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Increase in the Hydrophilicity and Lewis Acid-Base Properties of Solid Surfaces Achieved by Electric Gliding Discharge in Humid Air: Effects on Bacterial Adherence

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Plasma Science and Technology 2009年第2期11卷 187-193页

作者： J.O.KAmGANG m.NAITALI J.-m.HERRY m.-N.BELLON-fontaine J.-L.BRISSET R.BRIANDET Laboratory of Interfacial Electrochemistry and Analytical Chemistry University of Rouen INRA(National Institute for Agricultural Research) UMR 763 Bio-adhesion and Hygiene of Materials AgroParisTech UMR 763 Bio-adhesion and Hygiene of Materials AgroParisTech UMR763 Bio-adhesion and Hygiene of Materials

This study addressed the effects of treatment with gliding discharge plasma on the surface properties of solid materials, as well as the consequences concerning adherence of a model bacterium. As evaluated by contact angles with selected liquids, plasma treatment caused an increase in surface hydrophilicity and in the Lewis acid-base components of the surface energy of all materials tested. These modifications were more marked for low density polyethylene and stainless steel than for polytetrafiuoroethylene. After treatment, the hydrophilicity of the materials remained relatively stable for at least 20 days. moreover, analysis of the topography of the materials by atomic force microscopy revealed that the roughness of both polymers was reduced by glidarc plasma treatment. As a result of all these modifications, solid substrates were activated towards micro-organisms and the adherence of S. epidermidis, a negatively charged Lewis-base and mildly hydrophilic strain selected as the model, was increased in almost all the cases tested.

关键词： gliding arc plasma surface energy properties polymers stainless steel surface hydrophilicity atomic force microscopy

Spatial evolution of friction of a textured wafer surface

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Friction 2013年第1期1卷 92-97页

作者： Huaping XIAO Ke WANG Grant FOX michel BELIN Julien fontaine Hong LIANG mechanical Engineering Texas A&M UniversityCollege StationTexas 77843USA materials Science and Engineering Texas A&M UniversityCollege StationTexas 77843USA Ecole Centrale de Lyon/CNRS-UmR 5513 France

mechanical failure of integrated circuits and micro-electro-mechanical systems(mEmS)demands new understanding of friction in small *** present research,we demonstrated an in situ approach to measure sliding friction of a patterned surface composing multi-materials and *** effects of materials and surface morphology on friction and electrical contact resistance were *** material transfer at the interface of dissimilar materials was found to play dominating roles in *** current work provides important insights from the fundamentals of friction that benefit the design of new micro-devices.

关键词： micro-electro-mechanical systems(mEmS) patterned wafers friction transfer wear electrical contact resistance

Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?

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World Journal of Gastroenterology 2017年第46期23卷 8193-8199页

作者： Carrie Luu marisa Amaral Jason Klapman Cynthia Harris Khaldoun Almhanna Sarah Hoffe Jessica Frakes Jose m Pimiento Jacques P fontaine Department of Thoracic Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

AIm To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. mETHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS *** Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy.

关键词： Esophageal cancer Endoscopic ultrasound Staging Early esophageal cancer Endoscopic mucosal resection

Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity

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World Journal of Diabetes 2020年第12期11卷 622-643页

作者： Jessica fontaine Geneviève Tavernier Nathalie morin Christian Carpéné Institut des maladies métaboliques et Cardiovasculaires Institut National de la Santéet de la Recherche MédicaleINSERM UMR1048UniversitéPaul Sabatier Toulouse IIIToulouse 31432France INSERm UmR 1139 Facultéde Pharmacie Universitéde ParisParis 75006France

BACKGROUND Benzylamine and methylamine activate glucose uptake in *** tyramine,this effect has even been extended to *** To investigate the effects of catecholamines and other amines on glucose *** A screening compared 25 biogenic amines on 2-deoxyglucose(2-DG)uptake activation in rat *** approaches and transgenic mouse models were then used to decipher the mode of action of several *** In rat adipocytes,insulin stimulation of 2-DG uptake was reproduced with catecholamines.100μmol/L or 1 mmol/L adrenaline,noradrenaline,dopamine and deoxyepinephrine,maximally activated hexose transport only when sodium orthovanadate was added at 100μmol/*** activation was similar to that already reported for benzylamine,methylamine and tyramine,well-recognized substrates of semicarbazide-sensitive amine oxidase(SSAO)and monoamine oxidase(mAO).Several,but not all,tested agonists ofβ-adrenoreceptors(β-ARs)also activated glucose transport whileα-AR agonists were *** of blockade byα-andβ-AR antagonists indicated that catecholamine-induced 2-DG uptake was not mediated by AR *** from mice lackingβ1-,β2-andβ3-ARs(triple KO)also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100μmol/L *** mAO blocker pargyline,and SSAO inhibitors did not block the effects of adrenaline or noradrenaline plus vanadate,which were blunted by *** Catecholamines exert unexpected insulin-like actions in adipocytes when combined with *** limiting insulin resistance by activating glucose consumption at least in fat stores,we propose that catecholamine derivatives combined with vanadium can generate novel complexes that may have low toxicity and promising anti-diabetic properties.

