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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

Cardiovascular complications associated with spinal cord injury

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Journal of Acute Disease 2018年第4期7卷 139-144页

作者： Roberto Fabio Calvo-Infante Alexis Narvaez-Rojas Huber Padilla-zambrano Samer S.Hoz Amit Agrawal luis Rafael Moscote-Salazar University of Cartagena Cartagena de IndiasColombia Universidad Nacional Autonoma de Nicaragua Nicaragua Neurosurgeon Department of NeurosurgeryNeurosurgery teaching Hospital-BaghdadIraq Department of Neurosurgery Narayna Medical College HospitalChinthareddypalemNellore-524003Andhra PradeshIndia Neurosurgery-Critical Care Cartagena Neurotrauma Research GroupUniversidad de CartagenaCartagena de IndiasColombia

Spinal cord injury can lead to important functional, psychological and social sequelae. Despite the progress in medicine and greater understanding of the pathophysiological events associated with a traumatic spinal cord injury, spinal cord injury is still associated with a high morbidity and mortality. The involvement of the autonomic nervous system has implications in acute and chronic stages of the injured spinal cord patients. The most frequent cardiovascular complications in the acute phase of the traumatic spinal lesions are bradyarrhythmia, hypotension, increased vasovagal reflexes, ventricular and supraventricular ectopic beats, venous stasis, and vasodilation. In the chronic phase, we find orthostatic hypotension, alteration of the arterial pressure and the regulation of the body temperature as well as alteration of the blood volume. The knowledge of the cardiovascular alterations is of vital importance for the management and rehabilitation of the patients with spinal cord injury. In this article, we present a critical review of medical literature.

关键词： Complications Spinal cord trauma Spinal cord

从水产养殖目标到真实的社会和生态影响:评在墨西哥中部农村引进鲤鱼的功过

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AMBIO－人类环境杂志 2003年第4期32卷 252-257页

作者： Mбnica Tapia luis zambrano 李佩珍牛津大学国立墨西哥自治大学

水产养殖一直被认勾是贫穷国家农村地区居民获取食物/蛋白质的解决办法。它主要基于外来品种。一旦引进就会改变本地区系的动力学。水产养殖不仅改变淡水系统的生态,而且也导致社会关系的变化。到现在为止,水产养殖计划还没有充分地加... 详细信息

水产养殖一直被认勾是贫穷国家农村地区居民获取食物/蛋白质的解决办法。它主要基于外来品种。一旦引进就会改变本地区系的动力学。水产养殖不仅改变淡水系统的生态,而且也导致社会关系的变化。到现在为止,水产养殖计划还没有充分地加以分析和探究。我们利用墨西哥中部一个城市的案例做分析,对农村地区在浅水池塘养殖鲤鱼对生态产生的影响和当地的社会效益作了评估。我们采用'环境权利'法,研定结果表明:①养殖鲤鱼增加了水的浑浊度,减少了本地鱼品种,减少穷人捕捞本地鱼的机会;②水产养殖主要对池塘主有利而非对穷苦的农民有利。主要原因是捕捞权利的变化引起的。我们的论是:假如想要降低对生态产生的负面影响以及改善农村地区人们的生活条件应重新审议水产养殖的政策目标和对收益的假设。

关键词：水产养殖社会影响生态影响墨西哥中部农村鲤鱼引进

Cranio-cervical bone hyperpneumatization: An overview and illustrative case

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Journal of Acute Disease 2018年第4期7卷 145-148页

作者： Mohammed Maan AbdulAzeez Padilla-zambrano Huber Salima B.Alsaadi Cabreras-Nanclares B.Vladimir luis Rafael Moscote Salazar Samer S.Hoz College of Medicine Baghdad UniversityBaghdadIraq College of Medicine University of CartagenaCartagena de IndiasColombia Neuroradiology Department Neurosurgery Teaching HospitalBaghdadIraq Department of Neurosurgery Red-Latino-Colombia Neurosurgery Department Neurosurgery Teaching HospitalBaghdadIraq

