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Comprehensively analyzing the genetic alterations,and identifying key genes in ovarian cancer

Oncology Research 2023年第2期31卷 141-156页

作者： QINGLING TANG WARDA ATIQ SHAISTA MAHNOOR MOSTAFA A.ABDEL-MAKSOUD mohammed aufy HAMID YAZ JIANYU ZHU Department of Gynecology and Obstetrics Shanghai Songjiang District Jiuting HospitalShanghai20000China Department of Medicine Fatima Jinnah Medical UniversityLahore42000Pakistan Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaVienna1010Austria Department of Trauma Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China

Though significant improvements have been made in the treatment methods for ovarian cancer(OC),the prognosis for OC patients is still *** hub genes associated with the development of OC and utilizing them as appropriate potential biomarkers or therapeutic targets is highly *** this study,the differentially expressed genes(DEGs)were identified from an independent GSE69428 Gene Expression Omnibus(GEO)dataset between OC and control *** DEGs were processed to construct the protein-protein interaction(PPI)network using ***,hub genes were identified through Cytohubba analysis of the *** and survival profiling of the hub genes were validated using GEPIA,OncoDB,and *** exploring promoter methylation levels and genetic alterations in hub genes,MEXPRESS and cBioPortal were utilized,***,DAVID,HPA,TIMER,CancerSEA,ENCORI,DrugBank,and GSCAlite were used for gene enrichment analysis,subcellular localization analysis,immune cell infiltration analysis,exploring correlations between hub genes and different diverse states,lncRNA-miRNA-mRNA co-regulatory network analysis,predicting hub gene-associated drugs,and conducting drug sensitivity analysis,*** total,8947 DEGs were found between OC and normal samples in *** STRING and Cytohubba analysis,4 hub genes including TTK(TTK Protein Kinase),(BUB1 mitotic checkpoint serine/threonine kinase B)BUB1B,(Nucleolar and spindle-associated protein 1)NUSAP1,and(ZW10 interacting kinetochore protein)ZWINT were selected as the hub ***,it was validated that these 4 hub genes were significantly up-regulated in OC samples compared to normal controls,but overexpression of these genes was not associated with overall survival(OS).However,genetic alterations in those genes were found to be linked with OS and disease-free(DFS)***,this study also revealed some novel links between TTK,BUB1B,NUSAP1,and ZWINT overexpression and promoter meth

关键词： Ovarian cancer Prognosis Diagnosis Therapeutic targets

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Elucidating the clinical and immunological value of m6A regulatormediated methylation modification patterns in adrenocortical carcinoma

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Oncology Research 2023年第5期31卷 819-831页

作者： WENHAO XU HAOMING LI YASIR HAMEED MOSTAFA A.ABDEL-MAKSOUD SAEEDAH MUSAED ALMUTAIRI AYMAN MUBARAK mohammed aufy WAEL ALTURAIKI ABDULAZIZ J.ALSHALANI AYMAN M.MAHMOUD CHEN LI Department of Urology Urological Surgery Research InstituteFirst Affiliated HospitalArmy Medical University(Third Military Medical University)ChongqingChina Department of Urology Affiliated Hospital of Guilin Medical UniversityGuilinChina Department of Applied Biological Sciences Tokyo University of ScienceTokyoJapan Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadhSaudi Arabia Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of Medical Laboratory Sciences College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Life Sciences Faculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK Department of Biology ChemistryPharmacyFree University of BerlinBerlinGermany

N6-methyladenosine methylation(m6A)is a common type of epigenetic alteration that prominently affects the prognosis of tumor ***,it is unknown how the m6A regulator affects the tumor microenvironment(TME)cell infiltration in adrenocortical carcinoma(ACC)and how it affects the prognosis of ACC patients *** m6A alteration patterns of 112 ACC patients were evaluated,furthermore,the association with immune infiltration cell features was *** unsupervised clustering method was applied to typify the m6A alteration patterns of ACC *** principal component analysis(PCA)technique was taken to create the m6A score to assess the alteration pattern in specific *** found two independent patterns of m6A alteration in ACC *** TME cell infiltration features were significantly in accordance with phenotypes of tumor immune-inflamed and immune desert in both *** m6Ascore also served as an independent predictive factor in ACC *** somatic copy number variation(CNV)and patients prognosis can be predicted by m6A alteration ***,the ACC patients with high m6A scores had better overall survival(OS)and higher efficiency in immune checkpoint blockade *** work demonstrated the significance of m6A alteration to the ACC patients *** individual m6A alteration patterns analysis might contribute to ACC patients prognosis prediction and immunotherapy choice.

关键词： m6A Tumor microenvironment Adrenocortical carcinoma Immunotherapy Prognosis

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