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Long COVID and gut candidiasis:What is the existing relationship?

World Journal of Gastroenterology 2024年第37期30卷 4104-4114页

作者： Filippo Bistagnino Davide Pizzi Filippo Mantovani Jacopo Rosso Antonino marcos roberto tovani-palone Department of Medical Biotechnology and Translational Medicine International Medical SchoolUniversitàdegli Studi di MilanoMilan 20054Italy Department of Biomedical Sciences for Health Universitàdegli Studi di MilanoMilan 20133Italy Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

Since the beginning of the coronavirus disease(COVID)2019 pandemic,thou-sands of articles on the topic have been published,and although there is a growing trend of research on another associated condition,long coronavirus disease,important points still remain to be clarified in this *** evidence has suggested a relevant link between new clinical discoveries and molecular mechanisms that could be associated with the manifestations of different signs and symptoms involving cases of long ***,one of the existing gaps that requires further investigation concerns a possible rela-tionship between gut candidiasis and long *** recent studies also suggest an interplay between the occurrence of these two conditions,it is not yet fully clear how this may happen,as well as the specifics regarding the possible pathophysiological mechanisms *** this connection and with the advent of a potential strengthening of the body of evidence supporting the hypothesis of a link between gut candidiasis and long COVID,a better understanding of the clinical presentation,pathophysiology and clinical management of such a relationship should be essential and useful for both,additional advances towards more targeted research and appropriate case *** more about the signs,symptoms,and complications associated with cases of long COVID is essential in order to more effectively mitigate the related burden and provide a higher quality of care and life for the affected *** light of this and the need for better outcomes,here we review and discuss the content on different aspects of long COVID,including its pathophysiology and the existing evidence of a potential relationship between such a condition and gut candidiasis,as well as suggest propositions for future related *** Long coronavirus disease(COVID)is a condition characterized by the emergence of new symptoms or the persistence of existing symptoms for at least two months,

关键词： Post-acute COVID-19 syndrome COVID-19 Candidiasis Gastrointestinal microbiome Pandemics

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Potential role of the microbiome in liver injury during COVID-19: Further research is needed

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World Journal of Gastroenterology 2023年第3期29卷 503-507页

作者： marcos roberto tovani-palone Paolo Pedersini Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 600077India IRCCS Fondazione Don Carlo Gnocchi Milan 20148Italy

Although different studies have associated coronavirus disease 2019(COVID-19)with the occurrence of liver injury,the hepatic injury route during the COVID-19 course is not yet fully *** order to better understand the mechanisms of the disease,the human gut microbiota has been the subject of extensive discussion in the context of COVID-19 ***,many questions remain,including the risks of liver injury due to COVID-19 specific *** research in this field could allow the discovery of new personalized treatment strategies aimed at improving the microbiota composition,thereby reducing COVID-19 severity and its complications in different *** this article,we discussed basic mechanisms of severe acute respiratory syndrome coronavirus 2 infection and recent evidence on the relationship between COVID-19,the gut microbiome and liver injury as well as proposed recommendations for further research.

关键词： COVID-19 Gut microbiota Coronavirus Gut microbial-host-immune axis Gut-lung axis Liver injury

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Combined use of lactoferrin and vitamin D as a preventive and therapeutic supplement for SARS-CoV-2 infection: Current evidence

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World Journal of Clinical Cases 2022年第32期10卷 11665-11670页

作者： Massimiliano Cipriano Enzo Ruberti marcos roberto tovani-palone Department of Laparoscopic Surgery Umberto I General HospitalMedical School Sapienza UniversityRome 161Italy Department of Human Neuroscience Sapienza University of RomeRome 00185Italy Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

Lactoferrin is a multifunctional protein that exhibits anti-inflammatory,immune regulating and anti-infective *** of its receptor sites is located on severe acute respiratory syndrome coronavirus *** binding of lactoferrin with heparin sulfate proteoglycans may prevent the first contact between the virus and host cells,thus preventing subsequent *** that lactoferrin may act as a natural mucosal barrier,an intranasal treatment together with its oral intake can be hypothesized to prevent the spread,infection and inflammation caused by coronavirus disease 2019(COVID-19).Moreover,the literature reports that vitamin D plays an essential role in promoting immune *** its antiinflammatory and immunoregulatory properties,vitamin D is critical for activating the immune system’s defenses,improving immune cell *** studies also demonstrate that lactoferrin is a potential activator of the vitamin D *** this sense,the combined use of lactoferrin(through an association of oral intake and a nasal spray formulation)and vitamin D could represent a valuable therapy for COVID-19 treatment and ***,further randomized clinical trials are needed before recommending/prescribing them.

