Comprehensively analyzing the genetic alterations,and identifying key genes in ovarian cancer
作者机构：Department of Gynecology and ObstetricsShanghai Songjiang District Jiuting HospitalShanghai20000China Department of MedicineFatima Jinnah Medical UniversityLahore42000Pakistan Department of Botany and MicrobiologyCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Pharmaceutical SciencesDivision of Pharmacology and ToxicologyUniversity of ViennaVienna1010Austria Department of Trauma SurgeryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China
出 版 物：《Oncology Research》 (肿瘤学研究（英文）)
年 卷 期：2023年第31卷第2期
页 面：141-156页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Researchers Supporting Project Number(RSPD2023R725)King Saud University Riyadh Saudi Arabia
主 题：Ovarian cancer Prognosis Diagnosis Therapeutic targets
摘 要：Though significant improvements have been made in the treatment methods for ovarian cancer(OC),the prognosis for OC patients is still *** hub genes associated with the development of OC and utilizing them as appropriate potential biomarkers or therapeutic targets is highly *** this study,the differentially expressed genes(DEGs)were identified from an independent GSE69428 Gene Expression Omnibus(GEO)dataset between OC and control *** DEGs were processed to construct the protein-protein interaction(PPI)network using ***,hub genes were identified through Cytohubba analysis of the *** and survival profiling of the hub genes were validated using GEPIA,OncoDB,and *** exploring promoter methylation levels and genetic alterations in hub genes,MEXPRESS and cBioPortal were utilized,***,DAVID,HPA,TIMER,CancerSEA,ENCORI,DrugBank,and GSCAlite were used for gene enrichment analysis,subcellular localization analysis,immune cell infiltration analysis,exploring correlations between hub genes and different diverse states,lncRNA-miRNA-mRNA co-regulatory network analysis,predicting hub gene-associated drugs,and conducting drug sensitivity analysis,*** total,8947 DEGs were found between OC and normal samples in *** STRING and Cytohubba analysis,4 hub genes including TTK(TTK Protein Kinase),(BUB1 mitotic checkpoint serine/threonine kinase B)BUB1B,(Nucleolar and spindle-associated protein 1)NUSAP1,and(ZW10 interacting kinetochore protein)ZWINT were selected as the hub ***,it was validated that these 4 hub genes were significantly up-regulated in OC samples compared to normal controls,but overexpression of these genes was not associated with overall survival(OS).However,genetic alterations in those genes were found to be linked with OS and disease-free(DFS)***,this study also revealed some novel links between TTK,BUB1B,NUSAP1,and ZWINT overexpression and promoter meth
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