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A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study

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Oncology Research 2023年第2期31卷 207-220页

作者： GUSTAVO marTÍN VILLOLDO mar.a TERESA POMBO mar.aNA ARIS JOAQUÍN CHEMI PABLO MANDÓ SUPRIYA NAGARAJU JUAN CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA AMAT JOSÉLEÓN MELLADO JOSÉMORDOH ALBERTO VILLARONGA mar.a marcela barrio Urology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immunohistochemistry Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Centro de Investigaciones Oncológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Department MD Anderson Cancer CenterHoustonTX77030USA Pathology Department Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive *** induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor *** searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment ***-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by *** polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+*** addition,PD-1/PD-L1 staining was *** results correlated with BCG *** most non-responders,Th1/Th2 markers were compared in pre-and post-BCG *** was 65.6%in the study *** responders had a higher G/T ratio and a greater number of degranulated EPX+*** combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower ***-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of ***-L1/PD-1 expression was not associated with the response to *** results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity.

关键词： Non-muscle invasive bladder cancer BCG predictive biomarkers Lymphocyte polarization

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Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin

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World Journal of Gastroenterology 2018年第3期24卷 397-407页

作者： Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana mar.a Cabanne Gerardo Gabriel Zerbetto de Palma Liliana marchesi Olid mar.a mar.a Piskorz marcela Beatriz Zubillaga mar.ana Andrea Janjetic Cinthia Gabriela Goldman Universidad de Buenos Aires Facultad de Farmacia y BioquímicaCátedra de FísicaBuenos Aires C1113AADArgentina Hospital de Gastroenterología“Dr.Carlos Bonorino Udaondo” Sección Esófago-EstómagoBuenos Aires C1264AAAArgentina Hospital de Gastroenterología"Dr.Carlos Bonorino Udaondo” Unidad PatologíaBuenos Aires C1264AAAArgentina Universidad de Buenos Aires-CONICET Facultad de MedicinaInstituto de Microbiología y Parasitología Médica(IMPAM)Buenos Aires C1121ABGArgentina Universidad de Buenos Aires Facultad de MedicinaEscuela de NutriciónBuenos Aires C1121ABGArgentina Hospital de Clínicas“Joséde San martín” División GastroenterologíaBuenos Aires C1120AARArgentina National Scientific and Technical Research Council(CONICET) Buenos Aires C1425FQBArgentina

AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional *** Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear *** One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of *** status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with l

关键词： Helicobacter pylori cagA Ghrelin Leptin Pathology

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Multi-temporal NDVI analysis using UAV images of tree crowns in a northern Mexican pine-oak forest

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Journal of Forestry Research 2023年第6期34卷 1855-1867页

作者： JoséLuis Gallardo-Salazar marcela Rosas-Chavoya marín Pompa-García Pablito marcelo López-Serrano Emily García-Montiel Arnulfo Meléndez-Soto Sergio Iván Jiménez-Jiménez Instituto de Investigaciones Agropecuarias y Forestales Universidad Michoacana de San Nicolás de Hidalgo(UMSNH)58330 MoreliaMichoacánMexico Programa Institucional de Doctorado en Ciencias Agropecuarias y Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Facultad de Ciencias Forestales Universidad Juárez del Estado de DurangoRío Papaloapan y Blvd.DurangoValle del Sur s/n34120 DurangoDurangoMéxico Instituto de Silvicultura e Industria de la Madera Universidad Juárez del Estado de DurangoBoulevard del Guadiana 501Ciudad UniversitariaTorre de Investigación34120 DurangoMéxico INIFAP-CENID RASPA Centro Nacional de Investigación Disciplinaria en Relación Agua-Suelo-Planta-Atmósfera Margen derecha canal Sacramento km 6.5Zona industrial35140 Gómez PalacioDurangoMexico

The use of unmanned aerial vehicles(UAV)for forest monitoring has grown significantly in recent years,providing information with high spatial resolution and temporal *** with multispectral sensors allow the use of indexes such as the normalized difference vegetation index(NDVI),which determines the vigor,physiological stress and photo synthetic activity of *** study aimed to analyze the spectral responses and variations of NDVI in tree crowns,as well as their correlation with climatic factors over the course of one *** study area encompassed a 1.6-ha site in Durango,Mexico,where Pinus cembroides,Pinus engelmannii,and Quercus grisea *** images were acquired with UAV and information on meteorological variables was obtained from NASA/POWER *** ANOVA explored possible differences in NDVI among the three *** correlation was performed to identify the linear relationship between NDVI and meteorological *** differences in NDVI values were found at the genus level(Pinus and Quercus),possibly related to the physiological features of the species and their *** grisea had the lowest NDVI values throughout the year which may be attributed to its sensitivity to relative humidity and *** the use of UAV with a multispectral sensor for NDVI monitoring allowed genera differentiation,in more complex forest analyses hyperspectral and LiDAR sensors should be integrated,as well other vegetation indexes be considered.