关键词： Lactoferrin Vitamin D SARS-CoV-2 COVID-19 Pandemics

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Inequity in the global distribution of monkeypox vaccines

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World Journal of Clinical Cases 2023年第19期11卷 4498-4503页

作者： marcos roberto tovani-palone Neel Doshi Paolo Pedersini Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India Department of Medicine Pravara Institute of Medical SciencesAhmednagar 413736India IRCCS Fondazione Don Carlo Gnocchi Milan 20148Italy

Monkeypox(mpox)has been a public health emergency of international concern that emerged in mid-2022 and has spread to 110 *** clinical findings of the disease vary according to the seriousness of the *** its case fatality risk has not been high,a significant percentage of patients require *** this context,local initiatives were taken to extend the limited supply of vaccines against the disease;however,such measures have not been sufficient to contain the spread of cases and ensure an equitable distribution of health *** a result,endemic regions of low-income countries continue to have insufficient access to mpox *** this and considering the global scope of the disease,there is still little discussion in the literature about the difficulties in achieving adequate vaccination coverage rates for the target population of *** this article,we briefly discussed general aspects of the disease,including its surveillance,the current global context of challenges for mpox vaccination,and issues on global allocation of health resources as well as proposed related recommendations.

关键词： Monkeypox Smallpox vaccine Health inequities Vaccination coverage Vaccination hesitancy Healthcare financing

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eHealth,telehealth,and telemedicine in the management of the COVID-19 pandemic and beyond:Lessons learned and future perspectives

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World Journal of Clinical Cases 2022年第8期10卷 2363-2368页

作者： Andrea Giacalone Luca Marin Massimiliano Febbi Thomas Franchi marcos roberto tovani-palone Department of Industrial Engineering Technologies for Sports Medicine and RehabilitationUniversity of Rome Tor VergataRome 00133Italy Department of Research Asomi College of SciencesMarsa MRS 19112Malta The Medical School The University of SheffieldSheffield S102RXUnited Kingdom Department of Pathology and Legal Medicine Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão Preto 14049-900Brazil

In this article,we discuss evidence supporting the effective implementation of e Health,telehealth,and telemedicine during the coronavirus disease 2019 pandemic,with a view towards its permanent future integration in *** performed a literature search for articles describing the use of telehealth/telemedicine in the pandemic context using five *** articles selected describe the use of telemedicine as its advantages in terms of practicality and *** synthesis of articles is applicable to high-,middle-and lowincome *** of the notable benefits include breaking down geographical and time barriers,reducing waiting lists and crowding in healthcare facilities,and saving on national healthcare ***,there are a number of difficulties with the widespread implementation of telemedicine services that mainly relate to bureaucratic and regulatory ***,it is also important to make healthcare professionals and providers aware of the limits of this tool to avoid potential cases of *** in turn will have to be made aware of and be educated on the use of this new healthcare modality before it is accepted by *** the current socio-economic climate,it is therefore essential to implement a telehealth model aimed at efficiency and continuity of healthcare,as well as leading to an improvement in the quality of life of patients,whilst optimising existing resources and reducing *** that regard,the adoption of e Health,telehealth,and telemedicine services should be considered highly timely,despite current existing limitations.

关键词： eHealth Telehealth Telemedicine Coronavirus disease 2019 Pandemics Delivery of healthcare

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Reconstruction surgery in head and neck cancer patients amidst the COVID-19 pandemic:Current practice and lessons for the future

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World Journal of Clinical Cases 2023年第7期11卷 1434-1441页

作者： Daniele Lizambri Andrea Giacalone Pritik A Shah marcos roberto tovani-palone Department of Advanced Medical and Surgical Sciences University of Campania Luigi VanvitelliCaserta 81100Italy Department of Industrial Engineering Technologies for Sports Medicine and RehabilitationUniversity of Rome Tor VergataRome 00133Italy Bangalore Medical College and Research Institute Karnataka 560002India Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

