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替雷利珠单抗联合化疗治疗Ⅲb~Ⅳ期非小细胞肺癌患者的临床研究

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中国临床药理学杂志 2024年第3期40卷 335-339页

作者：李小雪张毅姚舒洋农靖颖首都医科大学宣武医院胸外科北京100053

目的分析替雷利珠单抗联合化疗治疗Ⅲb~Ⅳ期非小细胞肺癌(NSCLC)的临床疗效及其对T淋巴细胞免疫、生存预后的影响。方法将NSCLC患者按治疗方法不同分为对照组和试验组。对照组给予含铂双药联合化疗方案进行治疗,PC方案:第1天静脉滴注... 详细信息

目的分析替雷利珠单抗联合化疗治疗Ⅲb~Ⅳ期非小细胞肺癌(NSCLC)的临床疗效及其对T淋巴细胞免疫、生存预后的影响。方法将NSCLC患者按治疗方法不同分为对照组和试验组。对照组给予含铂双药联合化疗方案进行治疗,PC方案:第1天静脉滴注培美曲塞500 mg·m^(-2),第1天按血药浓度-时间曲线下面积(AUC)=5 mg·mL^(-1)·min^(-1)静脉滴注卡铂;TP方案:第1天静脉滴注紫杉醇135 mg·m^(-2),第1~3天按AUC=5 mg·mL^(-1)·min^(-1)静脉滴注卡铂。试验组在对照组治疗的基础上静脉输注替雷利珠单抗200 mg,每3周给药1次。3周为1个治疗周期,2组均治疗2个周期。比较2组患者的临床疗效、血清肿瘤标志物水平、T淋巴细胞免疫功能水平、无进展生存时间(PFS)和总生存时间(OS)以及治疗期间药物不良反应发生情况。结果对照组和试验组各40例。治疗后,对照组和试验组的总有效率分别为40.00%(16例/40例)和62.50%(25例/40例),疾病控制率分别为70.00%(28例/40例)和90.00%(36例/40例),癌胚抗原(CEA)分别为(9.21±2.03)和(5.42±1.36)ng·mL^(-1),糖抗原125(CA125)分别为(72.53±8.16)和(31.95±5.08)U·mL^(-1),糖抗原19-9(CA19-9)分别为(25.79±3.31)和(10.38±2.04)U·mL^(-1),细胞角质蛋白19片段抗原21-1(CYFRA21-1)分别为(6.47±1.34)和(4.26±0.91)ng·mL^(-1),CD3^(+)分别为(54.36±5.81)%和(61.85±4.96)%,CD4^(+)分别为(31.28±2.93)%和(43.08±3.15)%,CD4^(+)/CD8^(+)分别为1.43±0.40和1.91±0.46,生存率分别为47.37%(18例/38例)和67.57%(25例/37例),PFS分别为7.73个月(95%CI:6.42~9.03)和9.75个月(95%CI:8.68~10.82),OS分别为8.96个月(95%CI:7.94~9.97)和10.52个月(95%CI:9.78~11.27),在统计学上差异均有统计学意义(均P0.05)。结论替雷利珠单抗联合化疗治疗Ⅲb~Ⅳ期NSCLC效果较好,可有效降低血清肿瘤标志物水平,改善患者T淋巴细胞免疫功能,并延长患者生存时间,安全性良好。

关键词：替雷利珠单抗化疗非小细胞肺癌 T淋巴细胞生存预后

锦州市三级甲等医院实习护生职业决断力在欺凌行为与职业探索间的中介效应

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职业与健康 2024年第12期40卷 1673-1677页

作者：张健吴春燕李红玉锦州医科大学护理学院山西医科大学护理学院

目的了解锦州市三级甲等医院实习护生欺凌行为、职业决断力与职业探索的相关性,探讨职业决断力在欺凌行为与职业探索间的中介效应,为护理教育者和管理者采取针对性策略,提高护生职业探索水平提供依据。方法采用便利抽样法,选取2022年6月... 详细信息