The pneumatization of regions such as the apex of the temporal crag, the mastoid cells and the perilaberytic region is considered physiological in adults. The process of craniocervical pneumatization in unhealthy adults derives from a dysfunction at the level of the eustachian tube, which provides a valve effect causing an increase in pressure at the level of the middle ear, forcing the entry of air into the dome of the skull through the opening of the occipitomastoidal suture. The process of standard pneumatization of the temporal bones, begins in the final weeks preceding birth, characterized by a decrease in the embryonic mesenchyme at the antrum level and progresses through childhood until adolescence, when the stone portion at the level of the rock is pneumatized;Normal variants have been reported, such as pneumatization that extends from the temporal scale to behind the sigmoid sinus. With regard to the process of hyperneumatization, several etiologies have been proposed that a congenital process versus an acquired process to develop this condition should be compared. The present illustrative case is a seventy-three years old male presented to the outpatient clinic with chronic recurrent occipital headache, already investigated by general practitioner for elevated blood pressure which was excluded. We had checked him to exclude the cervical spinal origin of the occipital headache which was then excluded too. This case scenario demonstrates the debate about how to deal with such cases and thus the review will bring the attention of those who take care of such radiological findings to keep in mind the possible causes and complications according to the reported cases till now. We concluded that the hyperpneumatization of the craniocervical junction is an uncommon radiological finding that is usually asymptomatic although it can entail serious complications in some instances, especially when it enlarges progressively, which may be due to an acquired process. Thus,

关键词： Craniocervical bone Hyperpneumatization of cranial bones

Hyponatremia in the acute phase of spinal cord trauma: Review

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Journal of Acute Disease 2018年第3期7卷 103-107页

作者： luis Rafael Moscote Salazar Amit Agrawal Guru Dutta Satyarthee Huber S.Padilla-zambrano Boris Vladimir Cabrera-Nanclares Romario Mendoza-Flórez Samer Hoz Alexis Narvaez-Rojas Universidad de Cartagena Cartagena de IndiasColombia Department of Neurosurgery Narayna Medical College HospitalChinthareddypalemNellore-524003Andhra PradeshIndia All India Institute of Medical Sciences New DelhiIndia School of Medicine.Centro de Investigaciones Biomédicas(CIB).Cartagena Neurotrauma Research Group research line.Faculty of Medicine-University of Cartagena CartagenaColombia Neurosurgery Teaching Hospital BaghdadIraq Universidad Nacional Autonoma de Managua Nicaragua

Hyponatremia is a common electrolyte disturbance usually observed in neurosurgical patients undergoing surgical management of traumatic, as well as, nontraumatic intracranial pathology. The spinal cord trauma is also associated with occasional development of such hyponatremia;it usually occurs within the first two-weeks of the injury. Hyponatremia can lead to alterations of consciousness, convulsions, coma, cardiac arrhythmias and on rare occasions, death. Authors present a practical oriented review of the literature.

关键词： Hyponatremia Serum sodium Spinal cord trauma Neurotrauma Injury

Pharmacological potential of acetazolamide in traumatic intracranial hypertension

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Journal of Acute Disease 2018年第4期7卷 149-151页

作者： López-Cepeda Daniela Ramos-Villegas Yancarlos Padilla-zambrano Huber S. Andrade-López Andrea Quintana-Pájaro Loraine Corrales-Santander Hugo Samer S.Hoz luis Rafael Moscote-Salazar 无 University of Cartagena Cartagena de IndiasBolivarColombia Center for Biomedical Research Faculty of Medicine-University of CartagenaCartagena Colombia Cartagena Neurotrauma Research Group Universidad de CartagenaColombia Coordinator Center for Biomedical Research(CIB) Faculty of Medicine-University of CartagenaCartagena Colombia Medicine Program-Rafael Nú?ez University Corporation CartagenaColombia Specialist in Neurosurgery Faculty of Medicine-University of CartagenaCartagena de IndiasBolívarColombia Department of Neurosurgery Neurosurgery teaching Hospital-BaghdadIraq

Traumatic brain injuries are an important cause of morbidity and mortality around the world. These types of lesions are often associated with increased intracranial pressure and cerebral edema, proper management of this can reduce tissue damage of the brain and improve brain perfusion. The use of acetazolamide is not indicated in guidelines for the management of intracranial hypertension, which is used to a great extent for the management of idiopathic intracranial hypertension. However, it is not yet known in the management of traumatic intracranial hypertension.

