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World Journal of Clinical Cases 2021年第23期9卷 6582-6590页

作者： Francisco Javier Pérez Lara mar.a Belen Jimenez martinez Francisco Pozo Muñoz Andres Fontalba Navas Rogelio Garcia Cisneros mar.a jose Garcia Larrosa Ignacio Garcia Delgado mar.a del mar Callejon Gil Department of Surgery Hopital de AntequeraAntequera 29200MálagaSpain North Malaga Healthcare District Hopital de AntequeraAntequera 29200MálagaSpain

The coronavirus disease 2019,which is caused by severe acute respiratory syndrome coronavirus 2,was first identified in December 2019 in Wuhan,China,and has since spread rapidly,evolving into a full-blown *** would like to report our experience after 1 year of this pandemic in the surgical service of a district hospital in *** have been many changes(including new protocols)that our service and the hospital have undergone,to adapt to the new *** believe that this experience can be useful for other professionals who have lived and are living a similar situation.

关键词： COVID-19 Hospital Experience Surgery Service Treatment

Intracameral 5-fluorouracil and viscous dispersive viscoelastic for diffuse epithelial downgrowth management in aphakia

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 845-847页

作者： Santiago Montolío-marzo Ester Fernández-López jose Vicente Piá-Ludena Juan mar.a Davó-Cabrera Enrique Antonio Alfonso-Munoz Cristina Peris-martínez FISABIO Oftalmología Médica Valencia 46015Spain

Dear Editor,I am *** Montolío-marzo from FISABIO Oftalmología Médica,Valencia,Spain.I write you to present a case report of epithelial downgrowth in an aphakic *** epithelial downgrowth is one of the most feared complications in cases of penetrating ocular trauma or recurrent ocular *** progress can affect all the ocular structures,giving rise to corneal decompensation,retinal detachment,difficult-to-treat glaucoma or phthisis bulbi and many cases end in enucleation[1].Fortunately,the incidence of this condition is very low,there being between 0.08%and 0.12%after cataract surgery and 0.25%after penetrating *** infrequency means that scientific evidence is reduced to case series and the opinions of experts without there being a homogeneous criterion to guide the work of the doctor in *** these reasons,epithelial downgrowth is still a diagnostic and therapeutic challenge.

关键词： viscoelastic viscous camera

Severe COVID-19 after liver transplantation, surviving the pitfalls of learning on-the-go: Three case reports

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World Journal of Hepatology 2020年第10期12卷 870-879页

作者： Felipe Alconchel Pedro A Cascales-Campos jose A Pons mar.a martínez josefa Valiente-Campos Urszula Gajownik mar.a L Ortiz Laura martínez-Alarcón Pascual Parrilla Ricardo Robles Francisco Sánchez-Bueno Santiago Moreno Pablo Ramírez Department of Surgery and Organ Transplantation Virgen de la Arrixaca University HospitalMurcia 30120Spain Department of Digestive Endocrine and Abdominal Surgery and TransplantationBiomedical Research Institute of Murcia(IMIBVirgen de la Arrixaca)Murcia 30120Spain Department of Hepatology Virgen de la Arrixaca University HospitalMurcia 30120Spain Department of Intensive Care Unit Virgen de la Arrixaca University HospitalMurcia 30120Spain Department of Infectious Diseases Ramon y Cajal HospitalMadrid 28034Spain

BACKGROUND The novel coronavirus 2019(COVID-19)pandemic has dramatically transformed the care of the liver transplant *** patients who are immunosuppressed and with multiple comorbidities,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been associated with increased severity and *** main objective of this report is to communicate our experience in the therapeutic management of SARS-CoV-2 infection in 3 liver transplant ***,we stress the management and investigation of the contagious spreading into a liver transplant *** SUMmarY The patients were two women(aged 61 years and 62 years)and one man(aged 68 years),all of them having recently received a liver *** three patients required intensive care unit admission and invasive mechanical *** of them progressed severely until *** other one,who received tocilizumab,had a good *** the outbreak,the wife of one of the patients and four healthcare professionals involved in their care were also *** We illustrate in detail the evolution of a nosocomial COVID-19 outbreak in a liver transplant *** believe that these findings will contribute to a better understanding of the natural history of the disease and will improve the treatment of the liver transplant patient with COVID-19.