The coronavirus disease 2019(COVID-19)pandemic has imposed a radical change in daily life and work *** this context,health systems have suffered important and serious repercussions in all *** the changes brought about by the state of global health emergency,adjustments to guidelines,priorities,structures,professional teams,and epidemiological data stand *** light of this,the oncological field has witnessed several changes in the approach to cancer,whether due to delay in diagnosis,screening deficit,personnel shortage or the psychological impact that the pandemic has had on cancer *** article focuses on the management of oral carcinoma and the surgical approaches that oral and maxillofacial specialists have had at their disposal during the health *** this period,the oral and maxillofacial surgeons have faced many *** proximity of maxillofacial structures to the airways,the need of elective and punctual procedures in cancerous lesions,the aggressiveness of head and neck tumors,and the need for important healthcare costs to support such delicate surgeries are examples of some of the challenges imposed for this *** of the possible surgical'solutions'to the difficulties in managing surgical cases of oral carcinoma during the pandemic is locoregional flaps,which in the pre-COVID-19 era were less used than free ***,during the health emergency,its use has been widely *** setback may represent a precedent for opening up new *** the course of a long-term pandemic,a reassessment of the validity of different medical and surgical therapeutic approaches should be ***,given that the pandemic has highlighted vulnerabilities and shortcomings in a number of ways,including the issues of essential resource shortages,underinvestment in public health services,lack of coordination and versatility among politicians,policymakers and health leaders,resulting in overloaded health systems,rapi

关键词： Free tissue flaps Surgical flaps Head and neck neoplasms SARS-CoV-2 COVID-19 Pandemics

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ChatGPT and exercise prescription:Human *** or human plus machine?

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Journal of Sport and Health Science 2024年第5期13卷 661-662页

作者： Timothy Gustavo Cavazzotto Diego Bessa Dantas marcos roberto Queiroga Department of Physical Education Midwestern Parana State UniversityParana 85040-167Brazil Postgraduate Program in Physical Education UEM-UEL State University of LondrinaParana 86057-970Brazil

The power of artificial intelligence(AI)to create stories,music,art,and other creative projects has been demonstrated and criticized over recent decades in media,mainly because of the idea that AI will replace human *** recently,in November 2022,reactions to Chat Generative Pre-training Transformer(ChatGPT)release for public use reverberated in news and social media headlines,while its users exceeded100 million in just a few *** is a natural language processing program created by AI non-profit OpenAI Inc.

关键词： prescription replace Human

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ZnO/CeO_(2)/carbon xerogel composites with direct Z-scheme heterojunctions:Enhancing photocatalytic remediation of 4-chlorophenol under visible light

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Journal of Rare Earths 2024年第2期42卷 314-322,I0003页

作者： Nicolas Perciani de Moraes Maite Birkett de Campos Sanmartin Robson da Silva Rocha Abner de Siervo marcos roberto de Vasconcelos Lanza D.Amaranatha Reddy Lianqing Yu Liana Alvares Rodrigues Escola de Engenharia de Lorena-EEL/USP Estrada Municipal do Campinho S/NCEP 12602-810LorenaSao PauloBrazil Institute of Physics"Gleb Wataghin" Applied Physics DepartmentState University of Campinas13083-859CampinasSPBrazi Instituto de Quimica de Sao Carlos Universidade de Sao PauloAv.Trab.Sao Carlense400-Parque Arnold SchimidtSao CarlosSP13566-590Spain Department of Sciences Indian Institute of Information Technology Design and ManufacturingKurnoolAndhra Pradesh518007India School of Materials Science and Engineering China University of PetroleumQingdao266580China

This paper aims to create visible light driven ternary photocatalysts using zinc oxide(ZnO),cerium(IV)oxide(CeO_(2)),and carbon xerogel(CX) as constituent *** use of CeO_(2) is based on the creation of direct-Z-scheme heterojunctions with the ZnO and the consequent diminishing of charge recombination,whereas the carbon xerogel inclusion is predicted to minimize bandgap energy,decrease electro n-hole reco mbination,and boost specific surface *** re,the choice of the black-wattle tannin as a carbonaceous precursor was targeted at the development of an environmentally friendly and affordable *** existence of the hexagonal phase of zinc oxide and cubic structure of the cerium(IV) oxide in the ternary material was confirmed by X-ray diffractometry and X-ray photoelectron spectroscopy,with the latter also suggesting chemical bonding between the ZnO and the CX due to the creation of zinc oxycarbide *** inclusion of the carbon xerogel provokes a significant modification in the morphology of the ternary material,resulting in an increased surface area and smaller particle *** CX/ZnO-CeO_(2) ternary composite obtains the highest photocatalytic efficiency among all the materials studied,degrading 100% of 4-chlorophenol under simulated sunlight and 68% under visible radiation,after 5 *** increased photocatalytic activity can be attributed to the formation of direct Z-scheme heterojunctions between the semiconductors,higher visible light response,and higher specific surface area,as evidenced by the results obtained by active radical scavenging,chronoamperometry,diffuse reflectance spectroscopy,and N_(2) adsorption-desorption isotherms.

