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The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression

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Cellular & Molecular Immunology 2014年第4期11卷 343-354页

作者： Vanesa G. Martinez Cristina Escoda-Ferran Ines Tadeu Simees Satoko Arai Marc Orta Mascaro Esther Carreras Mario Martinez-Florensa Jose Yelamos Toru miyazaki Francisco Lozano Grup d'Immunoreceptors del Sistema Innat i Adaptatiu Institut d'Investigacions Biomediques August Pii Sunyer (IDIBAPS) Barcelona Spain Center for Disease Biology and Integrative Medicine Faculty of Medicine University of Tokyo Tokyo Cancer Research Program Hospital del Mar Medical Research Institute and Department of Immunology Hospital del Mar Barcelona Spain Servei d'Immunologia Centre de DiagnOstic Biomedic Hospital Clinic Barcelona Barcelona Spain Departament de Biologia Cellular Immunologia i Neurociencies Facultat de Medicina Universitat de Barcelona Barcelona Spain

Apoptosis inhibitor of macrophages （AIMs）, a homologue of human Spa, is a mouse soluble member of the scavenger receptor cysteine-rich superfamily （SRCR-SF）. This family integrates a group of proteins expressed by innate and adaptive immune cells for which no unifying function has yet been described. Pleiotropic functions have been ascribed to AIM, from viability support in lymphocytes during thymic selection to lipid metabolism and anti-inflammatory effects in autoimmune pathologies. In the present report, the pathogen binding properties of AIM have been explored. By using a recombinant form of AIM （rAIM） expressed in mammalian cells, it is shown that this protein is able to bind and aggregate Gram-positive and Gram-negative bacteria, as well as pathogenic and saprophytic fungal species. Importantly, endogenous AIM from mouse serum also binds to microorganisms and secretion of AIM was rapidly induced in mouse spleen macrophages following exposure to conserved microbial cell wall components. Cytokine release induced by well-known bacterial and fungal Toll-like receptor （TLR） ligands on mouse splenocytes was also inhibited in the presence of rAIM. Furthermore, mouse models of pathogen-associated molecular patterns （PAMPs）-induced septic shock of bacterial and fungal origin showed that serum AIM levels changed in a time-dependent manner. Altogether, these data suggest that AIM plays a general homeostatic role by supporting innate humoral defense during pathogen aggression.

关键词： innate immunity pattern recognition receptor scavenger receptor

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采用第6代IGBT硅片的IGBT模块

电力电子技术 2009年第9期43卷 85-86页

作者： Taketo Nishiyama Yuji miyazaki 三菱电机功率器件福冈制作所

从2007年开始上市的最新NX系列绝缘栅双极型晶体管(Insulated Gate Bipolar Transistor,简称IGBT)模块,采用统一的封装和功率硅片,其端子和电路结构具有前所未有的灵活性。在NX系列开发的第1阶段,采用的第5代载流子存储式沟槽型双极型... 详细信息

从2007年开始上市的最新NX系列绝缘栅双极型晶体管(Insulated Gate Bipolar Transistor,简称IGBT)模块,采用统一的封装和功率硅片,其端子和电路结构具有前所未有的灵活性。在NX系列开发的第1阶段,采用的第5代载流子存储式沟槽型双极型晶体管(Carrier Stored Trench Gate Bipolar Transistor,简称CSTBTTM)硅片技术实现了高效性能。介绍在NX系列开发的第2阶段所采用的1.2kV第6代IGBT硅片技术。新的第6代IGBT模块进一步提高了效率并降低了噪声,从而拓宽了客户的应用范围。

关键词：模块/绝缘栅双极型晶体管载流子存储式沟槽型双极型晶体管

EFFECT OF EARTHWORMS ON RESIDUAL CONCENTRATION OF HERBICIDE IN SOILS

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EFFECT OF EARTHWORMS ON RESIDUAL CONCENTRATION OF HERBICIDE ...

Large Scale Classical MD for Nano-Indentation

第二届中日化工学术研讨会

作者： Akane miyazaki Yoshio NAKANO Department of Environmental Science and Engineering Interdisciplinary Graduate School of Science and Technology Tokyo Institute of Technology 4259 Nagatsuta Midori-ku Yokohama 225-8502 JAPAN Department of Environmental Science and Engineering Interdisciplinary Graduate School of Science and Technology Tokyo Institute of Technology 4259 Nagatsuta Midori-ku Yokohama 225-8502 JAPAN

＜正＞ The effect of earthworms （Eisenia fetida） in decreasing the concentration of herbicide （Dymron） in soil was investigated in order to verify the ability of earthworms to remediate soil systems. The experiments were performed using two kinds of soil: an artificial soil and an agricultural soil obtained from a field. For both of the soils it was found that the decrease of Dymron concentration was larger in the soil containing earthworms than the soil without them. The activity of the earthworms significantly shortened the half-life of Dymron in the soils. Accumulation of Dymron in earthworm bodies was not observed. The validity of earthworm for remediating soil contaminated by Dymron was shown.

