Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

作     者：Fernando Lucas-Ruiz Caridad Galindo-Romero David García-Bernal María Norte-Munoz Kristy T. Rodríguez-Ramírez Manuel Salinas-Navarro Jose E. Millán-Rivero Manuel Vidal-Sanz Marta Agudo-Barriuso 

作者机构：Grupo de Oftalmologia ExperimentalInstituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of TalmologiaUniversidad de MurciaMurciaSpain Unidad de Terapia Celular y Trasplante HematopoyeticoInstituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca)MurciaSpain Department of Medicina InternaUniversidad de MurciaMurciaSpain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第11期

页      面：1851-1857页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the Spanish Ministry of Economy and Competitiveness,Instituto de Salud Carlos Ⅲ(ISCⅢ) Fondo Europeo de Desarrollo Regional “Una Manera de Hacer Europa”(SAF2015-67643-P to MVS and PI16/00031 to MAB) Fundación Séneca,Agencia de Ciencia y Tecnología Región de Murcia(19881/GERM/15 to MVS) 

主　　题：stem cells adipose stem cells umbilical cord bone marrow Wharton's jelly optic nerve axotomy neuroprotection 

摘      要：Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e.,Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.