关键词： Zinc oxide Cerium(Ⅳ)oxide Carbon xerogel Photocatalysis Direct Z-scheme heterojunction 4-Chlorophenol Rare earths

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Kinematics ofmandibular advancement devices(MADs):Why do some MADs move the lower jaw backward duringmouth opening?

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Bio-Design and Manufacturing 2024年第5期7卷 637-650页

作者： Juan A.Cabrera Alex Bataller Sergio Postigo marcos García Mechanical Engineering Department University of Malaga29071 MalagaSpain

Mandibular advancement devices(MADs)are widely used treatments for obstructive sleep *** function by advancing the lower jaw to open the upper *** increase patient comfort,most patients allow the mouth to be ***,not all systems maintain the lower jaw in a forward position during mouth opening,which results in the production of a retrusion that favors the collapse of the upper ***,the kinematic behavior of the mechanism formed by the mandible-device assembly depends on jaw *** means that,during mouth opening,some devices cause lower jaw protrusion in some patients,but cause its retraction in *** this study,we report the behavior of well-known devices currently on *** do so,we developed a kinematic model of the lower jawdevice *** validated for all devices analyzed using a high-resolution camera *** results show that some of the devices analyzed here did not produce the correct behavior during patient mouth opening.

关键词： Mandibular advancement devices Lower jaw kinematics Sleep apnea

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Plant-available water capacity of soils at a regional scale:Analysis of fixed and dynamic field capacities

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Pedosphere 2024年第3期34卷 590-605页

作者： Vinod PHOGAT Paul RPETRIE Casandra COLLINS marcos BONADA South Australian Research and Development Institute GPO Box 397Adelaide SA 5001(Australia) School of Agriculture Food and WineWaite Research InstituteUniversity of AdelaideWaite CampusPMB1Glen Osmond SA 5064(Australia) College of Science and Engineering Flinders UniversityBedford Park SA 5042(Australia) The University of New South Wales Sydney NSW 2052(Australia) ARC Training Centre for Innovative Wine Production University of AdelaidePMB1Glen Osmond SA 5064(Australia)

Estimation of the plant-available water capacity(PAWC)of soils at a regional scale helps in adopting better land use planning,developing suitable irrigation schedules for crops,and optimizing the use of scarce water *** the current study,72 soil profiles were sampled from the Barossa region of South Australia to estimate pedo-transfer functions deduced from easily estimated soil *** functions were then used to estimate the fixed(10 and 33 kPa)and dynamic pressure head(h_(fc))water contents at field capacity(FC)for minimum drainage flux(0.01 and 0.001 cm d^(-1)),which serves as the upper boundary for plant-available water in *** estimated residual water content was corrected for subsoil constraints,especially the exchangeable sodium percentage(ESP).The results showed that the mean values of h_(fc)in sand-dominated light and medium textured soils(i.e.,sand,loamy sand,sandy loam,and loam)varied in a narrow range(15.8-18.2 kPa),whereas those in the clay-dominated heavy textured soils(i.e.,clay loam)showed a wide range(11.3-49.3 kPa).There were large differences in PAWC for dynamic FC(PAWC_(fc))and fixed FC at 10 kPa(PAWC10),33 kPa(PAWC33),and a mix of 10and 33 kPa(PAWC_(10,33))pressure heads depending on soil ***,the difference between PAWC at 10 kPa and h_(fc)(ΔPAWC_(10))was positive,whereas that between 33 kPa and h_(fc)(ΔPAWC_(33))was negative across all ***,the estimation of PAWC assuming a fixed FC at 10 and 33 kPa pressures(i.e.,PAWC_(10,33))for sandy,clay,and silty soils reduced the difference between fixed and dynamic pressure PAWCs to<10% across the *** estimation of PAWC was improved by incorporating the impact of subsoil constraints,such as high ESP,which was more pronounced for clay and silty *** findings demonstrate the inherent inconsistencies between static pressure and flux-based dynamic FC estimations in *** heterogeneity,intra-texture variability,subsoil constraints,and swell

关键词： crop lower limit drained upper limit pedo-transfer function soil hydraulic parameter soil texture

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