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Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device

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World Journal of Cardiology 2015年第2期7卷 65-75页

作者： Sven m bius-Winkler Nicolas majunke marcus Sandri norman mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick Department of Internal medicine/Cardiology University of LeipzigHeart Center Columbia University medical Center Department of Pediatric Cardiology University of LeipzigHeart Center Clinic for Cardiology Hospital Barmherzige Brueder

Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke.

关键词： Atrial fibrillation Stroke prevention Left atrial appendage WATCHmAN device Complications

VISIOmETRICS OF 2D SHOCK-PLANAR S/F/S CURTAIN INTERACTIONS: VORTEX DOUBLE LAYERS, VORTEX PROJECTILES AND DECAYING STRATIFIED TURBULENCE

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Transactions of Nanjing University of Aeronautics and Astronautics 2001年第z1期18卷 32-38页

作者： norman J. Zabusky Shuang ZhangLaboratory of Visiometrics and modeling,Department of mechanical and Aerospace Engineering Laboratory of Visiometrics and modeling.Department of mechanical and Aerospace Engineering Rutgers University P.O. Box 909. Piscataway New Jersey 08855

Vortex double layers (VDLs) and vortex projectiles (VPs) are the essential coherent structures which emerge in the shock excited (s/f/s) planar parallel "curtain" simulations of a 2D shock tube with PPm. These opposite signed layers, formed by shock induced baroclinic deposition of vorticity, "ind" and are strongly affected by secondary reflected shocks and vortex interactions. In our visiometric mode of working, we quantify several of these processes and introduce time epochs to discuss the emerging phenomena and normalizations to scale (collapse) the data at m =1.5 and 2.0. This versatile configuration, easily obtained in the laboratory, allows us to study the formation, evolution and reacceleration of VPs and stratified turbulence and mixing.

关键词： visiometrics accelerated inhomogeneous flows (aifs) Richtmyer meshkov shock curtain baroclinic vorticity generation vortex double layers (VDLs) vortex projectiles (VPs) stratified turbulence

Studies on the chemical constituents of the South China Sea sponge Phacellia fusca

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Chinese Journal of Chemistry 1991年第2期9卷 136-143页

作者： ZENG,Long-mei FU,Xiong SU,Jing-Yu Department of Chemistry,Zhongshan University,Guangzhou 510275De GUZmAN,Florecita SCHmITZ,Francis J HOSSAIN,m.Bilayet van der HELm,Dick Department of Chemistry and Biochemistry,University of Oklahoma,norman,OK73019-0370,U.S.A. 1Department of Chemistry Zhongshan University Guangzhou 5102752Department of Chemistry and Biochemistry University of Oklahoma Norman OK 73019-0370 U.S.A.

Three pyrrololactam alkaloids have been isolated from the marine sponge Phacellia fusca Schmidt collected from the South China Sea,and their structures were determined as 1—3,on the grounds of spectral *** is the fir... 详细信息

关键词： Studies on the chemical constituents of the South China Sea sponge Phacellia fusca

A review of potential conservation and fisheries benefits of breaching four dams in the Lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.Schaller Charles E.Petrosky Robert L.Vadas Jr. Benjamin J.Clemens Gary Sprague norman mercado-Silva Brett Roper michael J.Parsley Edward Bowles Robert m.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)Snake River Basin Pacific Lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon

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变结构控制系统的计算机辅助设计

机器人 1986年第2期 12-16页

作者： norman E.GOUGH ,ZIYAD m.ISmAIL ,黄章树

本文叙述一种关于工作在滑动模式下的变结构单变量控制系统的设计和仿真的计算机方法。对于给定的一个以状态变量形式表示的线性系统,本文提出了一些算法。这些算法可用于寻求在变结构状态反馈规律上的条件。这些条件将保证:有一个滑动... 详细信息

本文叙述一种关于工作在滑动模式下的变结构单变量控制系统的设计和仿真的计算机方法。对于给定的一个以状态变量形式表示的线性系统,本文提出了一些算法。这些算法可用于寻求在变结构状态反馈规律上的条件。这些条件将保证:有一个滑动超平面存在、从状态空间的任何地方均可命中这个平面并保证运动的稳定性。由于不需要系统以友形式来表示,并且给出了基于有限个状态量测的修正条件,因此这些算法是有独创性的。文中给出的计算机辅助设计程序包是采用了一系列可链接的 BASIC 程序段来实现这些算法。这里还给出了程序的流程图。在控制器设计之后,接着就可以对这种变结构控制系统进行仿真并绘出其相位和时间响应曲线。这里包括一些典型的变结构控制系统的结果并讨论了这种控制方式的实际好处。

