Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin

作     者：Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman 

作者机构：Universidad de Buenos AiresFacultad de Farmacia y BioquímicaCátedra de FísicaBuenos Aires C1113AADArgentina Hospital de Gastroenterología“Dr.Carlos Bonorino Udaondo”Sección Esófago-EstómagoBuenos Aires C1264AAAArgentina Hospital de Gastroenterología"Dr.Carlos Bonorino Udaondo”Unidad PatologíaBuenos Aires C1264AAAArgentina Universidad de Buenos Aires-CONICETFacultad de MedicinaInstituto de Microbiología y Parasitología Médica(IMPAM)Buenos Aires C1121ABGArgentina Universidad de Buenos AiresFacultad de MedicinaEscuela de NutriciónBuenos Aires C1121ABGArgentina Hospital de Clínicas“Joséde San Martín”División GastroenterologíaBuenos Aires C1120AARArgentina National Scientific and Technical Research Council(CONICET)Buenos Aires C1425FQBArgentina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2018年第24卷第3期

页      面：397-407页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the Universidad de Buenos Aires (UBA), Buenos Aires, Argentina, No. UBACYT 20020100100837 and No. UBACYT 20020130100645BA to Goldman CG the International Atomic Energy Agency (IAEA), Vienna, Austria, Coordinated Research Project (CRP) E43025 No. ARG-16746 to Goldman CG. UBA 

主　　题：Helicobacter pylori cagA Ghrelin Leptin Pathology 

摘      要：AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional *** Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman s correlation and linear *** One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of *** status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with l