Elucidating the clinical and immunological value of m6A regulatormediated methylation modification patterns in adrenocortical carcinoma

作     者：WENHAO XU HAOMING LI YASIR HAMEED MOSTAFA A.ABDEL-MAKSOUD SAEEDAH MUSAED ALMUTAIRI AYMAN MUBARAK MOHAMMED AUFY WAEL ALTURAIKI ABDULAZIZ J.ALSHALANI AYMAN M.MAHMOUD CHEN LI 

作者机构：Department of UrologyUrological Surgery Research InstituteFirst Affiliated HospitalArmy Medical University(Third Military Medical University)ChongqingChina Department of UrologyAffiliated Hospital of Guilin Medical UniversityGuilinChina Department of Applied Biological SciencesTokyo University of ScienceTokyoJapan Department of Botany and MicrobiologyCollege of ScienceKing Saud UniversityRiyadhSaudi Arabia Department of Pharmaceutical SciencesDivision of Pharmacology and ToxicologyUniversity of ViennaViennaAustria Department of Medical Laboratory SciencesCollege of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Life SciencesFaculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK Department of BiologyChemistryPharmacyFree University of BerlinBerlinGermany 

出 版 物：《Oncology Research》 (肿瘤学研究（英文）)

年 卷 期：2023年第31卷第5期

页      面：819-831页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supporting Project Number(RSPD2023R725)King Saud University Riyadh Saud Arabia 

主　　题：m6A Tumor microenvironment Adrenocortical carcinoma Immunotherapy Prognosis 

摘      要：N6-methyladenosine methylation(m6A)is a common type of epigenetic alteration that prominently affects the prognosis of tumor ***,it is unknown how the m6A regulator affects the tumor microenvironment(TME)cell infiltration in adrenocortical carcinoma(ACC)and how it affects the prognosis of ACC patients *** m6A alteration patterns of 112 ACC patients were evaluated,furthermore,the association with immune infiltration cell features was *** unsupervised clustering method was applied to typify the m6A alteration patterns of ACC *** principal component analysis(PCA)technique was taken to create the m6A score to assess the alteration pattern in specific *** found two independent patterns of m6A alteration in ACC *** TME cell infiltration features were significantly in accordance with phenotypes of tumor immune-inflamed and immune desert in both *** m6Ascore also served as an independent predictive factor in ACC *** somatic copy number variation(CNV)and patients prognosis can be predicted by m6A alteration ***,the ACC patients with high m6A scores had better overall survival(OS)and higher efficiency in immune checkpoint blockade *** work demonstrated the significance of m6A alteration to the ACC patients *** individual m6A alteration patterns analysis might contribute to ACC patients prognosis prediction and immunotherapy choice.