关键词： Multispectral images Normalized diff erence Vegetation index Phenology Unmanned aerial vehicles Multitemporal analysis

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End Stage Renal Disease in a Child with Epidermolysis Bullosa

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International Journal of Clinical Medicine 2016年第7期7卷 433-436页

作者： Felipe Cavagnaro mar.a Joao Yubero marcela Valenzuela Francis Palisson Facultad de Medicina Clínica Alemana-Universidad del Desarrollo Santiago Chile Clínica Alemana de Santiago Santiago Chile Fundación DEBRA-Chile Santiago Chile Unidad de Nefrología Pediátrica Hospital Guillermo Grant Benavente Concepción Chile

Epidermolysis bullosa (EB) is an inherited connective tissue disease causing blisters in the skin and mucosal membranes. In severe cases, EB may be associated with renal damage through several mechanisms, mainly immunological ones. The present case described a young male with dystrophic recessive EB who developed an advanced chronic renal damage secondary to tubulointerstitial nephritis that was demonstrated by a renal biopsy. Unpublished previously, this complication should be considered among the possible causes of renal damage in EB. Also it is recommended a protocoled surveillance of renal and urinary tract complications in children with EB.

关键词： Epidermolysis Bullosa Tubulointerstitial Nephritis Chronic Renal Failure Dialysis

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A Deep Look into Extractive Text Summarization

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Journal of Computer and Communications 2021年第6期9卷 24-37页

作者： Jhonathan Quillo-Espino Rosa mar.a Romero-González Ana-marcela Herrera-Navarro Facultad de Informática Universidad Autónoma de Querétaro Querétaro México

This investigation has presented an approach to Extractive Automatic Text Summarization (EATS). A framework focused on the summary of a single document has been developed, using the Tf-ldf method (Frequency Term, Inverse Document Frequency) as a reference, dividing the document into a subset of documents and generating value of each of the words contained in each document, those documents that show Tf-Idf equal or higher than the threshold are those that represent greater importance, therefore;can be weighted and generate a text summary according to the user’s request. This document represents a derived model of text mining application in today’s world. We demonstrate the way of performing the summarization. Random values were used to check its performance. The experimented results show a satisfactory and understandable summary and summaries were found to be able to run efficiently and quickly, showing which are the most important text sentences according to the threshold selected by the user.

关键词： Text Mining Preprocesses Text Summarization Extractive Text Sumarization

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Proximate composition and seed lipid components of “kabuli”-type chickpea (Cicer arietinumL.) from Argentina

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Agricultural Sciences 2013年第12期4卷 729-737页

作者： Carla G. marioli Nobile Julia Carreras Rubén Grosso marcela Inga Mercedes Silva Roxana Aguilar mar.a José Allende Raúl Badini mar.a José martinez Centro de Excelencia en Productos y Procesos (CEPROCOR-MINCyT) Córdoba Argentina Facultad de Ciencias Agropecuarias (F.C.A.) Universidad Nacional de Córdoba (U.N.C.) Córdoba Argentina Laboratorio Calidad Nutricional de Granos Estación Experimental Agropecuaria (EEA) Instituto Nacional de Tecnología Agropecuaria (INTA) Manfredi Córdoba Argentina

Chickpea is an important pulse crop with a wide range of potential nutritional benefits because of its chemical composition. The purpose of the current work was to provide the chemical composition of “kabuli”-type chickpea (Cicer arietinum L.) developed in Argentina for nutritional purpose. Protein, oil and ash contents, fatty acid, tocopherol and mineral element compositions were studied. Among the studied genotypes, protein content ranged from 18.46 to 24.46 g/100g, oil content ranged from 5.68 to 9.01 g/100g and ash from 3.55 to 4.46 g/100g. Linoleic, oleic and palmitic acids were the most abundant fatty acids. The average oleic-to-linoleic ratio was 0.62 and average iodine value was 117.82. Tocopherols, well-established natural antioxidants, were found in chickpea seeds in relatively similar amounts across all genotypes. Mineral element analysis showed that chickpea was rich in macronutrients such as K, P, Mg and Ca. The nutritional composition of chickpea genotypes developed and grown in Argentina provides useful information for breeding programs, food marketing and consumers and establishes chickpea as component of a balanced human diet.

关键词： Chickpea Pulse Crop Fatty Acids Tocopherols Mineral Elements

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Microwave Dried Carrot Pomace as a Source of Fiber and Carotenoids

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Food and Nutrition Sciences 2013年第10期4卷 1037-1046页

作者： marcela Hernández-Ortega Guy Kissangou Hugo Necoechea-Mondragón mar.a Elena Sánchez-Pardo Alicia Ortiz-Moreno Coordinación de Cooperación Académica Edificio de la Secretaría Académica Instituto Politécnico Nacional México City México. Departamento de Ingeniería Bioquímica Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional México City México

