A silver-catalyzed[3+3]-annulation cascade of alkynyl alcohols andα,β-unsaturated ketones for the regioselective assembly of chromanes
[3 + 3]-annulation cascade of alkynyl alcohols and α,β-unsaturated ketones for the regioselective assembly of chromanes作者机构:Organic Chemistry DivisionCSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Academy of Scientific and Innovative Research(AcSIR)Ghaziabad-201002India Centre for Materials CharacterizationCSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Physical and Materials Chemistry DivisionCSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India
出 版 物:《Organic Chemistry Frontiers》 (有机化学前沿(英文))
年 卷 期:2022年第9卷第3期
页 面:802-809页
核心收录:
学科分类:081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金:A.K.N.thanks the DST-India for the INSPIRE fellowship,S.S.T.thanks CSIR-India for the Senior Research Fellowship(SRF) R.K.G.thanks DST-SERB for the Ramanujan fellowship(SB/S2/RJN-012/2017) Financial support from CSIR-New Delhi,India(INPROTICS-Pharma and Agro,HCP0011/No.9/1/CS/CIA/2017-MD)is gratefully acknowledged
主 题:alcohols unsaturated catalyzed
摘 要:An unprecedented Ag(I)-catalyzed[3+3]-annulation of alkynyl alcohols(5-hexyn-1-ols)andα,β-unsaturated ketones is reported to construct simple to complex *** transformation begins with hydroalkoxylation of alkynol through C-C triple bond activation to give cyclic-enol ether,followed by intermolecular 1,4-addition and intramolecular 1,2-addition of enol ethers onto the enone and oxidative aromatization or Grob-type elimination steps.