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Identification of novel mammalian viruses in tree shrews(Tupaia belangeri chinensis)

Zoological Research 2024年第2期45卷 429-438页

作者： Hong Zhou Ren-Rong Tian Xiu-Rong Wang Jin-Xuan Yang Yun-Xiao Wang Ming-Liang Zhao Xu-Dong Zhang Yu-Hua Ma Long-bao lv Edward CHolmes Yong-Tang Zheng Wei-Feng Shi School of Clinical and Basic Medical Sciences Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University and Shandong Academy of Medical SciencesTaianShandong 271000China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi’nanShandong 250117China National Resource Center for Non-Human Primates Kunming Primate Research CenterKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydneyNew South Wales 2006Australia Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute of Virology Shanghai Jiao Tong University School of MedicineShanghai 200025China

The Chinese tree shrew(Tupaia belangeri chinensis),a member of the mammalian order Scandentia,exhibits considerable similarities with primates,including humans,in aspects of its nervous,immune,and metabolic *** similarities have established the tree shrew as a promising experimental model for biomedical research on cancer,infectious diseases,metabolic disorders,and mental health ***,we used metatranscriptomic sequencing to analyze plasma,as well as oral and anal swab samples,from 105 healthy asymptomatic tree shrews to identify the presence of potential zoonotic *** total,eight mammalian viruses with complete genomes were identified,belonging to six viral families,including Flaviviridae,Hepeviridae,Parvovirinae,Picornaviridae,Sedoreoviridae,and ***,the presence of rotavirus was recorded in tree shrews for the first *** viruses-hepacivirus 1,parvovirus,and picornavirus-exhibited low genetic similarity(94%)to known viral *** analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study may be novel *** findings provide insights into the diverse viral spectrum present in captive Chinese tree shrews,highlighting the necessity for further research into their potential for crossspecies transmission.

关键词： Tree shrew(Tupaia belangeri chinensis) Meta-transcriptomic sequencing Mammalian viruses Genomic analysis

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-bao lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer bao-Ci Shan Fang Shen An-Zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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地源热泵技术在绿色建筑中的应用研究

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佛山陶瓷 2024年第8期34卷 137-139页

作者：吕宝峰济南蓝天热力有限公司济南250000

地源热泵技术作为一种可再生能源利用技术,在绿色建筑中的应用日益广泛。本文从地源热泵系统的工作原理出发,分析了其在绿色建筑中的优势,并通过实际工程案例,对地源热泵在采暖、制冷、热水等方面的应用进行了深入探讨,同时对相关的经... 详细信息

地源热泵技术作为一种可再生能源利用技术,在绿色建筑中的应用日益广泛。本文从地源热泵系统的工作原理出发,分析了其在绿色建筑中的优势,并通过实际工程案例,对地源热泵在采暖、制冷、热水等方面的应用进行了深入探讨,同时对相关的经济和环境效益进行了定量分析。研究结果表明,与传统能源方式相比,地源热泵技术可以显著提高能源利用效率,减少碳排放,对实现绿色建筑的目标具有重要意义。最后,针对地源热泵技术在实际应用中存在的问题,提出了相应的优化措施和发展建议。

关键词：地源热泵绿色建筑能源利用环境效益

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应用AMESim双转向器全液压转向系统特性分析

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机械设计与制造 2024年第3期 185-188页

作者：刘传慧孙玉凤介石磊吕宝占黄河交通学院河南焦作454950 河南理工大学机械与动力工程学院河南焦作454000

为全液压转向系统设置双转向器可以解决大排量需求的问题,但此种布置会影响系统的动态响应特性,因此分析系统的可行性。根据某自卸车全液压转向系统的结构特点,对单转向器系统的关键参数进行分析和设计,获取各参数的数值;根据车辆转向... 详细信息

为全液压转向系统设置双转向器可以解决大排量需求的问题,但此种布置会影响系统的动态响应特性,因此分析系统的可行性。根据某自卸车全液压转向系统的结构特点,对单转向器系统的关键参数进行分析和设计,获取各参数的数值;根据车辆转向参数的需求,对转向系统的压力损失和温升进行校核,以验证系统可否满足需求;根据前述分析,采用AMESim搭建分析模型,通过转角输入验证模型准确性,并验证负载、输入变化对系统特性的影响;基于转向系统试验台,通过输出特性分析,对前述设计和分析模型进行验证。结果可知:双转向器系统压力损失满足要求,最高温升控制在56.8℃,控制在系统要求的范围内;影响双转向器系统输出特性和油液流量的因素主要是方向盘转速和系统负载,其他因素基本无影响,仅对系统的响应时间产生影响;试验测试平台获取的角速度阶跃输入下的,转向器输出口压力、流量放大器输出口流量与仿真分析结果误差控制在5%以内,表明分析模型和结果的可靠性,为此类分析设计提供参考。