关键词： Brain injuries Intracranial hypertension Acetazolamide

A single subcutaneous dose of tramadol for mild to moderate musculoskeletal trauma in the emergency department

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World Journal of Emergency Medicine 2014年第4期5卷 275-278页

作者： Alejandro Cardozo Carlos Silva luis Dominguez Beatriz Botero Paulo zambrano Jose Bare?o Emergency Department Clinica Las Vegas Epidemiology Department Universidad CES

BACKGROUND: Mild to moderate musculoskeletal trauma is a common cause for an emergency room visit, and frequent pain is one of the cardinal symptoms of consultation. The objective of this study is to assess the perception of a single subcutaneous dose of 50 mg tramadol for pain management in patients with mild to moderate musculoskeletal trauma, likewise to appraise the perception of pain by subcutaneous ***: A total of 77 patients, who met inclusion criteria, received a single subcutaneous dose of tramadol. Pain control was evaluated based on the verbal numerical pain scale(0–10) at baseline, 20 and 60 minutes; similarly, pain perception was evaluated secondary to subcutaneous injection of the ***: On admission, the average pain perceived by patients was 8; twenty minutes later, 89% of the patients reported fi ve or less, and after sixty minutes, 94% had three or less on the verbal numerical pain scale. Of the patients, 88% reported pain perception by verbal numeric scale of 3 or less by injection of the drug, and 6.5% required a second analgesic for pain control. Two events with drug administration(soft tissue infection and mild abdominal rectus injection) were ***: We conclude that a single subcutaneous dose of tramadol is a safe and effective option for the management of patients with mild to moderate pain and musculoskeletal disease in the emergency department.

关键词： Tramadol Analgesic routes Subcutaneous Acute pain Emergency department

Fagus sylvatica and Quercus pyrenaica:Two neighbors with few things in common

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Forest Ecosystems 2023年第2期10卷 162-175页

作者： Sergio de Tomás Marín Jesús Rodríguez-Calcerrada Salvador Arenas-Castro Iván Prieto Guillermo González luis Gil Enrique G.de la Riva Department of Ecology Brandenburgische Technische Universität Cottbus-SenftenbergKonrad-Wachsmann-Allee 603046CottbusGermany Forest Genetics and Ecophysiology Research Group School of Forestry EngineeringUniversidad Politécnica de MadridMadridSpain Area of Ecology Botany DepartmentEcology and Plant PhysiologyFaculty of SciencesUniversidad de CórdobaCórdobaSpain Ecology Department Faculty of Biology and Environmental SciencesUniversidad de LeónLeónSpain

Background:The Iberian Peninsula comprises one of the largest boundaries between Mediterranean and Eurosiberian vegetation,known as sub-Mediterranean *** ecotone hosts many unique plant species and communities and constitutes the low-latitude(warm)margin of numerous central European species which co-occur with Mediterranean *** of the main species found in this region are the Eurosiberian European beech(Fagus sylvatica L.)and the Mediterranean Pyrenean oak(Quercus pyrenaica Willd.).It remains unclear how the different physiological and adaptive strategies of these two species reflect their niche partitioning within a subMediterranean community and to what extent phenotypic variation(intraspecific variability)is driving niche partitioning across Eurosiberian and Mediterranean ***:We quantified functional niche partitioning,based on the n-dimensional hypervolume to nine traits related to resource acquisition strategies(leaf,stem and root)plus relative growth rate as an additional wholeplant trait,and the environmental niche similarity between Pyrenean oak and European ***,we analyzed the degree of phenotypic variation of both target species and its relationship with relative growth rates(RGR)and environmental *** recruitment was measured for both target species as a proxy for the average ***:Species’functional space was highly segregated(13.09%overlap),mainly due to differences in niche breadth(59.7%)rather than niche replacement(25.6%),and beech showed higher trait variability,i.e.,had larger functional ***,both species shared the environmental space,i.e.,environmental niches were *** plant traits were not related to abiotic variables or RGR,neither did RGR to plant ***:Both target species share similar environmental space,however,show notably different functional resource-use strategies,promoting a high complementarity that contributes to maintaining a high functiona

