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A functional tacrolimus.releas.ng nerve wrap for enhancing nerve regeneration following s.rgical nerve repair

Neural Regeneration Res.arch 2025年第1期20卷 291-304页

作者： s.meon C.Daes.hler Katelyn J.W.s. Kons.antin Feinberg marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul s.nterre Tes.a Gordon Gregory HBors.hel s.ckKids.Res.arch Ins.itute Neuroscience and Mental Health ProgramTorontoONCanada Ins.itute of Biomaterials.and Biomedical Engineering University of TorontoTorontoONCanada Indiana Univers.ty s.hool of Medicine IndianapolisINUSA Divis.on of Plas.ic and Recons.ructive s.rgery the Hospital for Sick ChildrenTorontoONCanada Trans.ational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following s.rgical nerve repair is.s.ow and often incomplete,res.lting in poor functional recovery which s.metimes.contributes.to lifelong ***,there are no FDA-approved therapies.available to promote nerve *** accelerates.axonal regeneration,but s.s.emic s.de effects.pres.ntly outweigh its.potential benefits.for peripheral nerve *** authors.des.ribe herein a biodegradable polyurethane-bas.d drug delivery s.s.em for the s.s.ained local releas. of tacrolimus.at the nerve repair s.te,with s.itable properties.for s.alable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal s.s.emic drug *** is.encaps.lated into co-axially electros.un polycarbonate-urethane nanofibers.to generate an implantable nerve wrap that releas.s.therapeutic dos.s.of bioactive tacrolimus.over 31 *** and drug loading are adjus.able for applications.in s.all and large caliber nerves.and the wrap degrades.within 120 days.into biocompatible *** releas.d from the nerve wrap promotes.axon elongation in vitro and accelerates.nerve regeneration and functional recovery in preclinical nerve repair models.while off-target s.s.emic drug expos.re is.reduced by 80%compared with s.s.emic *** its.s.rgical s.itability and preclinical efficacy and s.fety,this.s.s.em may provide a readily trans.atable approach to s.pport axonal regeneration and recovery in patients.undergoing nerve s.rgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Univers.l Enveloping Algebras.of s.mple s.mplectic Anti-Jordan Triple s.s.ems

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Algebra Colloquium 2015年第2期22卷 281-292页

作者： marina Tvalavadze Univers.ty of Toronto (Mis.is.auga Campus. Mathematical and Computational s.iences.359 Mis.is.auga Rd. N Mississauga ON L5L 1C6 Canada

In this.work we axe concerned with the univers.l as.ociative envelope of a finite-dimens.onal s.mple s.mplectic anti-Jordan triple s.s.em （AJTs.. We prove that if T is.a triple s.s.em as.above, then there exis.s.an as.ociative algebra U（T） and an injective homomorphis. ε ： T→ U（T）, where U（T） is.an AJTs.under the triple product defined by （a, b, c） = abc- cba. Moreover, U（T） is.a univers.l object with res.ect to s.ch homomorphis.s. We explicitly determine the PBW-bas.s.of U（T）, the center Z（U（T）） and the Gelfand-Kirillov dimens.on of U（T）.

关键词： anti-Jordan triple s.s.ems univers.l enveloping algebras central elements.PBW-bas.s

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Photocatalytic Treatment of Was.e Water from Rice Hus. Alkaline Hydrolys.te

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Rice s.ience 2019年第4期26卷 257-260页

作者： Olga D. AREFIEVA marina s. vas.lyeva Ekaterina V. ERMOLENKO Anas.as.ia V. BYCHKOVA Far Eas.ern Federal Univers.ty Vladivostok 690950Russian Federation Ins.itute of Chemis.ry Far-Eastern BranchRussian Academy of Sciences Vladivostok 690022 Russian Federation National s.ientific Center of Marine Biology Far Eastern BranchRussian Academy of SciencesVladivostok 690041Russian Federation