关键词： Adipocyte Amine oxidases Insulin Diabetes Vanadium Obesity

Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis(Coss. & Dur.) maire

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Asian Pacific Journal of Tropical medicine 2016年第6期9卷 537-543页

作者： Hanene Zater Joelle Huet Veronique fontaine Samir Benayache Caroline Stevigny Pierre Duez Fadila Benayache Unite de recherche : Valorisation des Ressources Naturelles Molecules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL) Faculte des Sciences Exactes Universite Freres Mentouri Constantine 125000 ConstantineAlgerie Universite Ziane Achour Cite du 5 JuilletRoute Moudjbara BP:311717000 DjelfaAlgerie Laboratoire de Pharmacognosie de Bromatologie et de Nutrition Humaine Universite Libre de Bruxelles (ULB)1050 BruxellesBelgique Laboratoire de Biopolymere et nanomateriaux supramoleculaire Universite Libre de Bruxelles (ULB)1050 BruxellesBelgique Unite de microbiologie Pharmaceutique et Hygiene Faculte de Pharmacie Universite Libre de Bruxelles (ULB)1050 BrxellesBelgique Service de Chimie Therapeutique et de Pharmacognosie Universite de Mons (UMONS)7000MonsBelgique

Objective:To investigate the chemical composition of a moderately polar extract(CHC1_3 soluble part of the meOH-H_2O extract) obtained from the aerial parts(leaves and flowers) of Centaurea diluta ***(Coss.& Dur.) maire,a species endemic to Algeria and morocco on which no reports are available to *** evaluate in vitro the cytotoxic,antifungal and antimicrobial activities of this extract and the cytotoxic and antimicrobial activities of its isolated secondary ***:The cytotoxic effects of the extract were investigated on 3 human cancer cell lines *** A549 non-small-cell lung carcinoma(NSCLC),the mCF7 breast adenocarcinoma and the U373 glioblastoma using a mTT colorimetric *** data allowed to guide the fractionation of the extract by separation and purification on silica gel 60(CC and TLC).The isolated compounds which were characterized by spectral analysis,mainly HR-ESImS,HR-EImS,UV and NmR experiments(~1H,^(13)C,COSY,ROESY,HSQC and HmBC) and comparison of their spectroscopic data with those reported in the literature,were evaluated for cytotoxic activities on six cancer cell lines(A549,mCF7,U373,Hs683 human glioma,PC3 human prostate and B16-F10 murine melanoma).The direct and indirect antibacterial and antifungal activities were determined using microdilution methods for the raw extract and TLC-bioautography and microdilution methods against standard and clinical strains for the isolated ***:The raw extract reduced cell viability with IC_(50)s of 27,25 and 21 μg/mL on A549,mCF7 and U373,*** secondary metabolites:two phenolic compounds(vanillin 1,paridol 3),a lignan[(-)-arctigenin 2]and two flavonoid aglycones(eupatilin 4 and jaceosidin 5),were then isolated from this *** cytotoxic effects were observed for(-)-arctigenin 2(IC_(50)s:28 and 33μm on Hs683 and B16-F10,respectively),eupatilin 4(IC_(50)s:33 and 47 μm on B16-F10 and PC3,respectively) and jaceosidin 5(IC_(50)s:32 a

关键词： Flavonoids Lignans Centaurea diluta Asteraceae Cytotoxic activity Direct and indirect antimicrobial activity mRSA

Analysis and Simulink modeling of the Performance of Dynamic Web Server Using JSP and PHP

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Communications and Network 2018年第4期10卷 196-210页

作者： fontaine Rafamantanantsoa Paulson Ravomampiandra University of Fianarantsoa Fianarantsoa Madagascar