关键词： Liver transplantation COVID-19 SARS-CoV-2 Cross infection Nosocomial infection Case report

Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： jose A.Vega Stefano Arellano-Perez Juan Gabriel Alvarez-Gonzalez Cristina Fernandez Enrique Jimenez Pedro Cuinas jose mar.a Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-Gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

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Neural Regeneration Research 2019年第11期14卷 1851-1857页

作者： Fernando Lucas-Ruiz Caridad Galindo-Romero David García-Bernal mar.a Norte-Munoz Kristy T. Rodríguez-Ramírez Manuel Salinas-Navarro jose E. Millán-Rivero Manuel Vidal-Sanz mar.a Agudo-Barriuso Grupo de Oftalmologia Experimental Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Talmologia Universidad de MurciaMurciaSpain Unidad de Terapia Celular y Trasplante Hematopoyetico Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Medicina Interna Universidad de MurciaMurciaSpain

Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e.,Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.

关键词： stem cells adipose stem cells umbilical cord bone marrow Wharton's jelly optic nerve axotomy neuroprotection

Social correlates of sedentary behavior in young people:The UP&DOWN study

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Journal of Sport and Health Science 2020年第2期9卷 189-196页

作者： Veronica Cabanas-Sanchez Laura Garcia-Cervantes Laura Esteban-Gonzalo mar.a jose Girela-Rejon jose Castro-Pinero Oscar L.Veiga Department of Physical Education Sport and Human MovementAutonomous University of MadridMadrid 28049Spain Research Centre in Physical Activity Health and Leisure(CIAFEL)Faculty of SportUniversity of PortoPorto 4200-450Portugal Nursing Department Faculty of Biomedical and Health SciencesUniversidad Europea de MadridVillaviciosa de OdonMadrid 28670Spain Department of Didactic of Corporal Expression Faculty of Education SciencesUniversity of GranadaGranada 18010Spain Department of Physical Education School of EducationUniversity of CadizPuerto RealCadiz 11519Spain

Purpose:The aim of the present study was to analyze the associations of youths' sedentary behavior(SB) with parents' and siblings' SB and physical activity(PA),as well as the associations of youths' coparticipation with parents,siblings,and friends in PA and SB with youths' ***:The sample consisted of 1543 youths(12.02±2.51 years;788 boys) enrolled in the baseline cohort of the UP&DOWN *** was assessed by accelerometry and *** reported the time spent by their parents and siblings watching television,playing videogames,surfing the Internet,sitting/resting,and doing ***,participants reported coparticipation with parents,siblings,and friends in these *** mixed models,including school and city as random effects,were ***:Parents' television time was positively associated with youths' screen-based *** with friends in playing videogames(in boys) and in surfing the Internet(in girls) showed a positive association with screen-based SB and a negative association with educational-based ***,coparticipation with siblings and friends in PA was inversely associated with accelerometer-based SB in boys and ***:Our results emphasize the important role of social modeling in the development of sedentary lifestyles in *** aimed at reducing health risk behaviors in youths could be more effective if they are oriented from a social perspective that involves their families and networks of their closest friends.

关键词： Friends Parents Sedentary behavior Siblings Social environment

Thermal analysis of olive tree pruning and the by-products obtained by its gasification and pyrolysis: The effect of some heavy metals on their devolatilization behavior

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Journal of Energy Chemistry 2019年第5期28卷 105-117页

作者： Irene lanez-Rodriguez mar.a Angeles martin-Lara Gabriel Blazquez Oscar Osegueda Monica Calero Department of Chemical Engineering Faculty of SciencesUniversity of GranadaAvda.Fuentenuevas/n 18071 GranadaSpain Department of Process Engineering and Environmental Sciences Jose Simeon Canas Central American UniversityBulevar Los ProceresSan SalvadorEl Salvador