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Large Scale Classical MD for Nano-Indentation

In-situ evaluation for activated concrete in accelerator facility with scintillation-type gamma-ray spectrometer

The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational MechanicsⅠ

作者： Kenji Nishimura Noriyuki miyazaki Research Institute for Computational Sciences (RICS) Research Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Central 2 Tsukuba 305-8568 Japan Department of Chemical Engineering Kyushu University 6-10-1 Hakozaki Higashi-ku Fukuoka 812-8581

Nanoindentation method is applied to examine the mechanical properties of materials such as elastic and plastic deformation, fracture and friction. However, although the method has potential applications to determine nanoscale mechanical properties of small areas and thin films, the atomic scale mechanisms underlying the method are not well understood. In order to clarify the mechanisms, atomic scale simulations such as molecular dynamics have been carried out. The molecular dynamics simulations indicated that dislocation loops are nucleated under an indenter and glide on the slip plane, then dislocation structures due to dislocation interactions and the cross slip are formed in single crystalline metals [1,2]. Moreover, the influence of grain boundaries on the plastic deformation process in nanocrystalline metals [3] and the deformation process of ceramic materials [4] under nanoindentation were reported. In this study, we examine the initial stage of plastic deformation in nanoindentation process in a thin iron film using a molecular dynamics simulation. A rigid knife-like indenter is used in the simulation. We obtain a load-displacement curve under the action of an indenter. When the displacement of the indenter exceeds a yield point, the nucleation of dislocation loops is observed below the surface contacting with indenter sides. Then the Lomer-Cottrell reaction between the dislocation loops occurs directly beneath the indenter. In addition, new dislocation generated by the Lomer-Cottrell reaction moves in a different slip plane together with double kink formation with increasing the displacement and finally is separated into two dislocations.

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辐射防护 2020年第6期40卷 545-549页

作者： Go Yoshida Hiroshi Matsumura Koichi Nishikawa Akihiro Toyoda Yoshiharu miyazaki Kazuyoshi Masumoto Hajime Nakamura Taichi Miura High Energy Accelerator Research Organization(KEK) 1-1 OhoTsukubaIbaraki 305-0801Japan The Medical and Pharmacological Research Center Foundation Wo-32Inoyama-machiHakuiIshikawa 925-0613Japan

The assessment of activated concrete is particularly difficult during the decommissioning of an accelerator *** analysis by core boring is the only method of investigating the activity of concrete *** address this problem,an in-situ and nondestructive analysis method was developed to determineγ-ray-emitting nuclides and their specific activities in the concrete walls and floor by using a portable germanium semiconductor *** this work,we examined a substitute for Ge detector to establish a simpler and more convenient *** candidates,we focused on some scintillation type spectrometers,and the possibility of a substitute for a Ge detector was examined by both simulation and *** detection limits were roughly estimated through Monte Carlo simulation for various scintillation crystals,and it was found that 1.5-inch LaBr3,CeBr3,and SrI2 could distinguish the clearance *** was confirmed that the 1.5-inch LaBr3 could reproduce the calibration curve of the Ge detector in the *** required thickness and length of the radiation shield for suppressing the background radiation during the measurement was also determined for the convenience of an actual decommissioning work.

关键词： activation accelerator concrete scintillation detector PHITS code

Nitrogen Doping Effect in a-Ge:H Films Due To High Hydrogen Dilution

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Clinical differentiation of acute appendicitis and right colonic diverticulitis: A case-control study

1996年中国青年学者物理学讨论会

作者： Seiiehi miyazaki Masataka Hirose Dept.of Electrical Engineering Hiroshima University Higashi-Hiroshima 739Japan

A series of a-Ge:N:H films have been produced by employing d glow discharge decomposition of hydrogen-dilutd gas mixutres of NH and *** was found that hydrogen dilution induces the decrease of the nitrogen content in the films and the corresponding optical band gap is also rapidly *** dramatic increase of eonduetivity was explained in terms of the nitrogen doping effect.

