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Antiacanthamoebic properties of natural and marketed honey in Pakistan

Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 967-972页

作者： Farzana Abubakar Yousuf malik hassan mehmood Abdul malik Ruqaiyyah Siddiqui Naveed Ahmed Khan Department of Biological and Biomedical Sciences Aga Khan University Department of Biological Sciences Faculty of Science and Technology Sunway University

Objective: To determine antiacanthamoebic activity of natural and marketed honey ***: Natural honey samples were collected directly from the bee hive and marketed honey samples were purchased from the local market in Karachi, Pakistan. Both honey samples were tested for their flavonoid content(quercetin equivalent per gram of the extract) and phenolic content(gallic acid equivalent per gram). Furthermore, their antioxidant activity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl. Using amoebistatic and amoebicidal assays, the effects of honey samples were tested against growth and viability of Acanthamoeba ***: Natural honey exhibited potent amoebistatic and amoebicidal effects, in a concentration-dependent manner. Honey-treated Acanthamoeba castellanii showed loss of acanthopodia, following which amoebae detached, rounded up, reduced in size,decreased in cytoplasmic mass and they were observed floating in the culture ***, honey-treated amoebae did not revive when inoculated in fresh growth medium, however, glycerol-treated amoebae exhibited viable trophozoite and active growth. In contrast, marketed honey samples varied in their efficacy against Acanthamoeba castellanii. The proportion of flavonoid, as determined by quercetin measurements and the proportion of phenolic, as determined by gallic acid measurements was higher in natural honey compared with marketed honey. Similarly, the antioxidant activity, as determined by 2,2-diphenyl-1-picrylhydrazyl scavenging activity was higher in natural honey vs. marketed ***: This study shows that natural honey has antiacanthamoebic properties and possesses higher flavonoid, phenolic and antioxidant properties compared with the marketed honey. These findings are of concern to the public, health officials, and to the manufacturers regarding production of honey for medical applications.

关键词： Honey Acanthamoeba Amoebicidal Amoebistatic

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Helicobacter pylori outer membrane protein Q genotypes and their susceptibility to antiadhesive phytotherapeutic agents

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Journal of Integrative Medicine 2017年第5期15卷 398-406页

作者： Javed Yakoob Zaigham Abbas malik hassan mehmood Kanwal Tariq Saima Azhar Saleem Safia Awan Abdul malik Saeed Hamid Rustam Khan Wasim Jafri Department of Medicine Aga Khan UniversityKarachi 74800Pakistan Department of Biological Biomedical Sciences Aga Khan UniversityKarachi 74800Pakistan

OBJECTIVE： Helicobacter pylori is a Gram-negative organism. Its outer membrane protein Q（Hop Q） mediates host-pathogen interactions; Hop Q genotypes 1 and 2 are found associating with gastroduodenal pathologies. The authors measured the anti-adhesion effects of the extracts of Abelmoschus esculentus, Zingiber officinale, Trachyspermum ammi, Glycyrrhiza glabra, Curcuma longa and Capsicum annum against Hop Q genotypes and H. pylori cytotoxin-associated gene A（Cag A）.METHODS： DNA was extracted by polymerase chain reaction of the Hop Q genotypes（i.e., type 1, type 2 and Cag A） from 115 H. pylori strains. The effect of the extracts from selected dietary ingredients was determined using a gastric adenocarcinoma cell line and a quantitative DNA fragmentation assay. The anti-adhesive effect of these extracts on H. pylori was tested using an anti-adhesion ***： C. annum, C. longa and A. esculentus showed prominent anti-adhesion effects with resultant values of 17.3% ± 2.9%, 14.6% ± 3.7%, 13.8% ± 3.6%, respectively, against Hop Q type 1 and 13.1% ± 1.7%, 12.1% ± 2%, 11.1% ± 1.6%, respectively, against Hop Q type 2. C. longa（93%）, C. annum（89%） and A. esculentus（75%） had better anti-adhesive activity against H. pylori with Hop Q type 1 compared to Hop Q type 2 with respective values of 70%, 64% and 51%. Extracts of C. annum（14.7% ± 4.1%）, A. esculentus（12.3% ± 4.1%） and Z. officinale（8.4% ± 2.8%） had an anti-adhesion effect against Cag A-positive H. pylori strains compared to Cag A-negative strains.