目的了解锦州市三级甲等医院实习护生欺凌行为、职业决断力与职业探索的相关性,探讨职业决断力在欺凌行为与职业探索间的中介效应,为护理教育者和管理者采取针对性策略,提高护生职业探索水平提供依据。方法采用便利抽样法,选取2022年6月—2023年3月在锦州市2所三级甲等医院实习的318名护生为研究对象,以中文版护生遭受欺凌行为量表、职业探索问卷和职业决断力问卷对实习护生进行调查,并对数据进行分析。结果三甲医院实习护生欺凌行为总分[m(P_(25),P_(75))]为16.00(10.00,22.25)分,职业决断力总分为(32.50±6.57)分,职业探索总分为(57.98±11.10)分。职业探索与职业决断力呈显著正相关(P<0.01),与欺凌行为呈显著负相关(P<0.01);Bootstrap检验结果显示,职业决断力在三甲医院实习护生欺凌行为和职业探索间的中介效应为-0.152(95%CI:-0.208~-0.099),占总效应的59.6%。结论锦州市2所三级甲等医院实习护生欺凌行为、职业决断力与职业探索间两两相关,职业决断力在三甲医院实习护生欺凌行为和职业探索间起部分负向中介作用。护理教育者和管理者应重视护生的实习环境,采取有效措施减少欺凌行为的发生,提升其职业决断力,从而促进职业探索频率的增加。

关键词：欺凌行为职业决断力职业探索中介效应实习护生三级甲等医院

Comparative water relations of co-occurring trees in a mixed podocarp-broadleaf forest

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Journal of Plant Ecology 2019年第1期12卷 163-175页

作者： Julia Kaplick michael J.Clearwater Cate macinnis-ng School of Biological Sciences University of AucklandPrivate Bag 92019Auckland 1142New Zealand School of Science University of WaikatoPrivate Bag 3105Hamilton 3240 New Zealand

Aims As extreme climatic events including droughts and heat waves become more common in a changing climate,tree mortality has increased across the *** order to determine whether certain species have a competitive advantage over others,we explored the water-relations and leaf-gas exchange of four co-occurring spe-cies in a forest in northern Aotearoa-New *** studied the ecologically and culturally significant foundation species,Agathis australis(a conifer),two additional conifers,Phyllocladus tricho-manoides and Podocarpus totara and the angiosperm Knightia *** We measured sap flow,leaf-gas exchange and xylem water poten-tials of leaves and terminal branches with concurrent measures of micrometeorological data on days with very few *** derived whole tree hydraulic conductance and instantaneous water-use efficiency(WUEi)at our remnant forest in west Auckland during February 2015(southern hemisphere summer).Important Findings The four species behaved similarly in their diurnal curves of gas exchange and water *** of assimilation,stomatal con-ductance and WUEi were similar am.ng trees of different *** tree hydraulic conductance was also similar am.ng *** results indicate functional convergence in water relations,possibly driven by low nutrient soils at the *** results suggest that there is no species with a clear adaptive advantage over the others in the context of climate change.

关键词： southern conifers sap flow water potential hydraulic conductance leaf-gas exchange functional convergence

Incorporating geotechnical and geophysical investigations for underground obstruction detection:A case study

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Underground Space 2023年第4期11卷 116-129页

作者： Yaohui Liu Yannick C.H.ng Yunhuo Zhang Ping Yang Taeseo Ku School of mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221000China Department of Civil and Environmental Engineering National University of Singapore117576Singapore Geotechnical&Tunnel Division Land Transport Authority Singapore219428Singapore Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Department of Civil and Environmental Engineering Konkuk UniversitySeoul 05029South Korea

Determining the location and boundary of underground obstructions and/or anomalies is a common problem and often a great chal-lenge for tunneling and underground *** this study,geotechnical investigations(penetration tests and borehole drilling/sam-pling)and geophysical investigations(surface wave method and cross-hole seismic method)were conducted with the aim of identifying the location and boundary of rock obstructions in Changi East,*** surface wave method is frequently used in the sites with lateral homogeneity in previous studies,but its application in the sites with rock obstructions is *** experimental results of this study indicate that the surface wave method is also able to determine the upper surface of rock obstructions,but difficult to identify the lateral and bottom boundaries of rock *** improve the precision of detection,the full waveform inversion(FWI)method was used to process the data from the cross-hole seismic *** results indicate that the inversion precision of P-wave is higher than that of *** horizontal and vertical ranges of rock obstructions in the P-wave inversion results are 14–26 m and 7.5–11.0 m respectively,roughly consistent with the results of penetration tests(about 15–25 m)and borehole log(8.85–10.80 m).This result proves that the sequential application of first-arrival time analysis and FWI can effectively delineate the boundary of rock ***,the results of various detection methods were analyzed and compared in this *** the advantages of various methods,we propose a cost-effective and high-precision workflow containing both geotechnical and geophysical investigations.

