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Novel biomarkers of acute kidney injury: Evaluation and evidence in urologic surgery

World Journal of Nephrology 2015年第2期4卷 160-168页

作者： Marianne Schmid Deepansh Dalela Rana Tahbaz Jessica Langetepe marco Randazzo Roland Dahlem Margit Fisch Quoc-Dien Trinh Felix K-H Chun Center for Surgery and Public Health and Division of Urologic Surgery Brigham and Women’s HospitalHarvard Medical School Department of Urology University Hospital Hamburg-Eppendorf Center for Surgery and Public Health and Division of Urologic Surgery Brigham and Women’s Hospital Harvard Medical School Center for Outcomes Research Analytics and Evaluation Vattikuti Urology Institute Henry Ford Health System Department of Urology Cantonal Hospital Aarau Center for Surgery and Public Health and Division of Urologic Surgery Brigham and Women’s Hospital Harvard Medical School

Patients undergoing urologic surgery are at risk of acute kidney injury(AKI) and consequently longterm deterioration in renal function. AKI is further associated with significantly higher odds of perioperative complications, prolonged hospital stay, higher mortality and costs. Therefore, better awareness and detection of AKI, as well as identification of AKI determinants in the urological surgery setting is warranted to pre-empt and mitigate further deterioration of renal function in patients at special risk. New consensus criteria provide precise definitions of diagnosis and description of the severity of AKI. However, they rely on serum creatinine(SCr), which is known to be an inaccurate marker of early changes in renal function. Therefore, several new urinary and serum biomarkers promise to address the gap associated with the use of SCr. Novel biomarkers may complement SCr measurement or most likely improve the diagnostic accuracy of AKI when used in combinations. However, novel biomarkers have to prove their clinical applicability, accuracy, and cost effectiveness prior to implementation into clinical practice. Most preferably, novel biomarkers should help to positively improve a patient's long-term renal functional outcomes. The purpose of this review is to discuss currently available biomarkers and to review their clinical evidence within urologic surgery settings.

关键词：泌尿外科急性肾损伤肾病治疗方法

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Phytochemical Profile of Wollemia nobilis Half-Matured Female Cones and Their Potential Ethnopharmacological and Nutraceutical Activities

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Journal of Agricultural Science and Technology(A) 2018年第3期8卷 162-170页

作者： Claudio Frezza Alessandro Venditti Cecilia Scandurra Alessandro Ciccòla Ilaria Serafini Fabio Sciubba Sebastiano Foddai marco Franceschin Armandodoriano Bianco Mauro Serafini Dipartimento di Biologia Ambientale Università di Roma "La Sapienza" Piazzale Aldo Moro 5 Rome 00185 Italy Dipartimento di Chimica Università di Roma "La Sapienza" Piazzale Aldo Moro 5 Rome 00185 Italy

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3D打印技术

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现代装饰（家居） 2015年第3期 46-51页

作者： Alessandro Zambelli Aud Julie Befring Gio Tirotto&Stefano Rigolli Linlin&Pierre-Yves Lanzavecchia+Wai marco Lafiandra Maria Jennifer Carew Studio MeraldiRubini Serena Confalonieri Selvaggia Armani 3 DOTS COLLECTIVE 伏平范嘉苑

上世纪70年代,随着3D辅助设计的兴起,设计师能在电脑软件中看到虚拟的三维物体,但要将这些物体用粘土、木头或金属做成模型却非常不容易。3D打印技术的出现,令平面变成立体的过程一下子简单了很多,设计师的任何改动都可在短时间内重新... 详细信息

上世纪70年代,随着3D辅助设计的兴起,设计师能在电脑软件中看到虚拟的三维物体,但要将这些物体用粘土、木头或金属做成模型却非常不容易。3D打印技术的出现,令平面变成立体的过程一下子简单了很多,设计师的任何改动都可在短时间内重新打印出来,而不用花几周的时间等着工厂将新模型制造出来,大大缩短了制作周期,降低了制作成本。并且,随着科技的不断进步,更多材料的产品可以打印出来。

