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云南省高校专利产出与科技创新能力分析

农业图书情报学刊 2017年第7期29卷 89-94页

作者：刘敏惠李春艳曹克玲陆峻波云南农业大学图书馆云南昆明650201 云南农业大学成人教育学院云南昆明650201

随着知识经济和经济全球化的发展,知识产权成为建设创新型国家的重要支撑。高校作为国家科技创新体系中的重要组成部分,每年的专利申请量和授权量逐年增加,成为衡量高校科研实力和创新能力的重要指标之一。文章以云南省22所高校专利产... 详细信息

随着知识经济和经济全球化的发展,知识产权成为建设创新型国家的重要支撑。高校作为国家科技创新体系中的重要组成部分,每年的专利申请量和授权量逐年增加,成为衡量高校科研实力和创新能力的重要指标之一。文章以云南省22所高校专利产出为研究对象,利用Soo PAT专利搜索引擎中的专利分析,对1985年《专利法》实施以来云南省本科院校申请的专利从专利数量、年代分布、类型及发明授权专利、合作申请机构、技术领域等方面进行统计,从量化角度对高校科技创新能力进行分析,并针对高校专利现状提出对策建议。

关键词：高校专利科技创新

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莱钢4#高炉长期休风恢复炉况操作实践

山东冶金 2022年第5期44卷 1-2页

作者：张均宾高正卢军波廖寻志吴新闯山东钢铁股份有限公司莱芜分公司炼铁厂生产技术室山东莱芜271104 山东钢铁股份有限公司莱芜分公司山东莱芜271104

山钢股份莱芜分公司炼铁厂4#高炉有效容积864 m^(3),因炉缸铁口区域炉皮开裂,利用环保限产机会休风57 h进行处理。通过休风前精心准备,进一步优化和完善休复风方案,加强休复风过程参数控制等手段,实现了8 h全风操作,达到了快速恢复炉况... 详细信息

山钢股份莱芜分公司炼铁厂4#高炉有效容积864 m^(3),因炉缸铁口区域炉皮开裂,利用环保限产机会休风57 h进行处理。通过休风前精心准备,进一步优化和完善休复风方案,加强休复风过程参数控制等手段,实现了8 h全风操作,达到了快速恢复炉况的目的。

关键词：高炉长期休风复风操作参数控制

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国内外优秀网球单打运动员的技战术特点分析

成都电子机械高等专科学校学报 2011年第2期14卷 37-42页

作者：周继和李溪程亮巴洪冰陆俊波成都体育学院运动医学系成都610041

本文运用文献资料法、录像分析法、数理统计法,对四大公开赛男女单打的部分比赛(决赛、半决赛及部分1/4赛)进行技战术统计和分析,总结分析了国内外优秀网球运动员的技战术运用特点。

关键词：网球优秀运动员技战术

当前农科院校成人高等教育招生面临的形势及对策——以云南农业大学为例

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云南农业大学学报（社会科学版） 2015年第6期9卷 83-86页

作者：袁绍杰周芳梅夏惠芸陆峻波云南农业大学职业与继续教育学院云南昆明650201

农科院校成人高等教育在"三农"问题和新农村建设的人才培养中有着重要的地位和作用。然而,当前其招生面临着严峻的形势和困难。通过外部和内部影响农科院校成人高等教育招生因素的分析,从利用互联网提高招生宣传效率,建立长效激励机制,... 详细信息

农科院校成人高等教育在"三农"问题和新农村建设的人才培养中有着重要的地位和作用。然而,当前其招生面临着严峻的形势和困难。通过外部和内部影响农科院校成人高等教育招生因素的分析,从利用互联网提高招生宣传效率,建立长效激励机制,争取政策支持,改革传统函授教学模式等方面提出了加速农科院校成人高等教育招生改革的对策建议。

关键词：成人高等教育招生农科院校发展对策

丙型肝炎病毒依赖于RNA的RNA聚合酶基因克隆与原核表达

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生物技术通讯 2000年第4期11卷 244-248页

作者：陈忠斌陆军波管伟王升启军事医学科学院放射医学研究所北京100850

丙型肝炎病毒 (HCV)依赖于RNA的RNA聚合酶 (RdRp)是参与病毒基因组RNA复制的一个关键蛋白因子 ,是研究抗HCV新型药物的重要靶标 ,获得纯化的RdRp产物是建立靶向RdRp药物高通量筛选体系和抗病毒药物研究的关键步骤。以HCV病毒基因组全长c... 详细信息