We carried out photocatalytic treatment of a lignin-free s.lution of rice hus. alkaline hydrolys.te [pH of 2, chemical oxygen demand（COD） of 12.8 g/L] us.ng photo-Fenton proces. in the ultraviolet（UV, wavelength of 365 nm） and vis.ble s.ectrum. Oxidation of lignin was.performed at a cons.ant mas. ratio of COD:H2O2 as.1:2 and Fe2+ concentration of 80 mg/L. It was.es.ablis.ed that for the des.ruction of alkaline lignin, expos.re to vis.ble or UV radiation was.neces.ary. Decolorization efficiency of a lignin-free s.lution depends.on the dilution rate of the s.lution. The advanced oxidative photo-Fenton proces.(UV/Н2О2/Fe2+) made it pos.ible to reduce the color of lignin-free s.lution at a dilution ratio of 1:5 by 94% of decolorization efficiency, 87% of phenolic compound and 79% of COD. With the help of gas.chromatography, the products.of lignin des.ruction were low-toxic and us.ble.

关键词： chemical oxygen demand dilution ratio vis.ble s.ectrum

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High-res.lution Fourier s.ectros.opy as.a tool for s.udying quality of rare-earth-doped crys.als

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Journal of Rare Earths 2014年第3期32卷 230-235页

作者： marina N.Popova Ins.itute of s.ectros.opy Russian Academy of Sciences 5 Fizicheskaya Str. 142190 Troitsk Moscow Russia

Three examples.were cons.dered of the us. of high res.lution Fourier-trans.orm optical s.ectros.opy for s.udying quality of rare-earth-doped crys.als. The firs. example was.connected with defects.pres.nt in crys.als.grown by flux techniques. The s.cond example dealt with detection of s.res.es.and deformations.in rare-earth-containing crys.als. by regis.ering s.litting of s.ectral lines. The third example s.owed that a very s.all amount （at the level ofppm） of different RE ions.pres.nt in a crys.al could be determined us.ng high-res.lution s.ectros.opy. This.work was.carried out by the author＇s.group in collaboration with s.veral ins.itutions.in Rus. s.a and abroad.

关键词： Fourier-trans.orm optical s.ectros.opy high res.lution abs.rption s.ectra rare earths

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Myelinos.me organelles.in pathological retinas. ubiquitous.pres.nce and dual role in ocular proteos.as.s.maintenance

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Neural Regeneration Res.arch 2023年第5期18卷 1009-1016页

作者： marina G.Yefimova s.chenov Ins.itute of Evolutionary Phys.ology and Biochemis.ry Russian Academy of SciencesSt-PetersburgRussia Laboratoire s.IM CNRs.ERL 7003 Universitéde PoitiersPoitiersFrance

The timely and efficient elimination of aberrant proteins.and damaged organelles. formed in res.ons. to various.genetic and environmental s.res.ors. is.a vital need for all cells.of the body. Recent lines.of evidence point out s.veral non-clas.ical s.rategies.employed by ocular tis.ues.to cope with aberrant cons.ituents.generated in the retina and in the retinal pigmented epithelium cells.expos.d to various.s.res.ors. Along with conventional s.rategies.relying upon the intracellular degradation of aberrant cons.ituents.through ubiquitin-proteas.me and/or lys.s.me-dependent autophagy proteolys.s. two non-conventional mechanis.s.als. contribute to proteos.as.s.maintenance in ocular tis.ues. An exos.me-mediated clearing and a myelinos.me-driven s.cretion mechanis. do not require intracellular degradation but provide the export of aberrant cons.ituents.and “was.e proteins. outs.de of the cells. The current review is.centered on the non-degradative myelinos.me-driven s.cretion mechanis., which operates.in the retina of trans.enic Huntington’s.dis.as. R6/1 model mice. Myelinos.me-driven s.cretion is.s.pported by rare organelles.myelinos.mes.that are detected not only in degenerative Huntington’s.dis.as. R6/1 retina but als. in various.pathological s.ates.of the retina and of the retinal pigmented epithelium. The intra-retinal traffic and inter-cellular exchange of myelinos.mes.was.dis.us.ed in the context of a dual role of the myelinos.me-driven s.cretion mechanis. for proteos.as.s.maintenance in different ocular compartments. s.ecial focus.was.made on the interplay between degradative and non-degradative s.rategies.in ocular pathophys.ology, to delineate potential therapeutic approaches.to counteract s.veral vis.on dis.as.s.

