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Small fishes crossed a large mountain range:Quaternary stream capture events and freshwater fishes on both sides of the Taebaek mountains

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Integrative Zoology 2017年第4期12卷 292-302页

作者： Daemin KIm m.vincent HIRT Yong-Jin WON Andrew m.SImONS Division of EcoScience Ewha Womans UniversitySeoulKorea Department of Fisheries Wildlife and Conservation BiologySaint PaulMinnesotaUSA Bell museum of Natural History University of Minnesota100 Ecology BuildingSaint PaulMinnesotaUSA

The Taebaek mountains in Korea serve as the most apparent biogeographic barrier for Korean freshwater fishes,resulting in 2 distinct ichthyofaunal assemblages on the eastern(East/Japan Sea slope)and western(Yellow Sea and Korea Strait slopes)sides of the mountain *** nearly 100 species of native primary freshwater fishes in Korea,only 18 species occur naturally on both sides of the mountain ***,there are 5 rheophilic species(Phoxinus phoxinus,Coreoleuciscus splendidus,Ladislavia taczanowskii,Iksookimia koreensis and Koreocobitis rotundicaudata)found on both sides of the Taebaek mountains that are geographically restricted to the Osip River(and several neighboring rivers,for *** and ***)on the eastern side of the mountain *** Osip River and its neighboring rivers also shared a rheophilic freshwater fish,Liobagrus mediadiposalis,with the Nakdong River on the western side of the mountain *** assessed historical biogeographic hypotheses on the presence of these rheophilic fishes,utilizing DNA sequence data from the mitochondrial cytochrome b *** of our divergence time estimation indicate that ichthyofaunal transfers into the Osip River(and several neighboring rivers in East Sea slope)have occurred from the Han(Yellow Sea slope)and Nakdong(Korea Strait slope)Rivers since the Late *** inferred divergence times for the ichthyofaunal transfer across the Taebaek mountains were consistent with the timing of hypothesized multiple reactivations of the Osip River Fault(Late Pleistocene),suggesting that the Osip River Fault reactivations may have caused stream capture events,followed by ichthyofaunal transfer,not only between the Osip and Nakdong Rivers,but also between the Osip and Han Rivers.

关键词： biogeographic barrier comparative phylogeography divergence time Korean fishes Osipcheon fault

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Initial results for urban metal distributions in house dusts of Syracuse,New York,USA

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Science China(Life Sciences) 2005年第Z1期48卷 92-99页

作者： D.L.Johnson J.Hager A.Hunt D.A.Griffith S.Blount S.Ellsworth J.Hintz R.Lucci A.mittiga D.Prokhorova L.Tidd m.m.millones m.vincent SUNY College of Environmental Science and Forestry SyracuseNYUSA Upstate New York Specialist Environmental Consulting 15 Elizabeth St.BaldwinsvilleNYUSA Department of Geography Syracuse UniversitySyracuseNYUSA Department of Geography and Regional Studies University of MiamiCoral GablesFLUSA Department of Chemistry LeMoyne CollegeSyracuseNYUSA

A program of house dust sample collection and analysis has begun in Syracuse,New York,USA,in order to determine the feasibility of a geography-based exposure assessment for urban *** sampling program,and the protocols it employs,is described for two different types of wipe media,Ghost Wipes and Whatman *** results show that strong spatial patterns of floor dust loading(mg dust per square foot)can be observed for data aggregated at a spatial scale of about 1600 m(~2.5 km^(2)).Floor dust metal concentrations were similar to those found in other urban environments,with some regional *** median floor dust Pb concentration was~108 mg·kg^(-1)for this initial data set of~264 sampled residential locations,and varied from 50 to 1100 mg Pb·kg^(-1).

关键词： floor dust loading wipe tests GIS dust Pb concentration humidity corrections

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肌无力或与老年美国人的早期死亡存在因果关系:配对队列研究

肌无力或与老年美国人的早期死亡存在因果关系:配对队列研究

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作者： Ryan mcgrath Brena m.vincent mark D.Peterson Donald A.Jurivich Lindsey J.Dahl Kyle J.Hackney 宋安琪上海交通大学医学院附属仁济医院临床营养科

目的:用配对队列研究量化研究肌无力和死亡率之间的联系,帮助建立肌无力对早期死亡的影响。我们使用美国老年人群进行配对分析,来确定肌无力的人是否具有更高的死亡风险。设计:长期随访成组研究地点:包括身体测量的随访是面对面完成的,...

目的:用配对队列研究量化研究肌无力和死亡率之间的联系,帮助建立肌无力对早期死亡的影响。我们使用美国老年人群进行配对分析,来确定肌无力的人是否具有更高的死亡风险。设计:长期随访成组研究地点:包括身体测量的随访是面对面完成的,但是部分核心随访是通过电话完成。参与对象:19729名年龄50岁及以上的美国人的数据从2006-2014年Health and Retirement study里面提取并分析。方法:握力计用来测试每位受试者握力(handgrip strength,HGS)。男性HGSmatching algorithm方法来进行配对队列。结果:在1077例肌无力和正常的对子中,肌无力组401名(37%)、正常组296名(27.4%)美国人在4.5±2.5的随访时间内死亡。在1057例肌无力和强壮的对子中,肌无力组293名(37%)、强壮组243名(22.9%)受试者在4.5±2.5年的随访时间内死亡。和正常和强壮组人群相比,肌无力组人群死亡风险分别增加1.4 (95%可信区间:1.19,1.64)和1.54(95%可信区间:1.3,1.83)倍。结论:我们的研究提示在美国老年人群中,肌无力和死亡率可能存在因果联系。健康从业人员应该将HGS作为常规健康检查的一部分并且让患者知道肌无力的危害。