关键词：三维物体花几制作成本制作周期电脑软件三维设计快速成型技术这个世界加成型小球体

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纤维板生产厂附近的儿童中室外甲醛和二氧化氮暴露与遗传毒性标志物

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环境与职业医学 2014年第9期31卷 682-682页

作者： Alessandro marcon Maria Enrica Fracasso Pierpaolo Marchetti Denise Doria Paolo Girardi Linda Guarda Giancarlo Pesce Vanda Pironi Paolo Ricci Roberto de marco

[背景]工业空气污染是一种公共卫生危害。以前的证据表明,在意大利最大的纤维板生产区（Viadana）工厂附近生活的儿童中呼吸道症状和住院率升高。[目的]随机选取住在Viadana附近的儿童（6~12岁）,评估户外甲醛和二氧化氮（NO2）暴露与... 详细信息

[背景]工业空气污染是一种公共卫生危害。以前的证据表明,在意大利最大的纤维板生产区（Viadana）工厂附近生活的儿童中呼吸道症状和住院率升高。[目的]随机选取住在Viadana附近的儿童（6~12岁）,评估户外甲醛和二氧化氮（NO2）暴露与口腔黏膜细胞中早期遗传毒性损伤标志物之间的关联。[方法]在2010—2011年,用彗星和微核实验分别评价口腔脱落细胞中的DNA链断裂和核异常,并用被动采样监测甲醛和NO2。通过空间插值法将每年的污染物暴露估计值分配到每个孩子的住所。[结果]在656名儿童中,有413名（63%）参加了研究。住在纤维板厂附近（〈2 km）的孩子的甲醛和NO2暴露平均水平最高（P〈0.001）。甲醛水平每增加1个标准差（0.20μg/m3）与彗尾强度升高0.13%（95%CI：0.03~0.22）、尾矩升高0.007（95%CI：0.001~0.012）和核芽相对增加12%[相对危险度（RR）=1.12;95%CI：1.02~1.23]有关联。NO2水平每增加一个标准差（2.13μg/m3）与双核细胞增加0.13%（95%CI：0.07~0.19）和核芽相对增加16%（RR=1.16,95%CI：1.06~1.26）有关联。[结论]在纤维板生产区域附近生活的儿童,其污染物暴露与口腔脱落细胞遗传毒性的标志物有关联。将这些研究结果与先前报道的纤维板生产活动与儿童呼吸系统结局间的关联相结合,加剧了人们对Viadana地区企业生产相关暴露所致潜在不利健康影响的担忧。

关键词：纤维板生产遗传毒性口腔黏膜细胞核芽脱落细胞微核实验毒性损伤采样监测双核细胞空气污染

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大都会及杜嘉班纳总部大楼意大利米兰

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世界建筑导报 2018年第5期33卷 72-75页

作者： Luca Lazzerotti Micaela Bonomessi Silvia Calzetti Laura Cassani Gabriele Coi marco Dragoni Davide Fascione Suewoo Kim Magali Roig Liverato Michele Megna Elena Migliorati Gianni Mollo Andrea Palaia Salvatore Seggio 布鲁克.泰勒 Andrea Martiradonna Piuarch

大都会（Metrop01）项目是对米兰一座著名的地标建筑——可追溯到20世纪40年代的大都会影院进行的翻新。影院坐落于市中心的维亚尔皮亚韦（viale Piave）繁华地段，玛丽亚·卡拉斯（Maria Callas）曾在这里进行歌剧《诺玛》的录制。项... 详细信息