关键词：状态变量程序包计算机辅助设计计算机辅助技术变结构控制系统超平面状态空间滑动模式

Tumor heterogeneity and therapy resistance-implications for future treatments of prostate cancer

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Journal of Cancer metastasis and Treatment 2017年第1期3卷 302-314页

作者： Fiona m.Frame Amanda R.Noble Sandra Klein Hannah F.Walker Rakesh Suman Richard Kasprowicz Vin m.mann matt S.Simms norman J.maitland Cancer Research Unit Department of BiologyUniversity of YorkHeslingtonNorth Yorkshire YO105DDUK Black Family Stem Cell Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Phase Focus Limited Electric WorksSheffield Digital CampusSheffield S12BJUK Department of Urology Castle Hill Hospital(Hull and East Yorkshire Hospitals NHS Trust)Cottingham HU165JQUK Hull York medical School University of HullHull HU67RXUK.

Aim:To develop new therapies for prostate cancer,disease heterogeneity must be *** includes patient variation,multi-focal disease,cellular heterogeneity,genomic changes and epigenetic *** requires more representative models to be used in more innovative ***:This study used a panel of cell lines and primary prostate epithelial cell cultures derived from patient *** assays were used;alamar blue,colony forming assays,γH2AX and Ki67 immunofluorescence and comet *** quantitative phase imaging(QPI),a label-free imaging technique,combined with Cell Analysis Toolbox software,was implemented to carry out real-time analysis of cells and to retrieve morphological,kinetic and population ***:A combination of radiation and Vorinostat may be more effective than radiation *** prostate cancer stem-like cells are more resistant to etoposide than more differentiated *** of QPI images showed that cell lines and primary cells differ in their size,motility and proliferation rate.A QPI signature was developed in order to identify two subpopulations of cells within a heterogeneous primary ***:Use of primary prostate epithelial cultures allows assessment of therapies whilst taking into account cellular *** of rare cell populations and embracing novel techniques may ultimately lead to identifying and overcoming treatment resistance.

关键词： Prostate ptychography live-cell imaging primary cells quantitative phase imaging

Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells

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Cancer Drug Resistance 2020年第4期3卷 959-979页

作者： Kevin G.Chen George E.Duran mark J.mogul Yan C.Wang Kevin L.Ross Jean-Pierre Jaffrézou Lyn m.Huff Kory R.Johnson Tito Fojo norman J.Lacayo Branimir I.Sikic Division of Oncology Department of MedicineStanford University School of MedicineStanfordCA 94305USA Current Address:NIH Stem Cell Unit National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMD 20892USA Current Address:medical Affairs U.S. Servier PharmaceuticalsBostonMA 02210USA Current Address:Ross BioPharm Group Rocky PointNY 11778USA Current Address:French National Centre for Scientific Research Paris 75016France medicine Branch National Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Current Address Laboratory of Cell BiologyNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA Intramural IT and Bioinformatics Program National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMD 20892USA Current Address:Herbert Irving Comprehensive Cancer Center Columbia University Medical Center/New York-Presbyterian HospitalNew YorkNY 10032USA Division of Pediatric Hematology-Oncology-Stem Cell Transplantation and Cancer Biology Stanford University School of Medicine and Stanford Cancer InstitutePalo AltoCA 94305USA

Aim:Despite considerable efforts to reverse clinical multidrug resistance(mDR),targeting the predominant multidrug transporter ABCB1/P-glycoprotein(P-gp)using small molecule inhibitors has been unsuccessful,possibly due to the emergence of alternative drug resistance ***,the non-specific P-gp inhibitor cyclosporine(CsA)showed significant clinical benefits in patients with acute myeloid leukemia(AmL),which likely represents the only proof-of-principle clinical trial using several generations of mDR ***,the mutational mechanisms that may underlie unsuccessful mDR modulation by CsA are not elucidated because of the absence of CsA-relevant cellular *** this study,our aims were to establish CsA-resistant leukemia models and to examine the presence or absence of ABCB1 exonic mutations in these models as well as in diverse types of human cancer samples including ***:Drug-resistant lines were established by stepwise drug co-selection and characterized by drug sensitivity assay,rhodamine-123 accumulation,[3H]-labeled drug export,ABCB1 cDNA sequencing,and RNase protection *** genomic stability of the ABCB1 coding regions was evaluated by exome sequencing analysis of variant allele frequencies in human ***,the mutational spectrum of ABCB1 was further assessed in diverse types of cancer samples including AmLs in the Cancer Genome Atlas(TCGA)at the National Cancer ***:We report the development of two erythroleukemia variants,RVC and RDC,which were derived by stepwise co-selection of K562/R7 drug-resistant leukemia cells with the etoposide-CsA and doxorubicin-CsA drug combinations,***,both RVC and RDC cell lines,which retained P-gp expression,showed altered multidrug-resistant phenotypes that were resistant to CsA ***,no mutations were found in the ABCB1 coding regions in these variant cells even under long-term stringent drug ***,ABCB1

