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Innovative Analysis Ready data(ARd)product and process requirements,software system design,algorithms and implementation at the midstream as necessary-but-notsuffcient precondition of the downstream in a new notion of Space Economy 4.0-Part 1:Problem background in Artificial General Intelligence(AGI)

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Big Earth data 2023年第3期7卷 455-693页

作者： Andrea Baraldi luca d.sapia dirk Tiede Martin Sudmanns Hannah L.Augustin Stefan Lang Spatial Services GmbH SalzburgAustria CGI Italy FrascatiItaly department of Geoinformatics-Z_GIS University of SalzburgSalzburgAustria

Aiming at the convergence between Earth observation(EO)Big data and Artificial General Intelligence(AGI),this two-part paper identifies an innovative,but realistic EO optical sensory imagederived semantics-enriched Analysis Ready data(ARd)productpair and process gold standard as linchpin for success of a new notion of Space Economy *** be implemented in operational mode at the space segment and/or midstream segment by both public and private EO big data providers,it is regarded as necessarybut-not-sufficient“horizontal”(enabling)precondition for:(I)Transforming existing EO big raster-based data cubes at the midstream segment,typically affected by the so-called data-rich information-poor syndrome,into a new generation of semanticsenabled EO big raster-based numerical data and vector-based categorical(symbolic,semi-symbolic or subsymbolic)information cube management systems,eligible for semantic content-based image retrieval and semantics-enabled information/knowledge discovery.(II)Boosting the downstream segment in the development of an ever-increasing ensemble of“vertical”(deep and narrow,user-specific and domain-dependent)value–adding information products and services,suitable for a potentially huge worldwide market of institutional and private end-users of space *** the sake of readability,this paper consists of two *** the present Part 1,first,background notions in the remote sensing metascience domain are critically revised for harmonization across the multidisciplinary domain of cognitive *** short,keyword“information”is disambiguated into the two complementary notions of quantitative/unequivocal information-as-thing and qualitative/equivocal/inherently ill-posed ***,buzzword“artificial intelligence”is disambiguated into the two better-constrained notions of Artificial Narrow Intelligence as part-without-inheritance-of ***,based on a betterdefined and better-understood vocabulary of multid

关键词： Artificial Narrow Intelligence big data cognitive science computer vision Earth observation essential climate variables Global Earth Observation System of(component)Systems inductive/deductive/hybrid inference Scene Classification Map Space Economy 4.0 radiometric corrections of optical imagery from atmospheric,topographic,adjacency and bidirectional reflectance distribution function effects semantic content-based image retrieval 2d spatial topology-preserving/retinotopic image mapping world ontology(synonym for conceptual/mental/perceptual model of the world)

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Well-Posedness of Stochastic Continuity Equations on Riemannian Manifolds

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 81-122页

作者： luca GALIMBERTI Kenneth H.KARLSEN department of Mathematical Sciences NTNU Norwegian University of Science and TechnologyN-7491 TrondheimNorway department of mathematics University of OsloP.O.Box 1053BlindernN-0316 OsloNorway

The authors analyze continuity equations with Stratonovich stochasticity,■ρ+divh[ρo(u(t,x)+∑_(i=1)^(N)a_(i)(x)w_(i)(t))]=0defined on a smooth closed Riemannian manifold M with metric *** velocity field u is perturbed by Gaussian noise terms Wi(t),:WN(t)driven by smooth spatially dependent vector fields a1(x),...,aN(x)on *** velocity u belongs to L_(t)^(1)W_(x)^(1,2)with divh u bounded in Lf,for p>d+2,where d is the dimension of M(they do not assume div_(h) u∈L_(t,x)^(∞)).For carefully chosen noise vector fields ai(and the number N of them),they show that the initial-value problem is well-posed in the class of weak L^(2) solutions,although the problem can be ill-posed in the deterministic case because of concentration *** proof of this“regularization by noise”result is based on a L^(2) estimate,which is obtained by a duality method,and a weak compactness argument.

关键词： Stochastic continuity equation Riemannian manifold Hyperbolic equa-tion Non-smooth velocity field Weak solution Existence Uniqueness

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Corneal collagen cross-linking in patients with keratoconus from the dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： Ciro Caruso luca d’Andrea Mario Troisi Michele Rinaldi Raffaele Piscopo Salvatore Troisi Ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual *** therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced *** keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe *** consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks *** aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment ***,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol dresden protocol lambert-beer law Bunsen-roscoe law

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Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