In this work, the effect of the presence of nickel and lead in thermal decomposition of olive tree pruning (OTP), OTP-char and OTP-ashes was studied by thermogravimetry. Experiments were conducted in two kinds of atmosphere (nitrogen atmosphere and oxidizing atmosphere with 20% of O2) at a heating rate of 10 ℃/min. This investigation describes the chemical, physical and fuel properties of the OTP, which shows a similar composition to other lignocellulosic materials such as hazelnut husk and wood sawdust. In addition, SEM analysis indicated that OTP-char surface is higher than OTP surface with plenty of holes and channels. It makes the char an ideal support for metal retention specially for Pb metal (OTP retained 8.55 mg/g whereas OTP char retained 11.57 mg/g). On the other hand, metal retention occurred by adsorption or ion exchange, according to the IR spectrum of the samples. The results of thermogravimetric tests proved that the presence of lead did not have a strong effect on the decomposition of the samples, since TG and DTG curves were very similar. However, nickel increased the mass loss rate, accelerating the decomposition process, showing higher peaks in DTG curves. Additionally, for temperatures higher than 360 ℃, the volatilization of the samples was improved in the nickel-polluted sample, achieving a higher mass loss, getting more energy from the biomass and reducing the quantity of residues left after the process.

关键词： Biosorption Lead Metal-polluted biomass Nickel Thermal decomposition Thermogravimetric analysis

Novel suturing technique,based on physical principles,achieves a breaking point double that obtained by conventional techniques

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1039-1049页

作者： Francisco Javier Pérez Lara Rogelio Zubizarreta Jimenez Francisco Javier Moya Donoso jose Manuel Hernández Gonzalez Tatiana Prieto-Puga Arjona Ricardo marín Moya mar.a Pitarch martinez Department of Surgery Hopital de AntequeraMalaga 29200Spain DOXA Malaga 29730Spain

BACKGROUND Sutures have been used to repair wounds since ancient ***,the basic suture technique has not significantly *** Phase I of our project,we proposed a“double diabolo”suture design,using a theoretical physical study to show that this suture receives 50%less tension than conventional sutures,and so a correspondingly greater force must be applied to break *** To determine whether these theoretical levels of resistance were met by the new type of *** An observational study was performed to compare three types of sutures,using a device that exerted force on the suture until the breaking point was *** tension produced by this traction was *** following variables were considered:Tearing stress on entry/exit points,edge separation stress,and suture break *** study sample consisted of 30 sutures with simple interrupted stitches(Group 1),30 with continuous stitches(Group 2),and 30 with the“double diabolo”design(Group 3).RESULTS The mean degree of force required to reach the breaking point for each of these variables(tearing,separation,and final breaking)was highest in Group 3(14.56,18.28,and 21.39 kg),followed by Group 1(7.36,10.38,and 12.81 kg)and Group 2(5.77,7.7,and 8.71 kg).These differences were statistically significant(P<0.001)in all *** The experimental results show that with the“double diabolo”suture,compared with conventional sutures,greater force must be applied to reach the breaking point(almost twice as much as in the simple interrupted suture and more than double that required for the continuous suture).If these results are confirmed in Phase III(the clinical phase)of our study,we believe the double diabolo technique should be adopted as the standard approach,especially when the suture must withstand significant tension(e.g.,laparotomy closure,thoracotomy closure,diaphragm suture,or hernial orifice closure).

关键词： Suture Technique Physical principles Tension

Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

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Neural Regeneration Research 2020年第8期15卷 1408-1416页

作者： jose A.Fernandez-Albarral Rosa de Hoz Ana I.Ramirez Ines Lopez-Cuenca Elena Salobrar-Garcia mar.a D.Pinazo-Duran jose M.Ramirez Juan J.Salazar Instituto de Investigaciones Oftalmologicas Ramon Castroviejo MadridSpain Departamento de Inmunologia Oftalmologia y ORLFacultad de Optica y OptometriaMadridSpain Departamento de Inmunologia Oftalmologia y ORLFacultad de MedicinaMadridSpain Unidad de Investigacion Oftalmologica Santiago Grisolia Universidad de ValenciaValenciaSpain

Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal *** currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer *** addition,saffron has remar.able beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand ***,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in ***,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial *** present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular *** review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.

关键词： AMD crocetin crocin Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa saffron safranal