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journal of Physical Science and Application 2016年第1期6卷 212-220页

作者： Hadi j. M. A1-Agealy Department of Physics College of Education for pure Science Baghdad University Baghdad Iraq

Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： Gerie j.Glas janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello Gamma de Abreu Ignacio Martin-Loeches Paolo Pelosi Folke Sjoerg jan M.Binnekade Berry Cleffken Nicole P.juffermans Paul Knape Bert G.Loef David P.Mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro Marc jeschke jeffrey Lipman Matthieu Legrand johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho joa Manoel Silva junior Cintia M.C.Grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu jeanne Morgane Bacus Maite Chaussard marcus Lehnhardt Bassem Daniel Mikhail jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting marcus j.Schultz LAMiNAR investigators Academic Medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy Medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ jAN PALFIjN GENT Watersportlaan 5–9000 Gent–Belgium ABC Medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl Gustav Carus Dresden 01307Germany St james University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden Maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands Martini Hospital GroningenNT 9728The Netherlands University of Texas Medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive Care Research Centre.Monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece Middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 ICUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressuresjority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： Mechanical ventilation Inhalation trauma Lung-protective Critical care

三磁性的回声 arthrography 的评论联系了感染

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World journal of Radiology 2013年第2期5卷 41-44页

作者： Andrew T Vollman joseph G Craig Rachel Hulen Abraham Ahmed marcus j Zervos Marnix van Holsbeeck Wayne State University School of Medicine Detroit MI 48202 United States Departments of Radiology Henry Ford Health System Detroit MI 48202 United States Department of Radiology Cleveland Clinic Foundation Cleveland OH 44195 United States Departments of Infectious Disease Henry Ford Health System Detroit MI 48202 United States

We report three cases of intra-articular infection which followed injection for magnetic resonance arthrography. In an effort to reduce the risk of arthrogram related infection, representatives from radiology, infectious disease medicine, and microbiology departments convened to analyze the contributing factors. The proposed source was oral contamination from barium swallow studies which preceded the arthrogram injections in the same room. We propose safety measures to reduce incidence of arthrogram related infections.

关键词： Magnetic resonance arthrogram Infection Sepsis Patient safety joint infection

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肺动脉高压患者骨形态发生蛋白受体2突变

中华高血压杂志 2016年第3期24卷 299-299页

作者： Van Der Bruggen CE Happé CM Dorfmüller P Trip P Spruijt OA Rol N Hoevenaars F Houweling AC Girerd B marcus jT Mercier O Humbert M Handoko ML Van Der Velden j Vonk Noordegraaf A Bogaard Hj Goumans Mj de Man FS 刘莉叶鹏

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴... 详细信息

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴或不伴BMPR2突变的PAH患者的右心室功能进行评估。方法与结果：纳入原发性或家族性PAH患者95例进行基因筛选,结果示28例患者存在BMPR2突变,67例无突变。应用右心导管术和心脏核磁共振检测。

关键词：骨形态发生蛋白受体基因突变肺动脉高压患者 hypertension 受体2 receptor arterial

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前列腺癌:外照射放疗后生化指标增高的预测—Kattan列线图和直肠内MR成像

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国际医学放射学杂志 2012年第1期 73-73页

作者： A.C.Westphalen W.j.Koff F.V.Coakley V.F.Muglia j.M.Neuhaus R.T.marcus 李斌 Department of Radiology and Biomedical Imaging University of California San Francisco 505 Parnassus AveBox 0628Room M-372San FranciscoCA 94143-0628

目的确定纳入MR成像和MR波谱表现能否提高放射治疗后Kattan列线图的预测率。材料与方法此回顾性研究获得机构审查委员会批准,符合HIPAA要求。选择1998年1月—2007年7月间,在对前列腺癌进行体外照射放疗

关键词：列线图数值分析前列腺癌 Kattan MR 生化指标外照射直肠内

Caspase-1 activation and mature interleukin-1β release are uncoupled events in monocytes

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World journal of Biological Chemistry 2013年第2期4卷 30-34页

作者： Amy j Galliher-Beckley Li-Qiong Lan Shelly Aono Lei Wang jishu Shi Department of Anatomy and Physiology College of Veterinary MedicineKansas State University College of Life Sciences Sichuan University Department of Anatomy Physiologyand PharmacologyCollege of Veterinary MedicineAuburn University

AIM:To investigate whether caspase-1 activation/intracellular processing of pro-interleukin-1β(pro-IL-1β) and extracellular release of mature IL-1β from activated monocytes are separable ***:All experiments were performed on fresh or overnight cultured human peripheral blood monocytes(PBMCs) that were isolated from healthy *** were activated by lipopolysaccharide(LPS) stimulation before being treated with Adenosine triphosphate(ATP,1 mmol/L),human α-defensin-5(HD-5,50 μg/mL),and/or nigericin(Nig,30 μmol/L).For each experiment,the culture supernatants were collected separately from the *** lysates and supernatants were both subject to immunoprecipitation with anti-IL1β antibodies followed by western blot analysis with anti-caspase-1 and anti-IL-1β ***:We found that pro-IL-1β was processed to mature IL-1β in LPS-activated fresh and overnight cultured human monocytes in response to ATP *** the presence of HD-5,this release of IL-1β,but not the processing of pro-IL-1β to IL-1β,was completely ***,in the presence of HD-5,the release of IL-1β,but not the processing of IL-1β,was significantly inhibited from LPS-activated monocytes stimulated with ***,we treated LPS-activated monocytes with ATP and Nig and collected the *** found that both ATP and Nig stimulation could activate and release cleaved caspase-1 from the ***,and contrary to IL-1β processing and release,caspase-1 cleavage and release was not blocked by *** images are representative of three independent ***:These data suggest that caspase-1 activation/processing of pro-IL-1β by caspase-1 and the release of mature IL-1β from human monocytes are distinct and separable events.

