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Dietary plant extracts modulate gene expression profiles in alveolar macrophages of pigs experimentally infected with porcine reproductive and respiratory syndrome virus

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Journal of Animal Science and Biotechnology 2021年第1期12卷 372-385页

作者： Kwangwook Kim Peng Ji minho Song Tung m.Che David Bravo James E.Pettigrew Yanhong Liu Department of Animal Science University of CaliforniaDavisCAUSA. Department of Nutrition University of CaliforniaDavisCAUSA. Department of Animal Science and Biotechnology Chungnam National UniversityDaejeonSouth Korea Department of Animal Production Nong Lam UniversityHo Chi Minh CityVietnam Pancosma SA GenevaSwitzerland. Current address:Land O’Lakes Inc. Arden HillsMNUSA. Department of Animal Science University of IllinoisUrbanaILUSA.

Background: Our previous study showed that 3 plant extracts enhanced the immune responses and growth efficiency of weaned pigs infected with porcine reproductive and respiratory syndrome virus(PRRSV), which is one of the most economically important disease in swine industry. However, each plant extract differently effected on growth efficiency and immune responses. Therefore, the objective of this study was conducted to characterize the effects and investigate the potential underlying mechanisms of 3 plant extracts on gene expression of alveolar macrophages in weaned pigs experimentally infected with ***: PRRSV infection altered(P mpared with the infected CON, feeding capsicum(CAP), garlic botanical(GAR), or turmeric oleoresin(TUR) altered the expression of 46 genes(24 up, 22 down), 134 genes(59 up, 75 down), or 98 genes(55 up, 43 down) in alveolar macrophages of PRRSV-infected pigs, respectively. PRRSV infection up-regulated(P mmune system process, and response to stimulus, but downregulated(P mmune *** with the infected CON, feeding TUR or GAR reduced(P mentation of CAP, GAR, or TUR also enhanced(P mino acid metabolism, steroid hormone synthesis, or RNA degradation, ***: The results suggest that 3 plant extracts differently regulated the expression of genes in alveolar macrophages of PRRSV-infected pigs, especially altering genes involved in immunity.

关键词： Alveolar macrophages Gene expression Plant extracts PRRSV Weaned pigs

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利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张

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中华高血压杂志 2018年第1期26卷 83-83页

作者：刘青叶鹏 Blaser mC Wei K Adams RL Zhou YQ Caruso LL mirzaei Z lam A Tam RK Zhang H Heximer SP Henkelman m Simmons CA

主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽（C-type natriuretic peptide,CNP）抑制瓣膜间质细胞（valve interstitial cells,VIC）的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调... 详细信息

主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽（C-type natriuretic peptide,CNP）抑制瓣膜间质细胞（valve interstitial cells,VIC）的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。

关键词：主动脉瓣疾病野生型利钠肽受体升主动脉

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A Review of Unified A Posteriori Finite Element Error Control

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Numerical mathematics(Theory,methods and Applications) 2012年第4期5卷 509-558页

作者： C.Carstensen m.Eigel R.H.W.Hoppe C.Löbhard Department of mathematics Humboldt Universität zu BerlinD-10099 BerlinGermany Department of Computational Science and Engineering Yonsei UniversitySeoul 120-749Korea Department of mathematics University of HoustonHouston TX 77204-3008USA. Institute of mathematics University of AugsburgD-86159 AugsburgGermany

This paper aims at a general guideline to obtain a posteriori error estimates for the finite element error control in computational partial differential *** the abstract setting of mixed formulations,a generalised formulation of the corresponding residuals is proposed which then allows for the unified estimation of the respective dual ***,this can be done with an approach which is applicable in the same way to conforming,nonconforming and mixed ***,the unified approach is applied to various model *** particular,we consider the Laplace,Stokes,Navier-lamé,and the semi-discrete eddy current equations.