丙型肝炎病毒 (HCV)依赖于RNA的RNA聚合酶 (RdRp)是参与病毒基因组RNA复制的一个关键蛋白因子 ,是研究抗HCV新型药物的重要靶标 ,获得纯化的RdRp产物是建立靶向RdRp药物高通量筛选体系和抗病毒药物研究的关键步骤。以HCV病毒基因组全长cDNA质粒 (p90 HCVFL longpU)为模板 ,设计了特异性扩增RdRp的引物 ,通过CPR扩增获得编码RdRp的基因。将该基因克隆到T载体中 ,构建了重组质粒 ,通过克隆快速筛选和酶切分析筛选到含RdRp基因的阳性克隆(克隆号为 4 4 ) ,DNA序列分析证实 4 4号阳性克隆RdRp基因序列与cDNA质粒中的相应序列完全一致。将含RdRp基因的重组质粒 (44号 )用NheⅠ XhoⅠ双酶切 ,获得RdRp基因 ,将该基因连接到用NheⅠ XhoⅠ双酶切的原核表达载体pET2 8(a)中 ,构建了重组质粒pET2 8(a) NS5B ,用该重组质粒转化大肠杆菌BL2 1(DE3) ,经 1mmol LIPTG诱导 ,SDS PAGE分析 ,发现一条特异性蛋白带 ,相对分子质量约 6 6× 10 3 ,与预期的完全一致。HCVRdRp基因的克隆与表达为靶向RdRp的新型抗HCV药物研究。

关键词：丙型肝炎病毒 RNA聚合酶克隆表达

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

A novel evolutionary method for parameter-free MEMS structural design and its application in piezoresistive pressure sensors

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Microsystems & Nanoengineering 2023年第5期9卷 263-270页

作者： Qinggang Meng junbo Wang Deyong Chen Jian Chen Bo Xie Yulan lu State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of Sciences100190 BeijingChina School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of Sciences100049 BeijingChina

In this paper,a novel simulation-based evolutionary method is presented for designing parameter-free MEMS structures with maximum degrees of *** novel design method enabled semiautomatic structure evolution by weighing the attributes of each segment of the structure and yielded an optimal design after multiple *** proposed method was utilized to optimize the pressure-sensitive diaphragm of a piezoresistive pressure sensor(PPS).Finite element method(FEM)simulations revealed that,in comparison to conventional diaphragms without islands and with square islands,the optimized diaphragm increased the stress by 10%and 16%and reduced the nonlinearity by 57%and 77%,*** improvements demonstrate the value of this *** of the fabricated PPS revealed a high sensitivity of 8.8 mV V−1 MPa−1 and a low nonlinearity of 0.058%FS at 20°C,indicating excellent sensor performance.

关键词： parameter evolutionary nonlinearity

微酸性次氯酸电解水、臭氧和二氧化氯对桶装水中污染物铜绿假单胞菌的消毒效果及副产物的研究

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现代食品 2021年第5期6卷 209-211页

作者：陆俊波吴珍珍姚军余水红冯莉安庆市食品药品检验中心安徽安庆246000 安庆医药高等专科学校安徽安庆246052

目的:评价微酸性次氯酸电解水、臭氧及二氧化氯对桶装水污染物铜绿假单胞菌的消毒效果及副产物产生情况。方法:本项目采用试验模拟的方法,测定消毒效果并对消毒副产物三氯甲烷、四氯化碳残留量进行监测。结果:浓度为50 ppm的次氯酸电解... 详细信息

目的:评价微酸性次氯酸电解水、臭氧及二氧化氯对桶装水污染物铜绿假单胞菌的消毒效果及副产物产生情况。方法:本项目采用试验模拟的方法,测定消毒效果并对消毒副产物三氯甲烷、四氯化碳残留量进行监测。结果:浓度为50 ppm的次氯酸电解水在被稀释2 200倍以下均有杀菌作用且无副产物残留;二氧化氯有效氯含量在0.16 mg·L^(-1)以上均有杀菌效果且副产物不超标;臭氧浓度低于0.15 mg·L^(-1)时,消毒效果不明显。高于0.65 mg·L^(-1),有出现溴酸盐超标现象。结论:对桶装水的消毒要确保次氯酸电解水稀释倍数要低于2 200倍;二氧化氯中有效氯含量要控制在0.16 mg·L^(-1)以上;臭氧的杀菌浓度要控制在0.15~0.65 mg·L^(-1)。

关键词：桶装水微酸性次氯酸电解水二氧化氯铜绿假单胞菌三氯甲烷

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction