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Modeling and measuring glucose diffusion and consumption by colorectal cancer spheroids in hanging drops using integrated biosensors

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Microsystems & Nanoengineering 2022年第1期8卷 193-210页

作者： Nassim Rousset Rubén López Sandoval mario matteo modena Andreas Hierlemann Patrick M.Misun ETH Zürich Department of Biosystems Science and EngineeringBio Engineering LaboratoryMattenstrasse 26CH-4058 BaselSwitzerland

As 3D in vitro tissue models become more pervasive,their built-in nutrient,metabolite,compound,and waste gradients increase biological relevance at the cost of analysis *** these gradients and the resulting metabolic heterogeneity requires invasive and time-consuming *** alternative is using electrochemical biosensors and measuring concentrations around the tissue model to obtain size-dependent metabolism *** our hanging-dropintegrated enzymatic glucose biosensors,we conducted current measurements within hanging-drop compartments hosting spheroids formed from the human colorectal carcinoma cell line *** developed a physics-based mathematical model of analyte consumption and transport,considering(1)diffusion and enzymatic conversion of glucose to form hydrogen peroxide(H_(2)O_(2))by the glucose-oxidase-based hydrogel functionalization of our biosensors at the microscale;(2)H_(2)O_(2)oxidation at the electrode surface,leading to amperometric H_(2)O_(2)readout;(3)glucose diffusion and glucose consumption by cancer cells in a spherical tissue model at the microscale;(4)glucose and H_(2)O_(2)transport in our hangingdrop compartments at the macroscale;and(5)solvent evaporation,leading to glucose and H_(2)O_(2)*** model relates the measured currents to the glucose concentrations generating the *** low limit of detection of our biosensors(0.4±0.1μM),combined with our current-fitting method,enabled us to reveal glucose dynamics within our *** measuring glucose dynamics in hanging-drop compartments populated by cancer spheroids of various sizes,we could infer glucose distributions within the spheroid,which will help translate in vitro 3D tissue model results to in vivo.

关键词： diffusion hanging simplicity

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Antifouling Properties of Electrospun Polymeric Coatings Induced by Controlled Surface Morphology

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Energy & Environmental Materials 2024年第6期7卷 409-419页

作者： Fabio L.Favrin Lorenzo Zavagna matteo Sestini Semih Esin Bahareh Azimi Massimiliano Labardi mario Milazzo Giuseppe Gallone Giovanna Batoni Serena Danti Department of Civil and Industrial Engineering University of PisaLargo Lucio Lazzarino 256122PisaItaly Department of Translational Research and New Technologies in Medicine and Surgery University of Pisavia San Zeno 35-3956123PisaItaly Institute for Chemical and Physical Processes(IPCF) National Research Council(CNR)Pisa Research AreaVia Moruzzi 156124PisaItaly Department of Civil and Environmental Engineering Massachusetts Institute of Technology(MIT)Massachusetts Ave.77CambridgeMassachusetts 02139USA

Nosocomial infections affect implanted medical devices and greatly challenge their functional outcomes,becoming sometimes life threatening for the ***,aggressive antibiotic therapies are administered,which often require the use of last-resort drugs,if the infection is caused by multi-drug-resistant *** the risk of bacterial contamination of medical devices in the hospitals has thus become an emerging *** routes to control these infections are based on materials provided with intrinsic bactericidal properties(i.e.,chemical action)and on the design of surface coatings able to limit bacteria adhesion and fouling phenomena(i.e.,physical action),thus preventing bacterial biofilm ***,we report the development and validation of coatings made of layer-by-layer deposition of electrospun poly(vinylidene fluoride-co-trifluoro ethylene)P(VDF-TrFE)fibers with controlled orientations,which ultimately gave rise to antifouling *** obtained 10-layer surface morphology with 90°orientation fibers was able to efficiently prevent the adhesion of bacteria,by establishing a superhydrophobic-like behavior compatible with the Cassie-Baxter ***,the results highlighted that surface wettability and bacteria adhesion could be controlled using fibers with diameter comparable to bacteria size(i.e.,achievable via electrospinning process),by tuning the intra-fiber spacing,with relevant implications in the future design of biomedical surface coatings.

