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Association between Helicobacter pylori infection,mismatch repair,HeR2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo luis A Bernabe Joselyn sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri eloy Ruiz Juvenal sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro ebert Poquioma Raul Alatrista Claudio J Flores luis Taxa Faculty of Health sciences Universidad Cientifica del SurLima 15038Peru GeCO PeRU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HeR2-status and *** infection and their association with TIL levels in *** samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(sT)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HeR2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HeR2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while sT-TIL with grade-1(Pestinal-histology(Pecurrence(P=0.003).dMMR was associated with high TIL levels in the sT(P=0.019)and IB(P=0.01)compartments,and sTCD3(P=0.049)and sT-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and sT compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in sT)and high IT-CD3(P=0.021),sT-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUsION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HeR2 Mismatch repair

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Impact of sTAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-sosa Juan JoséMontesinos-Montesinos Mauricio salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(sTATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating sTAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using sTAT ***,we analyze the impact of different sTATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila luis O.soto-Rojas David Reyes-Corona Lourdes escobedo Minerva Maldonado-Berny Me Gutierrez-Castillo Armando J.espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais e.Valenzuela-Arzeta Claudia Luna-Herrera Francisco e.Lopez-salas Jaime santoyo-salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la educación y Desarrollo y la Investigación Científica de Iztacala(Red MeDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and s100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of sport and Health science 2024年第3期13卷 419-427页

作者： Andres Marmol-Perez Jose J.Gil-Cosano esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente Martinez-Vizcaino Jonatan R.Ruiz luis Gracia-Marco Department of Physical education and sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBeROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±sD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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Correlation between Intestinal Health and Coccidiosis Prevalence in Broilers during Different seasons of the Year in Brazil from 2012 to 2018

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Food and Nutrition sciences 2024年第3期15卷 179-198页

作者： Fabio luis Gazoni Gabriela Miotto Galli Marcel Manente Boiago Lenita Moura stefani Aline Zampar Marco A. Juárez-estrada Guillermo Tellez-Isaias Aleksandro s. da silva Animal Health and Reproduction Veterinary Medicine Graduate Program Federal University of Santa Maria (UFSM) Santa Maria Brazil Animal science Graduate Program Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Animal science Graduate Program Santa Catarina State University (UDESC) Chapecó Brazil Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Ciudad Universitaria Ciudad de Mexico Mexico Department of Poultry science Division of Agriculture University of Arkansas Fayetteville AR USA

Coccidiosis is a disease caused by intracellular protozoan parasites, specifically belonging to the genus eimeria. These parasites target the gastrointestinal tract in different types of hosts, causing sores in the intestinal lining. The presence of these lesions reduces the animal’s ability to digest and absorb nutrients, significantly impacting their overall performance. The current study aimed to explore the potential correlation between seasonal variations and the incidence of eimeria spp-induced lesions in broiler chickens’ gastrointestinal tracts in Brazil from 2012 to 2018. A total of 8,607 broiler chickens, aged 14 to 42 days, were sampled from 103 poultry integrated companies in Brazil to conduct intestinal health examinations. The sampling process involved selecting 3 to 6 chickens from each poultry house for examination. The assessment included various abnormalities such as shedding of intestinal cells and excessive fluid and mucus presence, thickening and tension of the intestines, food movement, roughened mucosal surface resembling a Turkish towel in the small intestine, tissue death, duodenal inflammation, intestinal inflammation, gizzard erosion, presence of worms and bedding material, and ingestion of mealworms. During the seasons, winter exhibited the highest average occurrence of eimeria maxima microorganisms at 52.83%, with e. acervulina following closely at 26.42% in second place. In spring, e. maxima had an occurrence of 11.31%, while in fall, e. tenella had the lowest occurrence at 6.74%. When analyzing the seasonal occurrence of eimeria, it was observed that e. maxima micro was more common during winter compared to summer (P = 0.0491). However, no discernible variation was observed in the occurrence of the remaining species across different seasons. Research findings suggest that subclinical coccidiosis is most prevalent during the winter season in Brazil. Likewise, clinical disease caused by e. acervulina is also prevalent during this time. I

