprise(cREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity cognition Heat stress Hyperthermia Motor function

Internet Gaming Disorder and Mental Health of children in china:A Latent Profile Analysis

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International Journal of Mental Health Promotion 2024年第7期26卷 517-529页

作者： Md Zahir Ahmed Oli Ahmed Lingfeng Gao mary c.Jobe Weijian Li School of Psychology Zhejiang Normal UniversityJinhua321004China Department of Psychology University of ChittagongChattogram4331Bangladesh Department of Psychological and Brain Sciences The George Washington UniversityWashington DC20052USA

In recent years,speculation of an increase in Internet Gaming Disorder(IGD)has surfaced with the growing popularity of internet gaming among chinese children and *** detrimental impact of IGD on mental health cannot be denied,even though only a small portion of the screen-dependent population exhibits psychopathological and behavioral *** present study aimed to explore a latent proﬁle analysis(LPA)of Internet Gaming Disorder on the mental health of chinese school *** data were collected from a sample of 1005 chinese school students(49.8%male;age M=13.32,SD=1.34 years)using a paper-pencil survey through convenience *** explored three latent proﬁles of internet gamers:regular gamers(62.4%),moderate gamers(28.1%),and probable disordered gamers(9.4%).Results showed that the probable disordered gamers had signiﬁcantly higher levels of depression,anxiety,emotional and conduct problems,hyperactivity,and peer problem symptoms as well as lower life satisfaction,and pro-social symptoms compared to regular and moderate gamers(p<0.05).This study would be helpful to mental health professionals in designing interventions for gamers who present IGD *** longitudinal studies should also be undertaken to assess whether mental health worsens for probable disordered gamers.

关键词： Internet gaming disorder latent proﬁle analysis mental health children and adolescents china

Trial characteristics and treatment effect estimates in randomized controlled trials of chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu claire c.W.Zhong mary Y.Jiang chen Mao Xiao-bo Yang Vincent c.H.chung Irene X.Y.Wu Jockey club School of Public Health and Primary care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of clinical Research on Traditional chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RcTs).Nevertheless,it remains unclear if similar associations exist in RcTs on chinese herbal medicine(cHM).Further,chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on cHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on cHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RcTs of cHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RcTs using the cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (cI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RcTs were *** binary outcomes,RcTs incorporated with syndrome differentiation (ROR:1.23;95%cI:[1.07,1.39]),adopting chinese medicine formula (ROR:1.19;95%cI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%cI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%cI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%cI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RcTs with chinese medicine diagnostic criteria (dSMD:0.23;95%cI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%cI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

2024 Adult compendium of Physical Activities:A third update of the energy costs of human activities

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Journal of Sport and Health Science 2024年第1期13卷 6-12页

作者： Stephen D.Herrmann Erik A.Willis Barbara E.Ainsworth Tiago V.Barreira mary Hastert chelsea L.Kracht John M.Schuna Jr. Zhenghui cai Minghui Quan catrine Tudor-Locke Melicia c.Whitt-Glover David R. Jacobs Jr. Kansas center for Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA center for Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA college of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and Health Shanghai University of SportShanghai 200438China Exercise Science Department Syracuse UniversitySyracuseNY 13244USA clinical Sciences Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of Exercise and Sport Science Oregon State UniversityCorvallisOR 97331USA college of Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA Gramercy Research Group KnightdaleNC 27545USA Division of Epidemiology and community Health School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Background:The compendium of Physical Activities was published in 1993 to improve the comparability of energy expenditure values assigned to self-reported physical activity(PA)across *** original version was updated in 2000,and again in 2011,and has been widely used to support PA research,practice,and public health ***:This 2024 update was tailored for adults 19-59 years of age by removing data from those≥60 *** a systematic review and supplementary searches,we identified new activities and their associated measured metabolic equivalent(MET)values(using indirect calorimetry)published since *** replaced estimated METs with measured values when ***:We screened 32,173 abstracts and 1507 full-text papers and extracted 2356 PA energy expenditure values from 701 *** added303 new PAs and adjusted 176 existing MET values and descriptions to reflect the addition of new data and removal of METs for older *** added a Major Heading(Video Games).The 2024 Adult compendium includes 1114 PAs(912 with measured and 202 with estimated values)across 22 Major ***:This comprehensive update and refinement led to the creation of The 2024 Adult compendium,which has utility across research,public health,education,and healthcare domains,as well as in the development of consumer health *** new website with the complete lists of PAs and supporting resources is available at https://***.