关键词： additive manufacturing Escherichia coli fibers Poly(vinylidene fluoride-cotrifluoro ethylene)P(VDF-TrFE) Pseudomonas aeruginosa superhydrophobic

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The interplay of drug therapeutics and immune responses to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 197-200页

作者： Valeria Fumagalli matteo Iannacone Division of Immunology Transplantationand Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly Experimental Imaging Centre IRCCS San Raffaele Scientific InstituteMilanItaly

The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative *** vaccines form the frontline of defense,antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures,particularly for those unable or unwilling to be *** review delves into the potential influence of nirmatrelvir on enduring *** parallel,the potential of drug repurposing is explored,with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory *** importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.

关键词： SARS-CoV-2 Nirmatrelvir Bisphosphonates Adaptive immunity Drug repurposing

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Recent Advances in the Synthesis and Polymerization of New CO_(2)-Based Cyclic

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Chinese Journal of Chemistry 2024年第4期42卷 430-443页

作者： matteo Lanzi Arjan W.Kleij Institute of Chemical Research of Catalonia(ICIQ) The Barcelona Institute of Science and Technology(BIST)Av.Països Catalans 1643007 TarragonaSpain Catalan Institute of Research and Advanced Studies(ICREA) Pg.Lluís Companys 2308010 BarcelonaSpain

Carbon dioxide can be converted into functional heterocycles known as cyclic carbonates,whose recent reactivity has been expanded towards the formation of tailor-made engineering *** minireview gives an overview of the most topical developments in this area with a special focus on the synthetic methods employed to prepare these CO_(2)based *** addition,their application potential in the area of polymer science using a variety of polymerization techniques is discussed that have in common the ring-opening of the carbonate *** perspectives are provided that provide impetus for the scientific communities aligning research to the use of sustainable processes for polymers from recyclable carbon sources such as CO_(2).

关键词： Carbon dioxide Cyclic carbonates Functional macromolecules Heterocycles Polycarbonates Recycling Ring opening polymerization

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Liver Lesions at Risk of Transformation into Hepatocellular Carcinoma in Cirrhotic Patients:Hepatobiliary Phase Hypointense Nodules without Arterial Phase Hyperenhancement

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 100-112页

作者： NicolòBrandi matteo Renzulli Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly

Recent technical advances in liver imaging and surveillance for patients at high risk for developing hepatocellular carcinoma(HCC)have led to an increase in the detection of borderline hepatic nodules in the gray area of multistep carcinogenesis,particularly in those that are hypointense at the hepatobiliary phase(HBP)and do not show arterial phase *** their potential to transform and advance into hypervascular HCC,these nodules have progressively attracted the interest of the scientific *** date,however,no shared guidelines have been established for the decision management of these borderline hepatic *** is therefore extremely important to identify features that indicate the malignant potential of these nodules and the likelihood of *** fact,a more complete knowledge of their history and evolution would allow outlining shared guidelines for their clinical-surgical management,to implement early treatment programs and decide between a preventive curative treatment or a watchful *** review aims to summarize the current knowledge on hepatic borderline nodules,particularly focusing on those imaging features which are hypothetically correlated with their malignant evolution,and to discuss current guidelines and ongoing management in clinical practice.

关键词： Nonhypervascular hypointense nodule Hepatocellular carcinoma Magnetic resonance imaging Gd-EOB Liver

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Perturbed initial orbit determination

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Astrodynamics 2024年第3期8卷 401-416页

作者： Alberto Fossà matteo Losacco Roberto Armellin Institut Supérieur de l’Aéronautique et de l’Espace Toulouse31400France Te PūnahaĀtea-Space Institute The University of AucklandAuckland1010New Zealand

An algorithm for robust initial orbit determination (IOD) under perturbed orbital dynamics is presented. By leveraging map inversion techniques defined in the algebra of Taylor polynomials, this tool returns a highly accurate solution to the IOD problem and estimates a range centered on the aforementioned solution in which the true orbit should lie. To meet the specified accuracy requirements, automatic domain splitting is used to wrap the IOD routines and ensure that the local truncation error, introduced by a polynomial representation of the state estimate, remains below a predefined threshold. The algorithm is presented for three types of ground-based sensors, namely range radars, Doppler-only radars, and optical telescopes, by considering their different constraints in terms of available measurements and sensor noise. Finally, the improvement in performance with respect to a Keplerian-based IOD solution is demonstrated using large-scale numerical simulations over a subset of tracked objects in low Earth orbit.

