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Correlation of Levels of Oncostatin M Cytokine in Crevicular Fluid and Serum in Periodontal Disease

International Journal of Oral Science 2010年第4期2卷 198-207页

作者： manojkumar thorat Pradeep AR Garima Garg Department of Periodontics Government Dental College and Research Institute

Aim The aim of this study was to measure the level of Oncostatin M （OSM） a gp130 cytokine in the gingival crevicular fluid （GCF） and serum of chronic periodontitis patients and to find any correlation between them before and after periodontal therapy （scaling and root planing,SRP）. Methodology 60 subjects （age 25-50 years） were enrolled into three groups （n=20 per group）,group Ⅰ （healthy）,group Ⅱ （gingivitis） and group III （chronic periodontitis）. Group Ⅲ subjects were followed for 6-8 weeks after the initial periodontal therapy （SRP） as the group Ⅳ （after periodontal therapy）. Clinical parameters were assessed as gingival index （GI）,probing depth （PD）,clinical attachment level （CAL）,and radiographic evidence of bone loss. GCF and serum levels of OSM were measured by using Enzyme Linked Immunosorbent Assay （ELISA）. Results It was found that mean OSM levels had been elevated in both the GCF and serum of chronic periodontitis subjects （726.65 ± 283.56 and 65.59 ± 12.37 pg·mL-1,res-pectively） and these levels were decreased proportionally after the periodontal therapy （95.50 ± 38.85 and 39.98 ± 16.69 pg·mL-1 respectively）. However,OSM was detected in GCF of healthy subjects （66.15 ± 28.10 pg·mL-1） and gingivitis-suffering subjects （128.33 ± 22.96 pg·mL-1） and was found as below the detectable limit （≈0.0 pg·mL-1） in the serum of same subjects. Significant correlation has been found between clinical parameters and GCF-serum levels of OSM. Conclusion Increased OSM level both in the GCF and serum,and the decreased levels after initial periodontal therapy （SRP） may suggest a use as an inflammatory bio-marker in the periodontal disease.

关键词： cytokine Oncostatin M chronic periodontitis gingivitis scaling and root planning

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CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells

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Nano Research 2023年第2期16卷 2915-2926页

作者： Hakmin Mun Yuriy Chaban Tanveer A.Tabish Nanasaheb thorat Nathan Cowieson CDavid Owen Helen E.Townley Nuffield Department of Women’s and Reproductive health University of OxfordOxford OX39DUUK Electron Bio-Imaging Centre Diamond Light SourceDidcot OX110DEUK Radcliffe Department of Medicine University of OxfordOxford OX37BNUK B21 Diamond Light SourceDidcot OX110DEUK Department of Engineering Science University of OxfordOxford OX13PJUK

Confining chemotherapy to tumour sites by means of active targeting nanoparticles(NPs)may increase the treatment effectuality while reducing potential side *** are one of the next-generation drug delivery nanocarriers by virtue of their biocompatibility and bioadhesion,sizeable payload encapsulation and high ***,an active tumour targeting system towards rhabdomyosarcoma(RMS)cells was *** were loaded with helenalin(a secondary metabolite from Arnica plants),which we have previously shown to induce apoptosis in RMS *** functionalization of the cubosomes was accomplished to enable binding to membrane receptors and translocation under a magnetic *** cells overexpress CD44 and CD221 on their membrane surface and,therefore,hyaluronic acid(HA,a ligand for CD44)and antibodies(Abs)against CD221 were coupled to cubosomes via electrostatic attraction and the thiol-Michael reaction,*** of the cubic phase NPs was achieved by embedding superparamagnetic iron oxide NPs(SPIONPs)into the cubic ***-function and multi-function cubosomes had Im3m cubic phase structures with well-organized lattice *** with 2%HA or anti-CD221 half Abs and/or 1%SPIONPs showed significantly higher uptake into RMS cells compared to unfunctionalized ***44 and CD221 directed magnetic(triple-function)cubosomes were capable of internalizing into RMS cells in an energy-independent ***-laden triple functionalized cubosomes showed limited impact on the viability of control fibroblast cells,while they induced a high degree cytotoxicity against RMS *** tumour cell death was observed in both two-dimensional(2D)culture and three-dimensional(3D)tumour spheroids.