关键词： Cancer leukemia multidrug resistance ABCB1 P-glycoprotein cyclosporine mutation

Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis

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World Journal of Gastroenterology 2017年第29期23卷 5412-5421页

作者： Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos maria Papp Institute of Internal medicine Department of Gastroenterology University of Debrecen Faculty of Medicine Department of Laboratory medicine University of Debrecen Faculty of Medicine Debrecen Inova Diagnostics Inc.San Diego 1^st Department of Pediatrics Semmelweis University 1^st Department of medicine University of Pecs Gastroenterology Department of medicine Borsod-Abauj Zemplen County Hospital 1^st Department of medicine Semmelweis University

To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis (PSC) patients. mETHODSSera of 67 PSC patients [median age (range): 32 (5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin (AAA IgA/IgG) and gliadin (AGA IgA/IgG)] and for serum level of intestinal fatty acid-binding protein (I-FABP) by ELISA. markers of lipopolysaccharide (LPS) exposure [LPS binding protein (LBP)] and various anti-microbial antibodies [anti-OmP Plus IgA and endotoxin core IgA antibody (EndoCAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99 (14-106) mo]. One hundred and fifty-three healthy subjects (HCONT) and 172 ulcerative colitis (UC) patients were the controls. RESULTSA total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA IgA, AAA IgG, AGA IgA and AGA IgG, respectively. Frequencies of AAA IgA and AAA IgG (P mpared to both of the HCONT and the UC groups. In survival analysis, AAA IgA-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15 (1.27-20.86), P = 0.022 or for the mayo risk score (HR = 4.24 (0.99-18.21), P = 0.052]. AAA IgA-positivity was significantly associated with higher frequency of anti-microbial antibodies (P mP Plus IgA) and higher level of the enterocyte damage marker (median I-FABPAAA IgA posvsneg: 365 vs 166 pg/mL, P = 0.011), but not with serum LBP level. CONCLUSIONPresence of IgA type AAA identified PSC patients with progressive disease. moreover, it is associated with enhanced mucosal immune response to various micr

关键词： Primary sclerosing cholangitis Gut barrier dysfunction Intestinal fatty acid-binding protein Anti-F-actin antibody Anti-gliadin antibody

Rapid,high-resolution detection of environmental change over continental scales from satellite data–the Earth Observation Data Cube

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International Journal of Digital Earth 2016年第1期9卷 106-111页

作者： Adam Lewis Leo Lymburner matthew B.J.Purss Brendan Brooke Ben Evans Alex Ip Arnold G.Dekker James R.Irons Stuart minchin norman mueller Simon Oliver Dale Roberts Barbara Ryan medhavy Thankappan Rob Woodcock Lesley Wyborn Geoscience Australia CanberraAustralia National Computational Infrastructure Australian National UniversityCanberraAustralia Commonwealth Scientific and Industrial Research Organisation CanberraAustralia NASA Goddard Space Flight Center GreenbeltMDUSA Research School of Finance Actuarial Studies and Applied StatisticsANUCanberraAustralia The Group on Earth Observations Secretariate GenevaSwitzerland

The effort and cost required to convert satellite Earth Observation(EO)data into meaningful geophysical variables has prevented the systematic analysis of all available *** overcome these problems,we utilise an integrated High Performance Computing and Data environment to rapidly process,restructure and analyse the Australian Landsat data *** this approach,the EO data are assigned to a common grid framework that spans the full geospatial and temporal extent of the observations–the EO Data *** approach is pixel-based and incorporates geometric and spectral calibration and quality assurance of each Earth surface reflectance *** demonstrate the utility of the approach with rapid time-series mapping of surface water across the entire Australian continent using 27 years of continuous,25 m resolution *** preliminary analysis of the Landsat archive shows how the EO Data Cube can effectively liberate high-resolution EO data from their complex sensor-specific data structures and revolutionise our ability to measure environmental change.

关键词： Earth Observation Data Cube HPD HPC surface water Landsat Australia