MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects
作者机构：Department of BiotechnologyKohsar University MurreeMurreePakistan Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese MedicinesTaipaMacao Department of Bioinformatics and BiosciencesCapital University of Science and TechnologyIslamabadPakistan Department of MicrobiologyKohsar University MurreeMurreePakistan
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2024年第48卷第3期
页 面：403-413页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：miRNAs Oncogenes Tumor suppressive genes Lung cancer therapy
摘 要：The global incidence of lung cancer is marked by a considerably elevated mortality ***(miRNAs)exert pivotal influence in the intricate orchestration of gene regulation,and their dysregulation can precipitate dire consequences,notably *** this context,miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer,wherein their actions may either foster angiogenesis,cell proliferation,and metastasis,or counteract these *** comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung ***-suppressive miRNAs,such as miR-204,miR-192,miR-30a,miR-34a,miR-34b,miR-203,and miR-212,exhibit heightened expression and demonstrate the capacity to inhibit cellular proliferation and ***,the deleterious effects of tumor-promoting miRNAs like miR-21,miR-106a,miR-155,miR-205,and miR-210 can be attenuated through the application of their respective *** miRNAs selectively target various oncogenes,including NUAK Family Kinase 1(NUAK1),Snail Family Transcriptional Repressor 1(Snai1),Astrocyte elevated gene-1(AEG-1),Vimentin,Proliferation and apoptosis adaptor protein 15(PEA-15/PED),Hypoxia-inducible factor 1-alpha(HIF1),as well as tumor suppressor genes such as phosphatase and tensin homolog(PTEN),Suppressor of cytokine signaling 1(SOCS1),Tumor protein P53 binding protein 1(TP53BP1),and PH Domain and Leucine Rich Repeat Protein Phosphatase 2(PHLP22).This investigative approach proves invaluable in elucidating the specific miRNAs implicated in the deregulation of crucial genes pivotal to the pathogenesis of cancer.
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