关键词： cubosome active targeting rhabdomyosarcoma helenalin nanoparticle functionalization

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Effect of Dietary Administration of Lathyrus sativus Pulse on Intestinal Biochemical Parameters in Normal and Scorbutic Guinea Pigs

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Biomedical and Environmental Sciences 2002年第4期15卷 315-322页

作者： ARCHANAAMBA manojkumar 等 FoodToxicologyLaboratory BiomembraneToxicologyLaboratoryIndustialToxicologyReserachCenter M.G.MargP.B.No.80.Lucknw－226001India

Objective In order to investigate that ascorbic acid deficiency is responcible for lathyrus toxicity, the effect of dietary feeding of lathyrus pulse in normal and scorbutic guinea pigs for 3 months, on intestinal biochemical parameters was undertaken. Methods The intestinal brush border membrane (BBM) marker and xenobiotic metabolising enzymes (XME) were assayed. Results Exposure to 80% lathyrus alone and in scorbutic conditions showed significant inhibition of alkaline phosphatase (28%-30%), sucrase (19%) and γ-glutamyl transpeptidase (GGT) (15%-27%) enzymes, while Ca2+-Mg2+-ATPase was significantly inhibited (38%) in scorbutic plus lathyrus treated group. The phase I XME (AHH) remained unchanged while the phase II enzyme glutathione-S-tranferase (GST) was significantly decreased (20%-22%) in lathyrus and scorbutic plus lathyrus treated groups. Quinone reductase (QR) activity was found to be significantly decreased in lathyrus exposed group (20%). The intestinal biomarker contents including hexose (25%-34%) and phospholipids (20%-40%) were significantly reduced in lathyrus and scorbutic plus lathyrus exposed animals, while sialic acid showed a significant decrease (28%) in scorbutic plus lathyrus treated group. However, cholesterol levels were signifcantly enhanced (15%-28%) in lathyrus and scorbutic plus lathyrus treated animals. Conclusion The results indicate that oral feeding of lathyrus pulse to guinea pigs can alter BBM parameters as well as XME, which may result in the intestinal toxicity. Further, ascorbic acid deficiency could be one of the pre-disposing factors of lathyrus toxicity.

关键词： Ascorbic acid BBM Lathyrus sativus Small intestine XME

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A silver-catalyzed[3+3]-annulation cascade of alkynyl alcohols andα,β-unsaturated ketones for the regioselective assembly of chromanes

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Organic Chemistry Frontiers 2022年第3期9卷 802-809页

作者： Ashwini K.Nakate Sagar S.thorat Shailja Jain Gamidi Rama Krishna Kumar Vanka Ravindar Kontham Organic Chemistry Division CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India Centre for Materials Characterization CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Physical and Materials Chemistry Division CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India

An unprecedented Ag(I)-catalyzed[3+3]-annulation of alkynyl alcohols(5-hexyn-1-ols)andα,β-unsaturated ketones is reported to construct simple to complex *** transformation begins with hydroalkoxylation of alkynol through C-C triple bond activation to give cyclic-enol ether,followed by intermolecular 1,4-addition and intramolecular 1,2-addition of enol ethers onto the enone and oxidative aromatization or Grob-type elimination steps.

关键词： alcohols unsaturated catalyzed

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Impact of La^(3+)substitution on electrical,magnetic,dielectric and optical properties of Ni_(0.7)Cu_(0.1)Zn_(0.2)LaxFe_(2-x)O_(4)(0

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Journal of Rare Earths 2023年第5期41卷 740-746,I0004页

作者： B.B.Patil A.D.Pawar S.S.Barate J.S.Ghodake J.B.thorat T.J.Shinde P.G.Department of Physics Smt.KRP Kanya MahavidyalayaIslampurMS415409India Department of Physics Shivaji UniversityKolhapurMS416004India Departments of Physics PDVP MahavidyalayaMahavidyalayaTasgaonMS416312India Department of Physics Sadguru Gadage Maharaj CollegeKaradMS415110