关键词： outer membrane protein Q Helicobacter pylori anti-adhesion Abelmoschus esculentus Capsicum annum Curcuma Ionga

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Recent advances on vaccines against malaria: A review

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 143-159页

作者： Shiza malik Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon MEU Research Unit Middle East UniversityAmman11831Jordan

This review aims to summarize the currently viable vaccine strategies including the approved vaccines and the those in trials for next-generation malaria *** on malaria vaccine development was collected through a comprehensive *** literature search was performed using databases including Google Scholar,PubMed,NIH,and Web of *** novel approaches of vaccination are being developed,including those based on radiation-attenuated strategies,monoclonal antibodies,targeted immunogenic peptides,RNA and DNA vaccines,nanoparticle-based vaccines,protein-based vaccination protocols,and whole organism-based vaccination *** on RTS,S have entered phase Ⅲtesting,and those based on blood-stage vaccines and vaccines to interrupt malarial transmission have advanced to higher stages of *** modeling,combined drug and vaccine strategies,mass drug administration,polyvalent vaccine formulations,and targeted vaccination campaigns is playing an important role in malarial ***,assessing coverage,accessibility,acceptability,deployment,compilation,and adherence to specific vaccination strategies in endemic regions is essential for vaccination drives against malaria.

关键词： Vaccines against malaria Drugs and adjuvant Malarial treatment Plasmodium RTS,S vaccine

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Unveiling a new regulator: Vacuolar V-ATPase mediates brassinosteroid signaling in Arabidopsis

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Molecular Plant 2024年第2期17卷 227-229页

作者： Shikha malik Justin W.Walley Department of Plant Pathology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Plant growth and development are intricately regulated by hormones such as auxins,gibberellins,jamonates,cytokinins,and brassinosteroids(BRs).BRs are a group of plant steroid hormones that play a vital role in plant growth and response to the *** regulate many biological processes including cell elongation,cell division,and male fertility,as well as abiotic and biotic stress responses.

关键词： media fertility brassinosteroid

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Detailed analysis of the relativistic configuration of Bardeen anisotropic spheres in modified f(G)gravity

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Communications in Theoretical Physics 2024年第6期76卷 45-56页

作者： Adnan malik Ayesha Almas Tayyaba Naz Rubab Manzoor M Z Bhatti School of Mathematical Sciences Zhejiang Normal UniversityJinhuaZhejiangChina Department of Mathematics University of Management and TechnologySialkot CampusLahorePakistan National University of Computer and Emerging Sciences Lahore CampusPakistan Department of Mathematics University of Management and TechnologyJohar Town CampusLahore 54782Pakistan Department of Mathematics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan

The aim of this work is to investigate anisotropic compact objects within the framework of f(G)modified theory of *** our present work,we utilize Krori-Barua metrics,i.e.,λ(r)=Xr^(2)+Y andβ(r)=Zr^(2).We use some matching conditions of spherically symmetric spacetime with Bardeen's model as an exterior ***,we establish some expressions of energy density and pressure components to analyze the stellar configuration of Bardeen compact stars by assuming viable f(G)*** examine the energy conditions for different stellar structures to verify the viability of our considered ***,we also investigate some other physical features,such as equilibrium condition,equation of state parameters,adiabatic index,stability analysis,mass function,surface redshift,and compactness factor,*** is worthwhile to mention here for the current study that our stellar structure in the background of Bardeen's model is more viable and stable.

关键词： Bardeen compact stars f(G)modified gravity Krori-Barua potential

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Advances in Zika virus vaccines and therapeutics:A systematic review

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 97-109页

作者： Shiza malik Khalid Muhammad Omar Ahsan Muhammad Tahir Khan Ranjit Sah Yasir Waheed Bridging Health Foundation Rawalpindi 46000Pakistan Department of Biology College of SciencesUAE University15551Al AinUnited Arab Emirates Department of Medicine Foundation University Medical CollegeFoundation University IslamabadIslamabad 44000Pakistan INTI International University Persiaran Perdana BBN Putra Nilai71800 NilaiNegeri SembilanMalaysia Institute of Molecular Biology and Biotechnology the University of LahoreKM Defence RoadLahore 58810Pakistan Zhongjing Research and Industrialization Institute of Chinese Medicine Zhongguancun Scientific ParkNanyang 473006China Department of Microbiology Tribhuvan University Teaching HospitalInstitute of MedicineKathmandu 44600Nepal Department of Microbiology Dr.D.Y.Patil Medical CollegeHospital and Research CentreDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPune 411018MaharashtraIndia Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American UniversityByblos 1401Lebanon

Zika virus(ZIKV)is the causative agent of a viral infection that causes neurological complications in newborns and adults *** wide transmission route and alarming spread rates are of great concern to the scientific *** trials have been conducted to develop treatment options for ZIKV *** review highlights the latest developments in the fields of vaccinology and pharmaceuticals developments for ZIKV infection.A systematic and comprehensive approach was used to gather relevant and up-to-date data so that inferences could be made about the gaps in therapeutic *** results indicate that several therapeutic interventions are being tested against ZIKV infection,such as DNA vaccines,subunit vaccines,live-attenuated vaccines,virus-vector-based vaccines,inactivated vaccines,virus-like particles,and mRNA-based *** addition,approved anti-ZIKV drugs that can reduce the global burden are *** many vaccine candidates for ZIKV are at different stages of development,none of them have received Food and Drug Authority approval for use up to *** issue of side effects associated with these drugs in vulnerable newborns and pregnant women is a major obstacle in the therapeutic pathway.