大都会（Metrop01）项目是对米兰一座著名的地标建筑——可追溯到20世纪40年代的大都会影院进行的翻新。影院坐落于市中心的维亚尔皮亚韦（viale Piave）繁华地段，玛丽亚·卡拉斯（Maria Callas）曾在这里进行歌剧《诺玛》的录制。项目对原建筑进行了全面改造，并扩建1，000平方米左右，现总占地面积约为3，500平方米。可以用于举办各类活动和接待宾客等。设计采用了建筑师和公司共同制定的常见主题：线性结构为主，采用地中海式材料，如浮石和暗乳白玻璃等，表面光鲜亮丽．灯光效果尤佳，完全符合杜嘉班纳（Dolce＆Gabbana）的风格。

关键词：大都会米兰意大利大楼地标建筑占地面积线性结构乳白玻璃

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Sonographic markers for early diagnosis of fetal malformations

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World Journal of Radiology 2013年第10期5卷 356-371页

作者： Maria Daniela Renna Paola Pisani Francesco Conversano Emanuele Perrone Ernesto Casciaro Gian Carlo Di Renzo marco Di Paola Antonio Perrone Sergio Casciaro National Council of Research Institute of Clinical Physiology c/o Campus Universitario Ecotekne Department of Ob-stetrics and Gynecology University of Perugia Santa Maria della Misericordia University Hospital Obstetrics and Gynecology Department "Vito Fazzi" Hospital Piazza Filippo Muratore

Fetal malformations are very frequent in industrialized *** advanced maternal age may affect pregnancy outcome adversely,80%-90%of fetal malformations occur in the absence of a specific risk factor for *** only effective approach for prenatal screening is currently represented by an ultrasound ***,ultrasound methods present two important limitations:the substantial absence of quantitative parameters and the dependence on the sonographer *** recent years,together with the improvement in transducer technology,quantitative and objective sonographic markers highly predictive of fetal malformations have been *** markers can be detected at early gestation(11-14 wk)and generally are not pathological in themselves but have an increased incidence in abnormal ***,prenatal ultrasonography during the second trimester of gestation provides a"genetic sonogram",including,for instance,nuchal translucency,short humeral length,echogenic bowel,echogenic intracardiac focus and choroid plexus cyst,that is used to identify morphological features of fetal Down’s syndrome with a potential sensitivity of more than 90%.Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal *** the future,sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis(amniocentesis,etc.).

关键词： Prenatal diagnosis Prenatal sonography Chromosome abnormalities nuchal translucency Fetal echocardiography Skeletal dysplasia

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Interdisciplinary management of central nervous system metastasis and neoplastic meningitis:recent developments and future perspectives

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 163-175页

作者： Ghazaleh Tabatabai Marilin Koch Cristiana Roggia Juliane Ebert Claus Garbe Friedegund Meier Sara Brucker Eva Maria Grischke Diethelm Wallwiener Robert Möhle Lothar Kanz Walter Erich Aulitzky Ulrike Ernemann Christian laFougere Konstantin Nikolaou Bernd Pichler Jens Schittenhelm Manuela Neumann Falko Fend Stefan Czemmel Sven Nahnsen Frank Paulsen Daniel Zips Maike van Lessen Hans-Otto Karnath Ulf Ziemann Constantin Roder marco Skardelly Jürgen Bernd Honegger marcos Tatagiba Interdisciplinary Division of Neuro-Oncology Departments of Vascular Neurology and NeurosurgeryUniversity Hospital TübingenHertie Institute for Clinical Brain ResearchEberhard Karls University72076 TübingenGermany Division of Dermato-Oncology Department of DermatologyUniversity Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Gynecology and Ostetrics University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Internal Medicine(II) University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Hematology and Oncology Robert Bosch Hospital StuttgartStuttgartGermanyComprehensive Cancer CenterTübingen StuttgartGermany Department of Diagnostic and Interventional Neuroradiology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Nuclear Medicine University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Diagnostic and Interventional Radiology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Preclinical Imaging and Radiopharmacy University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Pathology and Neuropathology University Hospital TübingenEberhard Karls University72076 TübingenGermany Department of Radiation Oncology University Hospital TübingenEberhard Karls University72076 TübingenGermany Division of Neuropsychology University Hospital TübingenHertie Institute for Clinical Brain ResearchEberhard Karls University72076 TübingenGermany Center for CNS tumors Comprehensive Cancer Center Tübingen StuttgartGermany Center for Personalized Medicine University Hospital TübingenEberhard Karls UniversityTübingenGermany Center for Dermato-Oncology University Hospital DresdenGermany Quantitative Biology Center(QBiC) Eberhard Karls UniversityTübingenGermany DKTK DKFZ partner site Tübingen.18Department of ImmunologyEberhard Karls University TübingenGermany