关键词： initial orbit determination(IOD) range radar Doppler radar optical telescope differential algebra(DA)

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Pediatric stricturing Crohn's disease

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World Journal of Gastroenterology 2024年第12期30卷 1651-1654页

作者： Alessandro Boscarelli matteo Bramuzzo Department of Pediatric Surgery and Urology Institute for Maternal and Child Health-IRCCS“Burlo Garofolo”Trieste 34137Italy Department of Gastrointestinal Endoscopy and Nutrition Institute for Maternal and Child Health-IRCCS"Burlo Garofolo"Trieste 34137Italy

Crohn’s disease(CD)is a chronic inflammatory disease of the digestive *** incidence of pediatric CD is increasing and is currently 2.5-11.4 per 100000 ***,approximately 25%of children with CD develop stricturing CD(SCD)that requires *** stricturing diseases refractory to pharmacological management frequently require non-pharmacological ***-pharmacological therapeutic strategies include endoscopic balloon dilatation,stricturoplasty,and surgical resection of the strictured ***,strictures tend to recur postoperatively regardless of treatment *** lifetime risk of surgery in patients with childhood SCD remains at 50%-90%.Thus,new and emerging strategies,advanced diagnostic tools,and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.

关键词： Stricturing Crohn’s disease Pediatrics Insights Future perspectives

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Revisiting the theoretical prediction of the explosive performance found by the Trauzl test

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Defence Technology（防务技术） 2024年第6期36卷 163-174页

作者： Ivana Dobrilovic mario Dobrilovic Muhamed Suceska Faculty of Mining Geology and Petroleum EngineeringDepartment of Mining Engineering and GeotechnicsUniversity of ZagrebPierottijeva 6Zagreb10000Croatia

The Trauzl lead block test allows the determination of the approximate performance of explosives in blasting applications by measuring the volume increase(expansion)that is produced by the detonation of an explosive charge in the cavity of a lead *** this paper,we reconsider the possibility of interpreting the Trauzl test results in terms of detonation parameters or *** detonation parameters used in the analysis are calculated using the thermochemical code EXPLO5,while the hydrocode AUTODYN is used to simulate the effect of explosive charge density and reaction rate on the results of the Trauzl *** increase in the volume of the lead block cavity was found to correlate best with the product of the detonation heat and the root of the volume of detonation *** simulation showed that the density of explosive charge and the rate of explosive decomposition affect the dynamics of the interaction of the detonation product and the lead block,and consequently the lead block cavity volume increase.

关键词： Trauzl lead block test Performance of explosives EXPLO5 AUTODYN Detonation heat

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Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled

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Signal Transduction and Targeted Therapy 2024年第2期9卷 341-342页

作者： Camilla Aurora Franchino Elisa Motori matteo Bergami Institute for Biochemistry University of Cologne50674 CologneGermany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases(CECAD) Faculty of Medicine and University Hospital CologneUniversity of Cologne50931 CologneGermany Center for Molecular Medicine 50931 CologneGermany

In a recently published study in Science,Naòn et *** two uncharacterized splice variants of Mitofusin 2(MFN2)that specifically shape and tether the endoplasmic reticulum(ER)to mitochondria.1 This work sheds new light on the pleiotropic effects previously ascribed to MFN2 loss-of-function mutations,and has important implications for associated metabolic and neurological diseases.

关键词： MFN2 reticulum

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Parenchymal sparing anatomical liver resections for hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 706-708页

作者： matteo Donadon Guido Torzilli Department of Health Sciences University of Piemonte OrientaleNovaraItaly Department of Surgery University Maggiore Hospital della CaritàNovaraItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Division of Hepatobiliary and General Surgery Department of SurgeryIRCCS Humanitas Research HospitalRozzanoItaly

The rationale of the performance of anatomic resection(AR)of the liver in case of hepatocellular carcinoma(HCC)is the removal of portal pedicle feeding the tumor because of the tumor’s tendency to invade the portal veins(1).This technical approach is expected to be effective from an oncological perspective for a disease such as HCC,which is associated with a high rate of intrahepatic recurrence(2,3).In the eighties,Makuuchi et *** the systematic subsegmentectomy(4)reporting excellent results(5),and later some other authors reported new techniques to identify the portal territory of a given HCC and perform a true AR of the liver(5-7).

关键词： Parenchymal sparing anatomical resections hepatocellular carcinoma(HCC) surgical margin

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