关键词：全液压转系统转向器压力损失动态特性试验台

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基于主成分分析-支持向量机的电脱盐工艺预测方法研究

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化工自动化及仪表 2024年第3期51卷 443-448页

作者：乔松吕宝林朱建新袁文彬合肥通用机械研究院有限公司国家压力容器与管道安全工程技术研究中心

原油电脱盐工艺水平直接影响常减压装置腐蚀状态和工艺催化剂活性。综合考虑电脱盐工艺参数,选择脱盐前盐质量浓度、含水量及电场强度等40个工艺参数共440组工况数据,进行电脱盐效果评价研究。根据脱后盐含量数据箱型图特征,将电脱盐效... 详细信息

原油电脱盐工艺水平直接影响常减压装置腐蚀状态和工艺催化剂活性。综合考虑电脱盐工艺参数,选择脱盐前盐质量浓度、含水量及电场强度等40个工艺参数共440组工况数据,进行电脱盐效果评价研究。根据脱后盐含量数据箱型图特征,将电脱盐效果等级分为3级,采用主成分分析法,提取原始数据累积贡献率90.91%以上的前3个主成分,与电脱盐等级建立数据集,最后通过支持向量机建立电脱盐等级评价模型。结果表明:该方法对指导电脱盐工艺优化具有较好的工程适用性。

关键词：主成分分析支持向量机电脱盐工艺参数

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基于非靶向代谢组学分析取食玉米和水稻后草地贪夜蛾肠道代谢谱的差异

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环境昆虫学报 2024年第4期46卷 969-977页

作者：陈玉莹唐雪吕宝乾孙强唐继洪卢辉张起恺刘卓黑龙江八一农垦大学农学院黑龙江大庆163319 中国热带农业科学院环境与植物保护研究所农业农村部热带作物有害生物综合治理重点实验室海南省热带农业有害生物监测与控制重点实验室海口571101

为了探究草地贪夜蛾Spodoptera frugiperda ***在不同寄主上的适应性,本试验采用室内饲养观察法比较其取食玉米Zea mays L.和水稻Oryza sativa L.叶片后的发育、存活和繁殖,同时,对草地贪夜蛾4龄幼虫肠道进行解剖,运用代谢组学分析方法... 详细信息

为了探究草地贪夜蛾Spodoptera frugiperda ***在不同寄主上的适应性,本试验采用室内饲养观察法比较其取食玉米Zea mays L.和水稻Oryza sativa L.叶片后的发育、存活和繁殖,同时,对草地贪夜蛾4龄幼虫肠道进行解剖,运用代谢组学分析方法,探究幼虫在分别取食两种寄主植物(玉米/水稻)后肠道代谢谱的差异,筛选与不同寄主取食相关的重要代谢物及代谢通路。结果显示,相较取食玉米叶片(对照组),取食水稻叶片(试验组)的世代周期延长(38.05±0.35 d),成虫前期存活率下降(0.46±0.01),生命表参数中净繁殖力R_(0)(191.68±33.54)、内禀增长率r(0.125±6.77)、周限增长率λ(1.133±7.65)均低于对照组;肠道代谢谱中,共有750个差异代谢物,其中下调587个,上调163个,取食水稻叶片较取食玉米叶片的草地贪夜蛾幼虫肠道中,下调的差异代谢物主要包括组氨酸、α-亚麻酸(ALA)和莽草酸;上调的代谢物有天冬酰胺基半胱氨酸以及N-乙酰氨基甲酸等,这些代谢物涉及氨基酸代谢和脂质代谢等通路。本研究结果可为草地贪夜蛾取食不同寄主的适应机制提供了线索。

关键词：草地贪夜蛾肠道代谢寄主转移存活率

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价值困境路径:课程思政引领高职院校彰显职教特色

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长沙航空职业技术学院学报 2024年第2期24卷 57-61页

作者：陈志峰母则闯吕加宝陈振清厦门东海职业技术学院福建厦门361100

在全面建设社会主义现代化国家的新征程中,不断加强课程思政建设是高职院校做好新时代思想政治工作、践行立德树人根本任务的必然要求,更是实现高职院校高质量发展、彰显职业教育特色的创新举措。新时代课程思政建设创新教育教学方式,... 详细信息