关键词： Zika virus Infection Therapeutics Antiviral agents Vaccines Therapies Treatment Novel therapeutic Clinical management

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The Combination of Achnatherum inebrians Extracts and Soil Microorganisms Inhibited Seed Germination and Seedling Growth in Elymus nutans

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 567-580页

作者： Rui Zhang Taixiang Chen Zhenjiang Chen Hao Chen Xuekai Wei malik Kamran Chunjie Li State Key Laboratory of Herbage Improvement and Grassland Agro-Ecosystems Key Laboratory of Animal Husbandry InnovationMinistry of Agriculture and Rural AffairsEngineering Research Center of Grassland AgricultureMinistry of EducationWest Gansu Province Prataculture Technology Innovation CenterCollege of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China Center for Grassland Research National Forestry and Grassland AdministrationCaFBeijing100091China

In a greenhouse experiment,the effects of soil microorganisms and extracts of Achnatherum inebrians on the seed germination and seedling growth of Elymus nutans were *** results showed that both the extracts from aboveground and belowground parts of *** signiﬁcantly inhibited the germination rate,germination potential,germination index,vigor index,seedling height,root length,and fresh weight of ***,but increased malondialdehyde content,catalase,peroxidase and superoxide dismutase activity of *** seedlings(p<0.05).The allelopathy of aqueous extracts of the aboveground parts of *** was stronger than that of the *** extracts of the aboveground parts of *** decreased seed germination rate,germination potential,germination index,vigor index,seedling length,root length,and seedling fresh weight by 10.45%-74.63%,24.18%-32.50%,19.03%-73.36%,37.83%-88.41%,21.42%-53.14%,2.65%-40.21%,and 20.45%-61.36%,respectively,and malondialdehyde content,peroxidase,catalase,and superoxide dismutase activity increased by 8.09%-62.24%,27.83%-86.47%,22.90%-93.17%,and 11.15%-75.91%,*** above indexes were higher in live soil than in sterilized *** microorganisms increased the allelopathy of *** seed germination rate,germination potential,germination index,vigor index,seedling length,and seedling fresh weight of *** planted in live soil decreased by 8.22%-48.48%,10.00%-51.85%,8.19%-53.26%,16.43%-60.03%,12.91%-28.81%,and 9.09%-22.86%compared with sterilized soil,*** content,peroxidase,catalase,and superoxide dismutase activity of *** planted in live soil increased by 53.91%-81.06%,15.71%-57.34%,33.33%-86.31%,and 9.78%-52.51%compared with sterilized soil,*** existence of soil microorganisms enhanced the allelopathy of the secondary metabolites of ***.A combination of microorganisms and aqueous extracts from the aboveground parts of *** had the s

关键词： Achnatherum inebrians water immersion liquid aqueous leachate precipitate allelopathy Elymus nutans soil microorganisms

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Trauma to the solid abdominal organs:The missed dark box of colonoscopy

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World Journal of Gastroenterology 2024年第7期30卷 624-630页

作者： Mohamed H Emara Usama Mazid Yasmine A Elshaer Mahmoud A Elkerdawy Dilaver Farooq malik Aya M Mahros Department of Hepatology Gastroenterologyand Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 31952Saudi Arabia

Colonoscopy is an integral part of the lower bowel care and is generally considered a potentially safe diagnostic and therapeutic procedure performed as a daycare outpatient *** is associated with different complications that are not limited to adverse events related to the bowel preparation solutions used,the sedatives used,but to the procedure related as well including bleeding and *** to the extra-luminal abdominal organs during colonoscopy are uncommon,however,serious complications related to the procedure have been reported infrequently in the *** threatening injuries to the spleen,liver,pancreas,mesentery,and urinary bladder have been reported as early as in *** injuries should not be overlooked by clinicians and *** increasing abdominal pain,abdominal distension,and hemodynamic instability in absence of rectal bleeding should raise the possibility of severe organ *** and hepatic injury following colonoscopy are usually serious and may be life *** conservative management may help,yet they usually need interventional radiology or surgical *** pancreatitis following colonoscopy is usually mild and is mostly managed *** mechanism of abdominal organ injuries during colonoscopy is not fully understood,however many risk factors have been identified,which can be classified as-organ related,procedure related,and local abdominal *** colonoscopy and prior intra-abdominal adhesions are probably the most relevant risk factors for these *** lateral position,avoidance of looping and excessive force during the procedure would probably reduce the risk of such injuries.