关键词： FWI Geotechnical and geophysical investigations Cross-hole seismic method Surface wave method Obstruction detection

Control of settlement and volume loss induced by tunneling under recently reclaimed land

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Underground Space 2019年第4期4卷 289-301页

作者： A.K.L.Kwong C.C.W.ng A.Schwob AECOm Hong KongChina Dragages-Bouygues Joint Venture Hong KongChina

The proposed Tuen mun-Chek Lap Kok Link(Tm-CLKL)project comprises a 9-km-long dual two-lane carriageway between Tuen mun and North Lantau,Hong *** of the two tunnels at the Northern Landfall Fall was carried out by two TBms:the northbound is referred to as mL03 and has an excavated diameter of 17.63 m,and the southbound is referred to as mL02 and has an excavated diameter of 14.00 *** use of TBms minimized the amount of dredging and removal of soft marine deposits,resulting in less impact to the environment within and near the work site of the *** treatment in the form of deep vibro-compaction was carried out at the sand fill and band drains installed in the marine deposit.A surcharge was also added above the final formation level to limit the residual settlement and differential settlement of the reclaimed land to less than 500 mm and 1 in 300,respectively,for a design life of 50 *** element analyses were performed to predict the settlement trough under different confinement pressures along the tunnel *** monitoring of the ground movement was carried out during the driving of the two TBms to ensure that the design confinement pressure of the slurry would not cause excessive settlement,heave,or blow out at the shallow tunnel sections or different facilities along the tunnel *** monitoring data was then used to back-calculate the percentage of volume loss,which is a key index describing the behavior of the ground during *** monitoring data showed that the measured settlement and back-calculated volume loss were much lower than the predicted values.

关键词： TBm excavation Settlement trough Volume loss Ground treatment Confinement pressure

溃疡性结肠炎患者肠黏膜屏障功能与外周血Th17/Treg比值、瘦素水平的相关性

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中国肛肠病杂志 2024年第5期44卷 40-42页

作者：宋伟罗小玲淮安市第一人民医院消化内科江苏淮安223200

目的:探讨溃疡性结肠炎(UC)患者肠黏膜屏障功能与外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)比值、瘦素水平的相关性。方法:选择2019年1月至2022年12月我院收治的88例UC患者作为研究对象,根据改良Truelove和Witts评分将疾病严重程度... 详细信息

目的:探讨溃疡性结肠炎(UC)患者肠黏膜屏障功能与外周血辅助性T细胞17(Th17)/调节性T细胞(Treg)比值、瘦素水平的相关性。方法:选择2019年1月至2022年12月我院收治的88例UC患者作为研究对象,根据改良Truelove和Witts评分将疾病严重程度分为轻、中、重度UC 3组,比较各组尿乳果糖/甘露醇(L/m)比值、Th17/Treg比值及瘦素水平,采用Spearman分析L/m与Th17/Treg、瘦素的相关性,绘制ROC曲线,计算Th17/Treg、瘦素预测肠黏膜屏障功能障碍的最佳截断值、敏感性和特异性。结果:重度UC组L/m、Th17/Treg比值及瘦素水平均明显高于中度UC组和轻度UC组,中度UC组L/m、Th17/Treg比值及瘦素水平高于轻度UC组,差异均有统计学意义,Pm比值均呈正相关(r值分别为0.791和0.661,均Png/mL,AUC(95%CI)为0.933(0.881~0.986)、0.903(0.843~0.964),敏感度为89.28%、81.34%,特异度为81.34%、83.47%。结论:UC患者肠黏膜屏障功能障碍严重程度与Th17/Treg比值、瘦素水平均呈正相关,监测Th17/Treg比值、瘦素水平对预测UC患者肠黏膜屏障功能障碍严重程度有较高的价值。

关键词：溃疡性结肠炎肠黏膜屏障功能乳果糖/甘露醇比值 Th17/Treg比值瘦素相关性

超高效液相-质谱法测定滴通鼻炎水中马兜铃酸Ⅰ、Ⅱ的含量

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中国药物警戒 2024年第4期21卷 386-390,396页

作者：郭日新肖萌刘静戴忠马双成中国食品药品检定研究院中药民族药检定所北京100050

目的测定滴通鼻炎水中马兜铃酸Ⅰ、马兜铃酸Ⅱ的含量,为其质量控制提供借鉴。方法采用超高效液相-质谱法(UPLC-mS/mS)同时测定滴通鼻炎水中马兜铃酸Ⅰ、马兜铃酸Ⅱ的含量。色谱柱采用Waters-ACQUI UPLC HSS T3 C_(18)(2.1 mm×100 mm,1.... 详细信息