Carrot pomace is a major by-product obtained during the industrial juice extraction process, which is discarded contributing to environmental pollution. This residue is rich in fiber, and contains high amounts of carotenoids and phenolic compounds that could contribute to its application as functional ingredient, improving the quality of foods and helping to reduce the environmental problem. In this study, carrot pomace powders obtained by microwave or hot air drying were incorporated into cookies in order to improve their phytochemical content. Cookies were prepared using a traditional cookie recipe substituting 30% of the wheat flour for either of the carrot pomace powders. Fiber, carotenoids and phenolic compounds were determined;image analysis and acceptability of the cookies were also conducted. The substitution of 30% of wheat flour for carrot pomace powders increased 3.7 fold the total dietary fiber of cookies, from 7.13 g/100gto26.44 g/100g;accounting the 7.4% of fiber daily intake with the consumption of one cookie (7 g). A similar pattern was found in the content of carotenoids and phenolic compounds. Carrot pomace dried with microwaves had the highest amount of these bioactive compounds. β-carotene, epicatechin, gallic and ferulic acids were identified in cookies with microwave carrot pomace powder. The cookies incorporated with carrot pomace powders exhibited improved antioxidant properties because of the increase in the phytochemical content. Acceptable cookies with appealing orange color were obtained. The results indicated that the replacement of wheat flour for carrot pomace powders yielded dietary fiber enriched cookies with improved carotenoid content.

关键词： Carrot Pomace Microwave Drying Fiber Carotenoids Phenolic Compounds Antioxidant Activity Cookie

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Soluble ST2:A new and promising activity marker in ulcerative colitis

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World Journal of Gastroenterology 2011年第17期17卷 2181-2190页

作者： David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos mar.a-Julieta González marcela A Hermoso Rodrigo Quera Disciplinary Program of Immunology Institute of Biomedical SciencesFaculty of MedicineUniversidad de ChileSantiagoCL 8380453Chile Department of Clinical Investigation Hospital Clínico de la Universidad de ChileSantiagoCL 8380456Chile Laboratory of Oncology and Molecular Genetics Colorectal Surgery UnitClínica Las CondesLo Fontecilla 441SantiagoCL 7591046Chile Department of Gastroenterology Pontificia Universidad Católica de ChileSantiagoCL 8380074Chile Cell and Molecular Biology Program Biomedical Sciences InstituteFaculty of MedicineUniversidad de ChileSantiagoCL 8380453Chile Gastroenterology Unit Department of Internal MedicineHospital Clínico de la Universidad de ChileSantiagoCL 8380456Chile Gastroenterology Unit Clínica Las CondesLo Fontecilla 441SantiagoCL 7591046Chile

AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive ***:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or *** serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to *** sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of ***:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of *** of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,*** AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r =

关键词： Inflammatory bowel disease Ulcerative colitis Soluble ST2 Biomarkers

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Incidence evaluation of Crypticerya multicicatricesand Maconellicoccus hirsutusin Colombian Seaflower Biosphere Reserve

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Agricultural Sciences 2013年第12期4卷 654-665页

作者： marcela Silva-Gomez John A. Quiroz-Gamboa Francisco C. Yepes mar.a F. Maya Adriana Santos Lilliana M. Hoyos-Carvajal Jardín Botánico de San Andrés Universidad Nacional de Colom-bia Sede Caribe San Andrés Colombia Universidad Nacional de Colombia Sede Medellín Medellín Colombia

An evaluation of the incidence of Crypticerya multicicatrices and Maconellicoccus hirsutus in Colombian Seaflower Biosphere Reserve in San Andrés, Providence and Santa Catalina islands, from mid-August to mid-November 2012 was made. 38 locations were sampled, and 34% of sites tested show an incidence of C. multicicatrices oscillating between a range of 80%-100%, 24% with 40%-80% of incidence, 18% between 10%-40% and 24% with a range of 0%-10%. The occurrence of M. hirsutus fluctuated between 0.5% and 17%. There were seven genera of ants associated C. multicicatrices and 94 hosts of this agriculturally important insect and we found high incidence of associated sooty mold in C. multicicatrices hosts. Observations also contained some developmental stages of C. multicatrices.

关键词： Colombia’s Caribbean Insular Pink Hibiscus Mealybug Multicicatrices Fluted Scale Sap Sucking Insects Honey Dew Sooty Mold

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HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium

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World Journal of Gastroenterology 2022年第29期28卷 3886-3902页

作者： Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa mar.a Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López marcela Salazar García Norma Velázquez-Guadarrama Laboratorio de Investigación en Enfermedades Infecciosas Hospital Infantil de México Federico GómezMexico City 06720Mexico Posgrado en Biomedicina y Biotecnología Molecular Laboratorio de Producción y Control de BiológicosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Adquisición de Hierro Universidad Autónoma de la Ciudad MéxicoPosgrado Ciencias GenómicaMexico City 03100Mexico Laboratorio Central de Microscopía Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Centro de estudios económicos y sociales en salud Hospital Infantil de México Federico GómezMexico City 06720Mexico Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental Hospital Infantil de México Federico GómezMexico City 06720Mexico

BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence *** To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) *** Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional *** HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium *** technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS *** analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein

关键词： Hypothetical protein HP0953 Adherence Helicobacter pylori Glycocalyx Virulence factor Persistence

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