关键词： Adults Energy expenditure Exercise MET Physical Activities

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意想不到的拼图

初中生 2024年第6期 24-27页

作者： mary c.canavan coocoo(编译) 不详

这是一个阴沉多雨的星期六,即便如此,贝姬还是很兴奋,因为今天是她挑选新拼图的日子。贝姬是一个“拼图迷”,至少她妈妈这样说。

关键词：拼图星期六意想不到

Structural perspectives of the cYP3A family and their small molecule modulators in drug metabolism

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Liver Research 2019年第3期3卷 132-142页

作者： William c.wright Jude chenge Taosheng chen Department of chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTNUSA Integrated Biomedical Sciences Program University of Tennessee Health Science CenterMemphisTNUSA

cytochrome P450(cYP)enzymes function to catalyze a wide range of reactions,many of which are critically important for drug *** of the human cytochrome P4503A(cYP3A)family are particularly important in drug clearance,and they collectively metabolize more than half of all currently prescribed *** ability of these enzymes to bind a large and structurally diverse set of compounds increases the chances of their modulating or facilitating drug metabolism in unfavorable *** evidence suggests that individual enzymes in the cYP3A family play discrete and important roles in catalysis and disease *** we review the similarities and differences among cYP3A enzymes with regard to substrate recognition,metabolism,modulation by small molecules,and biological consequence,highlighting some of those with clinical *** also present structural perspectives to further characterize the basis of these comparisons.

关键词： cytochrome P4503A(cYP3A)family cYP3A4 cYP3A5 Drug metabolism crystal structure Small molecule modulators

Review of clinically Relevant Drug Interactions with Next Generation Hepatitis c Direct-acting Antiviral Agents

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Journal of clinical and Translational Hepatology 2020年第3期8卷 322-335页

作者： Jenny Hong Robert c.wright Nilu Partovi Eric M.Yoshida Trana Hussaini Pharmaceutical Sciences Vancouver General HospitalVancouverBCCanada Faculty of Pharmaceutical Sciences University of British ColumbiaVancouverBCCanada Liver Transplant Program Vancouver General HospitalVancouverBCCanada Division of Gastroenterology Faculty of MedicineUniversity of British ColumbiaVancouverBCCanada

In this review,we examine the pharmacokinetics and clinically relevant drug interactions of the newer generation direct-acting antivirals(DAAs)for the treatment of chronic hepatitis c,specifically sofosbuvir/velpatasvir(Epclusa®),sofosbuvir/velpatasvir/voxilaprevir(Vosevi®),glecaprevir/pibrentasvir(Maviret®),and elbasvir/grazoprevir(Zepatier®).We searched MEDLINE(1948-January 2020),Embase(1964-January 2020),Google,and GoogleScholar using the terms pharmacokinetics,drug interaction,drug metabolism,sofosbuvir,velpatasvir,Epclusa,voxilaprevir,Vosevi,glecaprevir,pibrentasvir,Maviret,elbasvir,grazoprevir,and Zepatier,from inception to January 13,*** search was limited to randomized controlled trials,in vitro studies,prospective and retrospective human studies,drug monographs,abstracts,and conference *** relevant published literature on pharmacokinetic and pharmacodynamic interactions involving DAAs were reviewed and the data *** clinically relevant drug-drug interactions(DDIs)were identified with the newer generation DAAs and commonly prescribed ***3/4A protease inhibitors are more likely to be involved in DDIs,followed by NS5A inhibitors and NS5B polymerase *** majority of clinically relevant DDIs are predictable,according to known pharmacokinetic,pharmacodynamics,and physicochemical properties of DAAs;however,in select cases,unpredictable DDIs do *** expected,many drug interactions exist between newer generation DAAs and commonly prescribed *** the majority of clinically relevant interactions are predictable,many require therapeutic dose adjustment or careful selection of non-interacting *** select cases,severe and unpredictable drug interactions can *** should consult hepatitis c virus pharmacotherapy experts and tertiary drug interaction resources when initiating DAA therapy in patients taking other medications.

关键词： Hepatitis c Drug interactions Pharmacokinetics Direct-acting antiviral agents