The incidence of metastatic disease in the central nervous system(CNS)is *** to current estimates,up to a third of adult cancer patients will suffer from CNS *** evidence-based data from prospective randomized trials are rare,however,because CNS metastasis patients were often excluded from clinical trial *** management of CNS metastasis patients is therefore rather ill-defined and an interdisciplinary *** basic and translational science data have begun contributing to a more profound understanding of the molecular mechanisms leading to invasion of tumor cells into the *** report reviews advances,challenges,and perspectives in this field.

关键词： Brain tumor central nervous system metastases interdisciplinary management

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Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

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World Journal of Radiology 2016年第1期8卷 82-89页

作者： Francesco Fiz Silvia Morbelli Matteo Bauckneht Arnoldo Piccardo Giulia Ferrarazzo Alberto Nieri Nathan Artom Manlio Cabria Cecilia Marini marco Canepa Gianmario Sambuceti Nuclear Medicine Department of Health ScienceUniversity of Genoa and IRCCS San Martino-IST Nuclear Medicine Unit Galliera Hospital Clinic of Internal Medicine 1 Department of Internal MedicineUniversity of Genoa School of Medicine CNR Institute of Molecular Bioimaging and Physiology Milan section of Genoac/o Nuclear Medicine Cardiovascular Unit Department of Internal MedicineUniversity of Genoa

AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F) uptake,as a marker of ongoing calcification and cardiovascular risk ***: Seventy-eight patients(44 females,mean age 63,range 44-83) underwent whole body 18F-Na F positron emission tomography/computed tomography. Cardiovascular risk(CVR) was used to divide these patients in three categories: Low(LR),medium(MR) and high risk(HR). 18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic ***: A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84 ± 0.76 vs 1.07 ± 0.3,P < 0.001),but also between MR and HR-LR(1.4 ± 0.4,P < 0.02 and P < 0.01,respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P < 0.01). Myocardial uptake provided an effective CVR classes stratification(P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R = 0.67),but it peaked when correlating the descending thoracic segment(R = 0.75),in comparison with the aortic arch and the ascending segment(R = 0.55 and 0.53,respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients' risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination.

关键词： Positron emission tomography/computed tomography 18F-Natrium fluoride Plaque imaging Cardiovascular risk profile Thoracic aorta

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Evolution of Pre-Columbian Metallurgy from the North of Peru Studied with a Portable Non-invasive Equipment Using Energy-Dispersive X-Ray Fluorescence

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材料科学与工程（中英文B版） 2011年第1期1卷 48-81页

作者： Roberto Cesareo Angel Bustamante D Julio Fabian S Sandra Zambrano A Walter Alva Luis Chero del Carmen Espinoza C Rosendo Rodriguez R marco Seclen F Fidel Gutierrez V E.B. Ldvano Gonzales A. Marcia A. Rizzutto Enrico Poli Cristiane Calza Marcelino dos Anjos Ricardo T. Lopes Giovanni E. Gigante Gabriel M. Ingo Cristina Riccucci Carlos Elera Izumi Shimada Victor Curay Castillo G and Fabio Lopes Dipartimento di Matematica e Fisica Universith di Sassari Sassari Italy Universidad Nacional Mayor de San marcos Lima Peri4 Museo ＂Tumbas Reales de Sip6n ＂ Lambayeque Perlt Instituto de Fisica Universidade de S6o Paulo SP Brasil Asociaci6n cultural e Museo Enrico Poli Lima Peru COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Dipartimento di Energetica Universith di Roma ＂La Sapienza ＂ Rome Italy lstituto Studio dei Materiali Nanostrutturati-CNR Area Ricerca RM1-Montelibretti Rome Italy Museo de Sic6n Ferrahqfe Perit Istituto Nacional de Cultura Piura Peru Universidade Estadual de Londrina Londrina PR Brasil