关键词： autophagy Huntington’s.dis.as. Müller cells myelinos.me-driven s.cretion myelinos.mes ocular pathophys.ology proteos.as.s retina retinal pigmented epithelium ubiquitin-proteas.me s.s.em

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The birth hour of mammals.ins.ghts.from intra-s.ecific variation in wild blue monkeys

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Current Zoology 2022年第5期68卷 499-506页

作者： marina Cords.Emma Gometz Department of Ecology Evolution and Environmental BiologyColumbia UniversityNew YorkNY 10027USA New York Cons.rtium in Evolutionary Primatology 695 Park AvenueNew YorkNY 10065USA

While mos. mammals.s.ow birth hour peaks.at times.of the 24-h cycle when they are les. active,there are exceptions.to this.general *** exceptions.have been little explored,but may clarify evolutionary reas.ns.for the diel timing of *** inves.igated intras.ecific variation in birth hour in wild blue monkeys.Cercopithecus.mitis.s.uhlmanni,a diurnal primate,to identify factors.that differentiated daytime vers.s.nighttime *** and life his.ory data from 14 groups.over 14 years.revealed that 4%of 484 births.occurred during the *** of daytime birth varied with mother’s.age,peaking at 15.7 *** whos. annual timing deviated mos. from the population’s.peak birth months.were 5 times.more likely to occur during daytime than thos. that deviated *** was.no evidence that mother’s.rank or infant s.x influenced birth hour,and mixed evidence that daytime births.were more probable in larger *** did not differ s.gnificantly for infants.born during the day vers.s.***-aged mothers.may be able to handle the cons.quences.of an unus.al birth hour more s.cces.fully than mothers.with les. experience or thos. weakened by *** birth may be more advantageous.in the off-s.as.n becaus. nights.are colder at that time of *** findings.are cons.s.ent with hypothes.s.relating birth hour to the ris. of los.ng s.cial protection in group-living animals.but are not cons.s.ent with thos. emphas.zing ris. of cons.ecific *** of within-s.ecies.variation can help in evaluating evolutionary hypothes.s.for non-random birth hour.

关键词： birth timing Cercopithecus.mitis circadian pattern diel cycle guenon parturition

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s.ectros.opy of compounds.from the family of rare-earth orthoborates

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Journal of Rare Earths 2009年第4期27卷 607-611页

作者： marina N.Popova Ins.itute of s.ectros.opy Russian Academy of Sciences 5 Fizicheskaya Str. Troitsk Moscow Region 142190 Russia

This.paper is.devoted to the rare-earth borates.des.ribed by the general formula RM3（BO3）4, M = Al, Fe, and Cr, that have non-centros.mmetric trigonal s.ructure of the natural mineral huntite. It give a brief review of a s.ectros.opic res.arch on YbAI3（BO3）4 （YbAB）, on a large group of magnetic iron borates. and on NdCra（BO3）4.

关键词： YbAl3(BO3)4 rare-earth iron and chromium borates magnetic ordering Fourier-trans.orm optical s.ectros.opy

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Colorectal cancer and dormant metas.as.s.Put to s.eep or des.roy?

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World Journal of Gas.rointes.inal Oncology 2024年第6期16卷 2304-2317页

作者： marina A s.nchukova Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia

After reading the review by An et al“Biological factors.driving colorectal cancer metas.as.s.,which covers.the problem of the metas.as.s.of colorectal cancer(CRC),I had a des.re to dis.us. with readers.one of the exciting problems.as.ociated with dormant *** deaths.from CRCs.are caus.d by metas.as.s.which can be detected both at diagnos.s.of the primary tumor and s.veral years.or even decades.after *** is.becaus. tumor cells.that enter the bloods.ream can be des.royed by the immune s.s.em,caus. metas.atic growth,or remain dormant for a long *** tumor cells.may not manifes. thems.lves.throughout a pers.n’s.life or,after s.me time and under appropriate conditions.may give ris. to the growth of *** this.editorial,we will dis.us. the mos. important features.of dormant metas.as.s.and the mechanis.s.of premetas.atic niche formation,as.well as.factors.that contribute to the activation of dormant metas.as.s.in *** will pay s.ecial attention to the pos.ible mechanis.s.involved in the formation of circulating tumor cell complexes.and the choice of therapeutic s.rategies.that promote the dormancy or des.ruction of tumor cells.in CRCs.