In recent years, web technology carried on growing and at same time, the number of internet users increased significantly in number. Today, a Web server is capable of processing millions of requests per day, but during the peak period may collapse and becomes critical causing unavailability of the services offered by the servers. That is why Web server performance is a topic of great interest to many researchers. In this paper, we evaluate experimentally the impact of JSP and PHP dynamic content technology: JSP and PHP with access to a database of performance data of Apache Web server. Using the “ApacheBench” performance measurement tool, the approach is to compare the performances of four different configurations of a Web server, such as: Apache Web server implementing JSP technology with access to PostgreSQL database, Apache using PHP technology with the PostgreSQL as database, Apache Web server using the JSP technology with access to mySQL database, finally Apache and PHP with DBmS mySQL. At the end of this article, we also present a Simulink model of Web server performance based on the simple m/m/1 queue. During the modeling, the mATLAB software was used.

关键词： Analysis Queue JSP model Performances Evaluation PHP Web Server Simulink

Performance Comparison and Simulink model of Firewall Free BSD and Linux

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Communications and Network 2018年第4期10卷 180-195页

作者： fontaine Rafamantanantsoa Haja Louis Rabetafika University of Fianarantsoa Fianarantsoa Madagascar

In recent years, the number of users connected to the Internet has experienced a phenomenal growth. The security of systems and networks become essential. That is why the performance of Linux firewall and Berkeley Software Distribution (BSD) are of paramount importance in security systems and networks in all businesses. The following evaluates the firewall based tool that we have developed in Python and Scapy, which performs time measurements by serving packets traversing the firewall test. Several results were presented: the speed of the firewall under FreeBSD in terms of service time compared to the speed of the firewall under Linux as the number of rules increases;the speed of the filtering rule of a firewall stateless in terms of service time compared to the filtering rule of an active firewall gradually as the number of rules increases. Then, for care of simplicity, we have presented the queue m/m/1/K to model the performances of firewalls. The resulting model was validated using Simulink and mean squared error. The analytical model and Simulink of the firewalls are presented in the article.

关键词： Firewall Ipfw Iptables Python Scapy Simulink Statefull Firewall Stateless Firewall

Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia

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World Journal of Cardiology 2012年第10期4卷 296-301页

作者： Aimé Bonny Antonio De Sisti manlio F márquez Richard megbemado Franoise Hidden-Lucet Guy fontaine Hpital Pitié-Salpêtrière Unité de Rythmologie47-83 Boulevard de l'Hpital75651 ParisFrance Instituto Nacional de Cardiología Ignacio Chávez Departamento de ElectrofisiologíaJuan Badiano 1Col.Sección ⅩⅥ14080 Mexico CityMexico Hpital Saint Camille Service de Cardiologie2 Rue des Pères Camilliens94366 Bry-sur MarneFrance

We report three cases of sustained monomorphic ventricular tachycardia(VT) in the setting of coronary artery disease,resistant to beta-blockers in two patients and to amiodarone in all,successfully terminated by low doses of intravenous(IV) *** was the first manifestation of coronary artery disease in one patient,whereas the other two patients had a previous history of myocardial infarction and were recipients of an implantable cardioverter-defibrillator(ICD).One of these two patients experienced an arrhythmic *** had hemodynamic instability at the time of epinephrine administration.A single slow administration of IV epinephrine(0.5 to 1 mg administered over 30 to 60 s) restored sinus rhythm after 30-90 s with only minor side *** the ICD patient with recurrent VT and several cardioversions due to transformation of VT to ventricular fibrillation,epinephrine injection led to the avoidance of further *** potentially harmful,low doses of IV epinephrine used alone or in combination with beta-blocker treatment and electrical cardioversion may be an alternative effective therapy for sustained monomorphic VT refractory to *** role of epinephrine in the termination of VT should be studied further,especially in patients pre-treated with amiodarone in combination with beta-blockers.

关键词： Ventricular tachycardia Epinephrine Cardiopulmonary resuscitation Ischemic heart disease Coronary artery disease Amiodarone

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变压器用换位导线的最新进展

变压器 2002年第11期39卷 25-27页

作者：林正平 J.C.fontaine m.Ozino G.Properzi 魏德曼系统国际公司上海200336 Continuus/Kraft公司 Proteco公司 Continuus公司

介绍了变压器用带油道的换位导线及其特性和生产该换位导线的设备。

关键词：变压器换位导线电力变压器绕组特性抗拉强度