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Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO Martina dI FRANCESCO luca CESERACCIU Aiman ABU AMMAR Israel dVIR Thomas Lee MOORE Haytam KASEM Paolo dECUZZI Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy department of Chemistry and Industrial Chemistry University of GenovaGenoa 16146Italy Materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy department of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel department of Mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications,from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic ***,we assessed the tribological properties of a simulated synovial fluid enriched with non-spherical,poly lactic-co-glycolic acid(PLGA)microparticles(μPL)that have been previously demonstrated for the pharmacological management of osteoarthritis(OA).Three different μPL configurations were fabricated presenting a 20μm×20μm square base and a thickness of 5μm(thin,5H μPL),10μm(10H μPL),and 20μm(cubical,20H μPL).After extensive morphological and physicochemical characterizations,the apparent Young’s modulus of the μPL was quantified under compressive loading returning an average value of~6 kPa,independently of the particle ***,using a linear two-axis tribometer,the static(μ_(s))and dynamic(μ_(d))friction coefficients of the μPL-enriched simulated synovial fluid were determined in terms of particle configuration and concentration,varying from 0(fluid only)to 6×10^(5) μPL/*** particle morphology had a modest influence on friction,possibly because the μPL were fully squeezed between two mating surfaces by a 5.8 N normal load realizing boundary-like lubrication ***,friction was observed to depend on the dimensionless parameterW,defined as the ratio between the total volume of the μPL enriching the simulated synovial fluid and the volume of the fluid *** coefficients of friction were documented to grow withWreaching a plateau of μ_(s)~0.4 and μ_(d)~0.15,already at Ω~2×10^(-3).Future investigations will have to systematically analyze the effect of sliding velocity,normal load,and rigidity of the mating surfaces to elucidate in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

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Lower Continental Crusts Involved in the Alpine Orogeny:New Insight from the Santa Lucia Nappe Metasediments(Corsica,France)

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 904-920页

作者： Chiara FRASSI Maria dI ROSA luca PANdOLFI Michele MARRONI dipartimento di Scienze della Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto di Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to medium continental *** consists of composite basement affected by Permian granulite facies metamorphic conditions unconformably covered by a Late Cretaceous clastic sequence(Tomboni Conglomerate and Tralonca Flysch)affected by polyphase deformation and *** this work,we present a new reconstruction of the deformation events registered by the Tralonca Flysch during the Alpine *** d1 phase was testified by rare isoclinal *** d2 phase produced a continuous foliation and a map-scale sheath-fold with a top-to-W sense of *** d3 phase produced E-verging non-cylindrical folds and S3 crenulation cleavage that is not associated to metamorphic *** present the first temperature-pressure-deformation(P-T-d)path for the Tralonca Flysch,demonstrating that the Santa Lucia Nappe underwent accretion and then first stage exhumation in the Alpine wedge during the d1 phase with pressure and temperature peaks both occurred under blueschist metamorphic *** d2 phase occurred at lower pressure-temperature conditions during a second stage *** pressure-temperaturedeformation path is comparable with those of the Lower Units(i.e.,the subducted continental units of Alpine Corsica)suggesting a common geodynamic history.

关键词： blueschist-facies metamorphism P-T-d path Santa Lucia Nappe Corsica Alpine orogeny

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Effects of early postnatal gastric and colonic microbiota transplantation on piglet gut health

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Journal of Animal Science and Biotechnology 2024年第2期15卷 645-658页

作者： Christina Larsen Simone Margaard Offersen Anders Brunse Mattia Pirolo Soumya Kanti Kar luca Guadabassi Thomas Thymann department of Veterinary and Animal Science University of CopenhagenDyrlagevej 681870 Frederiksberg CDenmark Animal Nutrition Wageningen Livestock ResearchWageningen University&Research1 De Elst6708 WageningenThe Netherlands

Background diarrhea is a major cause of reduced growth and mortality in piglets during the suckling and weaning periods and poses a major threat to the global pig *** and gut dysbiosis may in part be prevented via improved early postnatal microbial colonization of the *** secure better postnatal gut colonization,we hypothesized that transplantation of colonic or gastric content from healthy donors to newborn recipients would prevent diarrhea in the recipients in the post-weaning *** objective was to examine the impact of transplanting colonic or gastric content on health and growth parameters and paraclinical parameters in recipient single-housed piglets exposed to a weaning transition and challenged with enterotoxigenic Escherichia coli(ETEC).Methods Seventy-two 1-day-old piglets were randomized to four groups:colonic microbiota transplantation(CMT,n=18),colonic content filtrate transplantation(CcFT,n=18),gastric microbiota transplantation(GMT,n=18),or saline(CON,n=18).Inoculations were given on d 2 and 3 of life,and all piglets were milk-fed until weaning(d 20)and shortly after challenged with ETEC(d 24).We assessed growth,diarrhea prevalence,ETEC concentration,organ weight,blood parameters,small intestinal morphology and histology,gut mucosal function,and microbiota composition and *** Episodes of diarrhea were seen in all groups during both the milk-and the solid-feeding phase,possibly due to stress associated with single ***,CcFT showed lower diarrhea prevalence on d 27,28,and 29 compared to CON(all Pd a lower ETEC prevalence on d 27(Pd a higher alpha diversity and a difference in beta diversity compared to CON(Pd other paraclinical endpoints were similar across *** In conclusion,only CcFT reduced ETEC-related post-weaning ***,the protective effect was marginal,suggesting that higher doses,more effective modalities of administration