关键词： Environmental niche European beech Forest dynamics Functional niche Hypervolume Pyrenean oak Species coexistence Sub-Mediterranean community

Evolution of Pre-Columbian Metallurgy from the North of Peru Studied with a Portable Non-invasive Equipment Using Energy-Dispersive X-Ray Fluorescence

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材料科学与工程（中英文B版） 2011年第1期1卷 48-81页

作者： Roberto Cesareo Angel Bustamante D Julio Fabian S Sandra zambrano A Walter Alva luis Chero del Carmen Espinoza C Rosendo Rodriguez R Marco Seclen F Fidel Gutierrez V E.B. Ldvano Gonzales A. Marcia A. Rizzutto Enrico Poli Cristiane Calza Marcelino dos Anjos Ricardo T. Lopes Giovanni E. Gigante Gabriel M. Ingo Cristina Riccucci Carlos Elera Izumi Shimada Victor Curay Castillo G and Fabio Lopes Dipartimento di Matematica e Fisica Universith di Sassari Sassari Italy Universidad Nacional Mayor de San Marcos Lima Peri4 Museo ＂Tumbas Reales de Sip6n ＂ Lambayeque Perlt Instituto de Fisica Universidade de S6o Paulo SP Brasil Asociaci6n cultural e Museo Enrico Poli Lima Peru COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Dipartimento di Energetica Universith di Roma ＂La Sapienza ＂ Rome Italy lstituto Studio dei Materiali Nanostrutturati-CNR Area Ricerca RM1-Montelibretti Rome Italy Museo de Sic6n Ferrahqfe Perit Istituto Nacional de Cultura Piura Peru Universidade Estadual de Londrina Londrina PR Brasil

On the north coast of present-day Peru, between the Andes and the Pacific Ocean, prospered approximately between 1000 BC and 1375 AD, several relevant cultures: Chavín (1000-200 BC), Vicús and Frías (200 BC - 300 AD), Moche (400 BC-700 AD), Sicán (700-1375 AD). These cultures are interconnected and characterized by a high metallurgical ability, demonstrated by the presence of beautiful artifacts on gold, silver and copper alloys. More than hundred metal artefacts from these cultures were analyzed with a portable equipment which uses the non-destructive and non-invasive technique of energy-dispersive X-ray fluorescence (EDXRF). Following objects were analyzed: (1) gold, silver and copper objects from the Chavín culture (Museo Municipal of Piura and and Museo Enrico Poli in Lima); (2) gold and silver objects from the Vicús and Frías cultures (Museo Municipal of Piura); (3) gold, silver and copper objects from the Moche culture ("Museo Tumbas Reales de Sipán", "Museo de Sitio de Huaca Rajada" in Lambayeque and Museo Enrico Poli in Lima); (4) gold, silver and copper objects from the Sicán culture (Museum of Sicán, Ferra?afe). Portable equipments were employed, mainly composed of a small size X-ray tube and a thermoelectrically cooled, small size, Si-PIN or Si-drift X-ray detectors. The main characteristics of the EDXRF-technique is of being non destructive and multi-elemental. Standard samples of gold and silver alloys were employed for calibration and quantitative analysis. The aims of this campaign of analysis were: (1) to analyze a large number of objects; (2) to differentiate gold, gilded copper and tumbaga (this last being a poor gold alloy enriched at the surface by depletion gilding); (3) to correlate, when possible, composition of analyzed alloys to the specific culture; (4) to determine a possible evolution of metallurgy; (5) to better determine characteristics and beginning time of tumbaga production. It was determined that the analyzed artefacts are composed

关键词： X射线荧光技术能量色散侵入性冶金鲁北设备使用便携式哥伦布