Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases

作     者：Jose A.Fernandez-Albarral Rosa de Hoz Ana I.Ramirez Ines Lopez-Cuenca Elena Salobrar-Garcia Maria D.Pinazo-Duran Jose M.Ramirez Juan J.Salazar Jose A. Fernández-Albarral;Rosa de Hoz;Ana I. Ramírez;Inés López-Cuenca;Elena Salobrar-García;María D. Pinazo-Durán;José M. Ramírez;Juan J. Salazar

作者机构：Instituto de Investigaciones Oftalmologicas Ramon CastroviejoMadridSpain Departamento de InmunologiaOftalmologia y ORLFacultad de Optica y OptometriaMadridSpain Departamento de InmunologiaOftalmologia y ORLFacultad de MedicinaMadridSpain Unidad de Investigacion Oftalmologica Santiago GrisoliaUniversidad de ValenciaValenciaSpain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第8期

页      面：1408-1416页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：the Ophthalmological Network OFTARED(RD16/0008/0005,RD16/0008/0022, of the Institute of Health of Carlos III of the Spanish Ministry of Economy by the PN I+D+i 2008–2011 by the ISCIII-Subdireccion General de Redes y Centros de Investigacion Cooperativa by the European program FEDER.SAF-2014-53779-R:from the Spanish Ministry of Economy and Competitiveness by Articulo 83 118-2017(UCM-Pharmactive Biotech) supported by a Predoctoral Fellowship(FPU17/01023)from the Spanish Ministry of Science,Innovation,and Universities supported by a Predoctoral Fellowship(CT42/18-CT43/18)from the Complutense University of Madrid 

主　　题：AMD crocetin crocin Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa saffron safranal 

摘      要：Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal *** currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer *** addition,saffron has remarkable beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand ***,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in ***,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial *** present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular *** review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.