A silver-catalyzed[3+3]-annulation cascade of alkynyl alcohols andα,β-unsaturated ketones for the regioselective assembly of chromanes

作     者：Ashwini K.Nakate Sagar S.Thorat Shailja Jain Gamidi Rama Krishna Kumar Vanka Ravindar Kontham 

作者机构：Organic Chemistry DivisionCSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Academy of Scientific and Innovative Research(AcSIR)Ghaziabad-201002India Centre for Materials CharacterizationCSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Physical and Materials Chemistry DivisionCSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India 

出 版 物：《Organic Chemistry Frontiers》 (有机化学前沿（英文）)

年 卷 期：2022年第9卷第3期

页      面：802-809页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：A.K.N.thanks the DST-India for the INSPIRE fellowship,S.S.T.thanks CSIR-India for the Senior Research Fellowship(SRF) R.K.G.thanks DST-SERB for the Ramanujan fellowship(SB/S2/RJN-012/2017) Financial support from CSIR-New Delhi,India(INPROTICS-Pharma and Agro,HCP0011/No.9/1/CS/CIA/2017-MD)is gratefully acknowledged 

主　　题：alcohols unsaturated catalyzed 

摘      要：An unprecedented Ag(I)-catalyzed[3+3]-annulation of alkynyl alcohols(5-hexyn-1-ols)andα,β-unsaturated ketones is reported to construct simple to complex *** transformation begins with hydroalkoxylation of alkynol through C-C triple bond activation to give cyclic-enol ether,followed by intermolecular 1,4-addition and intramolecular 1,2-addition of enol ethers onto the enone and oxidative aromatization or Grob-type elimination steps.