关键词： eimeria epidemiology Intestinal Pathology Broiler Chickens Brazil

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas sergio Cuenca-Lopez eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GeNYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery service.University Hospital Clínico san Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(sNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Revealing the complexity of vampire bat rabies "spillover transmission"

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Infectious Diseases of Poverty 2023年第1期12卷 102-110页

作者： luis e.escobar Andres Velasco-Villa Panayampalli s.satheshkumar Yoshinori Nakazawa Paige Van de Vuurst Department of Fish and Wildlife Conservation Virginia TechBlacksburgVAUSA Virginia Tech Graduate school Translational BiologyMedicineand Health ProgramBlacksburgVAUSA Global Change Center Virginia TechBlacksburgVAUSA Center for emerging Zoonotic and Arthropod‑Borne Pathogens Virginia TechBlacksburgVAUSA Facultad de Ciencias Agropecuarias Universidad de La SalleBogotáColombia Poxvirus and Rabies Branch Centers for Disease Control and Prevention1600 Clifton Rd.NEAtlantaGA 30333USA

Background The term virus'spillover’embodies a highly complex phenomenon and is often used to refer to viral transmission from a primary reservoir host to a new,naïve yet susceptible and permissive host *** transmission can result in a virus becoming pathogenic,causing disease and death to the new host if successful infection and transmission takes *** text The scientific literature across diverse disciplines has used the terms virus spillover,spillover transmission,cross-species transmission,and host shift almost indistinctly to imply the complex process of establishment of a virus from an original host(source/donor)to a naïve host(recipient),which have close or distant taxonomic or evolutionary *** transmission may result in unsuccessful onward transmission,if the virus dies off before ***,successful viral establishment in the new host can occur if subsequent secondary transmission among individuals of the same novel species and among other sympatric susceptible species *** such,virus spillover transmission is a common yet highly complex phenomenon that encompasses multiple subtle stages that can be deconstructed to be studied separately to better understand the drivers of disease *** virus(RABV)is a well-documented viral pathogen which still inflicts heavy impact on humans,companion animals,wildlife,and livestock throughout Latin America due substantial spatial temporal and ecological—natural and expansional—overlap with several virus reservoir ***,the rabies disease system represents a robust avenue through which the drivers and uncertainties surrounding spillover transmission can be unravel at its different subtle stages to better understand how they may be affected by coarse,medium,and fine scale *** The continued study of viral spillover transmission necessitates the elucidation of its complexities to better assess the cross-scale impacts of ecological force

关键词： Bat-borne diseases Rabies spillover Transmission

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species,growth form,and biogeographic diversity of summit vegetation along an elevation gradient in the tropical Andes:a baseline for climate change monitoring

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Journal of Mountain science 2022年第12期19卷 3441-3457页

作者： luis D.LLAMBI luis e.GAMeZ Roxibell PeLAYO Carmen J.AZOCAR Jesus e.TORRes Nelson J.MARQUeZ Monica B.BeRDUGO Francisco CUesTA Lirey A.RAMIReZ Institute of environmental and ecological sciences(ICAe) University of Los AndesMérida5101Venezuela Consorcium for susteinable Development of the Andean eco-Region(CONDesAN) Calle Germán Alemán E12-123Quito170504Ecuador Laboratory of Dendrology Environmental and Forestry FacultyUniversity of Los AndesMérida5101Venezuela ecological Plant Geography Faculty of GeographyUniv.of MarburgDeutschhausstrasse 10Marburg35032Germany Group of Biodiversity Environment and Health Research(BIOMAS)University of Las AméricasQuito170125Ecuador