关键词： Colonic content filtrate transplantation Colonic microbiota transplantation Gastric microbiota transplantation Gut microbiota Mucosa Neonatal Post-weaning diarrhea

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Minimally invasive surgical therapies(MISTs)for lower urinary tract symptoms(LUTS):promise or panacea?

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Asian Journal of Andrology 2024年第2期26卷 135-143页

作者： Gian Maria Busetto Andrea Checchia Marco Recchia Edoardo Tocci Ugo G Falagario Gennaro Annunziata Pasquale Annese Nicola d'Altilia Vito Mancini Matteo Ferro Felice Crocetto Octavian Sabin Tataru luca di Gianfrancesco Angelo Porreca Francesco del Giudice Ettore de Berardinis Carlo Bettocchi Luigi Cormio Giuseppe Carrieri University of Foggia Foggia 71122Italy department of Urology and Renal Transplantation Policlinico of FoggiaFoggia 71122Italy Urology Unit "G.Tatarlla"HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IE0)IRCcSMilan 20141Italy University of Naples Federico Il Naples 80126Italy G.E.Palade University of Medicine PharmacyScienceand Technology of Targu MuresTargu Mures 540142Romania department of Oncological Urology Veneto Institute of Oncology(IOv)IRccSPadua 35128Italy department of Maternal-Infant and Urological Sciences Sapienza Rome UniversityRoma 00161Italy Urology Unit "L.Bonomo"HospitalAndria 76123Italy

The increasing importance of treatment of lower urinary tract symptoms(LUTS),while avoiding side effects and maintaining sexual function,has allowed for the development of minimally invasive surgical therapies(MiSTs).Recently,the European Association of Urology guidelines reported a paradigm shift from the management of benign prostatic hyperplasia(BPH)to the management of nonneurogenic male *** aim of the present review was to evaluate the efficacy and safety of the most commonly used MisTs:ablative techniques such as aquablation,prostatic artery embolization,water vapor energy,and transperineal prostate laser ablation,and nonablative techniques such as prostatic urethral lift and temporarily implanted nitinol device(iTINd).MiSTs are becoming a new promise,even if clinical trials with longer follow-up are still *** of them are still under investigation and,to date,only a few options have been given as a recommendation for *** cannot be considered as standard of care and are not suitable for all *** and disadvantages should be underlined,without forgetting our objective:treatment of LUTS and re-treatment avoidance.

关键词： aquablation iTINd prostatic artery embolization prostatic urethral lift transperineal prostate laser ablation water vapor energy

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo donofrio Alessia Fischetti Georgios d Kotzalidis Giuseppe Marano Alessio Simonetti delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta domenico de Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria d'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria de Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero luca Lo Giudice Giulia Mastroeni Elisabetta Benini luca di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis luca Onori luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela de Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAd digestive disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUNd Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")ANd("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety depression

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Enhancing sensitivity of triple-negative breast cancer to dNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari dante Rotili Antonello Mai Alberto diana Michela Londero luca del Giacco Riccardo Masetti Alba di Leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly department of Biology and Biotechnologies“Charles darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly department of drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de luca Correa Lysleine Alves deus dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home dialysis Center and RenalClass Sao Paulo 01239-040Brazil department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(Hd) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in Hd patients,identification of possible risk factors related to the prothrombotic agent d-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher d-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six Hd patients volunteered for this study(all with a glomerular filtration rate of d of 50% arterial occlusion pressure during 50 min sessions of Hd(intradialytic exercise).RE repetitions included concentric and eccentric lifting phases(each lasting 2 s) and were supervised by a strength and conditioning ***:Several variables were associated with elevated levels of d-dimer,including higher blood glucose,citrate use,recent cardiovascular events,recent intercurrents,higher inflammatory status,catheter as vascular access,older patients(>70 years old),and Hd ***,RE+BFR significantly increases d-dimer after 4 *** with borderline baseline d-dimer levels(400-490 ng/mL) displayed increased risk of elevating d-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for Hd patients who wish to undergo RE+BFR.d-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

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