关键词： A posteriori error analysis finite element method nonconforming finite element method mixed finite element method adaptive algorithm Poisson equation laméequations Stokes equations maxwell equations unified a posteriori error analysis discontinuous Galerkin residual estimator

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DPHL:A DIA Pan-human Protein mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.m.Ijzermans John W.m.martens Renske D.m.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta mantoo Sze S.Lee Serene J.Y.Yeow Syed m.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry lam Ding ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREmEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus mC University medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus mC University medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus mC University medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(mS)-based targeted proteomic techniques,including the selected reaction monitoring(SRm),parallel reaction monitoring(PRm),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a mS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source mS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)mS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRm validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-mS and confirmed by *** data demonstrate that the DPHL supports DIA and PRm mS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

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Evaluation of Growth and Quality in Latuca Sativa L. under Different Photoperiods

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当代农业（中英文版） 2016年第2期5卷 8-12页

作者： K.W.lam J.C.W.Pang K.H.Loo Y.m.Lai S.Y.Chau Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hong Kong SAR China Pong Yuen Holdings Limited Hong Kong SAR China

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Review of relaxation oscillations in plasma processing discharges

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Chinese Physics B 2007年第3期16卷 758-765页

作者：周筑文 m. A. Lieberman Sungjin Kimb Department of Physics Guizhou Educational College Guiyang 550003 China Department of Electrical Engineering and Computer Sciences- 1770 University of California Berkeley CA 94720 U.S.A

Relaxation oscillations due to plasma instabilities at frequencies ranging from a few Hz to tens of kHz have been observed in various types of plasma processing discharges. Relaxation oscillations have been observed in electropositive capacitive discharges between a powered anode and a metallic chamber whose periphery is grounded through a slot with dielectric spacers. The oscillations of time-varying optical emission from the main discharge chamber show, for example, a high-frequency （- 40 kHz） relaxation oscillation at 13.33Pa, with an absorbed power being nearly the peripheral breakdown power, and a low-frequency （- 3 Hz） oscillation, with an even higher absorbed power. The high-frequency oscillation is found to ignite plasma in the slot, but usually not in the peripheral chamber. The kilohertz oscillations are modelled using an electromagnetic model of the slot impedance, coupled to a circuit analysis of the system including the matching network. The model results are in general agreement with the experimental observations, and indicate a variety of behaviours dependent on the matching conditions. In low-pressure inductive discharges, oscillations appear in the transition between low-density capacitively driven and high-density inductively driven discharges when attaching gases such as SF6 and Ar/SF6 mixtures are used. Oscillations of charged particles, plasma potential, and light, at frequencies ranging from a few Hz to tens of kHz, are seen for gas pressures between 0.133 Pa and 13.33 Pa and discharge powers in a range of 75 1200 W. The region of instability increases as the plasma becomes more electronegative, and the frequency of plasma oscillation increases as the power, pressure, and gas flow rate increase. A volume-averaged （global） model of the kilohertz instability has been developed; the results obtained from the model agree well with the experimental observations.

关键词： relaxation oscillation capacitive discharges inductive discharges plasma instability

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两步预烧工艺制备La-PmN-PT陶瓷的压电性能

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陶瓷学报 2023年第1期44卷 78-88页

作者：包国翠李坤杨光施东良林国豪方必军常州大学材料科学与工程学院江苏常州213164 常州大学石油化工学院江苏常州213164 香港理工大学电气工程系中国香港999077

镧系元素掺杂铌镁酸铅-钛酸铅基压电陶瓷是提高其压电性能的重要方式。纯钙钛矿结构是提高La-PmN-PT陶瓷压电性能的关键,但通过传统铌酸盐工艺制备La-PmN-PT陶瓷很难获得纯钙钛矿结构。采用两步预烧工艺制备Pb_(0.9625)La_(0.025)(mg1/3... 详细信息