Tropical alpine ecosystems exhibit outstanding plant diversity and endemism while being particularly sensitive to the impacts of climate *** understanding spatiotemporal changes in plant species composition,richness and community structure along tropical alpine altitudinal gradients is of primary importance,both the functional and historical/biogeographic dimensions of vegetation diversity remain largely *** used Generalized Linear Models and multivariate analyses to assess changes in species,growth forms,and biogeographic groups richness and abundance,in response to habitat variables along an elevation gradient in seven summits(3800 to 4600 m asl)in the Venezuelan Andes,studied using the standardized approach of the GLORIA-Andes monitoring *** habitat variables assessed were soil temperature(-10 cm),soil organic matter,slope inclination,and substrate *** found 113 species,representing72 genera,32 families,13 growth forms,and seven biogeographic origins,that included 25%of endemic *** observed richer vegetation,both in terms of species and growth forms,in summits with higher soil temperatures and higher sOM content,as well as higher biogeographic origin richness with increasing soil *** presence of holarctic elements increased toward higher elevations,while the occurrence of austral antarctic elements increased toward lower *** results indicate that biogeographic and functional approaches to vegetation diversity capture well the effect of abiotic filtering on community structuring in these tropical alpine *** findings constitute an important baseline for monitoring vegetation dynamics linked to climate change in the Venezuelan Andes by highlighting the functional and historical perspective on vegetation analyses,in contrast with more traditional approaches,based only on taxonomic species diversity.

关键词： Alpine vegetation Biogeography elevation gradient Functional diversity Páramo soil organic matter Temperature Tropical Andes

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Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease

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stroke & Vascular Neurology 2022年第3期7卷 251-257页

作者： Valentina Nardi John C Benson Anthony s Larson Waleed Brinjikji Luca saba Fredric B Meyer Giuseppe Lanzino Amir Lerman luis e savastano Department of Cardiovascular Diseases Mayo ClinicRochesterMinnesotaUSA Radiology Mayo ClinicRochesterMinnesotaUSA Radiology Azienda Ospedaliero UniversitariaCagliariItaly Neurosurgery Mayo ClinicRochesterMinnesotaUSA

Object We sought to determine the safety and efficacy in secondary stroke prevention of carotid endarterectomy(CeA)in patients with symptomatic non-stenotic carotid artery disease(syNC).Methods This was a single-centre retrospective case *** patients who underwent CeA for unilateral anterior circulation cerebrovascular events with ipsilateralstenosis from 2002 to 2020 were *** hallmarks including the degree of luminal stenosis and the presence of various vulnerable plaque characteristics(eg,intraplaque haemorrhage(IPH)on MR angiography,ulceration or low-density plaque on CT angiography)were *** presence of vulnerable plaque characteristics was compared between arteries ipsilateral to the ischaemic event and contralateral *** prevalence of perioperative/intraoperative complications,as well as recurrent ischaemic events at follow-up was *** Thirty-two patients were included in the analysis,of which 25.0%were *** arteries ipsilateral to an ischaemic event had a significantly higher prevalence of IPH when compared with contralateral arteries(80.0%vs 0.0%;pere were no intraoperative *** patient(3.1%)developed symptoms of transient ipsilateral ischaemia 1 day following CeA which resolved without *** a median follow-up of 18.0 months(IQR 5.0-36.0),only one patient(3.1%)experienced a transient neurologic deficit with complete resolution(annualised rate of recurrent stroke after CeA of 1.5%for a total follow-up of 788 patient-months following CeA).All other patients(31/32,96.9%)were free of recurrent ischaemic *** CeA appears to be safe and well-tolerated in patients with *** studies with larger cohorts and longer follow-up intervals are needed in order to determine the role of CeA in this patient population.

关键词： patients carotid prevention

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environmental geochemistry:Introduction

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Geoscience Frontiers 2022年第1期13卷 374-375页

作者： luis F.O.silva Marcos L.s.Oliveira Department of Civil and environmental.Universidad de la Costa CUCCalle 58#55-66BarranquillaAtlánticoColombia Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru

Assessing the physical,geographic,chemical,and geological aspects are important to understand environmental impacts as well as health concerns in view of building a more sustainable planet with circular economies that would last for the foreseeable *** the recent years,the significance of incorporating ecosystem,anthropogenic activities,and climate has fortified from being an academic concern(e.g.,WeF,2011)into a broadly societal concern as the forecasted realities of environmental deterioration and global climate change come to pass.

关键词： geochemistry climate planet

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