在全面建设社会主义现代化国家的新征程中,不断加强课程思政建设是高职院校做好新时代思想政治工作、践行立德树人根本任务的必然要求,更是实现高职院校高质量发展、彰显职业教育特色的创新举措。新时代课程思政建设创新教育教学方式,将思想政治教育价值引领与高职院校专业实践特色紧密结合,不断提升职业教育水平和社会认可度、提高高职院校人才培养质量、增强高职院校职业教育吸引力,充分发挥“上学选职业学校、技能提升找职业学校”的职业教育特色,让职业教育真正“有学头、有盼头、有奔头”,实现职业教育“立业”与“立人”相统一。

关键词：高职院校课程思政教育特色高质量发展

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Reinforcement learning based edge computing in B5G

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Digital Communications and Networks 2024年第1期10卷 1-6页

作者： Jiachen Yang Yiwen Sun Yutian Lei Zhuo Zhang Yang Li Yongjun bao Zhihan lv School of Electrical and Information Engineering Tianjin UniversityTianjin300072China Technology and Data Center ***Beijing100176China School of Data Science and Software Engineering Qingdao UniversityQingdao266101China

The development of communication technology will promote the application of Internet of Things,and Beyond 5G will become a new technology *** the same time,Beyond 5G will become one of the important supports for the development of edge computing *** paper proposes a communication task allocation algorithm based on deep reinforcement learning for vehicle-to-pedestrian communication scenarios in edge *** trial and error learning of agent,the optimal spectrum and power can be determined for transmission without global information,so as to balance the communication between vehicle-to-pedestrian and *** results show that the agent can effectively improve vehicle-to-infrastructure communication rate as well as meeting the delay constraints on the vehicle-to-pedestrian link.

关键词： Reinforcement learning Edge computing Beyond 5G Vehicle-to-pedestrian

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Superiority:China Mobile in the competition

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The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 117-122页

作者： FU Si-bao lv Ting-jie School of Economies and Management Beijing University of Posts andTelecommunications Beijing 100876 China

The market share between China Mobile and China Unicom has stabilized since 2002. It is found that China Mobile has the superiority in the competition, for example, the scissors movement between its revenue and cost indicates that it has a strong profit generating ability and there is enough room for it to reduce the price. The ratio between its price （marginal income） and marginal cost indicates that there is a very distant limit for it to reduce the price. Its demand is obviously flexible with the price, but it does not use the price weapon abundantly. The reason for the stabilization of the market is that China Mobile withdrew from the competition.

关键词： China Mobile superiority scissor movement between the revenue and cost convergent of the ratio between price and marginal cost elasticity restraint.

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Heteroepitaxial growth of Au@Pd core–shell nanocrystals with intrinsic chiral surfaces for enantiomeric recognition

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Rare Metals 2024年第1期43卷 225-235页

作者： Feng-Xia Wu Feng-Hua Li Xia-Li lv Qi-Xian Zhang Guo-bao Xu Wen-Xin Niu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shaoxing Institute of Technology Shanghai UniversityShaoxing 312000China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Shanghai UniversityShanghai 200436China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314113China University of Chinese Academy of Sciences Beijing 100039China

Noble metal surfaces with intrinsic chirality serve as an ideal candidate for investigating enantioselective chemistry due to their superior chemical durability and high catalytic ***,significant advance has been made in synthesizing metal nanocrystals with intrinsic ***,the majority reports are limited to ***,through a heteroepitaxial growth strategy,the synthesis of metal nanocrystals with intrinsic chirality to palladium was extended for the first time and their application in enantioselective recognition was *** heteroepitaxial growth strategy allows for transferring the chirality of homochiral Au nanocrystals to Au@Pd core–shell *** employing the chiral Au@Pd nanocrystals as enantiomeric recognizing elements,a series of electrochemical sensors for chiral discrimination were *** optimal conditions,the peak potential between D-dihydroxyphenylalanine(D-DOPA)and L-dihydroxyphenylalanine(L-DOPA)is about 80 m V,and the peak current of D-DOPA is 2 times as much as that of L-DOPA,which enables the determination of the enantiomeric excess(EE,%)of ***,this report not only introduces a heteroepitaxial growth strategy to synthesize metal nanocrystals with intrinsic chirality,but also demonstrates the superior capability of integrating intrinsic chirality and catalytic properties into metal nanocrystals for chiral recognition.

关键词： Core–shell nanostructures Chirality transfer Electrochemical sensors Chiral recognition Chiroplasmonics

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