On the north coast of present-day Peru, between the Andes and the Pacific Ocean, prospered approximately between 1000 BC and 1375 AD, several relevant cultures: Chavín (1000-200 BC), Vicús and Frías (200 BC - 300 AD), Moche (400 BC-700 AD), Sicán (700-1375 AD). These cultures are interconnected and characterized by a high metallurgical ability, demonstrated by the presence of beautiful artifacts on gold, silver and copper alloys. More than hundred metal artefacts from these cultures were analyzed with a portable equipment which uses the non-destructive and non-invasive technique of energy-dispersive X-ray fluorescence (EDXRF). Following objects were analyzed: (1) gold, silver and copper objects from the Chavín culture (Museo Municipal of Piura and and Museo Enrico Poli in Lima); (2) gold and silver objects from the Vicús and Frías cultures (Museo Municipal of Piura); (3) gold, silver and copper objects from the Moche culture ("Museo Tumbas Reales de Sipán", "Museo de Sitio de Huaca Rajada" in Lambayeque and Museo Enrico Poli in Lima); (4) gold, silver and copper objects from the Sicán culture (Museum of Sicán, Ferra?afe). Portable equipments were employed, mainly composed of a small size X-ray tube and a thermoelectrically cooled, small size, Si-PIN or Si-drift X-ray detectors. The main characteristics of the EDXRF-technique is of being non destructive and multi-elemental. Standard samples of gold and silver alloys were employed for calibration and quantitative analysis. The aims of this campaign of analysis were: (1) to analyze a large number of objects; (2) to differentiate gold, gilded copper and tumbaga (this last being a poor gold alloy enriched at the surface by depletion gilding); (3) to correlate, when possible, composition of analyzed alloys to the specific culture; (4) to determine a possible evolution of metallurgy; (5) to better determine characteristics and beginning time of tumbaga production. It was determined that the analyzed artefacts are composed

关键词： X射线荧光技术能量色散侵入性冶金鲁北设备使用便携式哥伦布

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Gynecological malignancies and hormonal therapies: Clinical management and recommendations

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World Journal of Obstetrics and Gynecology 2014年第4期3卷 162-170页

作者： Anna Myriam Perrone Federica Pozzati Donatella Santini Martina Rossi Martina Procaccini Lucia Casalini Erica Santi marco Tesei Claudio Zamagni Pierandrea De Iaco Oncologic Gynecology Unit Sant’Orsola-Malpighi Hospital40138 BolognaItaly Pathology Unit Sant’Orsola-Malpighi University Hospital40138 BolognaItaly Medical Oncology Unit Sant’Orsola-Malpighi University Hospital40138 BolognaItaly

Every year in the world a large number of women receive a diagnosis of gynecological cancer and undergo a therapy such as surgery, chemotherapy and radiotherapy to the pelvic region. A large portion of these patients are already in menopause, but for younger patients therapies are responsible of early menopause. The physical and psychological symptoms due to iatrogenic menopause significantly reduce the quality of life; however hormone replacement therapy(HRT) has a high efficacy in reducing menopausal symptoms. The prescription of HRT in patients with story of gynecological cancer is debated because its safety has not been completely proven. The main criticism is based on the theory that the hormone replacement could stimulate growth of residual cancer cells increasing the risk of recurrence.

关键词：妇科癌症治疗方法临床分析

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