Gynecological malignancies and hormonal therapies: Clinical management and recommendations

作     者：Anna Myriam Perrone Federica Pozzati Donatella Santini Martina Rossi Martina Procaccini Lucia Casalini Erica Santi Marco Tesei Claudio Zamagni Pierandrea De Iaco 

作者机构：Oncologic Gynecology UnitSant’Orsola-Malpighi Hospital40138 BolognaItaly Pathology UnitSant’Orsola-Malpighi University Hospital40138 BolognaItaly Medical Oncology UnitSant’Orsola-Malpighi University Hospital40138 BolognaItaly 

出 版 物：《World Journal of Obstetrics and Gynecology》 (世界妇产科杂志)

年 卷 期：2014年第3卷第4期

页      面：162-170页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Iatrogenic menopause Gynecological cancer Hormone replacement therapy Risk of recurrence Climateric symptoms Cardiovascular benefits Clinical practice 

摘      要：Every year in the world a large number of women receive a diagnosis of gynecological cancer and undergo a therapy such as surgery, chemotherapy and radiotherapy to the pelvic region. A large portion of these patients are already in menopause, but for younger patients therapies are responsible of early menopause. The physical and psychological symptoms due to iatrogenic menopause significantly reduce the quality of life; however hormone replacement therapy(HRT) has a high efficacy in reducing menopausal symptoms. The prescription of HRT in patients with story of gynecological cancer is debated because its safety has not been completely proven. The main criticism is based on the theory that the hormone replacement could stimulate growth of residual cancer cells increasing the risk of recurrence.