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machine Learning Empowered Security and Privacy Architecture for IoT Networks with the Integration of Blockchain

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Intelligent Automation & Soft Computing 2024年第2期39卷 353-379页

作者： Sohaib Latif m.Saad Bin Ilyas Azhar Imran Hamad Ali Abosaq Abdulaziz Alzubaidi vincent Karovic Jr. Department of Computer Science The University of ChenabGujrat50700Pakistan Department of Creative Technologies Air UniversityIslamabad42000Pakistan Computer Science Department College of Computer Science and Information SystemsNajran UniversityNajran66244Saudi Arabia Department of Computer Science Umm Alqura UniversityAlQunfudah28821Saudi Arabia Department of Information Systems Faculty of ManagementComenius University in BratislavaBratislava82005Slovakia

The Internet of Things(IoT)is growing rapidly and impacting almost every aspect of our lives,fromwearables and healthcare to security,traffic management,and fleet management *** has generated massive volumes of data and security,and data privacy risks are increasing with the advancement of technology and network *** access control solutions are inadequate for establishing access control in IoT systems to provide data protection owing to their vulnerability to single-point OF ***,conventional privacy preservation methods have high latency costs and overhead for resource-constrained *** machine learning approaches were also unable to detect denial-of-service(DoS)*** study introduced a novel decentralized and secure framework for blockchain *** avoid single-point OF failure,an accredited access control scheme is incorporated,combining blockchain with local peers to record each transaction and verify the signature to ***-based attribute-based cryptography is implemented to protect data storage privacy by generating threshold parameters,managing keys,and revoking users on the *** innovative contract-based DOS attack mitigation method is also incorporated to effectively validate devices with intelligent contracts as trusted or untrusted,preventing the server from becoming *** proposed framework effectively controls access,safeguards data privacy,and reduces the risk of *** results depict that the suggested framework outperforms the results in terms of accuracy,precision,sensitivity,recall,and F-measure at 96.9%,98.43%,98.8%,98.43%,and 98.4%,respectively.

关键词： machine learning internet of things blockchain data privacy security Industry 4.0

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Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer vincent Gröβer magdalena Huber Hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay vincentÉmond martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre maëva meynier Johan Gagniere vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie médicale CHU Clermont-FerrandClermont-Ferrand 63000France m2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIm To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni mohammad Sikander Andrew E.massey Bilal B.Hafeez manish K.Tripathi vincent P.Diego meena Jaggi Junming Yue Nadeem Zafar murali m.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORm),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORm maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORm effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EmT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Cervical myelopathy: Diagnostic Aspects, Surgical Treatment and Evolution of Patients Operated upon in Yaounde

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Open Journal of modern Neurosurgery 2024年第1期14卷 72-82页

作者： Bello Figuim Djoubairou Ben Ousmanou Oumarou Haman Nassourou Ndome Toto Orlande Amadou Tidjani Djientcheu vincent de Paul Yaounde Central Hospital Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1 Yaounde Cameroon Yaounde military Hospital Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon Douala General Hospital Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon Higher Institute of Health Sciences Université des Montagnes Bangangté Cameroon

Introduction: Although cervical myelopathy is the most common degenerative cervical spine pathology in adults, the indications and approaches of surgical treatment have not yet been clearly defined in the literature. Very few studies exist regarding these aspects in our setting, and they are mostly outdated. This study aimed to describe the diagnostic aspects, current surgical treatment with technical improvements, and progression in patients. Patients and methods: We conducted a multicentre retrospective descriptive study over a 10-year period between January 2011 and January 2020 in three referral centres in Yaoundé. All patients who underwent surgery for cervical myelopathy were included. Results: Fifty-two patients were recruited. The rate of operated cervical myelopathies among all degenerative spinal pathologies was 14.05%. The m/F sex ratio was 3/1, and the average age was 52 ± 10 years. All included patients had gait problems, 90.38% demonstrated motor deficiency, and 67.30% experienced at least three levels of compression. Surgery was decided based on the Nurick grade;a posterior approach was applied to 86.54% of patients. Postoperative progression showed a neurological improvement of 82% with an average follow-up of 4 years. Conclusion: In this study, the patients who underwent surgery were relatively young, their clinical presentations were mostly advanced, and surgical management showed good results in well-selected cases.

关键词： Cervical myelopathy Diagnosis Treatment Evolution Cameroon

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SO2和S2O基态表面的势能函数

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工程科学与技术 1987年第2期 94-94页

作者： J.N.murrell W.Craven m.vincent 朱正和英国Sussex大学化学与分子科学系英国Sussex大学化学与分子科学系英国Sussex大学化学与分子科学系成都科技大学化学系

就结构和动力学的需要而论,SO2和S2O势能表面的研究正在广泛受到极大关注。作者之一***由加有极化函数的ab initio计算,第一次发现SOS(CZY)分子构型。在这个引人注目的发现的推动之下,本文用多体展式法导出SO2和S2O的基态势能表面,它能... 详细信息

就结构和动力学的需要而论,SO2和S2O势能表面的研究正在广泛受到极大关注。作者之一***由加有极化函数的ab initio计算,第一次发现SOS(CZY)分子构型。在这个引人注目的发现的推动之下,本文用多体展式法导出SO2和S2O的基态势能表面,它能复现稳定异构体的光谱数据和介稳态的ab initio计算结果。

关键词：基态能级 S2O SO2

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