关键词： Colonoscopy Pancreatitis Trauma Complications Adhesions

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MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

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BIOCELL 2024年第3期48卷 403-413页

作者： SHAHID HUSSAIN HABIB BOKHARI XINGXING FAN SHAUKAT IQBAL malik SUNDAS IJAZ MUHAMMAD ADNAN SHEREEN AIMAN FATIMA Department of Biotechnology Kohsar University MurreeMurreePakistan Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines TaipaMacao Department of Bioinformatics and Biosciences Capital University of Science and TechnologyIslamabadPakistan Department of Microbiology Kohsar University MurreeMurreePakistan

The global incidence of lung cancer is marked by a considerably elevated mortality ***(miRNAs)exert pivotal inﬂuence in the intricate orchestration of gene regulation,and their dysregulation can precipitate dire consequences,notably *** this context,miRNAs encapsulated in exosomes manifest a diversiﬁed impact on the landscape of lung cancer,wherein their actions may either foster angiogenesis,cell proliferation,and metastasis,or counteract these *** comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung ***-suppressive miRNAs,such as miR-204,miR-192,miR-30a,miR-34a,miR-34b,miR-203,and miR-212,exhibit heightened expression and demonstrate the capacity to inhibit cellular proliferation and ***,the deleterious effects of tumor-promoting miRNAs like miR-21,miR-106a,miR-155,miR-205,and miR-210 can be attenuated through the application of their respective *** miRNAs selectively target various oncogenes,including NUAK Family Kinase 1(NUAK1),Snail Family Transcriptional Repressor 1(Snai1),Astrocyte elevated gene-1(AEG-1),Vimentin,Proliferation and apoptosis adaptor protein 15(PEA-15/PED),Hypoxia-inducible factor 1-alpha(HIF1),as well as tumor suppressor genes such as phosphatase and tensin homolog(PTEN),Suppressor of cytokine signaling 1(SOCS1),Tumor protein P53 binding protein 1(TP53BP1),and PH Domain and Leucine Rich Repeat Protein Phosphatase 2(PHLP22).This investigative approach proves invaluable in elucidating the speciﬁc miRNAs implicated in the deregulation of crucial genes pivotal to the pathogenesis of cancer.

关键词： miRNAs Oncogenes Tumor suppressive genes Lung cancer therapy

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Pregnancy stressors and postpartum symptoms of depression and anxiety:the moderating role of a cognitivebehavioural therapy(CBT)intervention

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General Psychiatry 2024年第1期37卷 112-121页

作者： Yunxiang Sun Soim Park Abid malik Najia Atif Ahmed Zaidi Atif Rahman Pamela J Surkan Department of International Health Johns Hopkins University Bloomberg School of Public HealthBaltimoreMarylandUSA Department of Public Mental Health Health Services AcademyIslamabadPakistan Human Development Research Foundation RawalpindiPakistan Department of Primary Care and Mental Health Institute of Population HealthUniversity of LiverpoolLiverpoolUK

Background Little is known about the association between stressors(especially positive stressors)during pregnancy and postpartum depression and *** We investigated the association between positive and negative stress events during different stages of pregnancy and postpartum mental health outcomes among low-income pregnant women with symptoms of anxiety in Pakistan and evaluated whether an intervention based on cognitive behavioural therapy(CBT)had a regulatory *** Participants were 621 pregnant Pakistani women with mild *** the Pregnancy Experience Scale-Brief Version,six scores were created to assess positive and negative *** performed a multivariate linear regression to examine whether these six scores,measured both at baseline and in the third trimester,were associated with postpartum anxiety and depressive *** effect of the intervention on this relationship was examined by adding an interaction term to the regression *** Hassles frequency measured in the third trimester was positively associated with depression(B=0.22,95%confidence interval(Cl):0.09 to 0.36)and anxiety(B=0.19,95%Cl:0.08to 0.30).At the same timepoint,uplifts intensity was negatively associated with symptoms of depression(B=-0.82,95%Cl:1.46 to-0.18)and anxiety(B=-0.70,95%Cl:-1.25 to-0.15),whereas hassles intensity was positively related to symptoms of depression(B=1.02,95%Cl:0.36 to 1.67)and anxiety(B=0.90,95%Cl:0.34 to 1.47).The intensity ratio of hassles to uplifts reported in the third trimester was positively related to both depression(B=1.40,95%Cl:0.59 to 2.20)and anxiety(B=1.26,95%Cl:0.57 to 1.96).The intervention strengthened the overall positive effects of uplfts and the negative effects of *** experiences at baseline during early pregnancy to mid-pregnancy were not associated with mental health *** Stressors in the third trimester but not earlier in pregnancy were associated with postpartum symptoms

关键词： postpartum stress behaviour

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