The oxalate co-precipitation method was used to synthesize the La3+substituted Ni-Cu-Zn(La-NCZ)nanoferrites having chemical composition Ni_(0.7)Cu_(0.1)Zn_(0.2)LaxFe_(2-x)O_(4)(x=0.015,0.025 and 0.035).DC resistivity study of nanoferrites shows both the conducting and semiconducting *** room temperature DC electrical resistivity of Ni-Cu-Zn(NCZ)nanoferrites decreases,whereas Curie temperature increases with increasing La^(3+)*** the temperature range of 30-170℃nanoferrites show p-type semiconducting behavior except x=0.015;thereafter,they show n-type *** frequency dispersive initial permeability(μi)associated with its real and imaginary(μ’andμ")parts are attributed to the domain wall movement and magnetic spin ***μi,u’andμ"of La-NCZ nanoferrites are higher than those of pure NCZ *** constant(ε’),dielectric loss(ε")and AC resistivity(ρAC)of La-NCZ nanoferrites show normal dielectric *** is found thatε’of NCZ nanoferrites decreases with the increasing content of La3+*** bandgap energy of La-NCZ nanoferrites is achieved in the range 1.36-1.70 eV confirming the semiconducting nature of materials.

关键词： Ni-Cu-La-Zn nanoferrites DC electrical Resistivity Permeability Dielectric properties Bandgap energy Rare earths

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Splenic lymphangioma masquerading as splenic abscess managed by laparoscopic splenectomy: A case report

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World Journal of Clinical Oncology 2023年第10期14卷 440-444页

作者： Santosh thorat Febin Mohammed Shaji Department of General Surgery Pimpri Chinchwad Municipal Corporation's Postgraduate Institute and Yashwantrao Chavan Memorial HospitalPune 411018MaharashtraIndia

BACKGROUND Primary benign splenic tumours are unique and account for<0.007%of all tumours identified during surgery and *** lymphangiomas are rarely seen in *** lymphangiomas may be asymptomatic,or may present with upper left abdominal pain,splenomegaly,hypersplenism,or splenic rupture with haemorrhagic *** clinical and radiological features of these lesions are not *** case report serves to remind the clinician to consider the rare but important differential diagnosis of splenic lymphangioma while treating splenic *** SUMMARY We report a case of splenic lymphangioma in a 22-year-old woman who presented with left upper quadrant abdominal pain for three *** investigations were unremarkable;however,computed tomography later revealed multiple splenic *** patient underwent laparoscopic splenectomy,and histopathological examination revealed splenic *** patient was discharged on postoperative day *** month after surgery,the abdominal pain resolved completely,with no new *** lymphangiomas present clinically as splenomegaly or left upper quadrant abdominal pain;prompt intervention is necessary for avoiding *** This case report concludes that splenic lymphangiomas should be considered in the differential diagnosis of splenomegaly or left upper quadrant pain,even in adults,because they are amenable to curative *** in surgical intervention may lead to severe complications,such as infection,rupture,and *** lesions can be safely managed with laparoscopy,involving less postoperative pain and early patient discharge with excellent cosmetic outcomes.

关键词： Spleen Lymphangioma Oncology Rare Laparoscopic splenectomy Hamartomatous process Case report

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A review on palaeogeographic implications and temporal variation in glaucony composition

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Journal of Palaeogeography 2016年第1期5卷 43-71页

作者： Santanu Banerjee Udita Bansal Anup Vilas thorat Department of Earth Sciences Indian Institute of Technology Bombay

This study presents a review on palaeogeographic implications and temporal variations of giaucony coveringboth modern and ancient records. Phanerozoic giaucony preferably forms in a shelf depositional setting. Deep marine conditions and low seawater temperature discourage formation of glaucony. Around 75% of glaucony is recorded from the Cretaceous to the Holo- eene sediments, which are related to the abundance of the most common substrates, faecal pellets and bioclasts. TFe203 （total）, A1203, K20 and MgO contents of glaucony vary appreciably through geological time. IMhile TFe203 content of most Mesozoic and Cenozoic giaucony ex- ceeds 20%, it is always less than 20% in Precambrian varieties. High K20, A1203, MgO and low TFe203 distinguish the Precambrian glaucony from its Phanerozoic counterpart. Precambrian glaucony, preferably formed within a K-feldspar substrate, is always rich in potassium irre- spective of its degree of evolution, while high K-content in Phanerozoic evolved glaucony in- dicates significant stratigraphic condensation. K20 iJs. TFe203 relationship of glaucony exhibits three different evolutionary trends corresponding to three common modes of origin. Depositional conditions may influence the composition of glaucony as slightly reducing conditions favour Fe enrichment, whereas oxidising conditions cause Fe depletion in giaucony.