镧系元素掺杂铌镁酸铅-钛酸铅基压电陶瓷是提高其压电性能的重要方式。纯钙钛矿结构是提高La-PmN-PT陶瓷压电性能的关键,但通过传统铌酸盐工艺制备La-PmN-PT陶瓷很难获得纯钙钛矿结构。采用两步预烧工艺制备Pb_(0.9625)La_(0.025)(mg1/3Nb2/3)_(1-x)Ti_(x)O_(3)(x=0.28~0.31)陶瓷,研究了Ti含量对陶瓷电学性能的影响。结果表明:陶瓷样品为纯钙钛矿结构,随着Ti含量的增加,样品的晶相结构由三方晶相逐渐转变为四方晶相,准同型相界出现在Ti含量为0.30附近。陶瓷晶粒平均尺寸为(4.50±0.23)μm。当x为0.30时,样品的压电应变系数d33~1010 pC·N^(-1),机电耦合系数kp~0.69,介电常数εr~10766,场致应变S~0.23%(1 Hz、1.5 kV·mm^(-1))。两步预烧工艺可以有效抑制焦绿石相的产生,从而提高陶瓷的电学性能。

关键词：压电陶瓷晶相结构压电性介电性铁电性

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Umbilical Cord Blood mononuclear Cell Treatment for Neonatal Rats with Hypoxic Ischemia

Umbilical Cord Blood Mononuclear Cell Treatment for Neonatal...

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第十六届中国医师协会神经外科医师年会

作者： Hao LYU Dong ming SUN Chi Ping NG Wendy S CHENG Jun Fan CHEN Yu Zhong HE Sin Yu lam Zhi Yuan ZHENG Guo Dong HUANG Chi Chiu WANG Wise Young Wai Sang POON Division of Neurosurgery Department of SurgeryFaculty of MedicineThe Chinese University of Hong Kong Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgerythe Shenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen University W.m.Keck Center for Collaborative Neuroscience RutgersState University of New Jersey Department of Neurosurgery Hainan Hospital of People's Liberation Army General Hospital Department of Obstetrics and Gynecology The Chinese University of Hong Kong

Background:Hypoxic-Ischemic Encephalopathy(HIE) occurs when an infant’s brain has not received adequate oxygen and blood supply,resulting in ischemic and hypoxic ***,supportive care and hypothermia therapy have been the standard treatment for ***,there are still over 20% of treated infants died and 19-30% survived with significant *** animal model was first established by Vannucci et al,involving the ligation of one common carotid artery followed by *** this study,we investigated human umbilical cord blood(HUCB) and its two components mononuclear cell(mNC) and red cell fraction(RCF) in both short and long term study using a modified HIE rat ***:In this modified HIE model,both common carotid arteries were occluded,breathing 8% oxygen in a hypoxic chamber for 60-minute,followed by the release of the common carotid arteries ligature,mimicking reperfusion *** cell therapeutic study,cells were intravenously injected to HIE rat pups,and both behavioral and histological changes were assessed at selected time ***:Statistically significant behavioral improvements were demonstrated on Day 7 and 1 month between saline treated HIE rats and UCB/mNC treated ***,at 3 months,the therapeutic improvements were only showed between saline treated HIE animals and mNC treated HIE *** histological analysis one month after cell injection,the number of functional neurons were statistically increased between saline treated HIE and UCB/mNC/RCF treated HIE *** 3 months,the significant increase in functional neurons was only present in mNC treated HIE ***:We have used a bilateral temporary occlusion of 60 minutes,a moderately brain damaged model,for cell therapeutic *** umbilical cord blood(HUCB) mononuclear cell(mNC) therapy showed benefits in neonatal HIE rats in both short and long term behavioral and histological assessments.

