Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled

作     者：Camilla Aurora Franchino Elisa Motori Matteo Bergami Camilla Aurora Franchino;Elisa Motori;Matteo Bergami

作者机构：Institute for BiochemistryUniversity of Cologne50674 CologneGermany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases(CECAD)Faculty of Medicine and University Hospital CologneUniversity of Cologne50931 CologneGermany Center for Molecular Medicine50931 CologneGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第2期

页      面：341-342页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：supported by the Deutsche Forschungsgemeinschaft(SFB1218-Grant No.269925409 and CECAD EXC 2030-Grant No.390661388 to E.M.and M.B. SFB1451-Grant No.431549029 to M.B.) 

主　　题：MFN2 reticulum 

摘      要：In a recently published study in Science,Naòn et *** two uncharacterized splice variants of Mitofusin 2(MFN2)that specifically shape and tether the endoplasmic reticulum(ER)to mitochondria.1 This work sheds new light on the pleiotropic effects previously ascribed to MFN2 loss-of-function mutations,and has important implications for associated metabolic and neurological diseases.