Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family
作者机构:GENYOCentre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of BiochemistryMolecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics UnitInstitute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San CecilioGranadaGranadaSpain Urology DepartmentUniversity Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology DepartmentFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain IbsBiosanitary Research InstituteGranadaGranadaSpain
出 版 物:《Cancer Communications》 (癌症通讯(英文))
年 卷 期:2024年第44卷第3期
页 面:443-447页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:The study was funded by the Ministerio de Ciencia e Innovación,Spain(No.PID2019-110512RA-I00/MCIN/AEI/10.13039/501100011033) Fundación para la Investigación en Urología(FIU)(No.G80445661)
摘 要:Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.