关键词： Glaucony Glauconite Evolutionary trend Substrate Palaeogeography Faecal pellet

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Distereoselective one-pot synthesis of pyrimidopyrimidines using sulfated tin oxide as a reusable catalyst:An extension of Biginelli-type reaction

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Chinese Chemical Letters 2013年第12期24卷 1070-1074页

作者： Rupali L.Magar Prashant B.thorat Pratima B.thorat Vinod V.thorat Bhagawan R.Patil Rajendra P.Pawar Department of Chemistry Deogiri College Department of Chemistry Dnyanopasak College Department of Chemistry Sharda Mahavidyalaya

The Biginelli-type compounds 4,5,8a-triarylhexahydropyrimido[4,5-d]pyrimidine-2,7（1H,3H）-diones were synthesized by a one-pot three-component reaction using sulfated tin oxide as a reusable catalyst. This method has the advantages of high yields, short reaction time, simple starting materials and reusability of catalyst for several times.

关键词： Biginelli-type reaction Multicomponent reactions Pyrimido[4 5-d]pyrimidine Sulfated tin oxide Reusable catalyst

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Synthesis,characterization and application of PVA/ionic liquid mixed matrix membranes for pervaporation dehydration of isopropanol

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Chinese Journal of Chemical Engineering 2017年第10期25卷 1402-1411页

作者： Ganesh B.thorat Smita Gupta Z.V.P.Murthy Department of Chemical Engineering Sardar Vallabhbhai National Institute of Technology Surat 395007 Gujarat India

In this study,polyvinyl alcohol(PVA)–ionic liquid(IL) membranes were prepared for the separation of isopropyl alcohol(IPA)–water azeotropic mixtures by ***-IL composite membranes were prepared by simple solvent evaporation method using four ILs,viz.,1-n-butyl-3-methylimidazolium chloride(BMIMCl),1-hexyl-3-methylimidazolium chloride(HMIMCl),1-hexyl-3-methylimidazolium tetra fluoroborate(HMIMBF4) and 1-octyl-3-methylimidazolium chloride(OMIMCl).Three ILs were used to study the effect of alkyl chain on the pervaporation *** study had focused on the effect feed water concentration from 10%–40%and effect of feed temperature from 50–80°*** properties of all the membranes were studied using Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM) and contact angle *** Arrhenius activation energies for permeation were estimated to be in the range 4–12 kJ·mol-1 from the temperature dependent permeation values.

关键词：渗透汽化液体混合聚乙烯醇异丙醇基质膜 Fourier 扫描电子显微镜合成

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OKO-SVM:Online kernel optimization-based support vector machine for the incremental learning and classification of the sentiments in the train reviews

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第6期9卷 100-126页

作者： Rashmi K.Thakur manojkumar V.Deshpande MPSTME NMIMS UniversityMumbaiIndia Prestige Institute of Engineering Management&Research Indore India

Online incremental learning is one of the emerging research interests among the researchers in the recent *** sentiment classification through the online incremental learning faces many challenges due to the limitations in the memory and the computing resources available for processing the online *** work has introduced an online incremental learning algorithm for classifying the train *** sentiments available in the reviews provided for the public services are necessary for improving the quality of the *** work proposes the online kernel optimizationbased support vector machine(OKO-SVM)classifier for the sentiment classification of the train *** paper is the extension of the previous work kernel optimizationbased support vector machine(KO-SVM).The OKO-SVM classifier uses the proposed fuzzy bound for modifying the weight for each incoming review database for the particular time *** simulation uses the standard train review and the movie review database for the *** the simulation results,it is evident that the proposed model has achieved a better performance with the values of 84.42%,93.86%,and 74.56%regarding the accuracy,sensitivity,and specificity while classifying the train review database.

关键词： Online incremental learning train reviews sentiment classification kernel optimization train review database.

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