关键词： Circulating tumor cells Colorectal cancer Dis.eminated tumor cells Dormant metas.as.s Metas.as.s Premetas.atic niche

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Genetic heterogeneity of colorectal cancer and the microbiome

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World Journal of Gas.rointes.inal Oncology 2023年第3期15卷 443-463页

作者： marina A s.nchukova Department of Oncology Orenburg State Medical UniversityOrenburg 460000Russia

In 2020,the International Agency for Res.arch on Cancer and the World Health Organization's.GLOBOCAN databas. ranked colorectal cancer(CRC)as.the third mos. common cancer in the *** cas.s.of CRC(>95%)are s.oradic and develop from colorectal polyps.that can progres. to intramucos.l carcinoma and *** evidence is.accumulating that the gut microbiota can play a key role in the initiation and progres.ion of CRC,as.well as.in the treatment of CRC,acting as.an important metabolic and immunological *** that may determine the microbiota role in CRC carcinogenes.s.include inflammation,changes.in intes.inal s.em cell function,impact of bacterial metabolites.on gut mucos.,accumulation of genetic mutations.and other *** this.review,I dis.us. the major mechanis.s.of the development of s.oradic CRC,provide detailed characteris.ics.of the bacteria that are mos. often as.ociated with CRC,and analyze the role of the microbiome and microbial metabolites.in inflammation initiation,activation of proliferative activity in intes.inal epithelial and s.em cells.and the development of genetic and epigenetic changes.in CRC.I cons.der longterm s.udies.in this.direction to be very important,as.they open up new opportunities.for the treatment and prevention of CRC.

关键词： Gut microbiota Bacterial metabolites Colorectal cancer Colorectal polyp s.em cells Epigenetic changes

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A Comparative s.udy on the Role of Cytokinins.in Caryops.s.Development in the Maize miniature1 s.ed Mutant and Its.Wild Type

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Journal of Integrative Plant Biology 2009年第9期51卷 840-849页

作者： Tomaz Rijavec Maja Kova Ale Kladnik Prem s.Chourey marina Dermas.ia National Ins.itute of Biology Department of Biotechnology and Systems Biology Department of Biology Biotechnical FacultyUniversity of Ljubljana Us.Department of Agriculture Agricultural Research ServiceChemistry Research Unit

We report here on a comparative developmental profile of plant hormone cytokinins.in relation to cell s.ze, cell number and endoreduplicaUon in developing maize caryops.s.of a cell wall invertas.-deficient miniature1 （mn1） s.ed mutant and its.wild type, Mn1, genotype. Both genotypes.s.owed extremely high levels.of total cytokinins.during the very early s.ages.of development, followed by a marked and genotype s.ecific reduction. While the decreas. of cytokinins.in Mn1 was.as.ociated with their deactivation by 9-glucos.lation, the abs.lute and the relative part of active cytokinin forms.was.higher in the mutant. During the exponential growth phas. of endos.erm between 6 d after pollination and 9 d after pollination, the mean cell doubling time, the abs.lute growth rate and the level of endoreduplication were s.milar in the two genotypes. However, the entire duration of growth was.longer in Mnl compared with mnl, res.lting in a s.gnificantly higher cell number in the Mnl endos.erm. Thes. data correlate with the previous.y reported peak levels.of the Mn1-encoded cell wall invertas.-2 （INCW2） at 12 d after pollination in the Mn1 endos.erm. A model s.owing pos.ible cros.talk among cytokinins. cell cycle and cell wall invertas. as.caus.l to increas.d cell number and s.nk s.rength of the Mn1 developing endos.erm is.dis.us.ed.

关键词： 9-glucos.lation cell wall invertas. cytokinins maize caryops.s miniature1.

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