关键词： Caspase-1 Human defensin Monocytes Interleukin-1β processing and release Inflammasome

3D半自动评估软件对动态CT心肌灌注成像的评价

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国际医学放射学杂志 2014年第2期 189-189页

作者： U.Ebersberger R.P.marcus U.j.Schoepf G.G.Lo Y.Wang P.Blanke 张印 Heart & Vascular Center Medical University of South CarolinaAshley River Tower 25 Courtenay Drive CharlestonSC 294252 260 USA

目的探讨3D半自动评估软件在动态CT心肌灌注成像中评估心肌血流量(MBF)及血容量(MBV)的应用价值。方法本研究纳入37例行动态CT心肌灌注成像病人,应

关键词：腺苷负荷心肌灌注成像自动化软件 CT 技术功效

母亲暴露于常规空气污染物与后代的先天性心脏缺陷:来自全国出生缺陷预防研究的结果

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环境与职业医学 2014年第12期31卷 929-929页

作者： jeanette A.Stingone Thomas j.Luben julie L.daniels Montserrat Fuentes David B.Richardson Arthur S.Aylsworth Amy H.Herring Marlene Anderka Lorenzo Botto Adolfo Correa Suzanne M.Gilboa Peter H.Langlois Bridget Mosley Gary M.Shaw Csaba Siffel Andrew F.Olshan National Birth Defects Prevention Study

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配... 详细信息

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配1周和7周里一氧化碳、二氧化氮、臭氧、二氧化硫的每日最高浓度平均值,以及细颗粒物和粗颗粒物的24 h测量值,采用的方法是在妊娠早期收集这些妇女住所50 km内最接近的空气监测点的测量值。根据不同的污染物,最多4 632例活产对照和3 328例活产、死胎或流产病例有空气污染暴露的数据。应用分层回归模型,并以产妇的人口统计学、烟草和酒精使用情况进行调整。对于多污染物共同暴露的情况,则采用主成分分析来评估这些关联。[结果]二氧化氮暴露与主动脉缩窄及肺动脉瓣狭窄之间存在正性关联。细颗粒物暴露与左室发育不良心脏综合征呈正性相关,但与房间隔缺损呈负性相关。检测个体的暴露周数表明,使用7周的平均水平未观察到污染物与缺陷之间的关联。多污染物分析的结果支持左室流出道阻塞与二氧化氮之间、左室发育不良心脏综合征与颗粒物之间存在关联,尽管在最高的暴露水平时估计值是下降的。[结论]采用每日最高污染物水平探讨个体暴露周数揭示了某些污染物与心脏缺陷之间存在一些正向关联,并且提示在妊娠期间存在潜在的敏感性窗口期。

关键词：先天性心脏缺陷空气污染物出生缺陷预防母亲暴露病例对照研究心脏综合征细颗粒物后代

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为什么有些零售商在疫情中反而蒸蒸日上

五金科技 2020年第6期48卷 74-76页

作者：马克·j·格列文中国管理咨询网

成功适应大流行的社会距离要求的零售商提供了一个快速数字化枢纽的模型。一场危机揭示了它所遭受的破坏。在冠状病毒爆发之前苦苦挣扎的零售商现在正在崩溃。杰西潘尼(jC Penney)的处境不佳,无法直面这场危机,它拥有800多家商店,近85,... 详细信息

成功适应大流行的社会距离要求的零售商提供了一个快速数字化枢纽的模型。一场危机揭示了它所遭受的破坏。在冠状病毒爆发之前苦苦挣扎的零售商现在正在崩溃。杰西潘尼(jC Penney)的处境不佳,无法直面这场危机,它拥有800多家商店,近85,000名员工,最近申请破产,在过去两个月中加入了Neiman marcus和***的零售破产名单。其他零售商被迫迅速转向,一些零售商也成功,如Target,它报告说,第一季度数字可比销售额增长了141%,尽管成本很大。沃尔玛似乎也处于有利地位,销售额也增长了10%,包括在线销售额增长了74%。

关键词：沃尔玛零售商销售额增长冠状病毒数字化

Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice

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世界最新医学信息文摘 2015年第A期 8-8页

作者： Anne Eckert Susanne Hauptmann Isabel Scherping jessica Meinhardt Virginie Rhein Stefan Dr?se Ulrich Brandt marcus F?ndrich Walter E.Müller jürgen G?tz

We recently provided evidence for a mitochondrial dysfunction in P301 l tau transgenic mice, a strain modeling the tau pathology of alzheimer's disease(ad) and frontotemporal dementia(ftd). in addition to tau aggregates, the ad brain is further characterized by Aβ peptide-containing plaques. When we addressed the role of Aβ, this indicated a synergistic action of tau and Aβ pathology on the mitochondria. In the present study, we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβ might be the actual toxic species. Interestingly, both oligomeric and fibrillar, but not disaggregated(mainly monomeric) Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301 L tau transgenic mice. This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons. Furthermore, we found reductions in state 3 respiration, the respiratory control ratio, and uncoupled respiration when incubating P301 L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42. Finally, we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic, but exert different degrees of toxicity.

关键词： Alzheimer’s disease Amyloid aggregates Amyloid β-peptide Amyloid toxicity Fibrils Frontotemporal dementia Globulomer Mitochondria oligomer Protein aggregation respiration tau transgenic mice