关键词： amorphous germanium nitrogen doping effect

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World Journal of Clinical Cases 2019年第12期7卷 1393-1402页

作者： Yosuke Sasaki Fumiya Komatsu Naoyasu Kashima Takahiro Sato Ikutaka Takemoto Sho Kijima Tadashi Maeda Takamasa Ishii Taito miyazaki Yoshiko Honda Nagato Shimada Yoshihisa Urita Department of General Medicine and Emergency Care Toho University School of Medicine

BACKGROUND Acute right colonic diverticulitis (ARCD) is an important differential diagnosis of acute appendicitis (AA) in Asian countries because of the unusually high prevalence of right colonic diverticula. Due to qualitative improvement and the high penetration rate of computed tomography (CT) scanning in Japan, differentiation of ARCD and AA mainly depends on this modality. But cost, limited availability, and concern for radiation exposure make CT scanning problematic. Differential findings of ARCD from AA are based on several small studies that used univariate comparisons from Korea and Taiwan. Previous studies on clinical and laboratory differences between AA and ARCD are limited. AIM To determine clinical differences between AA and ARCD for differentiation of these two diagnoses by creating a logistic regression model. METHODS We performed an exploratory single-center retrospective case-control study evaluating 369 Japanese patients (age ≥ 16 years), 236 (64.0%) with AA and 133 (36.0%) with ARCD, who were hospitalized between 2012 and 2016. Diagnoses were confirmed by CT images. We compared age, sex, onset-to-visit interval, epigastric/periumbilical pain, right lower quadrant (RLQ) pain, nausea/vomiting, diarrhea, anorexia, medical history, body temperature, blood pressure, heart rate, RLQ tenderness, peritoneal signs, leukocyte count, and levels of serum creatinine, serum C-reactive protein (CRP), and serum alanine aminotrans-ferase. We subsequently performed logistic regression analysis for differentiating AA from ARCD based on the results of the univariate *** In the AA and ARCD groups, median ages were 35.5 and 41.0 years, respectively (p=0.011);median onset-to-visit intervals were 1 [interquartile range (IQR): 0-1] and 2 (IQR: 1-3) days, respectively (P < 0.001);median leukocyte counts were 12600 and 11500/mm3, respectively (P = 0.002);and median CRP levels were 1.1 (IQR: 0.2-4.1) and 4.9 (IQR: 2.9-8.5) mg/dL, respectively (P < 0.001). In th

关键词： Abdominal pain Acute abdomen Appendicitis Clinical difference Creactive protein Diverticulitis Right lower quadrant pain

Performance and Internal Flow of Contra-Rotating Small-Sized Cooling Fan

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Open Journal of Fluid Dynamics 2018年第2期8卷 181-194页

作者： Toru Shigemitsu Keisuke miyazaki Katsuhiko Hirosawa Hiroaki Fukuda Institute of Science and Technology Tokushima University Tokushima Japan Graduate School of Advanced Technology and Science Tokushima University Tokushima Japan

High pressure and large flow rate small-sized cooling fans are used for servers in data centers and there is a strong demand to increase its performance because of increase of quantity of heat from servers. Contra-rotating rotors have been adopted for some of high pressure and large flow rate cooling fans to meet the demand. The performance curve of the contra-rotating small-sized cooling fan with 40 mm square casing was investigated by an experimental apparatus and its internal flow condition was clarified by the numerical analysis. The fan static pressure of the front rotor was extremely low and it increased significantly at the rear rotor. The uniform flow was achieved at the inlet of the rear rotor because of the special shape of the casing between the front and rear rotors. On the other hand, the tip leakage flow was large enough to influence on the main flow of the test cooling fan by the design specification of high pressure with compact rotor diameter.

关键词： Cooling Fan Small-Sized Axial Fan Contra-Rotating Rotors Performance Internal Flow

Internal Flow Condition between Front and Rear Rotor of Contra-Rotating Small-Sized Axial Fan at Low Flow Rate

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Open Journal of Fluid Dynamics 2017年第4期7卷 709-723页

作者： Toru Shigemitsu Kensuke Tanaka Katsuhiko Hirosawa Keisuke miyazaki Institute of Science and Technology Tokushima University Tokushima Japan Graduate School of Advanced Technology and Science Tokushima University Tokushima Japan

Contra-rotating small-sized fans are used as cooling fans for electric equipment. The internal flow condition between the front and rear rotors of the contra-rotating small-sized fan is not known well especially at the low flow rate. Furthermore, the blade row distance between the front and rear rotors is an important parameter for the contra-rotating small-sized fan and its influence on the internal flow condition is not clarified at the low flow rate. Therefore, the internal flow condition of the contra-rotating small-sized fan at the low flow rate is investigated by the numerical analysis in this research. The numerical analysis results are validated by comparing the fan static pressure curves of the numerical results to the experimental results. The internal flow condition at the low flow rate is clarified using the numerical models of the different blade row distance L = 10 mm and 30 mm. In the present paper, pressure fluctuations phase locked each front and rear rotor’s rotation are shown and the influences of the wake and the potential interference are discussed by the unsteady numerical analysis results at the low flow rate.

关键词： Small-Sized Axial Fan Contra-Rotating Rotors Wake Potential Interference Numerical Analysis