关键词： Hypoxic Ischemic Encephalopathy animal model cell therapeutic

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基于TNF-α/IKKβ/NF-κB信号通路研究消积丸治疗ApoE^(−/−)小鼠动脉粥样硬化的机制

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中草药 2022年第16期53卷 5074-5084页

作者：涂宛晴梁秋儿谢鹏程谢婷林丽群陈利国暨南大学中医学院广东广州510632

目的采用网络药理学和动物实验相结合的方法探讨消积丸治疗动脉粥样硬化(atherosclerosis,AS)的作用机制。方法通过网络药理学进行活性成分-靶点网络构建、蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络分析、基因本体(g... 详细信息

目的采用网络药理学和动物实验相结合的方法探讨消积丸治疗动脉粥样硬化(atherosclerosis,AS)的作用机制。方法通过网络药理学进行活性成分-靶点网络构建、蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络分析、基因本体(gene ontology,GO)功能和京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。50只雄性ApoE−∕−小鼠随机分为对照组、模型组、阿托伐他汀(1.3 mg/kg)组和消积丸低、高剂量(8.125、32.500 g/kg)组,模型组和各给药组以高脂饮食喂养,给予相应药物干预4周后,采用全自动生化仪分析小鼠血清脂质水平;采用ELISA法检测小鼠血清中白细胞介素-1β(interleukin-1β,IL-1β)、IL-6、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和氧化低密度脂蛋白(oxidized low density lipoprotein,ox-LDL)水平;采用苏木素-伊红(HE)、masson和油红O染色观察小鼠主动脉窦病理变化;采用Western blotting法检测小鼠主动脉组织中TNF-α/κB抑制因子激酶β(inhibitorκB kinaseβ,IKKβ)/核因子-κB(nuclear factor-κB,NF-κB)信号通路相关蛋白及CD36蛋白表达。结果共筛选出消积丸136个活性成分及277个作用靶点,4481个AS疾病相关靶点,消积丸和AS的共同靶点有205个,核心靶点主要包括TNF、IL-6、NF-κB、IL-1β等。GO功能和KEGG通路富集分析发现,消积丸治疗AS主要涉及炎症反应、一氧化氮生物合成等过程,调控癌症通路、乙肝通路、TNF信号通路等;在TNF信号通路中进一步筛选得到TNF-α/IKKβ/NF-κB信号通路。动物实验结果显示,与对照组相比,模型组小鼠血清中三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、IL-1β、IL-6、TNF-α、ox-LDL水平均显著升高(P<0.01);主动脉中TNF-α蛋白表达以及IKKβ、NF-κB p65磷酸化水平均显著升高(P<0.01);主动脉窦内膜不光滑,出现大量胶原纤维和脂质沉积(P<0.01),形成明显的AS斑块。与模型组相比,消积丸组小鼠血清中TC、TG、LDL-C、TNF-α、IL-6、ox-LDL水平均显著降低(P<0.05、0.01),血清中HDL-C水平显著升高(P<0.01);主动脉中TNF-α、CD36蛋白表达以及IKKβ、NF-κB p65磷酸化水平均显著降低(P<0.05、0.01);主动脉窦AS斑块减少,胶原蛋白和脂质沉积等情况均得到改善(P<0.05、0.01)。结论消积丸能够通过下调TNF-α/IKKβ/NF-κB信号通路相关蛋白表达,减轻炎症反应,调节脂质代谢,从而发挥治疗AS的作用。

关键词：消积丸网络药理学动脉粥样硬化肿瘤坏死因子-α/κB抑制因子激酶β/核因子-κB信号通路炎症反应脂质代谢大黄素大黄酚熊果酸

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跟腱黄色瘤:水-脂成分基线水平和治疗后的变化

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国际医学放射学杂志 2018年第1期 103-103页

作者： J.F.Griffth m.Hu D.K.W.Yeung P.Guo S.L.lam F.Xiao 徐凯 Department of Imaging Prince of Wales HospitalThe Chinese University of Hong Kong

摘要目的探究跟腱黄色瘤基线水平和治疗后的水脂成分并比较超声(US)和mRI的诊断价值。材料与方法共纳入24例并发48处临床典型的跟腱黄色瘤的家族性高胆固

关键词：腱黄色瘤基线水平横截面积

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