目的测定滴通鼻炎水中马兜铃酸Ⅰ、马兜铃酸Ⅱ的含量,为其质量控制提供借鉴。方法采用超高效液相-质谱法(UPLC-mS/mS)同时测定滴通鼻炎水中马兜铃酸Ⅰ、马兜铃酸Ⅱ的含量。色谱柱采用Waters-ACQUI UPLC HSS T3 C_(18)(2.1 mm×100 mm,1.8μm),采用乙腈为流动相A,0.1%甲酸含1 mmol·L^(-1)乙酸铵溶液为流动相B,梯度洗脱,电喷雾离子源(ESI),正离子多反应监测模式,以标准曲线法计算含量。结果17批滴通鼻炎水中有9批样品未检出马兜铃酸Ⅰ(检出限0.13 pg),8批样品中检出马兜铃酸Ⅰ,含量在0.41~3.60 ng·mL^(-1)。所有样品中均未检出马兜铃酸Ⅱ(检出限0.41 pg)。结论建立了UPLC-mS/mS同时测定滴通鼻炎水中马兜铃酸Ⅰ、马兜铃酸Ⅱ含量的方法,该方法专属性强、灵敏度高、重复性好,可为滴通鼻炎水中马兜铃酸Ⅰ、马兜铃酸Ⅱ的质量控制提供参考。

关键词：滴通鼻炎水马兜铃酸Ⅰ 马兜铃酸Ⅱ 超高效液相-质谱法含量测定

Spectral Analysis for Preconditioning of multi-Dimensional Riesz Fractional Diffusion Equations

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Numerical mathematics(Theory,methods and Applications) 2022年第3期15卷 565-591页

作者： Xin Huang Xue-Lei Lin michael K.ng Hai-Wei Sun Department of mathematics University of MacaoMacao SARChina Shenzhen JL Computational Science and Applied Research Institute Shenzhen 518131China Beijing Computational Science Research Center Beijing 100193China Department of mathematics The University of HongkongHong Kong SARChina

In this paper,we analyze the spectra of the preconditioned matrices arising from discretized multi-dimensional Riesz spatial fractional diffusion *** finite difference method is employed to approximate the multi-dimensional Riesz fractional derivatives,which generates symmetric positive definite ill-conditioned multi-level Toeplitz *** preconditioned conjugate gradient method with a preconditioner based on the sine transform is employed to solve the resulting linear ***,we prove that the spectra of the preconditioned matrices are uniformly bounded in the open interval(12,32)and thus the preconditioned conjugate gradient method converges linearly within an iteration number independent of the discretization ***,the proposed method can be extended to handle ill-conditioned multi-level Toeplitz matrices whose blocks are generated by functions with zeros of fractional *** theoretical results fill in a vacancy in the *** examples are presented to show the convergence performance of the proposed preconditioner that is better than other preconditioners.

关键词： multi-dimensional Riesz fractional derivative multi-level Toeplitz matrix sine transform based preconditioner preconditioned conjugate gradient method

An AlGaN/GaN HEmT with a reduced surface electric field and an improved breakdown voltage

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Chinese Physics B 2012年第8期21卷 360-364页

作者：谢刚 Edward Xu Niloufar Hashemi 张波 Fred Y.Fu Wai Tung ng The Edward S.Rogers Sr.Electrical and Computer Engineering Department University of Toronto State key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Crosslight Software Inc.Burnaby BCCanada

A reduced surface electric field in an AlGaN/GaN high electron mobility transistor （HEmT） is investigated by employing a localized mg-doped layer under the two-dimensional electron gas （2-DEG） channel as an electric field shaping layer. The electric field strength around the gate edge is effectively relieved and the surface electric field is distributed evenly as compared with those of HEmTs with conventional source-connected field plate and double field plate structures with the same device physical dimensions. Compared with the HEmTs with conventional sourceconnected field plates and double field plates, the HEmT with a mg-doped layer also shows that the breakdown location shifts from the surface of the gate edge to the bulk mg-doped layer edge. By optimizing both the length of mg-doped layer, Lm, and the doping concentration, a 5.5 times and 3 times the reduction in the peak electric field near the drain side gate edge is observed as compared with those of the HEmTs with source-connected field plate structure and double field plate structure, respectively. In a device with VGS = -5 V, Lm 1.5 m, a peak mg doping concentration of 8×10^17 cm-3 and a drift region length of 10 m, the breakdown voltage is observed to increase from 560 V in a conventional device without field plate structure to over 900 V without any area overhead penalty.

关键词： AlGaN/GaN HEmT reduced surface electric field mg-doped layer breakdown voltage